Connecting perspectives: from bytes and molecules to organisms and populations
"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".
Jordi Camí, General Director of the PRBB.
The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.
With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.
Hospital del Mar Medical Research Institute (IMIM)
Cancer
The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research
Epidemiology and Public Health
The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.
Biomedical Informatics
This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB).
Neuroscience
The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.
Inflammatory and Cardiovascular Disorders
This programme expands our knowledge of pathophysiological, inflammatory and genetic mechanisms of cardiovascular, respiratory and bone disorders, as well as other acute and chronic disorders, their diagnosis and treatment. The multidisciplinary team addresses basic biomedical scientific questions arising from clinical cases. This approach should lead to translational research that can be applied to medical care.
Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)
Cellular and Molecular Biology
The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.
Molecular Medicine
This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.
Evolutionary Biology and Complex Systems
The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.
Biomedical Informatics
The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.
Genetics and Neuroscience
The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.
Systems Bioengineering
The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.
Transversal Program
Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.
Centre for Genomic Regulation (CRG)
Bioinformatics and Genomics
Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).
Cell and Developmental Biology
The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.
Gene Regulation, Stem Cells and Cancer
The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.
Systems Biology
The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice.
The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.
Barcelona Institute for Global Health (ISGlobal, Mar Campus)
Climate and Health
Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.
Air pollution and urban environment
The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.
Non-communicable diseases and the environment
The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.
Childhood and Environment
This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.
Radiation
The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.
Other
ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.
Institute of Evolutionary Biology (IBE: CSIC-UPF)
Animal Biodiversity and Evolution
The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.
Comparative and Computational Genomics
This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.
Functional Genomics and Evolution
The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.
Population genetics
Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.
Complex Systems
This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.
European Molecular Biology Laboratory (EMBL)
Tissue biology and disease modelling
The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”
Institute of Applied Radiopharmacy of Barcelona (IRAB)
Research and Innovation
The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.
Animal research with the international accreditation from the AAALAC.
The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.
Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.
- Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
- The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
- The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).
For more information on the animal facility and animal experimentation visit:
Animal experimentation courses
The PRBB and Charles River Campus
Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.
The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:
- Euthanasia (Function b)
- Performing procedures (Function c)
- Designing projects and procedures (mice and fish/amphibians) (Function d)
The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.
●Last news
Shared facilities for high-impact research
"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."
Jordi Camí, General Director of the PRBB
The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.
The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection
Contact: Montserrat Torà
→ marbiobanc@imim.es
The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.
Contact: Julia Ponomarenko
→ biocore@crg.eu
The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.
Contact: Ivo Gut
→ projectmanager@cnag.crg.eu
This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.
Contact: Blanca Espinet
→ bespinet@parcdesalutmar.cat
This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.
Contact: Òscar Fornas
→ oscar.fornas@upf.edu
Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit
The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.
Contact: Dirección de secretaría
→ ceea@prbb.org
Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.
Contact: Dirección de secretaría
→ ceic-imas@imim.es
The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.
Contact: Secretaría
→ cbs@prbb.org
This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.
Contact: Carlo Carolis
→ bmspt@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit
BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.
Contact: Jordi Alonso
→ bibliopro@imim.es
The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.
Contact: Arcadi Navarro
→ helpdesk@ega-archive.org
This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.
Contact: Jochen Hecht
→ ngs@crg.eu
The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.
Contact: Montserrat Torà
→ margenomics@imim.es
The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.
Contact: Ferran Casals
→ genomica@upf.edu
The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.
Contact: Laura Batlle Morera
→ laura.batlle@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0
This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.
Contact: Ana Aldea
→ aaldea@imim.es
This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.
Contact: Jim Swoger
→ mif@embl.es
Web:
https://www.embl.es/services/mesoscopic-imaging-facility
The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.
Contact: Timo Zimmermann
→ timo.zimmermann@crg.es
Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit
Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)
Contact: David Andreu
→ david.andreu@upf.edu
This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.
Contact: Eduard Sabido Aguade
→ eduard.sabido@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit
Gene-specific facial dysmorphism in Axenfeld-Rieger syndrome caused by FOXC1 and PITX2 variants.
Souzeau E, Siggs OM, Pasutto F, Knight LSW, Perez-Jurado LA, McGregor L, Le Blanc S, Barnett CP, Liebelt J, Craig JE
Am J Med Genet A. 2020 Nov 24;
Glutamine-directed migration of cancer-activated fibroblasts facilitates epithelial tumor invasion.
Mestre-Farrera A, Bruch-Oms M, Peña R, Rodríguez-Morató J, Alba-Castellón L, Comerma L, Quintela-Fandino M, Duñach M, Baulida J, Pozo ÓJ, García de Herreros A
Cancer Res. 2020 Nov 23;
The evolution of relapse of adult T cell acute lymphoblastic leukemia.
Sentís I, Gonzalez S, Genescà E, García-Hernández V, Muiños F, Gonzalez C, López-Arribillaga E, Gonzalez J, Fernandez-Ibarrondo L, Mularoni L, Espinosa L, Bellosillo B, Ribera JM, Bigas A, Gonzalez-Perez A, Lopez-Bigas N
Genome Biol. 2020 Nov 23;21(1):284
Extended Connectivity Interaction Features: Improving Binding Affinity Prediction Through Chemical Description.
Sánchez-Cruz N, Medina-Franco JL, Mestres J, Barril X
Bioinformatics. 2020 Nov 23;
MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data.
González JR, López-Sánchez M, Cáceres A, Puig P, Esko T, Pérez-Jurado LA
BMC Bioinformatics. 2020 Nov 23;21(1):533
The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.
Boronat S, Marte L, Vega M, García-Santamarina S, Cabrera M, Ayté J, Hidalgo E
iScience. 2020 Nov 20;23(11):101725
Pancreatic cancer transcriptomes: molecular stratification in the adjuvant setting.
Real FX, Siveke JT
Ann Oncol. 2020 Nov 20;
Association between estimated whole-brain radiofrequency electromagnetic fields dose and cognitive function in preadolescents and adolescents.
Cabré-Riera A, van Wel L, Liorni I, Thielens A, Birks LE, Pierotti L, Joseph W, González-Safont L, Ibarluzea J, Ferrero A, Huss A, Wiart J, Santa-Marina L, Torrent M, Vrijkotte T, Capstick M, Vermeulen R, Vrijheid M, Cardis E, Röösli M, Guxens M
Int J Hyg Environ Health. 2020 Nov 19;231:113659
http://www.ncbi.nlm.nih.gov/en...
Cross-cultural adaptation and validation of the Spanish version of the Orthognathic Quality of Life Questionnaire for patients with dentofacial deformities.
Duarte V, Zaror C, Villanueva J, Werlinger F, Vidal C, Solé P, O'Ryan JA, Corona G, Dallaserra M, Moreno B, Muñoz M, Cuellar J, Ferrer M
J Craniomaxillofac Surg. 2020 Oct 31;
Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents.
Lubczynska MJ, Muetzel RL, El Marroun H, Hoek G, Kooter I, Thomson EM, Hillegers M, Vernooij MW, White T, Tiemeier H, Guxens M
Environ Res. 2020 Nov 19;:110446
Lessons from individuals with Down syndrome during COVID-19.
Del Carmen Ortega M, Borrel JM, de Jesús Bermejo T, González-Lamuño D, Manso C, de la Torre R, Mayer MA, de Asúa DR, Dierssen M, Spanish Trisomy 21 Research Society COVID-19 Taskforce.
Lancet Neurol. 2020 Dec;19(12):974-975
Coarse graining molecular dynamics with graph neural networks.
Husic BE, Charron NE, Lemm D, Wang J, Pérez A, Majewski M, Krämer A, Chen Y, Olsson S, de Fabritiis G, Noé F, Clementi C
J Chem Phys. 2020 Nov 21;153(19):194101
http://www.ncbi.nlm.nih.gov/en...
Neighbourhood walkability and physical activity: moderating role of a physical activity intervention in overweight and obese older adults with metabolic syndrome.
Colom A, Mavoa S, Ruiz M, Wärnberg J, Muncunill J, Konieczna J, Vich G, Barón-López FJ, Fitó M, Salas-Salvadó J, Romaguera D
Age Ageing. 2020 Nov 20;
http://www.ncbi.nlm.nih.gov/en...
Diffuse dermal mucinosis secondary to colony-stimulating factor 1 receptor monoclonal antibody treatment: A novel and peculiar drug-induced diffuse cutaneous mucinosis.
Olmos-Alpiste F, Segura S, Tomás-Velázquez A, Aguado L, España A, Arriola E, Martín-Algarra S, Barranco C, Lloreta J, Pujol RM
J Dermatol. 2020 Nov 20;
Maximizing the acquisition of unique reads in non-invasive capture sequencing experiments.
Fontsere C, Alvarez-Estape M, Lester J, Arandjelovic M, Kuhlwilm M, Dieguez P, Agbor A, Angedakin S, Ayimisin EA, Bessone M, Brazzola G, Deschner T, Eno-Nku M, Granjon AC, Head J, Kadam P, Kalan AK, Kambi M, Langergraber K, Lapuente J, Maretti G, Ormsby LJ, Piel A, Robbins MM, Stewart F, Vergnes V, Wittig RM, Kühl HS, Marques-Bonet T, Hughes DA, Lizano E
Mol Ecol Resour. 2020 Nov 20;
Host plant diet affects growth and induces altered gene expression and microbiome composition in the wood white (Leptidea sinapis) butterfly.
