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16/7/2014

CEXS-UPF: Study identifies two endogenous peptides involved in cocaine relapse

CEXS-UPF: Study identifies two endogenous peptides involved in cocaine relapse


News from CEXS-UPF


Currently, the main concern in treating opiate addiction is the possibility of relapse, even after long periods of abstinence. This concern is particularly relevant in the case of addiction to certain drugs, such as cocaine, for which there is no specific medical treatment.

A study published in the advanced online edition of the journal Neuropsychopharmacology, co-authored by Rafael Maldonado, director of the Neuropharmacology Laboratory at the UPF's Department of Experimental and Health Sciences (CEXS), along with Samantha Mancino, Sami Kummer and Elena Martín-García, all members of his research team, and involving researchers from University College Cork (Ireland), has identified the role of specific components of the endogenous opioid system in cocaine relapse.

The endogenous opioid system is involved in the control of brain reward circuits that play a role in addictive processes. The continued use of cocaine produces alterations in the expression of some of the system's components. The study's authors examined the involvement of endogenous opioid peptides and receptors in the process of cocaine relapse.

According to Maldonado, 'Our study has demonstrated that endogenous peptides that act on mu and delta opioid receptors play a role in cocaine relapse.' 'However', he added, 'our research also suggests that the opioid peptides derived from the precursor protein prodynorphin seem to play the opposite role of that of the identified peptides.'

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Reference:
Javier Gutierrez-Cuesta, Aurelijus Burokas, Samantha Mancino, Sami Kummer, Elena Martín-García and Rafael Maldonado. (2014). 'Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice'. Neuropsychopharmacology, 19 June.