News
15/11/2013

IMIM: Researchers from IMIM describe a new function of two molecules involved in metastasis

IMIM: Researchers from IMIM describe a new function of two molecules involved in metastasis


News from IMIM


Researchers from IMIM (Hospital del Mar Medical Research Institute) lead by Dr. Sandra Peiró have described a new function for two key molecules involved in tumor progression. Transcription factor SNAIL1 and enzyme LOXL2 are essential to Epithelial-Mesenchymal Transition (EMT); meaning the process by which tumor cells are able to move and reach other tissues. The study has been published in the journal Molecular Cell and places enzyme LOXL2 as a possible therapeutic target to treat cancers such as breast, lung or skin cancer.

Sandra Peiró, a researcher from the IMIM Research Group on Epithelial-Mesenchymal Transition and Tumor Progression explains: “EMT is a process consisting of converting epithelial cells, the ones covering the internal and external surfaces of the body, into what are known as mesenchymal cells. In this process, the cells acquire a series of new characteristics that enable them to migrate and resist apoptosis (programmed cell death), self-regenerate and, finally, invade neighboring tissues and reach other areas of the body. When this process occurs at the tumor epithelial cells, the resulting mesenchymal cells can migrate and generate metastases”.

More information:
News from IMIM

Reference:
Regulation of Heterochromatin Transcription By Snail1/ LOXL2 During Epithelial to Mesenchymal Transition”. Alba Millanes-Romero, Nicolás Herranz, Valentina Perrera, Ane Iturbide, Jordina Loubat, Jesús Gil, Thomas Jenuwein, Antonio García de Herreros, and Sandra Peiró. Molecular Cell.