Näsvall K, Wiklund C, Mrazek V, Künstner A, Talla V, Busch H, Vila R, Backström N
Mol Ecol. 2020 Nov 20;
Author Correction: Elephant shark genome provides unique insights into gnathostome evolution.
Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho S, Lorente-Galdos B, Quilez J, Marques-Bonet T, Raney BJ, Ingham PW, Tay A, Hillier LW, Minx P, Boehm T, Wilson RK, Brenner S, Warren WC
Nature. 2020 Nov 19;
http://www.ncbi.nlm.nih.gov/en...
Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer.
Bowden M, Nadal R, Zhou CW, Werner L, Barletta J, Juanpere N, Lloreta J, Hernandez-Llodrà S, Morote J, de Torres I, Orsola A, Cejas P, Long H, Bellmunt J
Sci Rep. 2020 Nov 18;10(1):20135
http://www.ncbi.nlm.nih.gov/en...
Swimming through the sands of the Sahara and Arabian deserts: Phylogeny of sandfish skinks (Scincidae, Scincus) reveals a recent and rapid diversification.
Šmíd J, Uvizl M, Shobrak M, Faqih Ali Salim A, Hamoud M AlGethami R, Raqi Algethami A, Saleh K Alanazi A, Dasman Alsubaie S, Busais S, Carranza S
Mol Phylogenet Evol. 2020 Nov 17;:107012
Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.
Ruiz-Arenas C, Cáceres A, López M, Pelegrí-Sisó D, González J, González JR
Genome Res. 2020 Nov 17;
Trajectories of asthma and allergies from 7 years to 53 years and associations with lung function and extrapulmonary comorbidity profiles: a prospective cohort study.
Bui DS, Lodge CJ, Perret JL, Lowe A, Hamilton GS, Thompson B, Giles G, Tan D, Erbas B, Pirkis J, Cicuttini F, Cassim R, Bowatte G, Thomas P, Garcia-Aymerich J, Hopper J, Abramson MJ, Walters EH, Dharmage SC
Lancet Respir Med. 2020 Nov 17;
Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure.
Merid SK, Bustamante M, Standl M, Sunyer J, Heinrich J, Lemonnier N, Aguilar D, Antó JM, Bousquet J, Santa-Marina L, Lertxundi A, Bergström A, Kull I, Wheelock ÅM, Koppelman GH, Melén E, Gruzieva O
Environ Int. 2020 Nov 16;146:106248
http://www.ncbi.nlm.nih.gov/en...
Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study.
Alonso-Molero J, Dierssen-Sotos T, Gomez-Acebo I, Fernandez de Larrea Baz N, Guevara M, Amiano P, Castaño-Vinyals G, Fernandez-Villa T, Moreno V, Bayo J, Molina-Barceloa A, Fernández-Ortíz M, Suarez-Calleja C, Marcos-Gragera R, Castells X, Gil-Majuelo L, Ardanaz E, Pérez-Gómez B, Kogevinas M, Pollán M, Llorca J
Int J Environ Res Public Health. 2020 Nov 13;17(22)
http://www.ncbi.nlm.nih.gov/en...
The usage, quality and relevance of information and communications technologies in patients with chronic urticaria: A UCARE study.
Maurer M, Weller K, Magerl M, Maurer RR, Vanegas E, Felix M, Cherrez A, Mata VL, Kasperska-Zajac A, Sikora A, Fomina D, Kovalkova E, Godse K, Rao ND, Khoshkhui M, Rastgoo S, Criado RFJ, Abuzakouk M, Grandon D, van Doorn M, Valle SOR, de Souza Lima EM, Thomsen SF, Ramón GD, Matos Benavides EE, Bauer A, Giménez-Arnau AM, Kocatürk E, Guillet C, Ignacio Larco J, Zhao ZT, Makris M, Ritchie C, Xepapadaki P, Ensina LF, Cherrez S, Cherrez-Ojeda I
World Allergy Organ J. 2020 Nov;13(11):100475
http://www.ncbi.nlm.nih.gov/en...
Effectiveness of a 4-week sophrology program for primary care patients with moderate to high anxiety levels: a randomised controlled trial.
van Rangelrooij K, Solans-Buxeda R, Fernández-García M, Caycedo-Desprez N, Selvam R, Bulbena A
Actas Esp Psiquiatr. 2020 Sep;48(5):200-208
http://www.ncbi.nlm.nih.gov/en...
The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization.
Cavaco M, Andreu D, Castanho MARB
Angew Chem Int Ed Engl. 2020 Nov 17;
Mutation bias within oncogene families is related to proliferation-specific codon usage.
Benisty H, Weber M, Hernandez-Alias X, Schaefer MH, Serrano L
Proc Natl Acad Sci U S A. 2020 Nov 16;
Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE Epsilon-4.
Sánchez-Benavides G, Salvadó G, Arenaza-Urquijo EM, Grau-Rivera O, Suárez-Calvet M, Milà-Alomà M, González-de-Echávarri JM, Minguillon C, Crous-Bou M, Niñerola-Baizán A, Perissinotti A, Gispert JD, Molinuevo JL, ALFA Study.
Alzheimers Dement (Amst). 2020;12(1):e12127
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Open Targets Platform: supporting systematic drug-target identification and prioritisation.
Ochoa D, Hercules A, Carmona M, Suveges D, Gonzalez-Uriarte A, Malangone C, Miranda A, Fumis L, Carvalho-Silva D, Spitzer M, Baker J, Ferrer J, Raies A, Razuvayevskaya O, Faulconbridge A, Petsalaki E, Mutowo P, Machlitt-Northen S, Peat G, McAuley E, Ong CK, Mountjoy E, Ghoussaini M, Pierleoni A, Papa E, Pignatelli M, Koscielny G, Karim M, Schwartzentruber J, Hulcoop DG, Dunham I, McDonagh EM
Nucleic Acids Res. 2020 Nov 16;
The Diversity of Primates: From Biomedicine to Conservation Genomics.
Orkin JD, Kuderna LFK, Marques-Bonet T
Annu Rev Anim Biosci. 2020 Nov 16;
Conservative route to genome compaction in a miniature annelid.
Martín-Durán JM, Vellutini BC, Marlétaz F, Cetrangolo V, Cvetesic N, Thiel D, Henriet S, Grau-Bové X, Carrillo-Baltodano AM, Gu W, Kerbl A, Marquez Y, Bekkouche N, Chourrout D, Gómez-Skarmeta JL, Irimia M, Lenhard B, Worsaae K, Hejnol A
Nat Ecol Evol. 2020 Nov 16;
The SHAMISEN Project: Challenging historical recommendations for preparedness, response and surveillance of health and well-being in case of nuclear accidents: Lessons learnt from Chernobyl and Fukushima.
Ohba T, Liutsko L, Schneider T, Francesc Barquinero J, Crouaïl P, Fattibene P, Kesminiene A, Laurier D, Sarukhan A, Skuterud L, Tanigawa K, Tomkiv Y, Cardis E
Environ Int. 2020 Nov 13;146:106200
Two-Step Digital Follow-up of Patients at High Risk for Melanoma: A Retrospective Analysis of 152 Patients.
Porcar Saura S, March-Rodriguez A, Pujol RM, Segura Tigell S
Actas Dermosifiliogr. 2020 Nov 13;
A system-level analysis of patient disease trajectories based on clinical, phenotypic and molecular similarities.
Giannoula A, Centeno E, Mayer MA, Sanz F, Furlong LI
Bioinformatics. 2020 Nov 13;
Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism.
Lachén-Montes M, Mendizuri N, Ausín K, Pérez-Mediavilla A, Azkargorta M, Iloro I, Elortza F, Kondo H, Ohigashi I, Ferrer I, de la Torre R, Robledo P, Fernández-Irigoyen J, Santamaría E
J Proteome Res. 2020 Nov 13;
Landscapes of becoming social: A systematic review of evidence for associations and pathways between interactions with nature and socioemotional development in children.
Mygind L, Kurtzhals M, Nowell C, Melby PS, Stevenson MP, Nieuwenhuijsen M, Lum JAG, Flensborg-Madsen T, Bentsen P, Enticott PG
Environ Int. 2020 Nov 12;146:106238
Early-life risk factors for reversible and irreversible airflow limitation in young adults: findings from the BAMSE birth cohort.
Wang G, Kull I, Bergström A, Hallberg J, Bergström PU, Guerra S, Pershagen G, Gruzieva O, van Hage M, Georgelis A, Janson C, Lindén A, Melén E
Thorax. 2020 Nov 12;
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Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis.
Neumann A, Walton E, Alemany S, Cecil C, González JR, Jima DD, Lahti J, Tuominen ST, Barker ED, Binder E, Caramaschi D, Carracedo Á, Czamara D, Evandt J, Felix JF, Fuemmeler BF, Gutzkow KB, Hoyo C, Julvez J, Kajantie E, Laivuori H, Maguire R, Maitre L, Murphy SK, Murcia M, Villa PM, Sharp G, Sunyer J, Raikkönen K, Bakermans-Kranenburg M, IJzendoorn MV, Guxens M, Relton CL, Tiemeier H
Transl Psychiatry. 2020 Nov 12;10(1):398
Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD.
Tang J, Curull V, Wang X, Ampurdanés C, Duran X, Pijuan L, Rodríguez-Fuster A, Aguiló R, Yélamos J, Barreiro E
Cancers (Basel). 2020 Nov 11;12(11)
Numbers Game and Immune Geography as Determinants of Coronavirus Pathogenicity.
