News from DCEXS-UPF
The evolutionary origin of the division of the hindbrain, the most posterior brain vesicle which during embryonic development s divided into seven segments called rhombomeres, has been discovered. “We found that the emergence, over 200 million years ago, of chromosome rearrangement in a large family of freshwater fish resulted in the reuse of a group of genes (rac3b/rfng/sgca) for this system of segmentation of the hindbrain”, explain Cristina Pujades, from DCEXS-UPF, and Juan Ramón Martinez-Morales, from the Andalusian Center for Development Biology, co-leaders of this study.
This research, where scientists from the Paris-Saclay Institute of Neuroscience and Pablo de Olavide University participated too, was published in PNAS. -CS/PRBB
Letelier, J, Terriente, J, Belzunce, I, Voltes, A, Undurraga, C, Polvillo, R, Devos, L, Tena, J, Maeso, I, Retaux, S, Gomez-Skarmeta, JL, Martinez-Morales, JR, Pujades, C. The evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. PNAS, March 2018.