News
15/5/2015

IMIM: Researchers demonstrate the key role of an enzyme in the pluripotency of embryonic stem cells

IMIM: Researchers demonstrate the key role of an enzyme in the pluripotency of embryonic stem cells


News from IMIM


Researchers at the IMIM have discovered the key role of an enzyme in the capacity of differentiation of embryonic stem cells. According to research published in the journal Molecular Cell, the LOXL2 enzyme would be involved in maintaining the balance between pluripotency and differentiation in such cells, which are able to become any cell in the body. The study, coordinated by the researcher in the IMIM Research Programme on Cancer, Sandra Peiró, deepens the understanding of the mechanism of specialization of embryonic stem cells and opens the door for better handling. Researchers from the Department of Experimental and Health Sciences of the Pompeu Fabra University were also involved in the study.

 

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Reference:
LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation” Ane Iturbide, Laura Pascual-Reguant, Laura Fargas, Joan Pau Cebrià, Berta Alsina, Antonio García de Herreros y Sandra Peiró. Molecular Cell 2015