Connecting perspectives: from bytes and molecules to organisms and populations
"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".
Jordi Camí, General Director of the PRBB.
The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.
With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.
Hospital del Mar Medical Research Institute (IMIM)
Cancer
The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research
Epidemiology and Public Health
The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.
Biomedical Informatics
This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB).
Neuroscience
The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.
Inflammatory and Cardiovascular Disorders
This programme expands our knowledge of pathophysiological, inflammatory and genetic mechanisms of cardiovascular, respiratory and bone disorders, as well as other acute and chronic disorders, their diagnosis and treatment. The multidisciplinary team addresses basic biomedical scientific questions arising from clinical cases. This approach should lead to translational research that can be applied to medical care.
Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)
Cellular and Molecular Biology
The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.
Molecular Medicine
This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.
Evolutionary Biology and Complex Systems
The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.
Biomedical Informatics
The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.
Genetics and Neuroscience
The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.
Systems Bioengineering
The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.
Transversal Program
Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.
Centre for Genomic Regulation (CRG)
Bioinformatics and Genomics
Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).
Cell and Developmental Biology
The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.
Gene Regulation, Stem Cells and Cancer
The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.
Systems Biology
The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice.
The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.
Barcelona Institute for Global Health (ISGlobal, Mar Campus)
Climate and Health
Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.
Air pollution and urban environment
The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.
Non-communicable diseases and the environment
The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.
Childhood and Environment
This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.
Radiation
The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.
Other
ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.
Institute of Evolutionary Biology (IBE: CSIC-UPF)
Animal Biodiversity and Evolution
The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.
Comparative and Computational Genomics
This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.
Functional Genomics and Evolution
The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.
Population genetics
Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.
Complex Systems
This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.
European Molecular Biology Laboratory (EMBL)
Tissue biology and disease modelling
The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”
Institute of Applied Radiopharmacy of Barcelona (IRAB)
Research and Innovation
The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.
Animal research with the international accreditation from the AAALAC.
The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.
Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.
- Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
- The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
- The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).
For more information on the animal facility and animal experimentation visit:
Animal experimentation courses
The PRBB and Charles River Campus
Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.
The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:
- Euthanasia (Function b)
- Performing procedures (Function c)
- Designing projects and procedures (mice and fish/amphibians) (Function d)
The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.
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Shared facilities for high-impact research
"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."
Jordi Camí, General Director of the PRBB
The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.
The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection
Contact: Montserrat Torà
→ marbiobanc@imim.es
The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.
Contact: Julia Ponomarenko
→ biocore@crg.eu
The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.
Contact: Ivo Gut
→ projectmanager@cnag.crg.eu
This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.
Contact: Blanca Espinet
→ bespinet@parcdesalutmar.cat
This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.
Contact: Òscar Fornas
→ oscar.fornas@upf.edu
Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit
The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.
Contact: Dirección de secretaría
→ ceea@prbb.org
Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.
Contact: Cristina Llop
→ CEIC-PSMAR@imim.es
The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.
Contact: Secretaría
→ cbs@prbb.org
This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.
Contact: Carlo Carolis
→ bmspt@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit
BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.
Contact: Jordi Alonso
→ bibliopro@imim.es
The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.
Contact: Arcadi Navarro
→ helpdesk@ega-archive.org
This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.
Contact: Jochen Hecht
→ ngs@crg.eu
The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.
Contact: Montserrat Torà
→ margenomics@imim.es
The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.
Contact: Ferran Casals
→ genomica@upf.edu
The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.
Contact: Laura Batlle Morera
→ laura.batlle@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0
This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.
Contact: Ana Aldea
→ aaldea@imim.es
This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.
Contact: Jim Swoger
→ mif@embl.es
Web:
https://www.embl.es/services/mesoscopic-imaging-facility
The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.
Contact: Nadia Halidi
→ nadia.halidi@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit
Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)
Contact: David Andreu
→ david.andreu@upf.edu
This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.
Contact: Eduard Sabido Aguade
→ eduard.sabido@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit
Risk factors for a second nonsimultaneous hip fracture in a prospective cohort study.
Larrainzar-Garijo R, Díez-Pérez A, Fernández-Tormos E, Prieto-Alhambra D
Arch Orthop Trauma Surg. 2021 Jun 14;
Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins.