Bocharov G, Casella V, Argilaguet J, Grebennikov D, Güerri-Fernandez R, Ludewig B, Meyerhans A
Front Cell Infect Microbiol. 2020;10:559209
Inflammatory Response of Ischemic Tolerance in Circulating Plasma: Preconditioning-Induced by Transient Ischemic Attack (TIA) Phenomena in Acute Ischemia Patients (AIS).
Colàs-Campàs L, Farre J, Mauri-Capdevila G, Molina-Seguín J, Aymerich N, Ois Á, Roquer J, Tur S, García-Carreira MDC, Martí-Fàbregas J, Cruz-Culebras A, Segura T, Arque G, Purroy F
Front Neurol. 2020;11:552470
Incomplete Sterility of Chromosomal Hybrids: Implications for Karyotype Evolution and Homoploid Hybrid Speciation.
Lukhtanov VA, Dinca V, Friberg M, Vila R, Wiklund C
Front Genet. 2020;11:583827
SARS-CoV-2 seroprevalence and antibody kinetics among health care workers in a Spanish hospital after three months of follow-up.
Moncunill G, Mayor A, Santano R, Jiménez A, Vidal M, Tortajada M, Sanz S, Méndez S, Llupià A, Aguilar R, Alonso S, Barrios D, Carolis C, Cisteró P, Chóliz E, Cruz A, Fochs S, Jairoce C, Hecht J, Lamoglia M, Martínez MJ, Moreno J, Mitchell RA, Ortega N, Pey N, Puyol L, Ribes M, Rosell N, Figueroa-Romero A, Sotomayor P, Torres S, Williams S, Barroso S, Vilella A, Trilla A, Varela P, Dobaño C, Garcia-Basteiro AL
J Infect Dis. 2020 Nov 11;
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Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels.
Indacochea A, Guerrero S, Ure Ntildea M, Araujo F, Coll O, LLeonart ME, Gebauer F
RNA. 2020 Nov 10;
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Antibiofilm Activity on Candida albicans and Mechanism of Action on Biomembrane Models of the Antimicrobial Peptide Ctn[15-34].
Aguiar FLL, Santos NC, de Paula Cavalcante CS, Andreu D, Baptista GR, Gonçalves S
Int J Mol Sci. 2020 Nov 6;21(21)
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The Presence of Human Herpesvirus 6 in the Brain in Health and Disease.
Santpere G, Telford M, Andrés-Benito P, Navarro A, Ferrer I
Biomolecules. 2020 Nov 6;10(11)
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An international survey on the impact of COVID-19 in individuals with Down syndrome.
Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, Brandão AC, Carfi A, Carmona-Iragui M, Chicoine BA, Ghosh S, Lakhanpaul M, Manso C, Mayer MA, Del Carmen Ortega M, de Asua DR, Rebillat AS, Russell LA, Sgandurra G, Valentini D, Sherman SL, Strydom A
medRxiv. 2020 Nov 5;
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Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.
Ibanez L, Heitsch L, Carrera C, Farias FHG, Dhar R, Budde J, Bergmann K, Bradley J, Harari O, Phuah CL, Lemmens R, Oliveira Souza AAV, Moniche F, Cabezas-Juan A, Arenillas JF, Krupinksi J, Cullell N, Torres-Aguila N, Muiño E, Cárcel-Márquez J, Marti-Fabregas J, Delgado-Mederos R, Marin-Bueno R, Hornick A, Vives-Bauza C, Navarro RD, Tur S, Jimenez C, Obach V, Segura T, Serrano-Heras G, Chung JW, Roquer J, Soriano-Tarraga C, Giralt-Steinhauer E, Mola-Caminal M, Pera J, Lapicka-Bodzioch K, Derbisz J, Davalos A, Lopez-Cancio E, Muñoz L, Tatlisumak T, Molina C, Ribo M, Bustamante A, Sobrino T, Castillo-Sanchez J, Campos F, Rodriguez-Castro E, Arias-Rivas S, Rodríguez-Yáñez M, Herbosa C, Ford AL, Arauz A, Lopes-Cendes I, Lowenkopf T, Barboza MA, Amini H, Stamova B, Ander BP, Sharp FR, Kim GM, Bang OY, Jimenez-Conde J, Slowik A, Stribian D, Tsai EA, Burkly LC, Montaner J, Fernandez-Cadenas I, Lee JM, Cruchaga C
medRxiv. 2020 Nov 3;
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Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.
Visser PJ, Reus LM, Gobom J, Jansen I, Dicks E, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuevo JL, Engelborghs S, Freund-Levi Y, Froelich L, Sleegers K, Dobricic V, Hong S, Lovestone S, Streffer J, Vos SJB, Bos I, Smit AB, Blennow K, Scheltens P, Teunissen CE, Bertram L, Zetterberg H, Tijms BM
medRxiv. 2020 Nov 3;
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Composition of the immunoglobulin G glycome associates with the severity of COVID-19.
Petrovic T, Alves I, Bugada D, Pascual J, Vuckovic F, Skelin A, Gaifem J, Villar-Garcia J, Vicente MM, Fernandes A, Dias AM, Kurolt IC, Markotic A, Primorac D, Soares A, Malheiro L, Trbojevic-Akmacic I, Abreu M, Sarmento E Castro R, Bettinelli S, Callegaro A, Arosio M, Sangiorgio L, Lorini LF, Castells X, Horcajada JP, Pinho SS, Allegri M, Barrios C, Lauc G
Glycobiology. 2020 Nov 10;
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Prediction Equations for Maximal Aerobic Capacity on Cycle Ergometer for the Spanish Adult Population.
Puente-Maestú L, Ortega F, Pedro JG, Rodríguez-Nieto MJ, Gómez-Seco J, Gáldiz B, Ojanguren I, Muñoz X, Blanco I, Burgos F, Rodríguez-Chiaradía DA, Gea J, García-Rio F
Arch Bronconeumol. 2020 Oct 10;
A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research.
Zahoránszky-Kohalmi G, Siramshetty VB, Kumar P, Gurumurthy M, Grillo B, Mathew B, Metaxatos D, Backus M, Mierzwa T, Simon R, Grishagin I, Brovold L, Mathé EA, Hall MD, Michael SG, Godfrey AG, Mestres J, Jensen LJ, Oprea TI
bioRxiv. 2020 Nov 5;
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The Value of Mouse Models of Rare Diseases: A Spanish Experience.
Murillo-Cuesta S, Artuch R, Asensio F, de la Villa P, Dierssen M, Enríquez JA, Fillat C, Fourcade S, Ibáñez B, Montoliu L, Oliver E, Pujol A, Salido E, Vallejo M, Varela-Nieto I
Front Genet. 2020;11:583932
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Massive gene presence-absence variation shapes an open pan-genome in the Mediterranean mussel.
Gerdol M, Moreira R, Cruz F, Gómez-Garrido J, Vlasova A, Rosani U, Venier P, Naranjo-Ortiz MA, Murgarella M, Greco S, Balseiro P, Corvelo A, Frias L, Gut M, Gabaldón T, Pallavicini A, Canchaya C, Novoa B, Alioto TS, Posada D, Figueras A
Genome Biol. 2020 Nov 10;21(1):275
Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report.
de Vries YA, Al-Hamzawi A, Alonso J, Andrade LH, Benjet C, Bruffaerts R, Bunting B, de Girolamo G, Florescu S, Gureje O, Haro JM, Karam A, Karam EG, Kawakami N, Kovess-Masfety V, Lee S, Mneimneh Z, Navarro-Mateu F, Ojagbemi A, Posada-Villa J, Scott K, Stagnaro JC, Torres Y, Xavier M, Zarkov ZN, Kessler RC, de Jonge P, WHO World Mental Health Survey collaborators.
Psychol Med. 2020 Nov 10;:1-10
Practice Parameters for Diagnosing and Managing Iodinated Contrast Media Hypersensitivity.
Torres MJ, Trautmann A, Böhm I, Scherer K, Barbaud A, Bavbek S, Bonadonna P, Cernadas J, Chiriac A, Gaeta F, Gimenez-Arnau AM, Kang H, Moreno E, Brockow K
Allergy. 2020 Nov 10;
A physical mechanism of TANGO1-mediated bulky cargo export.
Raote I, Chabanon M, Walani N, Arroyo M, Garcia-Parajo MF, Malhotra V, Campelo F
Elife. 2020 Nov 10;9
The changing chromatome as a driver of disease: A panoramic view from different methodologies.
Espejo I, Di Croce L, Aranda S
Bioessays. 2020 Nov 9;:e2000203
Ectopic activation of GABAB receptors inhibits neurogenesis and metamorphosis in the cnidarian Nematostella vectensis.
Levy S, Brekhman V, Bakhman A, Malik A, Sebé-Pedrós A, Kosloff M, Lotan T
Nat Ecol Evol. 2020 Nov 9;
Elimination profiles of prednisone and prednisolone after different administration routes: evaluation of the reporting level and washout periods to ensure safe therapeutic administrations.
Coll S, Monfort N, Alechaga É, Matabosch X, Pozo OJ, Pérez-Mañá C, Ventura R
Drug Test Anal. 2020 Nov 8;
Lessons learned from Chernobyl and Fukushima on thyroid cancer screening and recommendations in case of a future nuclear accident.
Cléro E, Ostroumova E, Demoury C, Grosche B, Kesminiene A, Liutsko L, Motreff Y, Oughton D, Pirard P, Rogel A, Van Nieuwenhuyse A, Laurier D, Cardis E
Environ Int. 2020 Nov 7;146:106230
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A patients' view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study.
