News from CRG
Researchers now report in ACS’ Journal of Proteome Research that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells’ powerhouses, the mitochondria. Eduard Sabidó, head of the Proteomics Unit at the Centre for Genomic Regulation, in Barcelona, Spain, Francisco Amado and colleagues explain that despite the well-documented benefits of exercise, the exact way that it helps the heart is not well understood.
The team found that laboratory mice (stand-ins for humans) that exercised for 54 weeks on a treadmill-running regimen had higher levels of certain proteins in the mitochondria of their heart cells than did mice that did not exercise. Mitochondria produce energy for the body’s cells. In particular, they identified two proteins, kinases called RAF and p38, which “seem to trigger the beneficial cardiovascular effects of lifelong exercise training,” they say.
Ferreira R, Vitorino R, Padrao AI, Espadas G, Mancuso FM, Moreira-Gonçalves D, Castro-Sousa G, Henriques-Coelho T, Oliveira PA, Barros AS, Duarte JA, Sabido E, Amado F. “Lifelong Exercise Training Modulates Cardiac Mitochondrial Phosphoproteome in Rats”. Journal of Proteome Research, (2014).