News
26/2/2014

IMIM: Identified a new immunological mechanism for the development of vaccines

IMIM: Identified a new immunological mechanism for the development of vaccines


News from IMIM


The presence of a new subtype of innate human lymphoid cells essential for the production of antibodies was discovered for the first time in the spleen. This discovery, published in the prestigious journal Nature Immunology, opens the door to the identification of new strategies for the development of more effective vaccines against encapsulated bacteria, that are considered highly virulent.

The research was undertaken by the research group in the Biology of B Cells of the IMIM involving also researchers from the Icahn School of Medicine at Mount Sinai in New York and the Riken Research Center for Integrative Medicine in Japan.

This finding improves our understanding of the mechanisms by which the immune system protects us against infections.

More information:
IMIM Press release

IMIM News (in Spanish)

 

Reference:
Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, Barra CM, Comerma L, Chudnovskiy A, Gentile M, Llige D, Cols M, Serrano S, Aróstegui JI, Juan M, Yagüe J, Merad M, Fagarasan S, Cerutti A
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
Nat Immunol. 2014 Feb 23;