News from IMIM
Dermatologists at the Hospital del Mar and researchers from the IMIM have found that NCoR, a protein known to regulate gene transcription, has a key role in the development of malignant melanoma. The study, published in the journal Oncotarget shows that the distribution of the NCoR protein within tumor cells is a predictive indicator of the evolution of malignant melanoma, even when analyzed in the initial stages of the disease. This is very relevant because until now there was no prognostic molecular markers that were indicative of a better or worse performance in this type of cancer.
Malignant melanoma is the most aggressive type of skin cancer and causes more than 20,000 deaths annually in Europe and more than 50,000 worldwide. It has a high cure rate when it is localized only in the skin but no cure when it has spread to lymph nodes or distant metastasis.
“Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance” Fernando Gallardo, Andreina Padrón, Ricard Garcia-Carbonell, Cristina Rius, Abel González-Perez, Montserrat Arumí-Uria, Mar Iglesias, Lara Nonell, Beatriz Bellosillo, Sonia Segura, Ramon Maria Pujol, Nuria Lopez-Bigas, Joan Bertran, Anna Bigas, Lluís Espinosa. Oncotarget 2015.