Connecting perspectives: from bytes and molecules to organisms and populations
"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".
Jordi Camí, General Director of the PRBB.
The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.
With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.
Hospital del Mar Medical Research Institute (IMIM)
Cancer
The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research
Epidemiology and Public Health
The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.
Biomedical Informatics
This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB).
Neuroscience
The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.
Inflammatory and Cardiovascular Disorders
This programme expands our knowledge of pathophysiological, inflammatory and genetic mechanisms of cardiovascular, respiratory and bone disorders, as well as other acute and chronic disorders, their diagnosis and treatment. The multidisciplinary team addresses basic biomedical scientific questions arising from clinical cases. This approach should lead to translational research that can be applied to medical care.
Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)
Cellular and Molecular Biology
The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.
Molecular Medicine
This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.
Evolutionary Biology and Complex Systems
The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.
Biomedical Informatics
The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.
Genetics and Neuroscience
The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.
Systems Bioengineering
The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.
Transversal Program
Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.
Centre for Genomic Regulation (CRG)
Bioinformatics and Genomics
Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).
Cell and Developmental Biology
The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.
Gene Regulation, Stem Cells and Cancer
The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.
Systems Biology
The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice.
The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.
Barcelona Institute for Global Health (ISGlobal, Mar Campus)
Climate and Health
Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.
Air pollution and urban environment
The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.
Non-communicable diseases and the environment
The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.
Childhood and Environment
This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.
Radiation
The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.
Other
ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.
Institute of Evolutionary Biology (IBE: CSIC-UPF)
Animal Biodiversity and Evolution
The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.
Comparative and Computational Genomics
This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.
Functional Genomics and Evolution
The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.
Population genetics
Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.
Complex Systems
This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.
European Molecular Biology Laboratory (EMBL)
Tissue biology and disease modelling
The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”
Institute of Applied Radiopharmacy of Barcelona (IRAB)
Research and Innovation
The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.
Animal research with the international accreditation from the AAALAC.
The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.
Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.
- Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
- The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
- The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).
For more information on the animal facility and animal experimentation visit:
Animal experimentation courses
The PRBB and Charles River Campus
Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.
The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:
- Euthanasia (Function b)
- Performing procedures (Function c)
- Designing projects and procedures (mice and fish/amphibians) (Function d)
The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.
●Latest news
Shared facilities for high-impact research
"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."
Jordi Camí, General Director of the PRBB
The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.
The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection
Contact: Montserrat Torà
→ marbiobanc@imim.es
The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.
Contact: Julia Ponomarenko
→ biocore@crg.eu
The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.
Contact: Ivo Gut
→ projectmanager@cnag.crg.eu
This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.
Contact: Blanca Espinet
→ bespinet@parcdesalutmar.cat
This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.
Contact: Òscar Fornas
→ oscar.fornas@upf.edu
Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit
The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.
Contact: Dirección de secretaría
→ ceea@prbb.org
Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.
Contact: Cristina Llop
→ CEIC-PSMAR@imim.es
The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.
Contact: Secretaría
→ cbs@prbb.org
This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.
Contact: Carlo Carolis
→ bmspt@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit
BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.
Contact: Jordi Alonso
→ bibliopro@imim.es
The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.
Contact: Arcadi Navarro
→ helpdesk@ega-archive.org
This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.
Contact: Jochen Hecht
→ ngs@crg.eu
The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.
Contact: Montserrat Torà
→ margenomics@imim.es
The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.
Contact: Ferran Casals
→ genomica@upf.edu
The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.
Contact: Laura Batlle Morera
→ laura.batlle@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0
This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.
Contact: Ana Aldea
→ aaldea@imim.es
This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.
Contact: Jim Swoger
→ mif@embl.es
Web:
https://www.embl.es/services/mesoscopic-imaging-facility
The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.
Contact: Nadia Halidi
→ nadia.halidi@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit
Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)
Contact: David Andreu
→ david.andreu@upf.edu
This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.
Contact: Eduard Sabido Aguade
→ eduard.sabido@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit
DOSAGE INDIVIDUALIZATION OF LINEZOLID: PRECISION DOSING OF LINEZOLID TO OPTIMISE EFFICACY AND MINIMISE TOXICITY.
Luque S, Hope W, Sorli L, Muñoz-Bermudez R, Campillo N, Barceló J, Álvarez-Lerma F, Horcajada JP, Masclans-Enviz JR, Neely M, Grau S
Antimicrob Agents Chemother. 2021 Apr 5;
Voxel-based morphometry for the evaluation of patients with pharmacoresistant epilepsy with apparently normal MRI.
González-Ortiz S, Medrano S, Capellades J, Vilas M, Mestre A, Serrano L, Conesa G, Pérez-Enríquez C, Arumi M, Bargalló N, Delgado-Martinez I, Rocamora R
J Neuroimaging. 2021 Apr 5;
Genomics and epigenomics of addiction.
Maldonado R, Calvé P, García-Blanco A, Domingo-Rodriguez L, Senabre E, Martín-García E
Am J Med Genet B Neuropsychiatr Genet. 2021 Apr 5;
Lack of expression of LMO2 clone SP51 identifies MYC rearrangements in aggressive large B-cell lymphomas.
Vazquez I, Papaleo N, Lop J, Puiggros A, Sanchez-Gonzalez B, Diez-Feijoo R, Gimeno E, Andrade-Campos M, Salar A, Espinet B, Salido M, Tapia G, Carreras J, Ferrer A, Arenillas L, Calvo X, Colomo L
Virchows Arch. 2021 Apr 3;
Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort.
Ingala S, De Boer C, Masselink LA, Vergari I, Lorenzini L, Blennow K, Chételat G, Di Perri C, Ewers M, van der Flier WM, Fox NC, Gispert JD, Haller S, Molinuevo JL, Muniz-Terrera G, Mutsaerts HJ, Ritchie CW, Ritchie K, Schmidt M, Schwarz AJ, Vermunt L, Waldman AD, Wardlaw J, Wink AM, Wolz R, Wottschel V, Scheltens P, Visser PJ, Barkhof F, EPAD consortium.
Alzheimers Dement. 2021 Apr 3;
The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells.
Giménez-Arnau AM, DeMontojoye L, Asero R, Cugno M, Kulthanan K, Yanase Y, Hide M, Kaplan AP
J Allergy Clin Immunol Pract. 2021 Apr 3;
Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice.
Martín-Sánchez A, Piñero J, Nonell L, Arnal M, Ribe EM, Nevado-Holgado A, Lovestone S, Sanz F, Furlong LI, Valverde O
Alzheimers Res Ther. 2021 Apr 2;13(1):73
Mapping the Synchronization Effect of Gamma-Aminobutyric Acid Inhibition on the Cerebral Cortex Using Magnetic Resonance Imaging.
Blanco-Hinojo L, Pujol J, Macià D, Martínez-Vilavella G, Martín-Santos R, Pérez-Sola V, Deus J
Brain Connect. 2021 Apr 1;
Empowering MYC carcinogenesis via RNA loops.
Mays SG, Valcárcel J
Mol Cell. 2021 Apr 1;81(7):1365-1367
Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease.
Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, Hindy G, Jiang L, Wei WQ, Feng Q, Karjalainen J, Havulinna A, Kiiskinen T, Bick A, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gupta N, Danesh J, Saleheen D, Chang KM, Vujkovic M, Voight B, Damrauer S, Lynch J, Kaplan D, Serper M, Tsao P, Program MV, Mercader J, Hanis C, Daly M, Denny J, Gabriel S, Kathiresan S
PLoS Genet. 2021 Apr;17(4):e1009503
Improved biotechnological production of paclitaxel in Taxus media cell cultures by the combined action of coronatine and calix[8]arenes.
Escrich A, Almagro L, Moyano E, Cusido RM, Bonfill M, Hosseini B, Palazon J
Plant Physiol Biochem. 2021 Mar 27;163:68-75
Special Issue: Diagnosis and Management of Addiction and Other Mental Disorders (Dual Disorders).
Adan A, Torrens M
J Clin Med. 2021 Mar 22;10(6)
Systematic Review: Comparison of the Main Variables of Interest in Publications of Canine Bite Accidents in the Written Press, Gray and Scientific Literature in Chile and Spain, between the Years 2013 and 2017.
Barrios CL, Aguirre V, Parra A, Pavletic C, Bustos-López C, Perez S, Urrutia C, Ramirez J, Fatjó J
Animals (Basel). 2021 Mar 21;11(3)
Understanding How to Improve the Use of Clinical Coordination Mechanisms between Primary and Secondary Care Doctors: Clues from Catalonia.
Esteve-Matalí L, Vargas I, Amigo F, Plaja P, Cots F, Mayer EF, Pérez-Castejón JM, Vázquez ML
Int J Environ Res Public Health. 2021 Mar 20;18(6)
A Mouse Model Suggests That Heart Failure and Its Common Comorbidity Sleep Fragmentation Have No Synergistic Impacts on the Gut Microbiome.
Khannous-Lleiffe O, Willis JR, Saus E, Cabrera-Aguilera I, Almendros I, Farré R, Gozal D, Farré N, Gabaldón T
Microorganisms. 2021 Mar 19;9(3)
From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis.
Rozas M, Hart de Ruijter A, Fabrega MJ, Zorgani A, Guell M, Paetzold B, Brillet F
Microorganisms. 2021 Mar 18;9(3)
High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma.
Marhuenda-Muñoz M, Rinaldi de Alvarenga JF, Hernáez Á, Tresserra-Rimbau A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Malcampo M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Sánchez VM, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Serra-Mir M, Vázquez-Ruiz Z, Nishi SK, Sorlí JV, Zomeño MD, Zulet MA, Vaquero-Luna J, Carabaño-Moral R, Notario-Barandiaran L, Morey M, García-Ríos A, Gómez-Pérez AM, Santos-Lozano JM, Buil-Cosiales P, Basora J, Portolés O, Schröder H, Abete I, Salaverria-Lete I, Toledo E, Babio N, Fitó M, Martínez-Huélamo M, Lamuela-Raventós RM
Antioxidants (Basel). 2021 Mar 17;10(3)
Expression of Phosphorylated BRD4 Is Markedly Associated with the Activation Status of the PP2A Pathway and Shows a Strong Prognostic Value in Triple Negative Breast Cancer Patients.
Sanz-Álvarez M, Cristóbal I, Luque M, Santos A, Zazo S, Madoz-Gúrpide J, Caramés C, Chiang CM, García-Foncillas J, Eroles P, Albanell J, Rojo F
Cancers (Basel). 2021 Mar 12;13(6)
Areas of Specific Subspecialization (ACE) in Pulmonology.
Gea J, Barrueco M, Martínez C, Jiménez-Ruíz C
Arch Bronconeumol. 2021 Mar 11;
The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives.
Pognan F, Steger-Hartmann T, Díaz C, Blomberg N, Bringezu F, Briggs K, Callegaro G, Capella-Gutierrez S, Centeno E, Corvi J, Drew P, Drewe WC, Fernández JM, Furlong LI, Guney E, Kors JA, Mayer MA, Pastor M, Piñero J, Ramírez-Anguita JM, Ronzano F, Rowell P, Saüch-Pitarch J, Valencia A, van de Water B, van der Lei J, van Mulligen E, Sanz F
Pharmaceuticals (Basel). 2021 Mar 8;14(3)
Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine.