Torres AG, Rodríguez-Escribà M, Marcet-Houben M, Santos Vieira HG, Camacho N, Catena H, Murillo Recio M, Rafels-Ybern À, Reina O, Torres FM, Pardo-Saganta A, Gabaldón T, Novoa EM, Ribas de Pouplana L
Nucleic Acids Res. 2021 Jun 14;
Reconstituted mRNA Covid-19 vaccines may maintain stability after continuous movement.
Grau S, Ferrández O, Martín-García E, Maldonado R
Clin Microbiol Infect. 2021 Jun 12;
http://www.ncbi.nlm.nih.gov/en...
Fiber burden and asbestos-related diseases: an umbrella review.
Ramada Rodilla JM, Calvo Cerrada B, Serra Pujadas C, Delclos GL, Benavides FG
Gac Sanit. 2021 Jun 11;
Epidemiology and prognosis of patients with a history of cancer admitted to intensive care. A multicenter observational study.
Olaechea Astigarraga PM, Álvarez Lerma F, Beato Zambrano C, Gimeno Costa R, Gordo Vidal F, Durá Navarro R, Ruano Suarez C, Aldabó Pallás T, Garnacho Montero J, ENVIN-HELICS Study Group., List of supervisors and units participating in the ONCOENVIN study, ordered by number of patients contributed to the epidemiological study.
Med Intensiva (Engl Ed). 2021 Jun 11;
Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model.
García-Baos A, Puig-Reyne X, García-Algar Ó, Valverde O
Biomed Pharmacother. 2021 Jun 11;141:111813
Small and overlooked: Phylogeny of the genus Trigonodactylus (Squamata: Gekkonidae), with the first record of Trigonodactylus arabicus from Jordan.
Pola L, Hejduk V, Zíka A, Winkelhöfer T, Šmíd J, Carranza S, Shobrak M, Abu Baker M, Amr ZS
Saudi J Biol Sci. 2021 Jun;28(6):3511-3516
http://www.ncbi.nlm.nih.gov/en...
Genetic Influences on Hippocampal Subfields: An Emerging Area of Neuroscience Research.
Vilor-Tejedor N, Evans TE, Adams HH, González-de-Echávarri JM, Molinuevo JL, Guigo R, Gispert JD, Operto G
Neurol Genet. 2021 Jun;7(3):e591
http://www.ncbi.nlm.nih.gov/en...
Positive screens for mental disorders among healthcare professionals during the first covid19 wave in Belgium.
Voorspoels W, Jansen L, Mortier P, Vilagut G, Vocht J, Kessler RC, Alonso J, Bruffaerts R
J Psychiatr Res. 2021 May 29;140:329-336
Kidney transplant after a COVID-19.
Pascual J
Nefrologia. 2021 May 28;
Is the COVID-19 pandemic a risk factor for suicide attempts in adolescent girls?
Gracia R, Pamias M, Mortier P, Alonso J, Pérez V, Palao D
J Affect Disord. 2021 May 27;292:139-141
Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey.
Alonso J, Vilagut G, Mortier P, Ferrer M, Alayo I, Aragón-Peña A, Aragonès E, Campos M, Cura-González ID, Emparanza JI, Espuga M, Forjaz MJ, González-Pinto A, Haro JM, López-Fresneña N, Salázar ADM, Molina JD, Ortí-Lucas RM, Parellada M, Pelayo-Terán JM, Pérez-Zapata A, Pijoan JI, Plana N, Puig MT, Rius C, Rodríguez-Blázquez C, Sanz F, Serra C, Kessler RC, Bruffaerts R, Vieta E, Pérez-Solà V, MINDCOVID Working group.
Rev Psiquiatr Salud Ment (Engl Ed). 2021 Apr-Jun;14(2):90-105
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea.
Durán Alonso MB, Vendrell V, López-Hernández I, Alonso MT, Martin DM, Giráldez F, Carramolino L, Giovinazzo G, Vázquez E, Torres M, Schimmang T
Front Cell Dev Biol. 2021;9:679325
http://www.ncbi.nlm.nih.gov/en...
In Memoriam: José Baselga's Journey in Cancer Medicine.
Kumar R, Hortobagy GN, Albanell J, Arribas J, Norton L
Clin Cancer Res. 2021 Jun 15;27(12):3499-3502
http://www.ncbi.nlm.nih.gov/en...
Impact of Remdesivir on the Treatment of COVID-19 During the First Wave in Spain.