Vitaloni M, Botto-van Bemden A, Sciortino R, Carné X, Quintero M, Santos-Moreno P, Espinosa R, Rillo O, Monfort J, de Abajo F, Oswald E, Matucci M, du Souich P, Möller I, Romera Baures M, Vinci A, Scotton D, Bibas M, Eakin G, Verges J
BMC Musculoskelet Disord. 2020 Nov 7;21(1):727
Results from an 18 country cross-sectional study examining experiences of nature for people with common mental health disorders.
Tester-Jones M, White MP, Elliott LR, Weinstein N, Grellier J, Economou T, Bratman GN, Cleary A, Gascon M, Korpela KM, Nieuwenhuijsen M, O'Connor A, Ojala A, van den Bosch M, Fleming LE
Sci Rep. 2020 Nov 6;10(1):19408
Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition.
Battistelli C, Garbo S, Riccioni V, Montaldo C, Santangelo L, Vandelli A, Strippoli R, Tartaglia GG, Tripodi M, Cicchini C
Cancer Res. 2020 Nov 6;
Defining pathways to healthy sustainable urban development.
Tonne C, Adair L, Adlakha D, Anguelovski I, Belesova K, Berger M, Brelsford C, Dadvand P, Dimitrova A, Giles-Corti B, Heinz A, Mehran N, Nieuwenhuijsen M, Pelletier F, Ranzani O, Rodenstein M, Rybski D, Samavati S, Satterthwaite D, Schöndorf J, Schreckenberg D, Stollmann J, Taubenböck H, Tiwari G, van Wee B, Adli M
Environ Int. 2020 Nov 5;146:106236
Profile of exposures and lung function in adults with asthma: an exposome approach in the EGEA study.
Guillien A, Lepeule J, Seyve E, Le Moual N, Pin I, Degano B, Garcia-Aymerich J, Pépin JL, Pison C, Dumas O, Varraso R, Siroux V
Environ Res. 2020 Nov 5;:110422
The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor.
Brandão A, Paulo P, Maia S, Pinheiro M, Peixoto A, Cardoso M, Silva MP, Santos C, Eeles RA, Kote-Jarai Z, Muir K, Ukgpcs Collaborators, Schleutker J, Wang Y, Pashayan N, Batra J, Apcb BioResource, Grönberg H, Neal DE, Nordestgaard BG, Tangen CM, Southey MC, Wolk A, Albanes D, Haiman CA, Travis RC, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Vega A, The Impact Study Steering Committee And Collaborators, Kogevinas M, Wiklund F, Penney KL, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, Ruyck K, Razack A, Newcomb LF, Canary Pass Investigators, Lessel D, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Roobol MJ, The Profile Study Steering Committee, The Practical Consortium, Teixeira MR
Cancers (Basel). 2020 Nov 4;12(11)
Dyslipidemias and stroke prevention: recommendations of the Study Group of Cerebrovascular Diseases of the Spanish Society of Neurology.
Palacio-Portilla EJ, Roquer J, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo MM, Fuentes B, García-Pastor A, Gomis M, Gómez-Choco M, López-Cancio E, Martínez-Sánchez P, Morales A, Rodríguez-Yáñez M, Segura T, Serena J, Vivancos-Mora J, de Leciñana MA, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología.
Neurologia. 2020 Nov 4;
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Quality of colonoscopy is associated with adenoma detection and post-colonoscopy colorectal cancer prevention in Lynch syndrome.
Sánchez A, Roos VH, Navarro M, Pineda M, Caballol B, Moreno L, Carballal S, Rodríguez-Alonso L, Ramon Y Cajal T, Llort G, Piñol V, Fernandez AL, Salces I, Picó MD, Rivas L, Bujanda L, Garzon M, Pizarro A, Martinez de Castro E, López-Arias MJ, Poves C, Garau C, Rodriguez-Alcalde D, Herraiz M, Alvarez-Urrutia C, Dacal A, Carrillo-Palau M, Cid L, Ponce M, Barreiro-Alonso E, Saperas E, Aguirre E, Romero C, Bastiaansen B, Gonzalez-Acosta M, Morales-Romero B, Ocaña T, Rivero-Sánchez L, Jung G, Bessa X, Cubiella J, Jover R, Rodríguez-Moranta F, Balmaña J, Brunet J, Castells A, Dekker E, Capella G, Serra-Burriel M, Moreira L, Pellise M, Balaguer F
Clin Gastroenterol Hepatol. 2020 Nov 3;
The Helsinki Declaration 2020: Europe that protects.
Halonen JI, Erhola M, Furman E, Haahtela T, Jousilahti P, Barouki R, Bergman Å, Billo NE, Fuller R, Haines A, Kogevinas M, Kolossa-Gehring M, Krauze K, Lanki T, Vicente JL, Messerli P, Nieuwenhuijsen M, Paloniemi R, Peters A, Posch KH, Timonen P, Vermeulen R, Virtanen SM, Bousquet J, Antó JM
Lancet Planet Health. 2020 Nov;4(11):e503-e505
Guidelines for Modeling and Reporting Health Effects of Climate Change Mitigation Actions.
Hess JJ, Ranadive N, Boyer C, Aleksandrowicz L, Anenberg SC, Aunan K, Belesova K, Bell ML, Bickersteth S, Bowen K, Burden M, Campbell-Lendrum D, Carlton E, Cissé G, Cohen F, Dai H, Dangour AD, Dasgupta P, Frumkin H, Gong P, Gould RJ, Haines A, Hales S, Hamilton I, Hasegawa T, Hashizume M, Honda Y, Horton DE, Karambelas A, Kim H, Kim SE, Kinney PL, Kone I, Knowlton K, Lelieveld J, Limaye VS, Liu Q, Madaniyazi L, Martinez ME, Mauzerall DL, Milner J, Neville T, Nieuwenhuijsen M, Pachauri S, Perera F, Pineo H, Remais JV, Saari RK, Sampedro J, Scheelbeek P, Schwartz J, Shindell D, Shyamsundar P, Taylor TJ, Tonne C, Van Vuuren D, Wang C, Watts N, West JJ, Wilkinson P, Wood SA, Woodcock J, Woodward A, Xie Y, Zhang Y, Ebi KL
Environ Health Perspect. 2020 Nov;128(11):115001
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Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in A-Beta pathology are detected.
Suárez-Calvet M, Karikari TK, Ashton NJ, Lantero Rodríguez J, Milà-Alomà M, Gispert JD, Salvadó G, Minguillon C, Fauria K, Shekari M, Grau-Rivera O, Arenaza-Urquijo EM, Sala-Vila A, Sánchez-Benavides G, González-de-Echávarri JM, Kollmorgen G, Stoops E, Vanmechelen E, Zetterberg H, Blennow K, Molinuevo JL, ALFA Study.
EMBO Mol Med. 2020 Nov 10;:e12921
Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk.
Sánchez-Quesada C, Toledo E, González-Mata G, Ramos-Ballesta MI, Peis JI, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, Cano-Ibáñez N, Matía-Martín P, Daimiel L, Sánchez-Rodríguez R, Vidal J, Vázquez C, Ros E, Hernández-Alonso P, Barragan R, Muñoz-Martínez J, López M, González-Palacios S, Vaquero-Luna J, Crespo-Oliva E, Zulet MA, Díaz-González V, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Galera A, Ripoll-Vera T, Buil-Cosiales P, Canudas S, Martinez-Lacruz R, Pérez-Vega KA, Rios Á, Lloret-Macián R, Moreno-Rodriguez A, Ruiz-Canela M, Babio N, Zomeño Fajardo MD, Gaforio JJ
Atherosclerosis. 2020 Oct 10;314:48-57
Markers of myocardial injury in the prediction of short-term COVID-19 prognosis.
Calvo-Fernández A, Izquierdo A, Subirana I, Farré N, Vila J, Durán X, García-Guimaraes M, Valdivielso S, Cabero P, Soler C, García-Ribas C, Rodríguez C, Llagostera M, Mojón D, Vicente M, Solé-González E, Sánchez-Carpintero A, Tevar C, Marrugat J, Vaquerizo B
Rev Esp Cardiol (Engl Ed). 2020 Sep 29;
The endocannabinoid system in modulating fear, anxiety, and stress?.
Maldonado R, Cabañero D, Martín-García E
Dialogues Clin Neurosci. 2020 Sep;22(3):229-239
Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity.
Tristán-Noguero A, Borràs E, Molero-Luis M, Wassenberg T, Peters T, Verbeek MM, Willemsen M, Opladen T, Jeltsch K, Pons R, Thony B, Horvath G, Yapici Z, Friedman J, Hyland K, Agosta GE, López-Laso E, Artuch R, Sabidó E, García-Cazorla À
Mov Disord. 2020 Nov 5;
Rethinking embryology in vitro: A synergy between engineering, data science and theory.
Gritti N, Oriola D, Trivedi V
Dev Biol. 2020 Nov 2;
Recognizing obesity as a disease: A true challenge.
Arrieta F, Pedro-Botet J
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Expanding the Geographic Characterisation of Epstein-Barr Virus Variation through Gene-Based Approaches.
Telford M, Hughes DA, Juan D, Stoneking M, Navarro A, Santpere G
Microorganisms. 2020 Oct 29;8(11)
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Soluble suppression of tumorigenicity-2 predicts pneumonia in patients with inhalation injury: Results of a pilot study.
Ruiz-Castilla M, Dos Santos B, Vizcaíno C, Baena J, Guilabert P, Marin-Corral J, Masclans JR, Roca O, Barret JP
Burns. 2020 Oct 21;
Children's visual impairment and visual care related to socioeconomic status in Catalonia (Spain).