Harjivan SG, Charneira C, Martins IL, Pereira SA, Espadas G, Sabidó E, Beland FA, Marques MM, Antunes AMM
Molecules. 2021 Mar 3;26(5)
Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury.
Arias-Cabrales C, Rodriguez-Garcia E, Gimeno J, Benito D, Pérez-Sáez MJ, Redondo-Pachón D, Buxeda A, Burballa C, Crespo M, Riera M, Pascual J
J Clin Med. 2021 Mar 2;10(5)
Prevention of cognitive decline in subjective cognitive decline APOE Epsilon-4 carriers after EGCG and a multimodal intervention (PENSA): Study design.
Forcano L, Fauria K, Soldevila-Domenech N, Minguillón C, Lorenzo T, Cuenca-Royo A, Menezes-Cabral S, Pizarro N, Boronat A, Molinuevo JL, de la Torre R, PENSA Study Group.
Alzheimers Dement (N Y). 2021;7(1):e12155
http://www.ncbi.nlm.nih.gov/en...
Coffee consumption and colorectal cancer risk: a multicentre case-control study from Italy and Spain.
Rosato V, Guercio V, Bosetti C, Gracia-Lavedan E, Villanueva CM, Polesel J, Toffoluti F, Moreno V, Martin V, Aragonés N, Dierssen-Sotos T, Olmedo-Requena R, Guevara M, Amiano P, Salas D, Fernandez-Tardon G, Alguacil J, Chirlaque López MD, Fernandez-Villa T, Pérez-Gómez B, Gomez-Acebo I, Jiménez-Moleón JJ, Moreno-Iribas C, José Molina A, Castaño Vinyals G, Pollan M, Kogevinas M, La Vecchia C, Tavani A
Eur J Cancer Prev. 2021 May 1;30(3):204-210
Deep genetic affinity between coastal Pacific and Amazonian natives evidenced by Australasian ancestry.
Castro E Silva MA, Ferraz T, Bortolini MC, Comas D, Hünemeier T
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14)
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Variation in predicted COVID-19 risk among lemurs and lorises.
Melin AD, Orkin JD, Janiak MC, Valenzuela A, Kuderna L, Marrone F 3rd, Ramangason H, Horvath JE, Roos C, Kitchener AC, Khor CC, Lim WK, Lee JGH, Tan P, Umapathy G, Raveendran M, Alan Harris R, Gut I, Gut M, Lizano E, Nadler T, Zinner D, Le MD, Manu S, Rabarivola CJ, Zaramody A, Andriaholinirina N, Johnson SE, Jarvis ED, Fedrigo O, Wu D, Zhang G, Farh KK, Rogers J, Marques-Bonet T, Navarro A, Juan D, Arora PS, Higham JP
Am J Primatol. 2021 Apr 1;:e23255
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Reconstructing Squamate Biogeography in Afro-Arabia Reveals the Influence of a Complex and Dynamic Geologic Past.
Tejero-Cicuéndez H, Patton AH, Caetano DS, Šmíd J, Harmon LJ, Carranza S
Syst Biol. 2021 Mar 31;
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Replication study of plasma proteins relating to Alzheimer's pathology.
Shi L, Winchester LM, Westwood S, Baird AL, Anand SN, Buckley NJ, Hye A, Ashton NJ, Bos I, Vos SJB, Kate MT, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Barkhof F, Andreasson U, Blennow K, Zetterberg H, Streffer J, Lill CM, Bertram L, Visser PJ, Kolb HC, Narayan VA, Lovestone S, Nevado-Holgado AJ
Alzheimers Dement. 2021 Mar 31;
Comparative Study of Formaldehyde 2% in Aqueous Solution vs True Test in Detecting Formaldehyde Sensitization.
Tatiana SS, Felipe HM, Ricardo GP, Susana CG, Gatica Ortega María E, Virginia FR, Leopoldo B, Pedro MG, Silvestre Salvador Juan F, Descalzo MA, Giménez-Arnau AM
Contact Dermatitis. 2021 Mar 30;
Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD.
Marcon Y, Bishop T, Avraam D, Escriba-Montagut X, Ryser-Welch P, Wheater S, Burton P, González JR
PLoS Comput Biol. 2021 Mar 30;17(3):e1008880
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Low HDL and high triglycerides predict COVID-19 severity.
Masana L, Correig E, Ibarretxe D, Anoro E, Arroyo JA, Jericó C, Guerrero C, Miret M, Näf S, Pardo A, Perea V, Pérez-Bernalte R, Plana N, Ramírez-Montesinos R, Royuela M, Soler C, Urquizu-Padilla M, Zamora A, Pedro-Botet J, STACOV-XULA research group.
Sci Rep. 2021 Mar 30;11(1):7217
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Characterization of the insular role in cardiac function through intracranial electrical stimulation of the human insula.
Sanchez-Larsen A, Principe A, Ley M, Navarro-Cuartero J, Rocamora R
Ann Neurol. 2021 Mar 30;
Comprehensive identification of somatic nucleotide variants in human brain tissue.
Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Brain Somatic Mosaicism Network., Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A
Genome Biol. 2021 Mar 29;22(1):92
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Evidence for additive and synergistic action of mammalian enhancers during cell fate determination.
Choi J, Lysakovskaia K, Stik G, Demel C, Söding J, Tian TV, Graf T, Cramer P
Elife. 2021 Mar 26;10
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Maier W, Bray S, van den Beek M, Bouvier D, Coraor N, Miladi M, Singh B, De Argila JR, Baker D, Roach N, Gladman S, Coppens F, Martin DP, Lonie A, Grüning B, Kosakovsky Pond SL, Nekrutenko A
bioRxiv. 2021 Mar 25;
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Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures.
Cadiou S, Basagaña X, Gonzalez JR, Lepeule J, Vrijheid M, Siroux V, Slama R
Environ Int. 2021 Mar 25;153:106509
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Vitamin D3 levels in women and factors contributing to explain metabolic variations.
Mena-Bravo A, Calderón-Santiago M, Lope V, Kogevinas M, Pollán M, Luque de Castro MD, Priego-Capote F
J Steroid Biochem Mol Biol. 2021 Mar 25;:105884
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
Traylor M, Persyn E, Tomppo L, Klasson S, Abedi V, Bakker MK, Torres N, Li L, Bell S, Rutten-Jacobs L, Tozer DJ, Griessenauer CJ, Zhang Y, Pedersen A, Sharma P, Jimenez-Conde J, Rundek T, Grewal RP, Lindgren A, Meschia JF, Salomaa V, Havulinna A, Kourkoulis C, Crawford K, Marini S, Mitchell BD, Kittner SJ, Rosand J, Dichgans M, Jern C, Strbian D, Fernandez-Cadenas I, Zand R, Ruigrok Y, Rost N, Lemmens R, Rothwell PM, Anderson CD, Wardlaw J, Lewis CM, Markus HS, Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group., National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network., UK DNA Lacunar Stroke Study Investigators., International Stroke Genetics Consortium.
Lancet Neurol. 2021 Mar 25;
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Genome-wide transcriptome study in skin biopsies reveals an association of E2F4 with cadasil and cognitive impairment.
Muiño E, Maisterra O, Jiménez-Balado J, Cullell N, Carrera C, Torres-Aguila NP, Cárcel-Márquez J, Gallego-Fabrega C, Lledós M, González-Sánchez J, Olmos-Alpiste F, Espejo E, March Á, Pujol R, Rodríguez-Campello A, Romeral G, Krupinski J, Martí-Fàbregas J, Montaner J, Roquer J, Fernández-Cadenas I
Sci Rep. 2021 Mar 25;11(1):6846
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Impact of diabetes in patients waiting for invasive cardiac procedures during COVID-19 pandemic.
Moreno R, Díez JL, Diarte JA, Salinas P, de la Torre Hernández JM, Andres-Cordón JF, Trillo R, Briales JA, Amat-Santos I, Romaguera R, Díaz JF, Vaquerizo B, Ojeda S, Cruz-González I, Morena-Salas D, Pérez de Prado A, Sarnago F, Portero P, Gutierrez-Barrios A, Alfonso F, Bosch E, Pinar E, Ruiz-Arroyo JR, Ruiz-Quevedo V, Jiménez-Mazuecos J, Lozano F, Rumoroso JR, Novo E, Irazusta FJ, García Del Blanco B, Moreu J, Ballesteros-Pradas SM, Frutos A, Villa M, Alegría-Barrero E, Lázaro R, Paredes E
Cardiovasc Diabetol. 2021 Mar 23;20(1):69
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Use of health services among long-term breast cancer survivors in Spain: longitudinal study based on real-world data.
Jansana A, Domingo L, Ibañez B, Prados A, Del Cura I, Padilla-Ruiz M, Sanz T, Poblador B, Tamayo I, Gimeno A, Alberquilla A, Abizanda M, Comas M, Lanzuela M, Burgui R, Holgado AD, Duarte-Salles T, Moreno C, Louro J, Baquedano J, Molina C, Del Carmen Martinez M, Gorricho J, Redondo M, Castells X, Sala M
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PARAMETRIC IMAGING OF DUAL-TIME-WINDOW [18F]FLUTEMETAMOL AND [18F]FLORBETABEN STUDIES: Parametric imaging dual-time-window amyloid PET.
Heeman F, Yaqub M, Hendriks J, Bader I, Barkhof F, Gispert JD, van Berckel BNM, Lopes Alves I, Lammertsma AA
Neuroimage. 2021 Mar 21;234:117953
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Genetic origins, singularity, and heterogeneity of Basques.
Flores-Bello A, Bauduer F, Salaberria J, Oyharçabal B, Calafell F, Bertranpetit J, Quintana-Murci L, Comas D
Curr Biol. 2021 Mar 19;
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Clinical practice guideline on pharmacological and psychological management of adult patients with depression and a comorbid substance use disorder.
Torrens M, Tirado-Muñoz J, Fonseca F, Farré M, Gonzalez-Pinto A, Arrojo M, Bernardo M, Arranz B, Garriga M, Saiz PA, Florez G, Goikolea JM, Zorrilla I, Cunill R, Castells X, Becoña E, Lopez A, San L
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Clinical Practice Guideline on Pharmacological and Psychological management of adult patients with Schizophrenia Spectrum Disorders and a comorbid substance use.
Arranz B, Garriga M, Bernardo M, Gonzalez-Pinto A, Arrojo M, Torrens M, Tirado-Muñoz J, Fonseca F, Saiz PA, Florez G, Goikolea JM, Zorrilla I, Cunill R, Castells X, Becoña E, Lopez A, San L
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Nighttime features derived from topic models for classification of patients with COPD.
Spina G, Casale P, Albert PS, Alison J, Garcia-Aymerich J, Clarenbach CF, Costello RW, Hernandes NA, Leuppi JD, Mesquita R, Singh SJ, Smeenk FWJM, Tal-Singer R, Wouters EFM, Spruit MA, den Brinker AC
Comput Biol Med. 2021 Mar 10;132:104322
Translational efficiency across healthy and tumor tissues is proliferation-related.
