News
7/3/2014

IMIM: The administration of insulin may help prevent early kidney damage in diabetes

IMIM: The administration of insulin may help prevent early kidney damage in diabetes


News from IMIM


A study by researchers from the Hospital del Mar and IMIM has shown that the administration of insulin to mice at an early stage of diabetes development acts as a prevention of renal failure, which is called diabetic nephropathy when at an early stage. The results of the study have been published in the journal PLosONe.

"Our study has found that the normalization of blood glucose levels by administering insulin to mice is able to reverse the lesions of early diabetic kidney disease while modulating the ECA2 enzyme, which is involved in the regulation of blood pressure", explains Dr. María José Soler, a nephrologist at the Hospital del Mar and a researcher in the nephropathy research group at the IMIM.

More information:

IMIM website (in Catalan)

 

Reference:

Riera M, Márquez E, Clotet S, Gimeno J, Roca H, Lloreta J, Juanpere N, Batlle D, Pascual J, Soler MJ.Effect of Insulin on ACE2 Activity and Kidney Function in the Non-Obese Diabetic Mouse. PLoS ONE 2014; 9(1): e84683.