Vila-Vidal N, Guisasola L, Rius A, Alonso J, Tresserras R
Child Care Health Dev. 2020 Nov 5;
Chemotherapy or Allogeneic Transplantation in High-Risk Philadelphia Chromosome-Negative Adult Lymphoblastic Leukemia.
Ribera JM, Morgades M, Ciudad J, Montesinos P, Esteve J, Genesca E, Barba P, Ribera J, García Cadenas I, Moreno MJ, Martínez-Carballeira D, Torrent A, Martínez-Sánchez P, Monsalvo S, Gil C, Tormo M, Artola MT, Cervera M, González-Campos J, Rodríguez-Medina C, Bermúdez A, Novo A, Soria B, Coll R, Amigo ML, López A, Fernández Martín R, Serrano J, Mercadal S, Cladera A, Giménez-Conca AD, Peñarrubia MJ, Abella E, Vall-Llovera F, Hernández-Rivas JM, Garcia A, Bergua Burgues JM, de Rueda B, Sánchez-Sánchez MJ, Serrano A, Calbacho M, Alonso Vence N, Méndez-Sánchez JÁ, García-Boyero R, Olivares M, Barrena S, Zamora L, Granada I, Lhermitte L, Feliu E, Orfao A
Blood. 2020 Nov 4;
The impact of the COVID-19 pandemic on harm reduction services in Spain.
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Impact Microindentation in Men with Impaired Fasting Glucose and Type 2 Diabetes.
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Bone. 2020 Oct 10;:115685
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Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling.
Hong SY, Sun B, Straub D, Blaakmeer A, Mineri L, Koch J, Brinch-Pedersen H, Holme IB, Burow M, Lyngs Jørgensen HJ, Albà MM, Wenkel S
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The development of chronic diuretic resistance can be predicted during a heart-failure hospitalization. Results from the REDIHF registry.
Blázquez-Bermejo Z, Farré N, Llagostera M, Caravaca Perez P, Morán-Fernández L, Fort A, De-Juan J, Ruiz S, Delgado JF
PLoS One. 2020;15(10):e0240098
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Systematics, biogeography and evolution of the Saharo-Arabian naked-toed geckos genus Tropiocolotes.
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Mol Phylogenet Evol. 2020 Oct 5;:106969
Prevalence of basal ganglia and carotid artery calcifications in patients with permanent hypoparathyroidism after total thyroidectomy.
Lorente-Poch L, Rifà-Terricabras S, Sancho JJ, Torselli-Valladares D, González-Ortiz S, Sitges-Serra A
Endocr Connect. 2020 Oct;9(10):955-962
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids.
Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, Contreras-Rodríguez O, Blasco G, Coll C, Biarnés C, Miranda-Olivos R, Latorre J, Moreno-Navarrete JM, Castells-Nobau A, Sabater M, Palomo-Buitrago ME, Puig J, Pedraza S, Gich J, Pérez-Brocal V, Ricart W, Moya A, Fernández-Real X, Ramió-Torrentà L, Pamplona R, Sol J, Jové M, Portero-Otin M, Maldonado R, Fernández-Real JM
Cell Metab. 2020 Oct 6;32(4):548-560.e7
Dietary Quality Changes According to the Preceding Maximum Weight: A Longitudinal Analysis in the PREDIMED-Plus Randomized Trial.
Bouzas C, Bibiloni MDM, Garcia S, Mateos D, Martínez-González MÁ, Salas-Salvadó J, Corella D, Schröder H, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Bueno-Cavanillas A, Micó-Pérez RM, Pintó X, Delgado-Rodríguez M, Ortíz-Ramos M, Altés-Boronat A, Luca BL, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Bernabé-Casanova A, Martin-Padillo M, Garcia-Rios A, Castro-Barquero S, Fernández-García JC, Santos-Lozano JM, Fernandez-Lazaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari FJ, Canudas S, Goday A, Tur JA
Nutrients. 2020 Oct 2;12(10)
Differences in breast cancer risk after benign breast disease by type of screening diagnosis.
Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, Alcantara R, Sanchez M, Quintana MJ, Del Riego J, Ferrer J, Peñalva L, Bargalló X, Prieto M, Sala M, Castells X
Breast. 2020 Sep 20;
Tumor Cell Attack by Crotalicidin (Ctn) and Its Fragment Ctn[15-34]: Insights into Their Dual Membranolytic and Intracellular Targeting Mechanism.
Pérez-Peinado C, Valle J, Freire JM, Andreu D
ACS Chem Biol. 2020 Oct 6;
Nonlinear interaction between APOE Epsilon-4 allele load and age in the hippocampal surface of cognitively intact individuals.
Martí-Juan G, Sanroma-Guell G, Cacciaglia R, Falcon C, Operto G, Molinuevo JL, González Ballester MÁ, Gispert JD, Piella G, Alzheimer's Disease Neuroimaging Initiative., ALFA Study.
Hum Brain Mapp. 2020 Oct 5;
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Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19).
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Additional Metabolic Effects of Bariatric Surgery in Patients with a Poor Mid-Term Weight Loss Response: A 5-Year Follow-Up Study.
Benaiges D, Bisbe M, Pedro-Botet J, de Vargas-Machuca A, Ramon JM, Pera M, Villatoro M, Fontané L, Julià H, Climent E, Castañer O, Flores-Le Roux JA, Goday A
J Clin Med. 2020 Oct 1;9(10)
MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma.
Pattanayak B, Garrido-Cano I, Adam-Artigues A, Tormo E, Pineda B, Cabello P, Alonso E, Bermejo B, Hernando C, Martínez MT, Rovira A, Albanell J, Rojo F, Burgués O, Cejalvo JM, Lluch A, Eroles P
Front Oncol. 2020;10:1661
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To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models.
Cavaco M, Pérez-Peinado C, Valle J, Silva RDM, Correia JDG, Andreu D, Castanho MARB, Neves V
Front Bioeng Biotechnol. 2020;8:552035
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Liquid biopsy in oncology: A consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.
Álvarez-Alegret R, Rojo Todo F, Garrido P, Bellosillo B, Rodríguez-Lescure Á, Rodríguez-Peralto JL, Vera R, de Álava E, García-Campelo R, Remon J
Rev Esp Patol. 2020 Oct - Dec;53(4):234-245
Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2-alfa.
Picón-Pagès P, Gutiérrez DA, Barranco-Almohalla A, Crepin G, Tajes M, Ill-Raga G, Guix FX, Menéndez S, Arumí-Uría M, Vicente R, Álvarez AR, Muñoz FJ
Oxid Med Cell Longev. 2020;2020:2739459
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Genome-wide postnatal changes in immunity following fetal inflammatory response.
Costa D, Bonet N, Solé A, González de Aledo-Castillo JM, Sabidó E, Casals F, Rovira C, Nadal A, Luis Marin J, Cobo T, Castelo R
FEBS J. 2020 Oct 2;
Correction to: Sickness absence trajectories following labour market participation patterns: a cohort study in Catalonia (Spain), 2012-2014.
Hernando-Rodriguez JC, Serra L, Benavides FG, Ubalde-Lopez M
BMC Public Health. 2020 Oct 1;20(1):1493
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Li X, Lehner B
Nat Commun. 2020 Oct 1;11(1):4923
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Glioblastoma TCGA mesenchymal and IGS 23 tumors are identifiable by immunohistochemistry and have an immune-phenotype indicating potential benefit from immunotherapy.
Carrato C, Alameda F, Esteve-Codina A, Pineda E, Arpí O, Martinez Garcia M, Mallo M, Gut M, Lopez-Martos R, Del Barco S, Ribalta T, Capellades J, Puig J, Gallego O, Mesia C, Muñoz-Mármol AM, Archilla I, Arumí M, Blanc JM, Bellosillo B, Menéndez S, Esteve A, Bague S, Hernandez A, Craven-Bartle J, Fuentes R, Vidal N, Aldecoa I, de la Iglesia N, Balana C
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The shaping of immunological responses through natural selection after the Roma Diaspora.
Dobon B, Ter Horst R, Laayouni H, Mondal M, Bianco E, Comas D, Ioana M, Bosch E, Bertranpetit J, Netea MG
Sci Rep. 2020 Sep 30;10(1):16134
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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development.
Brena D, Bertran J, Porta-de-la-Riva M, Guillén Y, Cornes E, Kukhtar D, Campos-Vicens L, Fernández L, Pecharroman I, García-López A, Islam ABMMK, Marruecos L, Bigas A, Cerón J, Espinosa L
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Development of Helicobacter pylori Whole-Proteome Arrays and Identification of Serologic Biomarkers for Noncardia Gastric Cancer in the MCC-Spain Study.
Jeske R, Reininger D, Turgu B, Brauer A, Harmel C, Fernández de Larrea-Baz N, Martín V, Moreno V, Kogevinas M, Pollán M, Hoheisel JD, Waterboer T, Butt J, Aragonés N, Hufnagel K
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Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory.
Gomis-González M, Galera-López L, Ten-Blanco M, Busquets-Garcia A, Cox T, Maldonado R, Ozaita A
Mol Neurobiol. 2020 Sep 30;
Topologically selective islet vulnerability and self-sustained downregulation of markers for beta-cell maturity in streptozotocin-induced diabetes.
Hahn M, van Krieken PP, Nord C, Alanentalo T, Morini F, Xiong Y, Eriksson M, Mayer J, Kostromina E, Ruas JL, Sharpe J, Pereira T, Berggren PO, Ilegems E, Ahlgren U
Commun Biol. 2020 Sep 30;3(1):541
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Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment.
De Toma I, Ortega M, Catuara-Solarz S, Sierra C, Sabidó E, Dierssen M
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Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects.
