News
14/3/2014

CEXS-UPF: Reelin protein restores cognitive abilities in animal models of Alzheimer's

CEXS-UPF: Reelin protein restores cognitive abilities in animal models of Alzheimer's


News from CEXS-UPF


Reelin, a protein essential for the plasticity of the cerebral cortex, is able to restore cognitive abilities in laboratory mice affected by Alzheimer's disease, according to one of the main findings of a paper published in the journal Nature Communications which was led by researchers at the University of Barcelona, and in which Rafael Maldonado, director of the Laboratory of Neuropharmacology, Department of Experimental and Health Sciences- UPF, has collaborated.

The work contributes to broaden the stage of research on new therapeutic targets against Alzheimer's, incorporating reelin and its signaling pathway as targets of study for the design of new drugs. In fact, the researchers are planning to have, in just a few months, a system to identify chemical compounds that boost reelin signaling.

"The interaction of reelin with Aβ42 peptides, has been considered the most toxic in Alzheimer's disease according to current hypotheses. Until now it had not been described in any scientific study, but this work shows for the first time that the toxicity of Aβ42 peptides on neurons is decreased in the presence of reelin" the authors claim.

More information:
CEXS-UPF News

Reference:
Lluís Pujadas, Daniela Rossi, Rosa Andrés, Cátia M. Teixeira, Bernat Serra-Vidal, Antoni Parcerisas, Rafael Maldonado, Ernest Giralt, Natàlia Carulla i Eduardo Soriano (2014), "Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease", Nature Communications, Nature Communications, 5, 3443, doi:10.1038/ncomms4443.