Hernandez-Alias X, Benisty H, Schaefer MH, Serrano L
Mol Syst Biol. 2021 Mar;17(3):e10097
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Global Longitudinal Strain Analysis Using Cardiac MRI in Aortic Stenosis: Comparison with Left Ventricular Remodeling, Myocardial Fibrosis, and 2-year Clinical Outcomes.
Spath NB, Gomez M, Everett RJ, Semple S, Chin CWL, White AC, Japp AG, Newby DE, Dweck MR
Radiol Cardiothorac Imaging. 2019 Oct;1(4):e190027
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The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid Beta and Tau.
Hansson O, Batrla R, Brix B, Carrillo MC, Corradini V, Edelmayer RM, Esquivel RN, Hall C, Lawson J, Bastard NL, Molinuevo JL, Nisenbaum LK, Rutz S, Salamone SJ, Teunissen CE, Traynham C, Umek RM, Vanderstichele H, Vandijck M, Wahl S, Weber CJ, Zetterberg H, Blennow K
Alzheimers Dement. 2021 Mar 31;
Accelerated long-term forgetting in individuals with subjective cognitive decline and amyloid-Beta positivity.
Tort-Merino A, Valech N, Laine M, Olives J, León M, Ecay-Torres M, Estanga A, Martínez-Lage P, Fortea J, Molinuevo JL, Sánchez-Valle R, Rodriguez-Fornells A, Rami L
Int J Geriatr Psychiatry. 2021 Mar 31;
Long-term exposure to outdoor air pollution and risk factors for cardiovascular disease within a cohort of older men in Perth.
Vander Hoorn S, Murray K, Nedkoff L, Hankey GJ, Flicker L, Yeap BB, Almeida OP, Norman P, Brunekreef B, Nieuwenhuijsen M, Heyworth J
PLoS One. 2021;16(3):e0248931
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Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study.
Maitre L, Julvez J, López-Vicente M, Warembourg C, Tamayo-Uria I, Philippat C, Gützkow KB, Guxens M, Andrusaityte S, Basagaña X, Casas M, de Castro M, Chatzi L, Evandt J, Gonzalez JR, Gražuleviciene R, Smastuen Haug L, Heude B, Hernandez-Ferrer C, Kampouri M, Manson D, Marquez S, McEachan R, Nieuwenhuijsen M, Robinson O, Slama R, Thomsen C, Urquiza J, Vafeidi M, Wright J, Vrijheid M
Environ Int. 2021 Mar 25;153:106523
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Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: analysis of the Spanish Registry.
Villanego F, Mazuecos A, Pérez-Flores IM, Moreso F, Andrés A, Jiménez-Martín C, Molina M, Canal C, Sánchez-Cámara LA, Zárraga S, Ruiz-Fuentes MDC, Aladrén MJ, Melilli E, López V, Sánchez-Álvarez E, Crespo M, Pascual J, Spanish Society of Nephrology COVID-19 Group.
Am J Transplant. 2021 Mar 23;
Primary Dwarfism, Microcephaly, and Chorioretinopathy due to a PLK4 Mutation in Two Siblings.
Martín-Rivada Á, Pozo-Román J, Güemes M, Ortiz-Cabrera NV, Pérez-Jurado LA, Argente J
Horm Res Paediatr. 2021 Mar 23;:1-6
Maternal sleep duration and infant birthweight: A population-based cohort study.
Marinelli M, Carsin AE, Turner MC, Fernández-Somoano A, Rodriguez-Dehli AC, Basterrechea M, Santa-Marina L, Iñiguez C, Lopez-Espinosa MJ, Sunyer J, Julvez J
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Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells.
Pekmezovic M, Hovhannisyan H, Gresnigt MS, Iracane E, Oliveira-Pacheco J, Siscar-Lewin S, Seemann E, Qualmann B, Kalkreuter T, Müller S, Kamradt T, Mogavero S, Brunke S, Butler G, Gabaldón T, Hube B
Nat Microbiol. 2021 Mar 22;
A redefinition of the genus Troglocharinus Reitter, 1908, with description of new species (Coleoptera, Leiodidae, Cholevinae, Leptodirini).
Fresneda J, Rizzo V, Comas J, Ribera I
Zootaxa. 2021 Feb 5;4926(2):zootaxa.4926.2.1
Developing and validating an individualized breast cancer risk prediction model for women attending breast cancer screening.
Louro J, Román M, Posso M, Vázquez I, Saladié F, Rodriguez-Arana A, Quintana MJ, Domingo L, Baré M, Marcos-Gragera R, Vernet-Tomas M, Sala M, Castells X, BELE and IRIS Study Groups.
PLoS One. 2021;16(3):e0248930
High resolution DNA barcode library for European butterflies reveals continental patterns of mitochondrial genetic diversity.
Dinca V, Dapporto L, Somervuo P, Voda R, Cuvelier S, Gascoigne-Pees M, Huemer P, Mutanen M, Hebert PDN, Vila R
Commun Biol. 2021 Mar 9;4(1):315
Computational modelling of stem cell-niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract aging.
Potapov I, García-Prat L, Ravichandran S, Muñoz-Cánoves P, Del Sol A
FEBS J. 2021 Mar 22;
Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets.
Postema MC, Hoogman M, Ambrosino S, Asherson P, Banaschewski T, Bandeira CE, Baranov A, Bau CHD, Baumeister S, Baur-Streubel R, Bellgrove MA, Biederman J, Bralten J, Brandeis D, Brem S, Buitelaar JK, Busatto GF, Castellanos FX, Cercignani M, Chaim-Avancini TM, Chantiluke KC, Christakou A, Coghill D, Conzelmann A, Cubillo AI, Cupertino RB, de Zeeuw P, Doyle AE, Durston S, Earl EA, Epstein JN, Ethofer T, Fair DA, Fallgatter AJ, Faraone SV, Frodl T, Gabel MC, Gogberashvili T, Grevet EH, Haavik J, Harrison NA, Hartman CA, Heslenfeld DJ, Hoekstra PJ, Hohmann S, Høvik MF, Jernigan TL, Kardatzki B, Karkashadze G, Kelly C, Kohls G, Konrad K, Kuntsi J, Lazaro L, Lera-Miguel S, Lesch KP, Louza MR, Lundervold AJ, Malpas CB, Mattos P, McCarthy H, Namazova-Baranova L, Nicolau R, Nigg JT, Novotny SE, Oberwelland Weiss E, O'Gorman Tuura RL, Oosterlaan J, Oranje B, Paloyelis Y, Pauli P, Picon FA, Plessen KJ, Ramos-Quiroga JA, Reif A, Reneman L, Rosa PGP, Rubia K, Schrantee A, Schweren LJS, Seitz J, Shaw P, Silk TJ, Skokauskas N, Soliva Vila JC, Stevens MC, Sudre G, Tamm L, Tovar-Moll F, van Erp TGM, Vance A, Vilarroya O, Vives-Gilabert Y, von Polier GG, Walitza S, Yoncheva YN, Zanetti MV, Ziegler GC, Glahn DC, Jahanshad N, Medland SE, ENIGMA ADHD Working Group., Thompson PM, Fisher SE, Franke B, Francks C
J Child Psychol Psychiatry. 2021 Mar 22;
Monitoring and telematic control of people with kidney transplant and suspected COVID-19 infection.
Bach-Pascual A, Pedreira-Robles G, Pérez-Sáez MJ, Buxeda-Porras A, Arias-Cabrales CE, Crespo-Barrio M, Junyent-Iglesias E, Redondo-Pachón MD
Rev Esp Salud Publica. 2021 Mar 22;95
The European Baseline series: criteria for allergen inclusion (with reference to formaldehyde releasers).
Wilkinson SM, Badulici S, Giménez-Arnau A, Dickel H, Gonçalo M, Hervella M, Isaksson M, Johansen JD, Mahler V, Thyssen JP, Uter W, European Baseline Series Taskforce of the European Society of Contact Dermatitis.
Contact Dermatitis. 2021 Mar 21;
Impact of statin therapy on LDL and non-HDL cholesterol levels in subjects with heterozygous familial hypercholesterolaemia.
Climent E, Marco-Benedí V, Benaiges D, Pintó X, Suárez-Tembra M, Plana N, Lafuente H, Ortega-Martínez de Victoria E, Brea-Hernando Á, Vila À, Civeira F, Pedro-Botet J
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Correction to: Unmet needs, health policies, and actions during the COVID-19 pandemic: a report from six European countries.
Miralles O, Sanchez-Rodriguez D, Marco E, Annweiler C, Baztan A, Betancor É, Cambra A, Cesari M, Fontecha BJ, Gasowski J, Gillain S, Hope S, Phillips K, Piotrowicz K, Piro N, Sacco G, Saporiti E, Surquin M, Vall-Llosera E
Eur Geriatr Med. 2021 Mar 22;
Associations between Bone Material Strength Index, Calcaneal Quantitative Ultrasound, and Bone Mineral Density in Men.
Rufus-Membere P, Holloway-Kew KL, Diez-Perez A, Kotowicz MA, Pasco JA
J Endocr Soc. 2021 Apr 1;5(4):bvaa179
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Drug-resistant hypertension in primary aldosteronism patients undergoing adrenal vein sampling: the AVIS-2-RH study.
Rossi GP, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Naruse M, Deinum J, Schultze Kool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, Rump LC, Vonend O, Willenberg HS, Fuller PJ, Yang J, Chee NYN, Margill SB, Shafigullina Z, Quinkler M, Oliveras A, Lee BC, Wu VC, Kratka Z, Seccia TM, Lenzini L
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Dairy consumption, plasma metabolites, and risk of type 2 diabetes.
Drouin-Chartier JP, Hernández-Alonso P, Guasch-Ferré M, Ruiz-Canela M, Li J, Wittenbecher C, Razquin C, Toledo E, Dennis C, Corella D, Estruch R, Fitó M, Eliassen AH, Tobias DK, Ascherio A, Mucci LA, Rexrode KM, Karlson EW, Costenbader KH, Fuchs CS, Liang L, Clish CB, Martínez-González MA, Salas-Salvadó J, Hu FB
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EXPRESS: International Stroke Genetics Consortium Recommendations for Studies of Genetics of Stroke Outcome and Recovery.
Lindgren A, Braun R, Majersik JJ, Clatworthy P, Mainali S, Derdeyn CP, Maguire JM, Jern C, Rosand J, Cole JW, Lee JM, Khatri P, Nyquist PA, Debette SP, Keat Wei L, Rundek T, Leifer D, Thijs V, Lemmens R, Heitsch L, Prasad K, Jimenez-Conde J, Dichgans M, Rost NS, Cramer SC, Bernhardt J, Worrall BB, Cadenas I
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DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease.
Sala-Vila A, Arenaza-Urquijo EM, Sánchez-Benavides G, Suárez-Calvet M, Milà-Alomà M, Grau-Rivera O, González-de-Echávarri JM, Crous-Bou M, Minguillón C, Fauria K, Operto G, Falcón C, Salvadó G, Cacciaglia R, Ingala S, Barkhof F, Schröder H, Scarmeas N, Gispert JD, Molinuevo JL, ALFA study.
