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11/10/2013

CRG: Scientists disclose minute-by-minute details of the biological clock of skin stem cells

CRG: Scientists disclose minute-by-minute details of the biological clock of skin stem cells


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Our skin regenerates daily and has to face harmful environmental factors such as sunlight and pathogens. In an article published in the journal Cell Stem Cell, scientists at the Centre for Genomic Regulation (CRG), in Barcelona, have described how the circadian rhythm (internal biological clock) modulates the function of human skin stem cells to achieve optimum regeneration and protection against harmful agents. The authors describe in detail the cyclic activity of the genes in skin stem cells during the course of a day. The correct balance of the biological clock of stem cells affects their function, and its disruption causes aging and can lead to predisposition to skin cancer.

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Reference:

Janich P, Toufighi K, Solanas G, Luis NM, Minkwitz S, Serrano L, Lehner B and Benitah SA. Human Epidermal Stem Cell Function is Regulated by Circadian Oscillations. Cell Stem Cell. 10 October 2013. DOI:http://dx.doi.org/10.1016/j.stem.2013.09.004