29/11/2013 - 12:00 - Auditori PRBB

How are chromosomes held together?

Sessions científiques, PRBB CRG Conferences

Kim Nasmyth

Dep. of Biochemistry, Univ. of Oxford, UK

Kim Nasmyth, from the Department of Biochemistry of the University of Oxford, UK, works on the mechanisms by which chromosomal DNA molecules are held together. His lab has proposed that cohesin holds sister DNAs together by trapping them within its ring structure, and he is trying to answer several questions related to this mechanism, such as how are DNAs prevented from exiting the ring, how is the ring opened in prophase during mitosis, how stable are the connections between sister DNAs mediated by cohesin and whether cohesin has an important role in regulating gene expression during interphase. He mostly uses the yeast Saccharomyces cerevisiae but also studies the regulation of cohesion in mouse oocytes and the role of cohesin in postmitotic cells in Drosophila. He has been invited by Pia Cosma (CRG).