News from CRG
In a paper published in Science, CRG researchers describe a new protein quality control system in the inner nuclear membrane. The new system has two main functions, to eliminate misfolded proteins and to protect the nucleus from accumulating mislocalised (or ectopic) proteins. This may be especially relevant in non-dividing cells such as neurones.
Other quality control systems have been described but exactly how misfolded proteins in the inner nuclear membrane were degraded was not known. Ombretta Foresti, Victoria Rodríguez-Vaello and Pedro Carvalho, from the Organelle Biogenesis and Homeostasis laboratory at the CRG have just described the new system. “We have found that this quality control system has two key functions. It gets rid of misfolded proteins and, surprisingly, it also helps prevent the nucleus accumulating proteins that should not be there”, explains Pedro Carvalho, principal investigator of this paper.
The studies have been conducted using a unicellular model organism (Baker’s yeast) but they may also apply to human physiology.
Ombretta Foresti, Victoria Rodríguez-Vaello, Charlotta Funaya and Pedro Carvalho. “Quality control of inner nuclear membrane proteins by the Asi complex”, Science (2014). DOI: 10.1126/science.1255638