News from CEXS-UPF
A new study performed by researchers with the group of Lucas Carey in the Systems Bioengineering Programme at Pompeu Fabra University provides a completely new paradigm regarding transcripcion factor response. The study, published in Cell Reports and led by Miquel Àngel Schikora Tamarit, shows that not only promoters, but all the regions of the target gene contribute to the transcription factor response, with many implications in cell behaviour.
The researchers used a combination of mathematical modelling and genetic engineering of cells to infer the role of several cellular processes in this response. They found that most target genes can buffer the effect of having high transcription factor activity. “This means that, even if the transcription factor is very active, the increase in expression of the target gene will not be proportional”, explains Miquel Àngel Schikora.
Miquel Àngel Schikora-Tamarit, Guillem Lopez-Grado i Salinas, Carolina Gonzalez Navasa, Irene Calderon, Xavi Marcos-Fa, Miquel Sas, Lucas Carey. Promoter activity buffering reduces the fitness cost of misregulation. Cell Reports. 2018. DOI: 10.1016/j.celrep.2018.06.059.