News from CEXS-UPF
The EU-ToxRisk project and the Toxicology in the 21st Century (Tox21) initiative in the US have agreed to collaborate on efforts to reduce the use of animals and achieve more efficient chemical safety assesments. A total of 28 representatives from both projects gathered in a workshop held in Mainz (Germany) on September 2016 to initiate collaboration across areas of mutual interest within the field of risk assessment.
As Andy White (Unilever), partner of EU-ToxRisk and chair of the workshop, comments, “this workshop marks the start of what is expected to be a fruitful collaboration between EU-ToxRisk and the ongoing American efforts in Tox21 and ToxCast. This collaboration will help to strengthen communication between both sides with the objective to foster synergies to accelerate the shift in toxicology towards a new mechanism-based chemical safety testing strategy. On both sides of the Atlantic, there is a drive to enhance scientific capabilities to improve safety assessment approaches based on alternatives to animal testing.”
Two groups of GRIB participate in the EU-ToxRisk project coordinating the application of computational methods: the PharmacoInformatics group led by Manuel Pastor and the Integrative Bioinformatics group led by Ferran Sanz, and therefore will play a major role in this collaboration. In particular, the GRIB will participate in the joint development and validation of core methodologies for hazard and risk assessment, as read-across, quantitative AOP and similarity metrics.