10/05/2013 - 12:00 - Sala Marie Curie

Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer

Sessions científiques, PRBB CRG Conferences

Stefano Volinia

Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università degli Studi. Ferrara, Italy

Stefano Volinia, from the University of Ferrara, Italy and the Ohio State University, USA, uses molecular genetics and bioinformatics to investigate mechanisms of cancer establishment and progression. He has been particularly involved in defining the role of microRNAs since their involvement in cancer.

Recently he has analysed the clinical parameters, the mRNA and microRNA expression, and the DNA methylation profiles of patients with primary invasive ductal carcinoma, the most common type of breast cancer, and has identified an integrated prognostic signature which could be important to determine the appropriate treatment for patients with early diagnosis. The signature includes the gene PIK3CA—one of the two most frequently mutated genes in breast cancer — for which different inhibitor drugs are in clinical trials worldwide. He has been invited by Heinz Himmelbauer (CRG).