Acute leukemias: molecular alterations as basis for novel targeted treatment approaches

Baldus,from the Charité – Universitätsmedizin in Berlin, Germany focuses on identifying new genetic targets implicated in the pathogenesis of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). She investigates genetic alterations of bone marrow stroma cells of AML patients. In particular she studies these alterations and their functional consequenses with respect to the role in the leukemia-stroma-interaction. Her research aims to unravel mechanisms of stroma induced drug resistance and to perform a small-molecule-screen in order to identify molecules to overcome stroma mediated chemotherapy resistance. She has been invited by Anna Bigas (IMIM).