News
25/6/2013

UPF: Identified the brain mechanism that alters motor coordination for chronic consumption of cannabis

UPF: Identified the brain mechanism that alters motor coordination for chronic consumption of cannabis


News from UPF


A team from the Laboratory of Neuropharmacology at the UPF has discovered the brain mechanism responsible for the impaired motor coordination associated with chronic exposure to the main psychoactive component of cannabis, delta9-tetrahydrocannabinol (THC).

In this experimental study, published in June 24 in the online edition of The Journal of Clinical Investigation, UPF researchers Laura Cutanda, Arnau Busquets, Emma Puighermanal, Maria Gomis, Rafael Maldonado and Andres Ozaita, together with colleagues from the University Pablo de Olavide in Seville have shown that mice exposed to THC developed a deficit in the function of the cerebellum, a brain area critical for the regulation of the coordination of successive chained movements and for motor learning.

More information:

UPF news (Catalan)

 

Reference:

Laura Cutando, Arnau Busquets-Garcia, Emma Puighermanal, Maria Gomis-González, José María Delgado-García, Agnès Gruart, Rafael Maldonado y Andrés Ozaita. "Microglial activations underlies cerebellar deficits produced by repeated cannabis exposure". The Journal of Clinical Investigation. 24/6/2013. doi:10.1172/JCI67569.