CEXS-UPF: A new and efficient method discovers switches predictive of cancer

CEXS-UPF: A new and efficient method discovers switches predictive of cancer

News from CEXS-UPF

For many years, scientists have struggled to understand and cure cancer. The study of the genome of multiple tumors has been fundamental to detect recurrent alterations in several types of cancer, and has facilitated their classification and the development of new therapeutic strategies.

Most of the strategies used in cancer genome projects are based on searching for genetic alterations or changes in the expression of genes. On the other hand, there is more and more evidence that alterations in the splicing regulatory program play an important role in tumor transformation. That has been demostrated in an study led by Eduardo Eyras, ICREA researcher at the Department of Experimental and Health Sciences (CEXS).

The work has been published in the journal Nucleic Acids Research which explains the results of applying a new computational method developed by these scientists to project data from the Cancer Genome Atlas (TCGA) branch funded by the National Institutes of Health (NIH) US project ICGC (International Cancer Genome Consortium). This work represents the first large-scale analysis published describing alterations in splicing of new cancers using RNA sequencing data from more than 4000 samples.

More information:

Endre Sebestyén, Michał Zawisza, Eduardo Eyras (2015), "Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer", Nucleic Acids Research, doi: 10.1093 / NAR / gku1392.