Soriano A, Montejano R, Sanz-Moreno J, Figueira JC, Grau S, Güerri-Fernández R, Castro-Gómez A, Pérez-Román I, Hidalgo-Vega Á, González-Domínguez A
Adv Ther. 2021 Jun 12;
http://www.ncbi.nlm.nih.gov/en...
Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort.
Medrano-Martorell S, Capellades J, Jiménez-Conde J, González-Ortiz S, Vilas-González M, Rodríguez-Campello A, Ois Á, Cuadrado-Godia E, Avellaneda C, Fernández I, Merino-Peña E, Roquer J, Martí-Fàbregas J, Giralt-Steinhauer E
Eur Radiol. 2021 Jun 11;
Monitoring Self-Perceived Occupational Health Inequities in Central America, 2011 and 2018.
Silva-Penaherrera M, Gimeno Ruiz de Porras D, Delclos GL, Rojas Garbanzo M, Merino-Salazar P, Lopez-Ruiz M, Benavides FG
Am J Public Health. 2021 Jun 10;:e1-e10
Data-Driven Clustering Approach to Derive Taste Perception Profiles from Sweet, Salt, Sour, Bitter, and Umami Perception Scores: An Illustration among Older Adults with Metabolic Syndrome.
Gervis JE, Chui KKH, Ma J, Coltell O, Fernández-Carrión R, Sorlí JV, Barragán R, Fitó M, González JI, Corella D, Lichtenstein AH
J Nutr. 2021 Jun 10;
Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation.
Bauer M, Vidal E, Zorita E, Üresin N, Pinter SF, Filion GJ, Payer B
Nat Commun. 2021 Jun 9;12(1):3499
http://www.ncbi.nlm.nih.gov/en...
Systematic benchmarking of tools for CpG methylation detection from nanopore sequencing.
Yuen ZW, Srivastava A, Daniel R, McNevin D, Jack C, Eyras E
Nat Commun. 2021 Jun 8;12(1):3438
http://www.ncbi.nlm.nih.gov/en...
The impact of the Catalonia Suicide Risk Code (CSRC) in a tertiary hospital: Reduction in hospitalizations and emergency room visits for any reason but not for suicide attempt.
Gomes-da-Costa S, Solé E, Williams E, Giménez A, Garriga M, Pacchiarotti I, Vázquez M, Cavero M, Blanch J, Pérez V, Palao D, Vieta E, Verdolini N
Rev Psiquiatr Salud Ment. 2021 Jun 7;
Proposal for a new classification of vibratory urticaria/angioedema.
Pastor-Nieto MA, Gatica-Ortega ME, Vergara-de-la-Campa L, Giménez-Arnau AM
J Allergy Clin Immunol Pract. 2021 Jun;9(6):2542-2543
Blood lead levels in indigenous peoples living close to oil extraction areas in the Peruvian Amazon.
O'Callaghan-Gordo C, Rosales J, Lizárraga P, Barclay F, Okamoto T, Papoulias DM, Espinosa A, Orta-Martinez M, Kogevinas M, Astete J
Environ Int. 2021 May 31;:106639
http://www.ncbi.nlm.nih.gov/en...
Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species.
Willis JR, Saus E, Iraola-Guzmán S, Cabello-Yeves E, Ksiezopolska E, Cozzuto L, Bejarano LA, Andreu-Somavilla N, Alloza-Trabado M, Blanco A, Puig-Sola A, Broglio E, Carolis C, Ponomarenko J, Hecht J, Gabaldón T
J Oral Microbiol. 2021 May 17;13(1):1897328
http://www.ncbi.nlm.nih.gov/en...
Cost-effectiveness evaluation of the use of PCSK9 inhibitors.
Civeira F, Pedro-Botet J
Endocrinol Diabetes Nutr. 2021 Jun-Jul;68(6):369-371
Viscosupplementation for the treatment of osteoarthritis. The contribution of EUROVISCO group.
Conrozier T, Raman R, Chevalier X, Henrotin Y, Monfort J, Diraçoglù D, Bard H, Baron D, Jerosch J, Richette P, Migliore A
Ther Adv Musculoskelet Dis. 2021;13:1759720X211018605
http://www.ncbi.nlm.nih.gov/en...
Integrating health indicators into urban and transport planning: A narrative literature review and participatory process.
