News from the FPM
Researchers from the Pasqual Maragall Foundation detected morphological brain alterations in healthy individuals who are carriers of the APOE-Ɛ4, which is the gene that confers the highest risk to develop Alzheimer’s disease. The research has been possible thanks to the magnetic resonance imaging tests carried out within the Alfa Study and represents the largest neuroimaging study in healthy carriers of APOE-Ɛ4.
“The morphological differences that we found are associated with Alzheimer’s disease because they appear in brain areas such as the hippocampus, which is among the first brain region suffering the neurodegeneration process of the disease”, reports the first author of the study, Raffaele Cacciaglia. The study was led by the team of José Luis Molinuevo and Juan Domingo Gispert at the FPM, with the collaboration of the head of the Cancer Epigenetics and Biology Program of the IDIBELL, Manel Esteller, who carried out the genetic determinations; and the CIBER on Bioengineering, Biomaterials and Nanomedicine, and the CIBER on Fragility and Healthy Ageing.
Cacciaglia R, Molinuevo JL, Falcón C, Brugulat-Serrat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillón C, Fauria K, Gispert JD Effects of APOE-E4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease. Alzheimers Dement. 2018 Mar 27