Ballestín R, Alegre-Zurano L, Ferrer-Pérez C, Cantacorps L, Miñarro J, Valverde O, Rodríguez-Arias M
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Sep 28;105:110123
Normative Data for Impact Microindentation for Australian Men: Cross-Sectional Data From the Geelong Osteoporosis Study.
Rufus-Membere P, Holloway-Kew KL, Kotowicz MA, Diez-Perez A, Pasco JA
JBMR Plus. 2020 Sep;4(9):e10384
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Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T, Hoekzema K, Vecchio D, Wu H, Sulovari A, Coe BP, Gillentine MA, Wilfert AB, Perez-Jurado LA, Kvarnung M, Sleyp Y, Earl RK, Rosenfeld JA, Geisheker MR, Han L, Du B, Barnett C, Thompson E, Shaw M, Carroll R, Friend K, Catford R, Palmer EE, Zou X, Ou J, Li H, Guo H, Gerdts J, Avola E, Calabrese G, Elia M, Greco D, Lindstrand A, Nordgren A, Anderlid BM, Vandeweyer G, Van Dijck A, Van der Aa N, McKenna B, Hancarova M, Bendova S, Havlovicova M, Malerba G, Bernardina BD, Muglia P, van Haeringen A, Hoffer MJV, Franke B, Cappuccio G, Delatycki M, Lockhart PJ, Manning MA, Liu P, Scheffer IE, Brunetti-Pierri N, Rommelse N, Amaral DG, Santen GWE, Trabetti E, Sedlácek Z, Michaelson JJ, Pierce K, Courchesne E, Kooy RF, SPARK Consortium., Nordenskjöld M, Romano C, Peeters H, Bernier RA, Gecz J, Xia K, Eichler EE
Nat Commun. 2020 Oct 1;11(1):4932
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How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.
Trujillo M, Prakash P, Faridi P, Radosevic A, Curto S, Burdio F, Berjano E
Int J Hyperthermia. 2020;37(1):1131-1138
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In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm.
Artigas L, Coma M, Matos-Filipe P, Aguirre-Plans J, Farrés J, Valls R, Fernandez-Fuentes N, de la Haba-Rodriguez J, Olvera A, Barbera J, Morales R, Oliva B, Mas JM
PLoS One. 2020;15(10):e0240149
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The cost-effectiveness of isavuconazole compared to voriconazole, the standard of care in the treatment of patients with invasive mould diseases, prior to differential pathogen diagnosis in Spain.
Azanza JR, Grau S, Vázquez L, Rebollo P, Peral C, López-Ibáñez de Aldecoa A, López-Gómez V
Mycoses. 2020 Sep 29;
Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL.
Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, Davis ZA, Yan XJ, Jeromin S, Schneider C, Pedersen LB, Tschumper R, Sutton LA, Baliakas P, Scarfò L, van Gastel EJ, Armand M, Tausch E, Biderman B, Baer C, Bagnara D, Navarro A, de Septenville A, Guido V, Mitterbauer-Hohendanner G, Dimovski A, Brieghel C, Lawless S, Meggendorfer M, Stranska K, Ritgen M, Facco M, Tresoldi C, Visentin A, Patriarca A, Catherwood M, Bonello L, Sudarikov A, Vanura K, Roumelioti M, Skuhrova Francova H, Moysiadis T, Veronese SM, Giannopoulos K, Mansouri L, Karan-Djurasevic T, Sandaltzopoulos R, Bödör C, Fais F, Kater AP, Panovska-Stavridis I, Rossi D, Alshemmari S, Panagiotidis P, Costeas PA, Espinet B, Antic D, Foroni L, Montillo M, Trentin L, Stavroyianni N, Gaidano G, Francia di Celle P, Niemann CU, Campo E, Anagnostopoulos A, Pott C, Fischer K, Hallek M, Oscier DG, Stilgenbauer S, Haferlach C, Jelinek DF, Chiorazzi N, Pospisilova S, Lefranc MP, Kossida S, Langerak AW, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K
Blood. 2020 Sep 29;
Author Correction: Characterization of partially ordered states in the intrinsically disordered N-terminal domain of p53 using millisecond molecular dynamics simulations.
Herrera-Nieto P, Pérez A, De Fabritiis G
Sci Rep. 2020 Sep 29;10(1):16374
Deficient muscle regeneration potential in sarcopenic COPD patients: Role of satellite cells.
Sancho-Muñoz A, Guitart M, Rodríguez DA, Gea J, Martínez-Llorens J, Barreiro E
J Cell Physiol. 2020 Sep 28;
Evaluation of Specific Absorption Rate in the Far-Field, Near-to-Far Field and Near-Field Regions for Integrative Radiofrequency Exposure Assessment.
Liorni I, Capstick M, van Wel L, Wiart J, Joseph W, Cardis E, Guxens M, Vermeulen R, Thielens A
Radiat Prot Dosimetry. 2020 Sep 28;
Stroke prevention in patients with type 2 diabetes or prediabetes. Recommendations from the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.
Fuentes B, Amaro S, Alonso de Leciñana M, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo M, García-Pastor A, Gomis M, Gómez Choco M, López-Cancio E, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Rodríguez-Yáñez M, Roquer J, Segura T, Serena J, Vivancos-Mora J, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología.
Neurologia. 2020 Sep 24;
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Experts Document About an Adequate Utilization of SYSADOAs in Controversial Clinical Situations.
Monfort J, Carné X, Abarca B, Giménez S, Romera M, Möller I, Bibas M, Vitaloni M, Batlle A, Vergés J
Reumatol Clin. 2020 Sep 24;
Recognition of air pollution as a risk factor for stroke in clinical practice guidelines: a literature review.
Avellaneda-Gómez C, Roquer J, Vivanco-Hidalgo R
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Chronic urticaria treatment patterns and changes in quality of life: AWARE study 2-year results.
Maurer M, Giménez-Arnau A, Ensina LF, Chu CY, Jaumont X, Tassinari P
World Allergy Organ J. 2020 Sep;13(9):100460
Phenotypic Variability in a Coinfection With Three Independent Candida parapsilosis Lineages.
Gómez-Molero E, Willis JR, Dudakova A, Carreté L, Weig M, Groß U, Gácser A, Gabaldón T, Bader O
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Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data.
Nicoara-Farcau O, Han G, Rudler M, Angrisani D, Monescillo A, Torres F, Casanovas G, Bosch J, Lv Y, Thabut D, Fan D, Hernández-Gea V, García-Pagán JC, pre-emptive TIPS individual data metanalysis, International Variceal Bleeding Study and Baveno Cooperation Study groups., Bureau C, Abraldes JG, Nevens F, Caca K, Laleman W, Appenrodt B, Luca A, Vinel JP, Mössner J, Di Pascoli M, Zipprich A, Sauerbruch T, Martinez-Lagares F, Ruiz-Del-Arbol L, Sierra A, Guevara C, Jimenez E, Marrero JM, Buceta E, Sanchez J, Castellot A, Penate M, Cruz A, Pena E, Procopet B, Giráldez Á, Amitrano L, Villanueva C, Ibañez-Samaniego L, Silva-Junior G, Martinez J, Genescà J, Trebicka J, Llop E, Palazon JM, Castellote J, Rodrigues S, Gluud LL, Ferreira CN, Barcelo R, Cañete N, Rodríguez M, Ferlitsch A, Mundi JL, Gronbaek H, Hernández-Guerra M, Sassatelli R, Dell'Era A, Senzolo M, Romero-Gómez M, Casas M, Masnou H, Primignani M, Krag A, Calleja JL, Jansen C, Robic MA, Conejo I, Catalina MV, Albillos A, Alvarado E, Guardascione MA, Tantau M, Zuo L, Zhu X, Zhao J, Xue H, Jiang Z, Zhuge Y, Zhang C, Sun J, Ding P, Ren W, Li Y, Zhang K, Zhang W, He C, Zhong J, Peng Q, Ma F, Luo J, Zhang M, Wang G, Sun M, Dong J, Bai W, Guo W, Wang Q, Yuan X, Wang Z, Yu T, Luo B, Li X, Yuan J, Han N, Zhu Y, Niu J, Li K, Yin Z, Nie Y, Fischer P, Stefanescu H, Pop A, Laursen SB, Turon F, Baiges A, Ferrusquía-Acosta J, Magaz M, Cerda E, Tellez L, Allegretti G, Macedo G, Haldrup D, Santos P, Moura M, Reis D, Meireles L, Sousa P, Alexandrino P, Navascues C, Augustin S, La Mura V, Bañares R, Diaz R, Gómez ML, Ripoll C
Gastroenterology. 2020 Sep 24;
General Analyses of Gene Expression Dependencies on Genetic Burden.
González-Colell M, Macía J
Front Bioeng Biotechnol. 2020;8:1017
Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells.
Benfield AH, Defaus S, Lawrence N, Chaousis S, Condon N, Cheneval O, Huang YH, Chan LY, Andreu D, Craik DJ, Henriques ST
Biochim Biophys Acta Biomembr. 2020 Sep 24;1863(1):183480
Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain Study).
Weitzer J, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, Guevara M, Amiano P, Martín V, Molina-Barceló A, Alguacil J, Moreno V, Suarez-Calleja C, Jiménez-Moleón JJ, Marcos-Gragera R, Papantoniou K, Pérez-Gómez B, Llorca J, Ascunce N, Gil L, Gracia-Lavedan E, Casabonne D, Lope V, Pollán M, Kogevinas M
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The evolutionary history of Neanderthal and Denisovan Y chromosomes.
