CEXS-UPF: Recent advances in the study of proteins and their interactions

CEXS-UPF: Recent advances in the study of proteins and their interactions

News from CEXS-UPF

The Structural Bioinformatics Research Group led by Baldo Oliva, a researcher in UPF's Department of Experimental and Health Sciences (DCEXS), has presented two web servers that will facilitate the study of protein configuration and the gene expression involved in the manifestation of several conditions.

One of the servers developed by the research group in Structural Bioinformatics, named FRAGRUS, is focused on protein design. This work has been published in the journal Bioinformatics and has been undertaken in collaboration with Narcís Fernández-Fuentes, head of the Bioinformatics group at the University of Aberystwyth (UK), who is doing a research stay at Universitat Pompeu Fabra for two years through an ACCIÓ TecnioSpring grant.

The GUILDify web server is easy to use for the phenotypic characterization of genes and it is presented in an article that has also been published in the journal Bioinformatics. This server is expected to be useful for studying conditions, predicting therapeutic targets, and suggesting the most appropriate drugs for any specific condition selected by the user. According to Baldo Oliva, "the study of physical interactions between proteins encoded by genes involved in specific conditions has enabled the use of the principle of "guilt by association" to predict these new targets."

More information:

Jaume Bonet, Joan Segura, Joan Planas-Iglesias, Baldomero Oliva i Narcís Fernández-Fuentes (2014), "Frag'rUs: knowledge-based sampling of protein backbone conformations for de novo structure-based protein design", Bioinformatics, doi: 10.1093/bioinformatics/btu129.

Emre Guney, Javier García-García, Baldo Oliva (2014), "GUILDify: a web server for phenotypic characterization of genes through biological data integration and network-based priorization algorithms", Bioinformatics, doi: 10-1093/bioinformatics/btu092.