News from CEXS-UPF
Nuria Lopez-Bigas, ICREA researcher and head of the Biomedical Genomics group at the Department of Experimental Sciences and Health (CEXS) UPF and her team of scientists have gathered 4,623 mutations described in tumors arising in thirteen different organs to identify genes involved in disease development and to progress towards personalized cancer medicine. The results were published on September 15 in the journal Nature Methods.
In this paper the authors describe "IntOGen-Mutations", a computational platform that analyzes the characteristics of the mutations observed in tumors using algorithms developed in the Biomedical Genomics group. The software displays the results in an intuitively navigable interface within a conventional web system .
"The joint analysis of many genomes of tumors allows us to identify patterns that indicate which genes and mutations are crucial for the development of cancer," said Lopez-Bigas, researcher of the study.
UPF press release (in Catalan)
Abel González-Pérez, Christian Pérez-Llamas, Jordi Deu-Pons, David Tamborero, Michael P Schroeder, Alba Jené-Sanz, Alberto Santos i Nuria López-Bigas (2013), "IntOGen-mutations identifies cancer drivers across tumor types", Nature Methods, 10.1038/nmeth.2642, 15 de septembre.