Am J Clin Nutr. 2021 Mar 18;
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TorchMD: A Deep Learning Framework for Molecular Simulations.
Doerr S, Majewski M, Pérez A, Krämer A, Clementi C, Noe F, Giorgino T, De Fabritiis G
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In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood.
Stratakis N, Golden-Mason L, Margetaki K, Zhao Y, Valvi D, Garcia E, Maitre L, Andrusaityte S, Basagana X, Borràs E, Bustamante M, Casas M, Fossati S, Grazuleviciene R, Haug LS, Heude B, McEachan RRC, Meltzer HM, Papadopoulou E, Roumeliotaki T, Robinson O, Sabidó E, Urquiza J, Vafeiadi M, Varo N, Wright J, Vos MB, Hu H, Vrijheid M, Berhane KT, Conti DV, McConnell R, Rosen HR, Chatzi L
Hepatology. 2021 Mar 17;
Clinical impact of pre-surgery circulating tumor DNA after total neoadjuvant treatment in locally advanced rectal cancer: a biomarker study from the GEMCAD1402 Trial.
Vidal J, Casadevall D, Bellosillo B, Pericay C, Garcia-Carbonero R, Losa F, Layos L, Alonso V, Capdevila J, Gallego-Plazas J, Vera R, Salud A, MArtín Richard M, Nogué M, Cillan E, Maurel J, Faull I, Raymond VM, Fernández-Martos C, Montagut C
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Translational adaptation of human viruses to the tissues they infect.
Hernandez-Alias X, Benisty H, Schaefer MH, Serrano L
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SYLVIUS: A multimodal and multidisciplinary platform for epilepsy surgery.
Higueras-Esteban A, Delgado-Martínez I, Serrano L, Principe A, Pérez Enriquez C, González Ballester MÁ, Rocamora R, Conesa G, Serra L
Comput Methods Programs Biomed. 2021 Mar 7;203:106042
Consumption of ultra-processed foods and drinks and colorectal, breast, and prostate cancer.
Romaguera D, Fernández-Barrés S, Gracia-Lavedán E, Vendrell E, Azpiri M, Ruiz-Moreno E, Martín V, Gómez-Acebo I, Obón M, Molinuevo A, Fresán U, Molina-Barceló A, Olmedo-Requena R, Tardón A, Alguacil J, Solans M, Huerta JM, Ruiz-Dominguez JM, Aragonés N, Fernández-Villa T, Dierssen-Sotos T, Moreno V, Guevara M, Vanaclocha-Espi M, Lozano-Lorca M, Fernández-Tardón G, Castaño-Vinyals G, Pérez-Gómez B, Molina AJ, Llorca J, Gil L, Castilla J, Pollán M, Kogevinas M, Amiano P
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Variety in fruits and vegetables, diet quality and lifestyle in an older adult mediterranean population.
López-González L, Becerra-Tomás N, Babio N, Martínez-González MÁ, Díaz-López A, Corella D, Goday A, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones F, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, Álvarez-Álvarez L, Vidal J, Vázquez C, Ros E, Vázquez-Ruiz Z, Canudas S, Carrión RF, Castañer O, Zulet MÁ, Sierra LT, Ajejas Bazán MJ, López García CM, Martín M, García-Ríos A, Casas R, Gómez-Pérez AM, Santos-Lozano JM, Goñi E, Guillem-Saiz P, Lassale C, Abete I, Lete IS, Eguaras S, Schröder H, Salas-Salvadó J, PREDIMED-Plus Investigators.
Clin Nutr. 2021 Feb 24;40(4):1510-1518
Impact of chronic endometritis in infertility: a SWOT analysis.
Espinós JJ, Fabregues F, Fontes J, García-Velasco JA, Llácer J, Requena A, Checa MÁ, Bellver J, Spanish Infertility SWOT Group (SISG).
Reprod Biomed Online. 2021 Feb 11;
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Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin JR, Hurst KE, de Oliveira Taveira M, Johnson NT, Oldham WM, Kalocsay M, Berberich MJ, Boswell SA, Kothari A, Johnson S, Dillon DA, Lipschitz M, Rodig S, Santagata S, Garber JE, Tung N, Yélamos J, Thaxton JE, Mittendorf EA, Sorger PK, Shapiro GI, Guerriero JL
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Psoriasiform Eruption Secondary to PI3K-delta Inhibitor: Expanding the Spectrum of Psoriasiform Paradoxical Reactions?
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Huntington's disease-specific mis-splicing unveils key effector genes and altered splicing factors.
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QCloud2: An Improved Cloud-based Quality-Control System for Mass-Spectrometry-based Proteomics Laboratories.
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Nebulized micafungin treatment for Scopulariopsis/Microascus tracheobronchitis in lung transplant recipients.
Los-Arcos I, Berastegui C, Martín-Gómez MT, Grau S, Campany-Herrero D, Deu M, Sacanell J, Campillo N, Bravo C, Len O
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Nat Commun. 2021 Mar 15;12(1):1679
Prognostic Value of Inflammatory Biomarkers in 5-Year Survival After Endovascular Repair of Abdominal Aortic Aneurysms in a Predominantly Male Cohort: Implications for Practice.
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Lancet Oncol. 2021 Mar 12;
Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome.
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Short pulsed microwave ablation: computer modeling and ex vivo experiments.
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Int J Hyperthermia. 2021;38(1):409-420
Breaking Down and Building Up: Gentrification, Its drivers, and Urban Health Inequality.
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The counteracting effects of demography on functional genomic variation: the Roma paradigm.
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Probiotic Properties of Alcaligenes faecalis Isolated from Argyrosomus regius in Experimental Peritonitis (Rat Model).
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Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients.
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Does surrounding greenness moderate the relationship between apparent temperature and physical activity? Findings from the PHENOTYPE project.
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Lifetime Prevalence and Temporal Trends of Incidence of Child’s Mental Disorder Diagnoses in Catalonia, Spain.
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The impact of urban and transport planning on health: Assessment of the attributable mortality burden in Madrid and Barcelona and its distribution by socioeconomic status.
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Day-night and seasonal variation of human gene expression across tissues.
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bioRxiv. 2021 Mar 1;
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Unraveling COVID-19: a large-scale characterization of 4.5 million COVID-19 cases using CHARYBDIS.
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Confirmatory factor analysis of the International Pain Outcome questionnaire in surgery.
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Varicella complicated with pneumonia in a patient infected by COVID-19: the need to rule out other viral coinfections in SARS-CoV-2 patients with vesicular eruptions.
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Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment.
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Nat Commun. 2021 Mar 8;12(1):1503
Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study.
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Sci Rep. 2021 Mar 8;11(1):5375
Narrative review of citizen science in environmental epidemiology: Setting the stage for co-created research projects in environmental epidemiology.
Froeling F, Gignac F, Hoek G, Vermeulen R, Nieuwenhuijsen M, Ficorilli A, De Marchi B, Biggeri A, Kocman D, Robinson JA, Grazuleviciene R, Andrusaityte S, Righi V, Basagaña X
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A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies.
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Electron Paramagnetic Resonance Gives Evidence for the Presence of Type 1 Gonadotropin-Releasing Hormone Receptor (GnRH-R) in Subdomains of Lipid Rafts.
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Cerebral amyloid-Beta load is associated with neurodegeneration and gliosis: Mediation by p-tau and interactions with risk factors early in the Alzheimer's continuum.
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Alzheimers Dement. 2021 Mar 4;
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Adult specifier E93 takes control of reproductive cyclicity in mosquitoes.
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Proc Natl Acad Sci U S A. 2021 Mar 23;118(12)
Volitional learning promotes theta phase coding in the human hippocampus.
Pacheco Estefan D, Zucca R, Arsiwalla X, Principe A, Zhang H, Rocamora R, Axmacher N, Verschure PFMJ
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10)
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ATypical advanced interatrial block due to giant atrial lipoma.
Lorente DIG, Scott L, Escobar-Robledo LA, Maya MAM, Costa FC, Baranchuk A, Martínez-Sellés M, Elosua R, Bayés-Genís A, Bayés-de-Luna A
Pacing Clin Electrophysiol. 2021 Mar 6;
Digital breast tomosynthesis compared to diagnostic mammographic projections (including magnification) among women recalled at screening mammography: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC).
Canelo-Aybar C, Carrera L, Beltrán J, Posso M, Rigau D, Lebeau A, Gräwingholt A, Castells X, Langendam M, Pérez E, Giorgi Rossi P, Van Engen R, Parmelli E, Saz-Parkinson Z, Alonso-Coello P
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Diagnostic usefulness of immunohistochemical evaluation of CD1a antigen and polyclonal anti-leishmania antibodies in cutaneous leishmaniasis.
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Halo effect of a Mediterranean-lifestyle weight-loss intervention on untreated family members' weight and physical activity: a prospective study.
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Radio-frequency electromagnetic field exposure and contribution of sources in the general population: an organ-specific integrative exposure assessment.
van Wel L, Liorni I, Huss A, Thielens A, Wiart J, Joseph W, Röösli M, Foerster M, Massardier-Pilonchery A, Capstick M, Cardis E, Vermeulen R
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Publisher Correction: Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice.
Cáceres M, Quesada R, Iglesias M, Real FX, Villamonte M, de Villarreal JM, Pérez M, Andaluz A, Moll X, Berjano E, Dorcaratto D, Sánchez-Velázquez P, Grande L, Burdío F
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Physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease: a cross-sectional analysis.
Delgado-Ortiz L, Arbillaga-Etxarri A, Rodríguez-Chiaradía DA, Gimeno-Santos E, Barberan-Garcia A, Balcells E, Rodríguez-Roisin R, Garcia-Aymerich J
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Sarcopenia, Malnutrition, and Cachexia: Adapting Definitions and Terminology of Nutritional Disorders in Older People with Cancer.
Meza-Valderrama D, Marco E, Dávalos-Yerovi V, Muns MD, Tejero-Sánchez M, Duarte E, Sánchez-Rodríguez D
Nutrients. 2021 Feb 26;13(3)
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Role of the NUDT Enzymes in Breast Cancer.
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Int J Mol Sci. 2021 Feb 25;22(5)
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Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients.
Barrera-Conde M, Ausin K, Lachén-Montes M, Fernández-Irigoyen J, Galindo L, Cuenca-Royo A, Fernández-Avilés C, Pérez V, de la Torre R, Santamaría E, Robledo P
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Wound infection by Pantoea agglomerans after penetrating plant injury.
Alpiste FO, Ezquerra GM, Pujol RM
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Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach.
Carcereny E, Fernández-Nistal A, López A, Montoto C, Naves A, Segú-Vergés C, Coma M, Jorba G, Oliva B, Mas JM
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An Operant Conditioning Model Combined with a Chemogenetic Approach to Study the Neurobiology of Food Addiction in Mice.
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Surgical Induction of Endometriosis in Female Mice.
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An Alternative Maze to Assess Novel Object Recognition in Mice.
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Application of Mechanical Forces on Drosophila Embryos by Manipulation of Microinjected Magnetic Particles.
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Osteoarticular Cryptococcosis Successfully Treated with High-Dose Liposomal Amphotericin B Followed by Oral Fluconazole.
