01/07/2015 - 12:00 - Sala Ramón y Cajal

Everything you wanted to know about spindle assembly but were afraid to ask

Sessions científiques, CRG Group Leader Seminars

Isabelle Vernos

Microtubule Function and Cell Division Group, Cell and Developmental Biology Programme, CRG

Brief biography and summary of talk

Isabelle Vernos obtained her PhD on the molecular organization of the Drosophila bithorax complex at the Autonoma University (Madrid). During a first postdoc at the Welcome/CRC Institute in Cambridge (UK), she became interested in the role of microtubules in cell organization and she identified several novel kinesin-like proteins. In 1992, she joined the European Molecular Biology Laboratory in Heidelberg as a postdoc and established her independent research group in 2001. She joined the CRG as an ICREA research professor in 2005.

Her current research focuses on understanding the mechanism underlying the faithful segregation of the chromosomes during mitosis and meiosis. This process relies on the assembly of a molecular machine, the bipolar spindle. Using a combination of approaches in vitro, in Xenopus egg extracts and in tissue culture cells, her group has identified novel mechanisms that ensure the assembly of a functional spindle and a successful outcome of cell division. Her talk will summarize recent work on these mechanisms.