News
10/1/2014

CRG: The effects of genetic variation in space and time

CRG: The effects of genetic variation in space and time


News from CRG


CRG researchers describe in a paper published in Nature that many genetic differences between individuals influence the dynamic patterns of how genes are switched on or off during development. The research will contribute to the understanding of how the differences in our genomes affect dynamic processes such as disease progression.

In a paper published on the 9th January, CRG researchers Ben Lehner and Mirko Francesconi describe an efficient experimental and computational design to study how genetic differences in a genome influence the expression of all genes in both space and time. 

Applying the approach to the model nematode C. elegans, they reconstruct how the genetic variation between two individuals changes gene expression in different organs and tissues throughout 12 hours of the animal's development.

More information:
CRG website

Reference:

Francesconi M, Lehner B. The effects of genetic variation on gene expression dynamics during development. Nature. 9 January 2014 2014. DOI: http://dx.doi.org/10.1038/nature12772