IMIM: New advances on the mechanism of formation of epithelial tumors

IMIM: New advances on the mechanism of formation of epithelial tumors

News from IMIM

The research, led by scientists at UAB and the IMIM and published in Molecular Cell, focuses on the analysis of cancerous transformation mechanisms and suggests the use of new compounds as antitumor agents.

In response to signals coming from the outside, such as hormones or growth factors, cells activate a series of chain reactions known as signal transmission paths. These paths end at the activation of the expression of proteins involved in various cell functions such as growth or acquisition of mobility. In tumors many of these pathways are activated in a constitutive manner, which means that no external signal is required. This is due to mutations that activate any of the elements of these routes.

In the article Vinyoles et al. published in the journal Molecular Cell, the groups of Dr. Mireia Duñach of the Autonomous University of Barcelona and Dr. Antonio García de Herreros from IMIM, have investigated how inhibition of GSK3 action occurs on beta-catenin.

More information:
IMIM website (in Spanish and Catalan)

Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6”. Meritxell Vinyoles, Beatriz Del Valle-Pérez, Josué Curto, Rosa Viñas-Castells, Lorena Alba-Castellón, Antonio García de Herreros, and Mireia Duñach1. Molecular Cell