News
19/7/2013

CRG: Rapid whole-genome sequencing dramatically reduces time taken to diagnose XDR Tuberculosis

CRG: Rapid whole-genome sequencing dramatically reduces time taken to diagnose XDR Tuberculosis


News from CRG


The researcher from the Centro Nacional de Análisis Genómico (CNAG) and the Centre for Genomic Regulation (CRG) Marc A. Marti-Renom has participated in a study that reveals the potential of rapid whole-genome sequencing in a hospital setting to reduce the time taken to diagnose extensively drug-resistant (XDR) tuberculosis from weeks to days. The study published as a Letter to the Editor in the prestigious journal The New England Journal of Medicine reported a finding that might guide clinicians and reference laboratories in the identification of drug resistant tuberculosis.

The study, led by researchers from the University of Cambridge and Public Health England, started when a 38-year old male patient had a first admission to a hospital with clinical and radiological features consistent with pulmonary tuberculosis. Current laboratory methods of identifying and typing Mycobacterium tuberculosis complex (causative agent of most cases of tuberculosis) were performed. In parallel, DNA was extracted from the sample and sequenced with the use of the Illumina MiSeq platform.

More information:

CRG press release

Reference:

Whole-Genome Sequencing for Rapid Susceptibility Testing of M. tuberculosis. Claudio U. Köser, Josephine M. Bryant, Jennifer Becq, M. Estée Török, Matthew J. Ellington, Marc A. Marti-Renom, Andrew J. Carmichael, Julian Parkhill, Geoffrey P. Smith, Sharon J. Peacock. The New England Journal of Medicine (2013) doi: 10.1056/NEJMc1215305