News from CRG
A group of researchers from the Centre for Genomic Regulation have discovered a faster and more efficient mechanism for reprogramming induced pluripotent stem cells (iPS). The discovery, published online in Nature, decreases the time needed for cell reprogramming from a couple of weeks to a few days and reveals new information on the reprogramming process for iPS cells and their potential medical applications.
"Our group was using a particular transcription factor (C/EBPα) to reprogramme one type of blood cell into another (transdifferentiation). We have now discovered that this factor also acts as a catalyst when reprogramming adult cells into iPS", explains the leader of the study Thomas Graf, senior group leader at the CRG and ICREA research professor.
Bruno Di Stefano, Jose Luís Sardina, Chris van Oevelen, Samuel Collombet, Eric M. Kallin, Guillermo P. Vicent, Jun Lu, Denis Thieffry, Miguel Beato and Thomas Graf. 'C/EBPα poises B cells for rapid reprogramming into iPS cells' Nature. Online advanced 15 Dec 2013. DOI:http://dx.doi.org/10.1038/nature12885.