Deus G, Gómez-Zorrilla S, Echeverria-Esnal D, Siverio A, Güerri-Fernandez R, Ares J, Campillo N, Letang E, Knobel H, Grau S, Horcajada JP
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Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
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Economic burden of recurrent Clostridioides difficile infection in adults admitted to Spanish hospitals. A multicentre retrospective observational study.
Bouza E, Cobo J, Rodríguez-Hernández MJ, Salavert M, Horcajada JP, Iribarren JA, Obi E, Lozano V, Maratia S, Cuesta M, Uría E, Limón E
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Estimating peptide half-life in serum from tunable, sequence-related physicochemical properties.
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Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey.
Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, Brandão AC, Carfi A, Carmona-Iragui M, Chicoine BA, Ghosh S, Lakhanpaul M, Manso C, Mayer MA, Ortega MDC, de Asua DR, Rebillat AS, Russell LA, Sgandurra G, Valentini D, Sherman SL, Strydom A, T21RS COVID-19 Initiative.
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Assessing the impact of COVID-19 on liver cancer management (CERO-19).
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
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Perceived helpfulness of bipolar disorder treatment: Findings from the World Health Organization World Mental Health Surveys.
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Ecto-GPR37: a potential biomarker for Parkinson's disease.
Morató X, Garcia-Esparcia P, Argerich J, Llorens F, Zerr I, Paslawski W, Borràs E, Sabidó E, Petäjä-Repo UE, Fernández-Dueñas V, Ferrer I, Svenningsson P, Ciruela F
Transl Neurodegener. 2021 Feb 26;10(1):8
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Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome.
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Guidelines for FAIR sharing of preclinical safety and off-target pharmacology data.
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Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation.
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Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nielsen SF, Nordestgaard BG, Wiklund F, Tangen CM, Giles GG, Wolk A, Albanes D, Travis RC, Blot WJ, Zheng W, Sanderson M, Stanford JL, Mucci LA, West CML, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Menegaux F, Khaw KT, Park JY, Ingles SA, Maier C, Hamilton RJ, Thibodeau SN, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Penney KL, Huff C, Teixeira MR, Multigner L, Leach RJ, Cannon-Albright L, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Pandha H, Razack A, Newcomb LF, Fowke JH, Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Bush WS, Roobol MJ, Parent MÉ, Hu JJ, Mills IG, Andreassen OA, Dale AM, Seibert TM, UKGPCS collaborators., APCB (Australian Prostate Cancer BioResource)., NC-LA PCaP Investigators., IMPACT Study Steering Committee and Collaborators., Canary PASS Investigators., Profile Study Steering Committee., PRACTICAL Consortium.
Nat Commun. 2021 Feb 23;12(1):1236
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Household cleaning and poor asthma control among elderly women.
Dumas O, Bédard A, Marbac M, Sedki M, Temam S, Chanoine S, Severi G, Boutron-Ruault MC, Garcia-Aymerich J, Siroux V, Varraso R, Le Moual N
J Allergy Clin Immunol Pract. 2021 Feb 22;
Factors Associated With the Risk of Developing Moderate to Severe Acute Postoperative Pain After Primary Total Knee Arthroplasty: Results From the PAIN OUT Registry.
García-López J, Polanco-García M, Montes A
J Arthroplasty. 2021 Feb 6;
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition.
Ros-Rocher N, Pérez-Posada A, Leger MM, Ruiz-Trillo I
Open Biol. 2021 Feb;11(2):200359
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Hospital-at-Home Expands Hospital Capacity During COVID-19 Pandemic.
Nogués X, Sánchez-Martinez F, Castells X, Díez-Pérez A, Sabaté RA, Petit I, Brasé A, Horcajada JP, Güerri-Fernández R, Pascual J
J Am Med Dir Assoc. 2021 Jan 31;
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High-density lipoprotein functional traits and coronary artery disease in a general population: a case-cohort study.
Sanllorente A, Castañer O, Lassale C, Almanza-Aguilera E, Elosua R, Vila J, Soldado M, Blanchart G, Muñoz-Aguayo D, Subirana I, Marrugat J, Hernáez Á, Fitó M
Eur J Prev Cardiol. 2020 Dec 28;
Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers.
Head SA, Hernandez-Alias X, Yang JS, Ciampi L, Beltran-Sastre V, Torres-Méndez A, Irimia M, Schaefer MH, Serrano L
PLoS Biol. 2021 Feb 23;19(2):e3001138
Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain.
Ramírez-López Á, Pastor A, de la Torre R, La Porta C, Ozaita A, Cabañero D, Maldonado R
Eur J Pain. 2021 Feb 22;
Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion.
Faria M, Prats E, Rosas Ramírez JR, Bellot M, Bedrossiantz J, Pagano M, Valls A, Gomez-Canela C, Porta JM, Mestres J, Garcia-Reyero N, Faggio C, Gómez Oliván LM, Raldua D
Sci Total Environ. 2021 Feb 15;775:145671
Reduced expansion of CD94/NKG2C+ NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.
Puiggros A, Blanco G, Muntasell A, Rodríguez-Rivera M, Nonell L, Altadill M, Puigdecanet E, Arnal M, Calvo X, Gimeno E, Abella E, Abrisqueta P, Bosch F, Yélamos J, Ferrer A, López-Botet M, Espinet B
Int J Lab Hematol. 2021 Feb 22;
Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent.
Collij LE, Salvadó G, Shekari M, Alves IL, Reimand J, Wink AM, Zwan M, Niñerola-Baizán A, Perissinotti A, Scheltens P, Ikonomovic MD, Smith APL, Farrar G, Molinuevo JL, Barkhof F, Buckley CJ, van Berckel BNM, Gispert JD, ALFA study., AMYPAD consortium.
Eur J Nucl Med Mol Imaging. 2021 Feb 22;
Obstructive Sleep Apnea Syndrome as a Trigger of Cardiac Arrhythmias.
Martí-Almor J, Jiménez-López J, Casteigt B, Conejos J, Valles E, Farré N, Flor MF
Curr Cardiol Rep. 2021 Feb 20;23(3):20
A Gender Perspective of Addictive Disorders.
Fonseca F, Robles-Martínez M, Tirado-Muñoz J, Alías-Ferri M, Mestre-Pintó JI, Coratu AM, Torrens M
Curr Addict Rep. 2021 Feb 16;:1-11
Swine T-Cells and Specific Antibodies Evoked by Peptide Dendrimers Displaying Different FMDV T-Cell Epitopes.
de León P, Cañas-Arranz R, Defaus S, Torres E, Forner M, Bustos MJ, Revilla C, Dominguez J, Andreu D, Blanco E, Sobrino F
Front Immunol. 2020;11:621537
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Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study.
Cortes-Canteli M, Gispert JD, Salvadó G, Toribio-Fernandez R, Tristão-Pereira C, Falcon C, Oliva B, Mendiguren J, Fernandez-Friera L, Sanz J, Garcia-Ruiz JM, Fernandez-Ortiz A, Sanchez-Gonzalez J, Ibanez B, Molinuevo JL, Fuster V
J Am Coll Cardiol. 2021 Feb 23;77(7):888-898
Complete genomic characterization of a new KLRC2 allele, NKG2C*03.
Asenjo J, Muntasell A, López-Botet M, Moraru M, Vilches C
HLA. 2021 Feb 20;
Predictors of Metachronous Risk Polyps After Index Colonoscopy.
Carot L, Navarro G, Naranjo-Hans D, Iglesias-Coma M, Dalmases A, Fernández L, Seoane A, Buron A, Bellosillo B, Bessa X, Andreu M, Alvarez-Urturi C
Clin Transl Gastroenterol. 2021 Feb 18;12(2):e00304
The longitudinal association of eating behaviour and ADHD symptoms in school age children: a follow-up study in the RHEA cohort.
Leventakou V, Herle M, Kampouri M, Margetaki K, Vafeiadi M, Kogevinas M, Chatzi L, Micali N
Eur Child Adolesc Psychiatry. 2021 Feb 18;
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Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease.
Grau-Rivera O, Navalpotro-Gomez I, Sánchez-Benavides G, Suárez-Calvet M, Milà-Alomà M, Arenaza-Urquijo EM, Salvadó G, Sala-Vila A, Shekari M, González-de-Echávarri JM, Minguillón C, Niñerola-Baizán A, Perissinotti A, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Gispert JD, Molinuevo JL, ALFA Study.
Alzheimers Res Ther. 2021 Feb 17;13(1):46
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Neuropsychiatric involvement in systemic lupus erythematosus: A review.
Carrión-Barberà I, Salman-Monte TC, Vílchez-Oya F, Monfort J
Autoimmun Rev. 2021 Feb 17;:102780
Reduction in new cardiac electronic device implantations in Catalonia during COVID-19.
Arbelo E, Angera I, Trucco E, Rivas-Gándara N, Guerra JM, Bisbal F, Jáuregui-Abularach M, Vallés E, Martin G, Sbraga F, Tolosana JM, Linhart M, Francisco-Pascual J, Montiel-Serrano J, Pereferrer D, Menéndez-Ramírez D, Jiménez J, Elamrani A, Borrás R, Dallaglio PD, Benito E, Santos-Ortega A, Rodríguez-Font E, Sarrias A, González-Matos CE, Martí-Almor J, Cabrera S, Mont L
Europace. 2021 Feb 17;
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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.
Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD
Mol Cell. 2021 Feb 10;
Kidney transplant after a COVID-19.
Pascual J
Nefrologia. 2021 Jan 9;
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Transitioning from a coronary to a critical cardiovascular care unit: trends over the past three decades.
Ferrer M, García-García C, El Ouaddi N, Rueda F, Serra J, Oliveras T, Labata C, Dégano IR, Montero S, De Diego O, Elosúa R, Lupón J, Bayes-Genis A
Eur Heart J Acute Cardiovasc Care. 2020 Jul 16;
Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.
Bousquet J, Czarlewski W, Zuberbier T, Mullol J, Blain H, Cristol JP, De La Torre R, Pizarro Lozano N, Le Moing V, Bedbrook A, Agache I, Akdis CA, Canonica GW, Cruz AA, Fiocchi A, Fonseca JA, Fonseca S, Gemicioglu B, Haahtela T, Iaccarino G, Ivancevich JC, Jutel M, Klimek L, Kraxner H, Kuna P, Larenas-Linnemann DE, Martineau A, Melén E, Okamoto Y, Papadopoulos NG, Pfaar O, Regateiro FS, Reynes J, Rolland Y, Rouadi PW, Samolinski B, Sheikh A, Toppila-Salmi S, Valiulis A, Choi HJ, Kim HJ, Anto JM
Int Arch Allergy Immunol. 2021 Feb 10;:1-15
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The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS.
Orkin JD, Montague MJ, Tejada-Martinez D, de Manuel M, Del Campo J, Cheves Hernandez S, Di Fiore A, Fontsere C, Hodgson JA, Janiak MC, Kuderna LFK, Lizano E, Martin MP, Niimura Y, Perry GH, Valverde CS, Tang J, Warren WC, de Magalhães JP, Kawamura S, Marquès-Bonet T, Krawetz R, Melin AD
Proc Natl Acad Sci U S A. 2021 Feb 16;118(7)
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Long-term risks after kidney donation: How do we inform potential donors? A survey from descartes and EKITA transplantation working groups.
