14/11/2012 - 12:00 - Auditori PRBB

The many ways to skin a cat: Translational regulation by cytoplasmic polyadenylation

Sessions científiques, CRG Group Leader Seminars

Fátima Gebauer

Gene Regulation, Stem Cells and Cancer Programme, CRG

Fátima Gebauer is a group leader at the Gene Regulation, Stem Cells and Cancer Program of the CRG. She received her PhD in 1990 from the Autónoma University of Madrid, where she was trained in Virology. She did postdocs in the labs of Joel D. Richter (WFBR, Massachusetts) and Matthias  W. Hentze (EMBL, Germany), where she became interested in the regulation of mRNA translation. In 2000 she was appointed  Staff Scientist at EMBL, and in 2002 she obtained a group leader position at the CRG. Gebauer is interested in the regulation of  mRNA translation during embryonic development and cell homeostasis.  Her research focuses on the molecular mechanisms of translational control exerted by RNA-binding proteins (RBPs) and on the consequences of altered RBP function in disease.


The regulation of mRNA translation is coming up as a mechanism as prevalent as transcriptional control in the regulation of cell function. During my talk, her talk, she will introduce a mechanism of translational control called cytoplasmic polyadenylation. She will describe her group’s efforts to unravel the machineries carrying this process, and the surprising novel roles of "famous" RNA-binding proteins with established roles in small RNA regulation.