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14/2/2014

CEXS-UPF: Discovery of a new function for non-coding RNAs

CEXS-UPF: Discovery of a new function for non-coding RNAs


News from CEXS-UPF


A scientific study performed by the Cell Signalling Research Group, directed by Francesc Posas (Department of Experimental and Health Sciences, UPF) and the European Molecular Biology Laboratory (EMBL, Germany) has shown the existence of a new class of non-coding RNAs (lncRNA) relevant to the adaptation process of cellular environmental changes.

The paper, published on February 7 th in the online edition of Molecular Cell, represents an important advance in the field of molecular biology and has been carried out in collaboration between the Cellular Signalling Research Group, led by Francesc Posas and Eulàlia de Nadal, and an EMBL group led by Lars Steinmetz.

The presence of non-coding RNAs or lncRNA exist in all studied organisms, however its function is not fully elucidated. The result of this work will allow a better understanding of the role of lncRNAs in cell physiology. As stated by Eulàlia de Nadal, co-author of the work, "our team has demonstrated that in response to stress, activation of SAPK (Hog1) promotes the transcription of lncRNAs that overlap with coding regions (genes). The example described is the lncRNA that regulates the transcription of Cdc28 (CDK1), the kinase that regulates the yeast cell cycle."

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News from CEXS-UPF

Reference:
Nadal-Ribelles M, Solé C, Xu Z, Steinmetz LM, de Nadal E, Posas F (2014) Control of CDC28 CDK1 by a stress-induced lncRNA. Molecular Cell 53: 1-13, February 20.