Petr M, Hajdinjak M, Fu Q, Essel E, Rougier H, Crevecoeur I, Semal P, Golovanova LV, Doronichev VB, Lalueza-Fox C, de la Rasilla M, Rosas A, Shunkov MV, Kozlikin MB, Derevianko AP, Vernot B, Meyer M, Kelso J
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Beyond clinical outcomes: the social and healthcare system implications of hepatitis C treatment.
Torrens M, Soyemi T, Bowman D, Schatz E
BMC Infect Dis. 2020 Sep 24;20(1):702
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Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk.
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Cardboard floor: about the barriers for social progression and their impact on the representativeness of epidemiological studies.
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Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome.
Bullón-Vela V, Abete I, Zulet MA, Xu Y, Martínez-González MA, Sayón-Orea C, Ruiz-Canela M, Toledo E, Sánchez VM, Estruch R, Lamuela-Raventós RM, Almanza-Aguilera E, Fitó M, Salas-Salvadó J, Díaz-López A, Tinahones FJ, Tur JA, Romaguera D, Konieczna J, Pintó X, Daimiel L, Rodriguez-Mateos A, Alfredo Martínez J
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Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein-Protein Interaction Data.
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Health policy strategies for Patient Blood Management implementation throughout the Spanish health systems.
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Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.
Pont L, Alechaga É, Terrero A, Monfort N, Ventura R
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Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis.
Cáceres A, González JR
Neurobiol Aging. 2020 Sep 2;96:104-108
Detection of postoperative plasma circulating tumour DNA and lack of CDX2 expression as markers of recurrence in patients with localised colon cancer.
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Synthetic soil crusts against green-desert transitions: a spatial model.
Vidiella B, Sardanyés J, Solé RV
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Mutations make gut antibodies promiscuous.
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methylclock: a Bioconductor package to estimate DNA methylation age.
Pelegí-Sisó D, de Prado P, Ronkainen J, Bustamante M, González JR
Bioinformatics. 2020 Sep 22;
Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus.
Müller PC, Kapp JR, Vetter D, Bonavina L, Brown W, Castro S, Cheong E, Darling GE, Egberts J, Ferri L, Gisbertz SS, Gockel I, Grimminger PP, Hofstetter WL, Hölscher AH, Low DE, Luyer M, Markar SR, Mönig SP, Moorthy K, Morse CR, Müller-Stich BP, Nafteux P, Nieponice A, Nieuwenhuijzen GAP, Nilsson M, Palanivelu C, Pattyn P, Pera M, Räsänen J, Ribeiro U, Rosman C, Schröder W, Sgromo B, van Berge Henegouwen MI, van Hillegersberg R, van Veer H, van Workum F, Watson DI, Wijnhoven BPL, Gutschow CA
Dis Esophagus. 2020 Sep 22;
Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.
Doñate-Macian P, Duarte Y, Rubio-Moscardo F, Pérez-Vilaró G, Canan J, Díez J, González-Nilo F, Valverde MA
Br J Pharmacol. 2020 Sep 21;
Extensive germline genome engineering in pigs.
Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, Wu J, Xiong J, Goswami D, Yang M, Lamriben L, Xu M, Zhang Q, Luo Y, Guo J, Mao S, Jiao D, Nguyen TD, Li Z, Layer JV, Li M, Paragas V, Youd ME, Sun Z, Ding Y, Wang W, Dou H, Song L, Wang X, Le L, Fang X, George H, Anand R, Wang SY, Westlin WF, Güell M, Markmann J, Qin W, Gao Y, Wei HJ, Church GM, Yang L
Nat Biomed Eng. 2020 Sep 21;
Analysis of hydroxylated phenylalkylamine stimulants in urine by GC-APPI-HRMS.
Bressan C, Ayala-Cabrera JF, Santos FJ, Cuadras S, Garrostas L, Monfort N, Alechaga É, Moyano E, Ventura R
Anal Bioanal Chem. 2020 Sep 21;
The global burden of chronic urticaria for the patient and society.
Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, Ben-Shoshan M, Bernstein JA, Ensina LF, Fomina D, Galvàn CA, Godse K, Grattan C, Hide M, Katelaris CH, Khoshkhui M, Kocatürk E, Kulthanan K, Medina I, Nasr I, Peter J, Staubach P, Wang L, Weller K, Maurer M
Br J Dermatol. 2020 Sep 21;
Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive Candidiasis- The STRIVE Trial.
Thompson GR, Soriano A, Skoutelis A, Vazquez JA, Honore PM, Horcajada JP, Spapen H, Bassetti M, Ostrosky-Zeichner L, Das AF, Viani RM, Sandison T, Pappas PG
Clin Infect Dis. 2020 Sep 21;
Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status.
Mayneris-Perxachs J, Arnoriaga-Rodríguez M, Luque-Córdoba D, Priego-Capote F, Pérez-Brocal V, Moya A, Burokas A, Maldonado R, Fernández-Real JM
Microbiome. 2020 Sep 20;8(1):136
Effects of high fat diet and maternal binge-like alcohol consumption and their influence on cocaine response in female mice offspring.
Duart-Castells L, Cantacorps L, López-Arnau R, Montagud-Romero S, Puster B, Mera P, Serra D, Camarasa J, Pubill D, Valverde O, Escubedo E
Int J Neuropsychopharmacol. 2020 Sep 19;
http://www.ncbi.nlm.nih.gov/en...
Maturity Assessment model for Patient Blood Management to assist hospitals in improving patients' safety and outcomes. The MAPBM project.
Bisbe E, Garcia-Casanovas A, Illa C, Varela J, Basora M, Barquero M, Colomina MJ, González L, Hofmann A, MAPBM Working Group., Rodríguez LEF, Gosálbez AA, Fornet AP, Soler X, Planella T, Ricos P, Goterris R, Olmedilla L, Jericó C, Morales A, Gala JMG, Dueñas V, Fernández C, Tolos R, Villanueva MA, Cassinello C, Graciani IF, Aragon S, Subira M, Turcu V, Vilariño SAD, Zavala E, González LM, Moreno G, de Gracia SR, García A, Gallofre AP, Duque P, Sánchez LL, Vagace JM, Medina Á, Rodríguez MO, Faura A, Rosello L, Johansson E, Poch P, Santamaría MA, Rubio ML, Jara I, Carmona C, Lluch CR, Almirante M, López ÁF, Caldes M, Loureiro E, Quintana M, Azparren G, Puerta J, Romero EM, Rubio AA, Santaella J, Cerdan G, Arbones R, Palacios Á, Llamas P
Blood Transfus. 2020 Sep 18;
Mechanisms of cell specification and differentiation in vertebrate cranial sensory systems.
Alsina B
Curr Opin Cell Biol. 2020 Sep 17;67:79-85
Brain Functional Connectivity Correlates of Subclinical Obsessive-Compulsive Symptoms in Healthy Children.
Suñol M, Saiz-Masvidal C, Contreras-Rodríguez O, Macià D, Martínez-Vilavella G, Martínez-Zalacaín I, Menchón JM, Pujol J, Sunyer J, Soriano-Mas C
J Am Acad Child Adolesc Psychiatry. 2020 Sep 17;
Respiratory muscle senescence in ageing and chronic lung diseases.
Gea J, Ausín P, Martínez-Llorens JM, Barreiro E
Eur Respir Rev. 2020 Sep 30;29(157)
http://www.ncbi.nlm.nih.gov/en...
Circulating cell-free DNA improves the molecular characterisation of Ph-negative myeloproliferative neoplasms.
Garcia-Gisbert N, Fernández-Ibarrondo L, Fernández-Rodríguez C, Gibert J, Andrade-Campos M, Arenillas L, Camacho L, Angona A, Longarón R, Salar A, Calvo X, Besses C, Bellosillo B
Br J Haematol. 2020 Sep 18;
Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M
Science. 2020 Sep 18;369(6510):1450-1455
The Chronic Urticaria Registry (CURE):Rationale, Methods, and Initial Implementation.
Weller K, Giménez-Arnau A, Grattan C, Asero R, Mathelier-Fusade P, Bizjak M, Hanna M, Maurer M, Cure Investigators.
J Eur Acad Dermatol Venereol. 2020 Sep 18;
http://www.ncbi.nlm.nih.gov/en...
Elimination profiles of betamethasone after different administration routes: evaluation of the reporting level and washout periods to ensure safe therapeutic administrations.
Coll S, Monfort N, Alechaga É, Matabosch X, Pérez-Mañá C, Ventura R
Drug Test Anal. 2020 Sep 18;
Feasibility, tolerability, and effects of exercise-based prehabilitation after neoadjuvant therapy in esophagogastric cancer patients undergoing surgery: an interventional pilot study.
Argudo N, Rodó-Pin A, Martínez-Llorens J, Marco E, Visa L, Messaggi-Sartor M, Balañá-Corberó A, Ramón JM, Rodríguez-Chiaradía DA, Grande L, Pera M
Dis Esophagus. 2020 Sep 17;
Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study.
Trinka E, Rocamora R, Chaves J, Moreira J, Ikedo F, Soares-da-Silva P, BIA-2093-311/EXT Investigators Study Group.
Epilepsia. 2020 Sep 17;
http://www.ncbi.nlm.nih.gov/en...
B Cells and Tertiary Lymphoid Structures Influence Survival in Lung Cancer Patients with Resectable Tumors.
Tang J, Ramis-Cabrer D, Curull V, Wang X, Mateu-Jiménez M, Pijuan L, Duran X, Qin L, Rodríguez-Fuster A, Aguiló R, Barreiro E
Cancers (Basel). 2020 Sep 16;12(9)
http://www.ncbi.nlm.nih.gov/en...