Mjøen G, Maggiore U, Kessaris N, Kimenai D, Watschinger B, Mariat C, Sever MS, Crespo M, Peruzzi L, Spasovski G, Sørensen SS, Heemann U, Pascual J, Viklicky O, Courtney AE, Hadaya K, Wagner L, Nistor I, Hadjianastassiou V, Durlik M, Helanterä I, Oberbauer R, Oniscu G, Hilbrands L, Abramowicz D, European Renal Association-European Dialysis Transplant Association (ERA-EDTA) Developing Education Science and Care for Renal Transplantation in European States (DESCARTES) working group and the European Society of Organ Transplantation (ESOT) European Kidney Transplant Association (EKITA) – Collaborators are in the Appendix.
Nephrol Dial Transplant. 2021 Feb 15;
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies.
Dobaño C, Santano R, Jiménez A, Vidal M, Chi J, Melero NR, Popovic M, López-Aladid R, Fernández-Barat L, Tortajada M, Carmona-Torre F, Reina G, Torres A, Mayor A, Carolis C, García-Basteiro AL, Aguilar R, Moncunill G, Izquierdo L
Transl Res. 2021 Feb 12;
Smoking modifies pancreatic cancer risk loci on 2q21.3.
Mocci E, Kundu P, Wheeler W, Arslan AA, Beane Freeman LE, Bracci PM, Brennan P, Canzian F, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Le Marchand L, Neale RE, Shu XO, Visvanathan K, White E, Zheng W, Albanes D, Andreotti G, Babic A, Bamlet WR, Berndt SI, Blackford AL, Bueno-de-Mesquita B, Buring JE, Campa D, Chanock SJ, Childs EJ, Duell EJ, Fuchs CS, Gaziano JM, Giovannucci EL, Goggins MG, Hartge P, Hassan MM, Holly EA, Hoover RN, Hung RJ, Kurtz RC, Lee IM, Malats N, Milne RL, Ng K, Oberg AL, Panico S, Peters U, Porta M, Rabe KG, Riboli E, Rothman N, Scelo G, Sesso HD, Silverman DT, Stevens VL, Strobel O, Thompson IM, Tjonneland A, Trichopoulou A, Van Den Eeden SK, Wactawski-Wende J, Wentzensen N, Wilkens LR, Yu H, Yuan F, Zeleniuch-Jacquotte A, Amundadottir LT, Li D, Jacobs EJ, Petersen GM, Wolpin BM, Risch HA, Kraft P, Chatterjee N, Klein AP, Stolzenberg-Solomon RZ
Cancer Res. 2021 Feb 11;
Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome.
Atzeni A, Galié S, Muralidharan J, Babio N, Tinahones FJ, Vioque J, Corella D, Castañer O, Vidal J, Moreno-Indias I, Torres-Collado L, Fernández-Carrión R, Fitó M, Olbeyra R, Martínez-González MA, Bulló M, Salas-Salvadó J
Microorganisms. 2021 Feb 10;9(2)
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A Transdisciplinary Approach to Recovering Natural and Cultural Landscape and Place Identification: A Case Study of Can Moritz Spring (Rubí, Spain).
Cervera M, Bell S, Muñoz F, Mishra HS, Fleming LE, Grellier J, Carrasco-Turigas G, Nieuwenhuijsen MJ, Vert C, Gascon M
Int J Environ Res Public Health. 2021 Feb 10;18(4)
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Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms.
Oliveras A, Galceran I, Goday A, Vázquez S, Sans L, Riera M, Benaiges D, Pascual J
J Clin Med. 2021 Feb 10;10(4)
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Cooperative epithelial phagocytosis enables error correction in the early embryo.
Hoijman E, Häkkinen HM, Tolosa-Ramon Q, Jiménez-Delgado S, Wyatt C, Miret-Cuesta M, Irimia M, Callan-Jones A, Wieser S, Ruprecht V
Nature. 2021 Feb 10;
Cell memory of epithelial-mesenchymal plasticity in cancer.
Berenguer J, Celià-Terrassa T
Curr Opin Cell Biol. 2021 Feb 9;69:103-110
Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection.
Vogel-González M, Talló-Parra M, Herrera-Fernández V, Pérez-Vilaró G, Chillón M, Nogués X, Gómez-Zorrilla S, López-Montesinos I, Arnau-Barrés I, Sorli-Redó ML, Horcajada JP, García-Giralt N, Pascual J, Díez J, Vicente R, Güerri-Fernández R
Nutrients. 2021 Feb 9;13(2)
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Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19.
Barbui T, De Stefano V, Alvarez-Larran A, Iurlo A, Masciulli A, Carobbio A, Ghirardi A, Ferrari A, Cancelli V, Elli EM, Andrade-Campos MM, Kabat MG, Kiladjian JJ, Palandri F, Benevolo G, Garcia-Gutierrez V, Fox ML, Foncillas MA, Morcillo CM, Rumi E, Osorio S, Papadopoulos P, Bonifacio M, Cervantes KSQ, Serrano MS, Carreno-Tarragona G, Sobas MA, Lunghi F, Patriarca A, Elorza BN, Angona A, Mazo EM, Koschmieder S, Carli G, Cuevas B, Hernandez-Boluda JC, Abadia EL, Cirici BX, Guglielmelli P, Garrote M, Cattaneo D, Daffini R, Cavalca F, Bellosillo B, Benajiba L, Curto-Garcia N, Bellini M, Betti S, Harrison C, Rambaldi A, Vannucchi AM
Blood Cancer J. 2021 Feb 4;11(2):21
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Incidence of pulmonary embolism in patients with non-invasive respiratory support during COVID-19 outbreak.
González-García JG, Pascual-Guardia S, Aguilar Colindres RJ, Ausín Herrero P, Alvarado Miranda M, Arita Guevara M, Badenes Bonet D, Bellido Calduch S, Caguana Vélez OA, Cumpli Gargallo C, Dominguez-Alvarez M, Gea J, Grau N, Khilzi K, Martínez-Llorens J, Sánchez Ortiz M, Sánchez-Font A, Sancho-Muñoz A, Parrilla-Gómez FJ, Marín Corral J, Pérez Terán P, Rodríguez-Sevilla JJ, Chalela R, Rodríguez-Chiaradia D
Respir Med. 2021 Feb 4;178:106325
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Variation in predicted COVID-19 risk among lemurs and lorises.
Melin AD, Orkin JD, Janiak MC, Valenzuela A, Kuderna L, Marrone F, Ramangason H, Horvath JE, Roos C, Kitchener AC, Khor CC, Lim WK, Lee JGH, Tan P, Umapathy G, Raveendran M, Harris RA, Gut I, Gut M, Lizano E, Nadler T, Zinner D, Johnson SE, Jarvis ED, Fedrigo O, Wu D, Zhang G, Farh KK, Rogers J, Marques-Bonet T, Navarro A, Juan D, Arora PS, Higham JP
bioRxiv. 2021 Feb 3;
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From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities.
Hernáez Á, Jaramillo S, García-Borrego A, Espejo-Calvo JA, Covas MI, Blanchart G, de la Torre R, Carrasco-Pancorbo A, Mesa MD, Fernández-Prior MÁ, Castañer O, Fitó M
Antioxidants (Basel). 2021 Jan 30;10(2)
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Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic.
Grau S, Echeverria-Esnal D, Gómez-Zorrilla S, Navarrete-Rouco ME, Masclans JR, Espona M, Gracia-Arnillas MP, Duran X, Comas M, Horcajada JP, Ferrández O
Antibiotics (Basel). 2021 Jan 29;10(2)
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Characterization of nuclear mitochondrial insertions in the whole genomes of primates.
Dayama G, Zhou W, Prado-Martinez J, Marques-Bonet T, Mills RE
NAR Genom Bioinform. 2020 Dec;2(4):lqaa089
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A fully integrated machine learning scan of selection in the chimpanzee genome.
Nye J, Mondal M, Bertranpetit J, Laayouni H
NAR Genom Bioinform. 2020 Sep;2(3):lqaa061
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On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF.
Meseguer A, Årman F, Fornes O, Molina-Fernández R, Bonet J, Fernandez-Fuentes N, Oliva B
NAR Genom Bioinform. 2020 Sep;2(3):lqaa046
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First Person Account COVID 19 Delirium in a Doctor: When Death Stalks the Mind.
Arumi A, Bulbena-Cabre A, Bulbena A
Front Psychiatry. 2021;12:626648
The Immunobiogram, a Novel In Vitro Assay to Evaluate Treatment Resistance in Patients Receiving Immunosuppressive Therapy.
Portoles JM, Jimenez C, Janeiro D, Lopez-Oliva MO, Ortega-Carrion A, Blanquez D, Arribas L, Gomez C, Diez T, Pascual J, Portero I
Front Immunol. 2020;11:618202
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Efficacy and safety of oral fosfomycin for asymptomatic bacteriuria in kidney transplant recipients: Results from a Spanish multicenter cohort.
Ruiz-Ruigómez M, Fernández-Ruiz M, Silva JT, Vidal E, Origüen J, Calvo-Cano A, Luna-Huerta E, Merino E, Hernández D, Jironda-Gallegos C, Escudero-Sánchez R, Gioia F, Moreno A, Roca C, Cordero E, Janeiro D, Sánchez-Sobrino B, Montero MM, Redondo D, Candel FJ, Pérez-Flores I, Armiñanzas C, González-Rico C, Fariñas MC, Rodrigo E, Loeches B, López-Oliva MO, Montejo M, Lauzurica R, Horcajada JP, Pascual J, Andrés A, Aguado JM, López-Medrano F, REIPI, REDinREN, and GESITRA-IC/SEIMC.
Antimicrob Agents Chemother. 2021 Feb 8;
Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study.
Fernández-Castillejo S, Pedret A, Catalán Ú, Valls RM, Farràs M, Rubió L, Castañer O, Macià A, Fitó M, Motilva MJ, Covas MI, Giera M, Remaley AT, Solà R
Mol Nutr Food Res. 2021 Feb 9;:e2001192
miR-24-3p regulates CDX2 during intestinalization of cardiac-type epithelium in a human model of Barrett's esophagus.
Gil-Gómez G, Fassan M, Nonell L, Garrido M, Climent M, Anglada R, Iglesias M, Guzzardo V, Borga C, Grande L, de Bolós C, Pera M
Dis Esophagus. 2021 Feb 9;
Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity.
Ruiz de Azua I, Martin-Garcia E, Domingo-Rodriguez L, Aparisi Rey A, Pascual Cuadrado D, Islami L, Turunen P, Remmers F, Lutz B, Maldonado R
Neuropsychopharmacology. 2021 Feb 8;
A Loading Micafungin Dose in Critically Ill Patients Undergoing Continuous Veno-Venous Hemofiltration or Continuous Veno-Venous Hemodiafiltration: A Population Pharmacokinetic Analysis.
Garbez N, Mbatchi LC, Maseda E, Luque S, Grau S, Wallis SC, Muller L, Lipman J, Roberts JA, Lefrant JY, Roger C
Ther Drug Monit. 2021 Feb 8;
Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial.
