10/07/2013 - 12:00 - Sala Ramón y Cajal

Linking transdifferentiation and reprogramming to pluripotency

Sessions científiques, CRG Group Leader Seminars

Thomas Graf

Hematopoietic Stem Cell Biology & Differentiation Group, Gene Regulation, Stem Cells & Cancer Programme, CRG

Brief biography & abstract

Thomas Graf did his PhD at the Max Planck Institute in Tuebingen and his postdoc at Duke University. In 1973 he became a Group Leader first at the Max Planck Institute in Tuebingen and then at the German Cancer Research Center in Heidelberg. Between 1983 and 1998 he was a Programme Coordinator at EMBL in Heidelberg, from where he moved to the Albert Einstein College of Medicine in New York. Since 2006 he co-coordinates the Gene Regulation, Stem Cells and Cancer Program at the Center for Genomic Regulation (CRG) in Barcelona.

In his early work with acute avian leukemia viruses Graf co-discovered several oncogenes, including Myc, Myb and ErbB, and showed that at least two oncogenes are needed to cause an acute leukemia. He also demonstrated that some leukemia inducing oncogenes act by inducing a reversible block in blood cell differentiation. In the last two decades he showed that specific transcription factors can reprogram specialized blood cells into other functional cell types. His talk will be on the molecular mechanisms of how the transcription factor C/EBPalpha induces transdifferentiation of immune cells and how this process can be linked to reprogramming into pluripotency.


This talk will be the last Group Leader Seminar of the season. These seminars will start again in September.