02/12/2015 - 12:00 - Sala Marie Curie

Transcriptional complexity in stem cells

Sesiones científicas, CRG Group Leader Seminars

Luciano Di Croce

Epigenetic Events in Cancer Group, Gene Regulation, Stem Cells and Cancer Programme, CRG

Short biography

Luciano Di Croce obtained his PhD from the University of Rome “La Sapienza”. In 1996 he moved to Marburg (Germany) as a postdoctoral fellow in the laboratory of Miguel Beato where he became interested in understanding the link between transcription and chromatin structure. After a second postdoctoral stage at the European Institute for Oncology (IEO) in Milan with PierGiuseppe Pelicci, he established his laboratory at the CRG in 2003, as an ICREA Professor.

Summary of research

Since its formation, Di Croce’s group has focused its research efforts on understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, cell differentiation and transformation. Leukaemia is the primary cancer model system studied in their lab, and they use either mouse models that recapitulate human leukaemia or primary samples from human leukemic patients to investigate the links between epigenetic alterations and the leukemogenesis processes.

More recently, Di Croce lab is interested in understanding how variations in the assembly of the Polycomb complexes occur and influence mES cell differentiation and animal development.