Díaz-López A, Becerra-Tomás N, Ruiz V, Toledo E, Babio N, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Cano Ibañez N, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, de Paz JA, Vidal J, Vázquez C, Ruiz-Canela M, Bulló M, Sorlí JV, Goday A, Fiol M, García-de-la-Hera M, Tojal Sierra L, Pérez-Farinós N, Zulet MÁ, Sánchez-Villegas A, Sacanella E, Fernández-García JC, Santos-Lozano JM, Gimenez-Gracia M, Del Mar Bibiloni M, Diez-Espino J, Ortega-Azorin C, Castañer O, Morey M, Torres-Collado L, Sorto Sanchez C, Muñoz MÁ, Ros E, Martinez-Gonzalez MA, Salas-Salvadó J, PREDIMED-Plus Investigators.
Am J Nephrol. 2021 Feb 8;:1-14
LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry.
Climent E, Bea AM, Benaiges D, Brea-Hernando Á, Pintó X, Suárez-Tembra M, Perea V, Plana N, Blanco-Vaca F, Pedro-Botet J, Dyslipidaemia Registry of the Spanish Atherosclerosis Society.
Cardiovasc Drugs Ther. 2021 Feb 8;
Pathways linking biodiversity to human health: A conceptual framework.
Marselle MR, Hartig T, Cox DTC, de Bell S, Knapp S, Lindley S, Triguero-Mas M, Böhning-Gaese K, Braubach M, Cook PA, de Vries S, Heintz-Buschart A, Hofmann M, Irvine KN, Kabisch N, Kolek F, Kraemer R, Markevych I, Martens D, Müller R, Nieuwenhuijsen M, Potts JM, Stadler J, Walton S, Warber SL, Bonn A
Environ Int. 2021 Feb 6;150:106420
Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy.
Linares J, Marín-Jiménez JA, Badia-Ramentol J, Calon A
Front Cell Dev Biol. 2020;8:621070
Effects of Environmental Factors on Severity and Mortality of COVID-19.
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Assessing Autophagy in Muscle Stem Cells.
Campanario S, Ramírez-Pardo I, Hong X, Isern J, Muñoz-Cánoves P
Front Cell Dev Biol. 2020;8:620409
Accidental extubation in prone position: Report of two cases and proposal of an algorithm for airway management.
Bosch L, Pacreu S, Castelltort L, Gallart L
Eur J Anaesthesiol. 2021 Mar 1;38(3):319-322
PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses.
Acera Mateos P, Balboa RF, Easteal S, Eyras E, Patel HR
Sci Rep. 2021 Feb 5;11(1):3209
http://www.ncbi.nlm.nih.gov/en...
Antimyeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis.
Rodríguez E, Latzke B, Sierra M, Romera AM, Siedel D, Agraz I, Soler MJ, García-Carro C, Draibe J, de la Prada FJ, Villacorta J, Buxeda A, Sierra-Ochoa A, Lozano I, Durán X, Barrios C, Pascual J, Spanish Group for the Study of Glomerular Diseases (GLOSEN).
Nephrol Dial Transplant. 2021 Feb 3;
Frequency of sensitisation to the individual fragrances of Fragrance Mix I and II according to the factors included in the MOAHLFA index.
Sánchez-Pujol MJ, Docampo-Simón A, Mercader P, González-Pérez R, Hervella-Garcés M, Sanz-Sánchez T, Córdoba S, Sánchez-Pérez J, Heras-Mendaza F, Giménez-Arnau AM, Gatica-Ortega ME, Pastor-Nieto MA, Zaragoza V, Carrascosa JM, García-Bravo B, Ruiz-González I, Borrego L, Sánchez-Pedreño P, de Frutos JO, Armario-Hita JC, García-Gavín J, Fernández-Redondo V, Serra E, Silvestre JF
Contact Dermatitis. 2021 Feb 3;
Interplay between Humoral and CLA+ T Cell Response against Candida albicans in Psoriasis.
de Jesús-Gil C, Sans-de San Nicolàs L, Ruiz-Romeu E, Ferran M, Soria-Martínez L, García-Jiménez I, Chiriac A, Casanova-Seuma JM, Fernández-Armenteros JM, Owens S, Celada A, Howell MD, Pujol RM, Santamaria-Babí LF
Int J Mol Sci. 2021 Feb 3;22(4)
http://www.ncbi.nlm.nih.gov/en...
Benchmarking the performance of Pool-seq SNP callers using simulated and real sequencing data.
Guirao-Rico S, González J
Mol Ecol Resour. 2021 Feb 3;
Habitat preference and diversification rates in a speciose lineage of diving beetles.
Villastrigo A, Abellán P, Ribera I
Mol Phylogenet Evol. 2021 Feb 2;:107087
Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease.
Dávalos-Yerovi V, Marco E, Sánchez-Rodríguez D, Duran X, Meza-Valderrama D, Rodríguez DA, Muñoz E, Tejero-Sánchez M, Muns MD, Guillén-Solà A, Duarte E
Nutrients. 2021 Jan 26;13(2)
http://www.ncbi.nlm.nih.gov/en...
EAACI Biologicals Guidelines-dupilumab for children and adults with moderate-to-severe atopic dermatitis.
Agache I, Akdis C, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong PY, O'Mahony L, Schwarze J, Warner A, Werfel T, Palomares O, Jutel M
Allergy. 2020 Dec 7;
Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics.
Heerlein K, Young AH, Otte C, Frodl T, Degraeve G, Hagedoorn W, Oliveira-Maia AJ, Perez Sola V, Rathod S, Rosso G, Sierra P, Morrens J, Van Dooren G, Gali Y, Perugi G
J Affect Disord. 2020 Nov 30;283:115-122
http://www.ncbi.nlm.nih.gov/en...
Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome.
Garrido-Martín D, Borsari B, Calvo M, Reverter F, Guigó R
Nat Commun. 2021 Feb 1;12(1):727
Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans.
Papaseit E, Olesti E, Pérez-Mañá C, Torrens M, Fonseca F, Grifell M, Ventura M, de la Torre R, Farré M
Pharmaceuticals (Basel). 2021 Jan 28;14(2)
Do Pregnancy-Induced Brain Changes Reverse? The Brain of a Mother Six Years after Parturition.
Martínez-García M, Paternina-Die M, Barba-Müller E, Martín de Blas D, Beumala L, Cortizo R, Pozzobon C, Marcos-Vidal L, Fernández-Pena A, Picado M, Belmonte-Padilla E, Massó-Rodriguez A, Ballesteros A, Desco M, Vilarroya Ó, Hoekzema E, Carmona S
Brain Sci. 2021 Jan 28;11(2)
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.
López de Maturana E, Rodríguez JA, Alonso L, Lao O, Molina-Montes E, Martín-Antoniano IA, Gómez-Rubio P, Lawlor R, Carrato A, Hidalgo M, Iglesias M, Molero X, Löhr M, Michalski C, Perea J, O'Rorke M, Barberà VM, Tardón A, Farré A, Muñoz-Bellvís L, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Gress T, Greenhalf W, Sharp L, Arnes L, Cecchini L, Balsells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Márquez M, Mora J, O'Driscoll D, Scarpa A, Ye W, Yu J, PanGenEU Investigators., García-Closas M, Kogevinas M, Rothman N, Silverman DT, SBC/EPICURO Investigators., Albanes D, Arslan AA, Beane-Freeman L, Bracci PM, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Du M, Gallinger S, Gaziano JM, Goodman PJ, Gunter M, LeMarchand L, Li D, Neale RE, Peters U, Petersen GM, Risch HA, Sánchez MJ, Shu XO, Thornquist MD, Visvanathan K, Zheng W, Chanock SJ, Easton D, Wolpin BM, Stolzenberg-Solomon RZ, Klein AP, Amundadottir LT, Marti-Renom MA, Real FX, Malats N
Genome Med. 2021 Feb 1;13(1):15
The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.
Seuma M, Faure A, Badia M, Lehner B, Bolognesi B
Elife. 2021 Feb 1;10
Environment and the COVID-19 pandemic.
Sunyer J, Dadvand P, Foraster M, Gilliland F, Nawrot T
Environ Res. 2021 Jan 29;:110819
Suicidality among healthcare professionals during the first COVID19 wave.
Bruffaerts R, Voorspoels W, Jansen L, Kessler RC, Mortier P, Vilagut G, De Vocht J, Alonso J
J Affect Disord. 2021 Jan 11;283:66-70
Differential associations of APOE-epsilon2 and APOE-epsilon4 alleles with PET-measured amyloid-Beta and tau deposition in older individuals without dementia.
Salvadó G, Grothe MJ, Groot C, Moscoso A, Schöll M, Gispert JD, Ossenkoppele R, Alzheimer’s Disease Neuroimaging Initiative.
Eur J Nucl Med Mol Imaging. 2021 Feb 1;
COVID-19 Incidence in Patients With Immunomediated Inflammatory Diseases: Influence of Immunosuppressant Treatments.
Soldevila-Domenech N, Tío L, Llorente-Onaindia J, Martín-García E, Nebot P, de la Torre R, Gurt A, Maldonado R, Monfort J, Covidmar Study Group.
Front Pharmacol. 2020;11:583260
The Prevalence and Clinical and Sociodemographic Factors of Problem Online Gambling: A Systematic Review.
Mora-Salgueiro J, García-Estela A, Hogg B, Angarita-Osorio N, Amann BL, Carlbring P, Jiménez-Murcia S, Pérez-Sola V, Colom F
J Gambl Stud. 2021 Jan 29;
Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways.
Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Contreras-Rodríguez O, Burokas A, Ortega-Sanchez JA, Blasco G, Coll C, Biarnés C, Castells-Nobau A, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Barretina J, Gich J, Pérez-Brocal V, Moya A, Fernández-Real X, Ramio-Torrentà L, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Maldonado R, Fernández-Real JM
Gut. 2021 Jan 29;
http://www.ncbi.nlm.nih.gov/en...
Augmentation of EMDR with multifocal transcranial current stimulation (MtCS) in the treatment of fibromyalgia: study protocol of a double-blind randomized controlled exploratory and pragmatic trial.
Gardoki-Souto I, Martín de la Torre O, Hogg B, Redolar-Ripoll D, Valiente-Gómez A, Martínez Sadurní L, Blanch JM, Lupo W, Pérez V, Radua J, Amann BL, Moreno-Alcázar A
Trials. 2021 Jan 29;22(1):104
http://www.ncbi.nlm.nih.gov/en...
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation.
Vilarrasa-Blasi R, Soler-Vila P, Verdaguer-Dot N, Russiñol N, Di Stefano M, Chapaprieta V, Clot G, Farabella I, Cuscó P, Kulis M, Agirre X, Prosper F, Beekman R, Beà S, Colomer D, Stunnenberg HG, Gut I, Campo E, Marti-Renom MA, Martin-Subero JI
Nat Commun. 2021 Jan 28;12(1):651
http://www.ncbi.nlm.nih.gov/en...
Polycythemia Vera and Essential Thrombocythemia Patients Exhibit Unique Serum Metabolic Profiles Compared to Healthy Individuals and Secondary Thrombocytosis Patients.
