News from IBE (CSIC-UPF)
In this work, researcher from IBE make use of previously reported CNVs (copy number variations of genes) in modern dog breeds to explore the evolutionary origin of these sites by using a novel panel of wolf-like canids (4 purebred dogs, one dingo, 15 gray wolves, one red wolf, one coyote and one golden jackal). This expanded dataset, combined with their custom-designed higher density array, allowed them to determine the ancestral state and to polarize the process of CNV formation in dogs. They identified some candidate genes within CNV regions that are highly differentiated between dogs and wolves, which provide insights into the role of structural variation in the process of dog domestication and in diversification of phenotypes observed among dog breeds.
Ramirez, O., Olalde, I., Berglund,J. Lorente-Galdos, B., Hernandez-Rodriguez, J., Quilez, J., Webster,M.T., Wayne, R., Lalueza-Fox, C., Vilà, C., Marques-Bonet T. Analysis of structural diversity in wolf-like canids reveals post-domestication variants. 2014. BMC Genomics 15:465 doi:10.1186/1471-2164-15-465