News
21/2/2014

CEXS-UPF: Identified a causal factor of muscle degeneration in ageing

CEXS-UPF: Identified a causal factor of muscle degeneration in ageing


News from the UPF


Researchers from the Cell Biology Group at the CEXS, led by Pura Muñoz-Cànoves, have identified for the first time a physiological mechanism involved in the irreversible ageing process of muscle stem cells.

The study shows that, in old mice (20-24 months old), the muscle stem cells lose their regenerative capacity (their ability to divide) due to the activation of a signalling pathway associated with cell senescence.

Similar processes may also participate in muscle degeneration associated with advanced ageing in humans. The results of this scientific study were published on February 12 th in the online edition of the prestigious journal Nature.

More information:

CEXS-UPF website

 

Reference:

Pedro Sousa-Victor, Susana Gutarra, Laura García-Prat, Javier Rodriguez-Ubreva, Laura Ortet, Vanessa Ruiz-Bonilla, Mercè Jardí, Esteban Ballestar, Susana González, Antonio L. Serrano, Eusebio Perdiguero and Pura Muñoz-Cánoves, "Geriatric muscle stem cells switch reversible quiescence into senescence", Nature, 12/2/2014.