Gómez-Cebrián N, Rojas-Benedicto A, Albors-Vaquer A, Bellosillo B, Besses C, Martínez-López J, Pineda-Lucena A, Puchades-Carrasco L
Cancers (Basel). 2021 Jan 27;13(3)
http://www.ncbi.nlm.nih.gov/en...
Uncovering de novo gene birth in yeast using deep transcriptomics.
Blevins WR, Ruiz-Orera J, Messeguer X, Blasco-Moreno B, Villanueva-Cañas JL, Espinar L, Díez J, Carey LB, Albà MM
Nat Commun. 2021 Jan 27;12(1):604
http://www.ncbi.nlm.nih.gov/en...
Tergal and pleural wing-related tissues in the German cockroach and their implication to the evolutionary origin of insect wings.
Clark-Hachtel C, Fernandez-Nicolas A, Belles X, Tomoyasu Y
Evol Dev. 2021 Jan 27;:e12372
Tunnels for Protein Export from the Endoplasmic Reticulum.
Raote I, Malhotra V
Annu Rev Biochem. 2021 Jan 27;
http://www.ncbi.nlm.nih.gov/en...
Subcellular relocalization and nuclear redistribution of the RNA methyltransferases TRMT1 and TRMT1L upon neuronal activation.
Jonkhout N, Cruciani S, Santos Vieira HG, Tran J, Liu H, Liu G, Pickford R, Kaczorowski D, Franco GR, Vauti F, Camacho N, Abedini SS, Najmabadi H, Ribas de Pouplana L, Christ D, Schonrock N, Mattick JS, Novoa EM
RNA Biol. 2021 Jan 27;
The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4-5 Years of Age in the INMA Project.
Compañ Gabucio LM, García de la Hera M, Torres Collado L, Fernández-Somoano A, Tardón A, Guxens M, Vrijheid M, Rebagliato M, Murcia M, Ibarluzea J, Martí I, Vioque J
Nutrients. 2021 Jan 23;13(2)
http://www.ncbi.nlm.nih.gov/en...
Assessing the Policy Environment for Active Mobility in Cities-Development and Feasibility of the PASTA Cycling and Walking Policy Environment Score.
Kahlmeier S, Boig EA, Fernandez A C, Smeds E, Benvenuti F, Eriksson U, Iacorossi F, Nieuwenhuijsen MJ, Int Panis L, Rojas-Rueda D, Wegener S, de Nazelle A
Int J Environ Res Public Health. 2021 Jan 22;18(3)
http://www.ncbi.nlm.nih.gov/en...
Meeting report of the 17th Spanish Society for Developmental Biology Meeting (SEBD2020).
Araújo SJ, Almudi I, Bozal-Basterra L, Casares F, Casas-Tintó S, Escalante A, García-Moreno F, Losada-Pérez M, Maeso I, Marcon L, Ocaña O, Pampliega O, Rada-Iglesias Á, Rayon T, Sharpe J, Sutherland JD, Villa Del Campo C, Barrio R
Int J Dev Biol. 2021 Jan 22;
Minimal Residual Disease, Metastasis and Immunity.
Badia-Ramentol J, Linares J, Gómez-Llonin A, Calon A
Biomolecules. 2021 Jan 20;11(2)
http://www.ncbi.nlm.nih.gov/en...
Skin microbiome transplantation and manipulation: Current state of the art.
Callewaert C, Knödlseder N, Karoglan A, Güell M, Paetzold B
Comput Struct Biotechnol J. 2021;19:624-631
http://www.ncbi.nlm.nih.gov/en...
Cocaine-seeking behaviour is differentially expressed in male and female mice exposed to maternal separation and is associated with alterations in AMPA receptors subunits in the medial prefrontal cortex.
Castro-Zavala A, Martin-Sanchez A, Montalvo-Martínez L, Camacho-Morales A, Valverde O
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jan 23;:110262
Evaluation of Computationally Designed Peptides against TWEAK, a Cytokine of the Tumour Necrosis Factor Ligand Family.
Badia-Villanueva M, Defaus S, Foj R, Andreu D, Oliva B, Sierra A, Fernandez-Fuentes N
Int J Mol Sci. 2021 Jan 21;22(3)
Comment on "Does Thermal Ablation Increase or Decrease the Risk of Tumor Local Recurrence?"
Burdío F, Sánchez-Velázquez P, Grande L, Mulier S, Radosevic A, Berjano E, Moll X, Andaluz A, García-Tejedor A
Ann Surg. 2021 Jan 22;
Progression of Motor and Non-Motor Symptoms in Multiple System Atrophy: A Prospective Study from the Catalan-MSA Registry.
Pérez-Soriano A, Giraldo DM, Ríos J, Muñoz E, Compta Y, Martí MJ, Catalán MSA Registry (CMSAR) .
J Parkinsons Dis. 2021 Jan 21;
Risk of cancer associated with low-dose radiation exposure: comparison of results between the INWORKS nuclear workers study and the A-bomb survivors study.
Leuraud K, Richardson DB, Cardis E, Daniels RD, Gillies M, Haylock R, Moissonnier M, Schubauer-Berigan MK, Thierry-Chef I, Kesminiene A, Laurier D
Radiat Environ Biophys. 2021 Jan 21;
http://www.ncbi.nlm.nih.gov/en...
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19.
De Toma I, Dierssen M
Sci Rep. 2021 Jan 21;11(1):1930
http://www.ncbi.nlm.nih.gov/en...
Validity and responsiveness of the Daily- and Clinical visit-PROactive Physical Activity in COPD (D-PPAC and C-PPAC) instruments.
Garcia-Aymerich J, Puhan MA, Corriol-Rohou S, de Jong C, Demeyer H, Dobbels F, Erzen D, Frei A, Gimeno-Santos E, Hopkinson NS, Ivanoff N, Karlsson N, Louvaris Z, Polkey MI, Rabinovich RA, Scuri M, Tabberer M, Vogiatzis I, Troosters T, PROactive consortium.
Thorax. 2021 Jan 21;
http://www.ncbi.nlm.nih.gov/en...
Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study.
Mortamais M, Gutierrez LA, de Hoogh K, Chen J, Vienneau D, Carrière I, Letellier N, Helmer C, Gabelle A, Mura T, Sunyer J, Benmarhnia T, Jacquemin B, Berr C
Environ Int. 2021 Jan 20;148:106376
http://www.ncbi.nlm.nih.gov/en...
Premature mortality due to air pollution in European cities: a health impact assessment.
Khomenko S, Cirach M, Pereira-Barboza E, Mueller N, Barrera-Gómez J, Rojas-Rueda D, de Hoogh K, Hoek G, Nieuwenhuijsen M
Lancet Planet Health. 2021 Jan 19;
http://www.ncbi.nlm.nih.gov/en...
Vulnerability to addiction.
Maldonado R, Calvé P, García-Blanco A, Domingo-Rodriguez L, Senabre E, Martín-García E
Neuropharmacology. 2021 Jan 19;:108466
Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection.
Belarte-Tornero LC, Valdivielso-Moré S, Vicente Elcano M, Solé-González E, Ruíz-Bustillo S, Calvo-Fernández A, Subinara I, Cabero P, Soler C, Cubero-Gallego H, Vaquerizo B, Farré N
J Clin Med. 2021 Jan 17;10(2)
http://www.ncbi.nlm.nih.gov/en...
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM Jr, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA
Nat Genet. 2021 Jan 20;
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JEM career launchpad.
Bigas A, Zanoni I, Hepworth MR, Eisenbarth SC, Masters SL, Kipnis J, Vinuesa CG, Good-Jacobson KL, Tangye SG, Yamazaki S, Hivroz C, Tait Wojno E, Shulman Z, Colonna M
J Exp Med. 2021 Feb 1;218(2)
http://www.ncbi.nlm.nih.gov/en...
Does death from Covid-19 arise from a multi-step process?
Pearce N, Moirano G, Maule M, Kogevinas M, Rodo X, Lawlor DA, Vandenbroucke J, Vandenbroucke-Grauls C, Polack FP, Custovic A
Eur J Epidemiol. 2021 Jan 18;
Disease burden and treatment history among adults with atopic dermatitis receiving systemic therapy: baseline characteristics of participants on the EUROSTAD prospective observational study.
Bruin-Weller M, Pink AE, Patrizi A, Gimenez-Arnau AM, Agner T, Roquet-Gravy PP, Ferrucci SM, Arenberger P, Svensson A, Schuttelaar MLA, Nosbaum A, Jayawardena S, Rizova E, Ardeleanu M, Eckert L, Ozturk ZE
J Dermatolog Treat. 2021 Jan 18;:1-19
Gender and ST-elevation myocardial infarction. Response.
Tizón-Marcos H, Subirana I, Marrugat J
Rev Esp Cardiol (Engl Ed). 2021 Jan 14;
Oral microbiome in down syndrome and its implications on oral health.
Willis JR, Iraola-Guzmán S, Saus E, Ksiezopolska E, Cozzuto L, Bejarano LA, Andreu-Somavilla N, Alloza-Trabado M, Puig-Sola A, Blanco A, Broglio E, Carolis C, Hecht J, Ponomarenko J, Gabaldón T
J Oral Microbiol. 2020 Dec 30;13(1):1865690
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Atherogenic dyslipemia: the other pandemic, associated with diabesity.
Núñez-Cortés JM, Pedro-Botet J
Clin Investig Arterioscler. 2021 Jan-Feb;33(1):30-32
Autosomal recessive variants in TUBGCP2 alter the gamma-tubulin ring complex leading to neurodevelopmental disease.
Gungor S, Oktay Y, Hiz S, Aranguren-Ibáñez Á, Kalafatcilar I, Yaramis A, Karaca E, Yis U, Sonmezler E, Ekinci B, Aslan M, Yilmaz E, Özgör B, Balaraju S, Szabo N, Laurie S, Beltran S, MacArthur DG, Hathazi D, Töpf A, Roos A, Lochmuller H, Vernos I, Horvath R
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Top quality research with the utmost integrity
The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.
At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:
- The PRBB Code of Good Scientific Practices, approved by all the centres.
- An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
- Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.
To learn more about the code, the working group on good scientific practices and the various activities organised, visit:
More information
Contact
●Latest news
Patents and companies
- The following links allow you to explore the technology on offer in the park’s centres:
Technology at the IMIM-Hospital del Mar
UPF Business Shuttle and Innovation Unit
Technology and Business Development Office at the CRG
Analysis and Global Development at ISGlobal
EMBLEM Technology Transfer
- The following start-ups have been created within the PRBB environment:
Acellera
Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.
→ https://www.acellera.comChemotargets
Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.
→ http://www.chemotargets.com/qGenomics
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qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.
→ https://qgenomics.comZeClinics
ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.
→ http://www.zeclinics.comMicroomics
Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.
→ http://www.microomics.euFlomics
World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.
→ http://www.flomics.comBioinspired Materials
This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.
→ http://biom.techMedBioinformatics Solutions
MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.
→ http://www.disgenetplus.com/medbioinformatics/Pulmobiotics
A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.
→ https://www.pulmobio.com/●Latest news
Public-private collaboration to develop a treatment for fragile X syndrome
