07/11/2012 - 12:00 - Auditori PRBB

Chromatin, gene regulation and cancer

Sessions científiques, CRG Group Leader Seminars

Luciano di Croce

Gene Regulation, Stem Cells and Cancer, CRG

Luciano Di Croce obtained his PhD from the University of Rome “La Sapienza”. In 1996 he moved to Marburg (Germany) as a postdoctoral fellow in the laboratory of Miguel Beato where he became interested in understanding the link between transcription and chromatin structure. After a second postdoctoral stage at the European Institute for Oncology (IEO) in Milan with PierGiuseppe Pelicci, he established his laboratory at CRG in 2003, as an ICREA Professor.

Since its formation, Di Croce’s group has focused its research efforts on understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, cell differentiation and transformation). Leukaemia is the primary cancer model system studied in their lab, and they use either mouse models that recapitulate human leukaemia or primary samples from human leukemic patients to investigate the links between epigenetic alterations and the leukemogenesis processes.

More recently, the Di Croce lab has been interested in understanding how variations in the assembly of the Polycomb complexes occur and influence mES cell differentiation and animal development.