High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study.
Papandreou C, Hernández-Alonso P, Bulló M, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Cofán M, Fitó M, Razquin C, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J
J Nutr. 2020 Sep 16;
Relation of Interatrial Block to Cognitive Impairment in Patients ? 70 Years of Age (From the CAMBIAD Case-Control Study).
Herrera C, Bruña V, Abizanda P, Díez-Villanueva P, Formiga F, Torres R, Carreras J, Ayala R, Martin-Sánchez FJ, Bayés-Genis A, Elosua R, Bayés-de-Luna A, Martínez-Sellés M, CAMBIAD investigators (Appendix).
Am J Cardiol. 2020 Sep 16;
Drug repositioning and repurposing for Alzheimer disease.
Ballard C, Aarsland D, Cummings J, O'Brien J, Mills R, Molinuevo JL, Fladby T, Williams G, Doherty P, Corbett A, Sultana J
Nat Rev Neurol. 2020 Sep 16;
Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015-2018.
Uter W, Bauer A, Belloni Fortina A, Bircher AJ, Brans R, Buhl T, Cooper SM, Czarnecka-Operacz M, Dickel H, Dugonik A, Geier J, Giménez-Arnau AM, Gonçalo M, Johansen JD, Johnston GA, Mahler V, Rustemeyer T, Sanchez-Perez J, Schuttelaar MLA, Simon D, Spiewak R, Valiukevicien S, Weisshaar E, White IR, Wilkinson M, ESSCA working group.
Contact Dermatitis. 2020 Sep 18;
Managing dual disorders: a statement by the Informal Scientific Network, UN Commission on Narcotic Drugs.
Volkow ND, Torrens M, Poznyak V, Sáenz E, Busse A, Kashino W, Krupchanka D, Kestel D, Campello G, Gerra G
World Psychiatry. 2020 Oct;19(3):396-397
MassIVE.quant: a community resource of quantitative mass spectrometry-based proteomics datasets.
Choi M, Carver J, Chiva C, Tzouros M, Huang T, Tsai TH, Pullman B, Bernhardt OM, Hüttenhain R, Teo GC, Perez-Riverol Y, Muntel J, Müller M, Goetze S, Pavlou M, Verschueren E, Wollscheid B, Nesvizhskii AI, Reiter L, Dunkley T, Sabidó E, Bandeira N, Vitek O
Nat Methods. 2020 Oct;17(10):981-984
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.
Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A
Cell. 2020 Oct 1;183(1):94-109.e23
Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A.
Lai CQ, Parnell LD, Smith CE, Guo T, Sayols-Baixeras S, Aslibekyan S, Tiwari HK, Irvin MR, Bender C, Fei D, Hidalgo B, Hopkins PN, Absher DM, Province MA, Elosua R, Arnett DK, Ordovas JM
Am J Clin Nutr. 2020 Sep 15;
OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming.
Saxena K, Srikrishnan S, Celia-Terrassa T, Jolly MK
Cells Tissues Organs. 2020 Sep 15;:1-10
Primary resistance to integrase strand transfer inhibitors in Spain using ultrasensitive HIV-1 genotyping.
Casadellà M, Santos JR, Noguera-Julian M, Micán-Rivera R, Domingo P, Antela A, Portilla J, Sanz J, Montero-Alonso M, Navarro J, Masiá M, Valcarce-Pardeiro N, Ocampo A, Pérez-Martínez L, Pasquau J, Vivancos MJ, Imaz A, Carmona-Oyaga P, Muñoz-Medina L, Villar-García J, Barrufet P, Paredes R, Santos JR, Bravo I, Chamorro A, Miranda C, Micán R, González J, Antela A, Diez M, Portilla I, Carreres M, Giner L, Boix V, Reus S, Merino E, Torrús D, Portilla J, Sanz J, Liarte ÁG, Berrocal AG, Domingo P, Del M, Gutiérrez M, Mateo MG, Rodríguez JM, Montero-Alonso M, Curran A, Torrella A, Planas B, Navarro J, Masiá M, Padilla S, Robledano C, Adsuar A, Montolio F, Gutiérrez F, Pardeiro NV, Álvarez H, Mariño A, Ocampo A, Rodríguez A, Miralles C, Pérez-Martínez L, Blanco JR, Vallecillos CG, Pasquau J, Pérez-Elías MJ, Dronda F, Vivancos MJ, Moreno S, Imaz A, Podzamczer D, Ibarguren M, Kortajarena X, Carmona MP, Iribarren JA, Moreno LM, Quero JH, Villar-García J, Knobel H, Barrufet P, Force L, Casadellà M, Paredes R, Noguera-Julian M
J Antimicrob Chemother. 2020 Sep 15;
Impact of response to treatment in health-related quality of life patient-reported outcomes in elderly patients with relapsed multiple myeloma.
Oriol A, Ibarra G, Abella E, Motlló C, Cibeira MT, Garcia A, Escoda L, Granell M, Ben-Azaiz R, Cervera M, Cabezudo E, Fernandez C, Rosiñol L
Leuk Lymphoma. 2020 Sep 15;:1-11
The SEEN comprehensive clinical survey of adult obesity: Executive summary.
Ballesteros Pomar MD, Vilarrasa García N, Rubio Herrera MÁ, Barahona MJ, Bueno M, Caixàs A, Calañas Continente A, Ciudin A, Cordido F, de Hollanda A, Diaz MJ, Flores L, García Luna PP, García Pérez-Sevillano F, Goday A, Lecube A, López Gómez JJ, Miñambres I, Morales Gorria MJ, Morinigo R, Nicolau J, Pellitero S, Salvador J, Valdés S, Bretón Lesmes I
Endocrinol Diabetes Nutr. 2020 Sep 12;
Gastrointestinal involvement attenuates COVID-19 severity and mortality.
Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, Parigi TL, Ramos I, Dunleavy K, Lee B, Dixon R, Chen ST, Martinez-Delgado G, Nagula S, Ko HM, Reidy J, Naymagon S, Grinspan A, Ahmad J, Tankelevich M, Gordon R, Sharma K, Britton GJ, Chen-Liaw A, Spindler MP, Plitt T, Wang P, Cerutti A, Faith JJ, Colombel JF, Kenigsberg E, Argmann C, Merad M, Gnjatic S, Harpaz N, Danese S, Rahman A, Kumta NA, Aghemo A, Petralia F, van Bakel H, Garcia-Sastre A, Mehandru S
medRxiv. 2020 Sep 9;
http://www.ncbi.nlm.nih.gov/en...
Incidence and Grading of Complications after Gastrectomy for Cancer Using the GASTRODATA Registry: A European Retrospective Observational Study.
Baiocchi GL, Giacopuzzi S, Reim D, Piessen G, Costa PMD, Reynolds JV, Meyer HJ, Morgagni P, Gockel I, Santos LL, Jensen LS, Murphy T, D'Ugo D, Rosati R, Fumagalli Romario U, Degiuli M, Kielan W, Mönig S, Kolodziejczyk P, Polkowski W, Pera M, Schneider PM, Wijnhoven B, de Steur WO, Gisbertz SS, Hartgrink H, van Sandick JW, Botticini M, Hölscher AH, Allum W, De Manzoni G
Ann Surg. 2020 Sep 10;
Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children.
Aguilar-Lacasaña S, Vilor-Tejedor N, Jansen PR, López-Vicente M, Bustamante M, Burgaleta M, Sunyer J, Alemany S
Psychol Med. 2020 Sep 14;:1-9
http://www.ncbi.nlm.nih.gov/en...
Asthma exacerbations, air pollution, and allergens.
Sunyer J, Antó JM
Lancet. 2020 Sep 12;396(10253):753
http://www.ncbi.nlm.nih.gov/en...
Air pollution and IgE sensitization in four European birth cohorts - the MeDALL project.
Melén E, Standl M, Gehring U, Altug H, Antó JM, Berdel D, Bergström A, Bousquet J, Heinrich J, Koppelman GH, Kull I, Lupinek C, Markevych I, Schikowski T, Thiering E, Valenta R, van Hage M, von Berg A, Vonk JM, Wickman M, Wijga A, Gruzieva O
J Allergy Clin Immunol. 2020 Sep 11;
http://www.ncbi.nlm.nih.gov/en...
Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial.
Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós F, Fiol M, Serra-Majem L, Ros E, Estruch R
Mol Nutr Food Res. 2020 Sep 12;:e2000350
Top quality research with the utmost integrity
The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.
At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:
- The PRBB Code of Good Scientific Practices, approved by all the centres.
- An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
- Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.
To learn more about the code, the working group on good scientific practices and the various activities organised, visit:
More information
Contact
●Last news
Patents and companies
- The following links allow you to explore the technology on offer in the park’s centres:
Technology at the IMIM-Hospital del Mar
UPF Business Shuttle and Innovation Unit
Technology and Business Development Office at the CRG
Analysis and Global Development at ISGlobal
EMBLEM Technology Transfer
- The following start-ups have been created within the PRBB environment:
Acellera
Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.
→ https://www.acellera.comChemotargets
Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.
→ http://www.chemotargets.com/qGenomics
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qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.
→ https://qgenomics.comZeClinics
ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.
→ http://www.zeclinics.comMicroomics
Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.
→ http://www.microomics.euFlomics
World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.
→ http://www.flomics.comBioinspired Materials
This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.
→ http://biom.techMedBioinformatics Solutions
MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.
→ http://www.disgenet.orgPulmobiotics
A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.
→ https://www.pulmobio.com/●Last news
Microomics: next-generation sequencing to analyze the microbiome