News from CRG
Two studies published in Cell describe senescence as a normal and critical process during embryogenesis. They attribute a completely new and unexpected role to this process, which was always linked to aging and cancer. The researchers at the Centre for Genomic Regulation (CRG) in Barcelona share these findings with researchers at the Centro Nacional de Investigaciones Oncológicas (CNIO) in Madrid, publishing two back-to-back papers in the journal Cell.
“For the first time, these studies clearly show that senescence is a programmed developmental mechanism. This new description helps us to understand the role and significance of senescence as a normal cellular process”, explains Bill Keyes, head of the Mechanisms of Cancer and Aging laboratory at the CRG. “Our work demonstrates that in the embryo, the senescent cells are required, and through their normal secretory function, instruct tissue growth and patterning”, adds Dr. Keyes.
Senescence is a developmental mechanism that contributes to embryonic growth patterning. Mekayla A Storer, Alba Mas, Alexandre Robert-Moreno, Matteo Pecoraro, M Carmen Ortells, Valeria Di Giacomo, Reut Yosef, Noam Pilpel, Valery Krizhanovsky, James Sharpe, Bill Keyes. Cell (2013).
Programmed cell senescence during mammalian embryonic development. Daniel Muños-Espín, Marta Cañamero, Antonio Maraver, Gonzalo Gómez-López, Julio Contreras, Silvia Murillo-Cuesta, Alfonso Rodríguez-Baeza, Isabel Varela-Nieto, Jesús Ruberte, Manuel Collado, Manuel Serrano. Cell (2013).