CRG & UPF: New advances in the chronic lymphocytic leukaemia genome

CRG & UPF: New advances in the chronic lymphocytic leukaemia genome

News from CRG & UPF

A study led by Dr. Roderic Guigó from the Centre for Genomic Regulation in Barcelona, as part of the Chronic Lymphatic Leukaemia Genome Consortium, has made new advances in the study of this disease. The work, which was published (in print version) last week in the journal Genome Research, scrutinised the functional profile of the genes and mutations associated with leukaemia. 

The Spanish Chronic Lymphatic Leukaemia Genome Consortium had previously identified the principal mutations involved in the development of the disease. However, its functional profile, the activity of these mutated genes, had not been studied. Now, the researchers have sequenced the functional part of the genome of the leukaemia cells, the RNA, and several populations of healthy B lymphocytes from 98 patients.

The scientists, which include researchers from the CRG and the UPF, found that there are thousands of genes that are expressed in a distinct way in leukaemia cells in comparison to the healthy B lymphocytes, and that their functions are also very different. In particular, in the leukaemia cells many genes are expressed relating to certain metabolic pathways that make them more active.

More information:
CRG News

UPF News (in Catalan)

Ferreira, P. et al. Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia. Genome Res. 2014. 24: 212-226.