News from CREAL
A large European study of more than 20000 children finds that coexistence of eczema, rhinitis, and asthma in the same child is more frequently observed than it would be expected if these were independent entities, according to one of the largest studies of its kind, published in The Lancet Respiratory Medicine.
Given that the 20% of children have at least one of these diseases and 4% of children are affected by two or three of them, “patients and doctors should be aware of the tendency of these diseases to occur in the same children and the need an integrated approach”, warns the corresponding author Prof. Josep M Antó, director of the Centre for Research in Environmental Epidemiology (CREAL) in Barcelona, an ISGlobal alliance research centre.
The study details that children with two or three allergic diseases (eczema, rhinitis, and asthma) at 4 years are between 30 and 60 time more likely to have two or three of these diseases at 8 years. Even the children with only one of these diseases at 4 years are 4 to 7 times more likely to have two or three of these diseases at 8 years. These increased risks were found in both sensitised and non-sensitised children against at least one of the common allergens under study.
Comorbidity of eczema, rhinitis, and asthma in IgE–sensitised and non–IgE–sensitised children in MeDALL: a population–based cohort study. Pinart M, Benet M, Annesi–Maesano I, von Berg A, Berdel D, Carlsen KCL, Carlsen K-H, Bindslev–Jensen C, Eller E, Fantini MP, Lenzi J, Gehring U, Heinrich J, Hohmann C, Just J, Keil T, Kerkhof M, Kogevinas M, Kolezko S, Koppelman GH, Kull I, Lau S, Melén E, Momas I, Porta D, Postma DS, Rancière F, Smit HA, Stein RT, Tischer CG, Torrent M, Wickman M, Wijga AH, Bousquet J, Sunyer J, Basagaña X, Guerra S, Garcia–Aymerich J, Antó JM. The Lancet Respiratory Medicine. DOI: 10.1016/S2213-2600(13)70277-7