Mueller N, Daher C, Rojas-Rueda D, Delgado L, Vicioso H, Gascon M, Marquet O, Vert C, Martin I, Nieuwenhuijsen M
Int J Hyg Environ Health. 2021 Jun 5;235:113772
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Blokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R, Schizophrenia Working Group of the Psychiatric Genomics Consortium., St Clair D, Lencz T, Mowry BJ, Periyasamy S, Cairns MJ, Tooney PA, Wu JQ, Kelly B, Kirov G, Sullivan PF, Corvin A, Riley BP, Esko T, Milani L, Jönsson EG, Palotie A, Ehrenreich H, Begemann M, Steixner-Kumar A, Sham PC, Iwata N, Weinberger DR, Gejman PV, Sanders AR, Buxbaum JD, Rujescu D, Giegling I, Konte B, Hartmann AM, Bramon E, Murray RM, Pato MT, Lee J, Melle I, Molden E, Ophoff RA, McQuillin A, Bass NJ, Adolfsson R, Malhotra AK, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium., Martin NG, Fullerton JM, Mitchell PB, Schofield PR, Forstner AJ, Degenhardt F, Schaupp S, Comes AL, Kogevinas M, Guzman-Parra J, Reif A, Streit F, Sirignano L, Cichon S, Grigoroiu-Serbanescu M, Hauser J, Lissowska J, Mayoral F, Müller-Myhsok B, ?wi?tkowska B, Schulze TG, Nöthen MM, Rietschel M, Kelsoe J, Leboyer M, Jamain S, Etain B, Bellivier F, Vincent JB, Alda M, O'Donovan C, Cervantes P, Biernacka JM, Frye M, McElroy SL, Scott LJ, Stahl EA, Landén M, Hamshere ML, Smeland OB, Djurovic S, Vaaler AE, Andreassen OA, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium., Baune BT, Air T, Preisig M, Uher R, Levinson DF, Weissman MM, Potash JB, Shi J, Knowles JA, Perlis RH, Lucae S, Boomsma DI, Penninx BWJH, Hottenga JJ, de Geus EJC, Willemsen G, Milaneschi Y, Tiemeier H, Grabe HJ, Teumer A, Van der Auwera S, Völker U, Hamilton SP, Magnusson PKE, Viktorin A, Mehta D, Mullins N, Adams MJ, Breen G, McIntosh AM, Lewis CM, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium., iPSYCH., Hougaard DM, Nordentoft M, Mors O, Mortensen PB, Werge T, Als TD, Børglum AD, Petryshen TL, Smoller JW, Goldstein JM
Biol Psychiatry. 2021 Mar 23;
Calcifediol treatment and COVID-19-related outcomes.
Nogues X, Ovejero D, Pineda-Moncusí M, Bouillon R, Arenas D, Pascual J, Ribes A, Guerri-Fernandez R, Villar-Garcia J, Rial A, Gimenez-Argente C, Cos ML, Rodriguez-Morera J, Campodarve I, Quesada-Gomez JM, Garcia-Giralt N
J Clin Endocrinol Metab. 2021 Jun 7;
Associations between sources of particle number and mortality in four European cities.
Rivas I, Vicens L, Basagaña X, Tobías A, Katsouyanni K, Walton H, Hüglin C, Alastuey A, Kulmala M, Harrison RM, Pekkanen J, Querol X, Sunyer J, Kelly FJ
Environ Int. 2021 Jun 4;155:106662
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Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy.
Suay-Corredera C, Pricolo MR, Herrero-Galán E, Velázquez-Carreras D, Sánchez-Ortiz D, García-Giustiniani D, Delgado J, Galano-Frutos JJ, García-Cebollada H, Vilches S, Domínguez F, Molina MS, Barriales-Villa R, Frisso G, Sancho J, Serrano L, García-Pavía P, Monserrat L, Alegre-Cebollada J
J Biol Chem. 2021 Jun 4;:100854
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Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status.
Nerpin E, Ferreira DS, Weyler J, Schlunnsen V, Jogi R, Raherison Semjen C, Gislasson T, Demoly P, Heinrich J, Nowak D, Corsico A, Accordini S, Marcon A, Squillacioti G, Olivieri M, Nielsen R, Johannessen A, Gómez Real F, Garcia-Aymerich J, Urrutia I, Pereira-Vega A, Gullón JA, Olin AC, Forsberg B, Emilsson ÖI, Pin I, Jarvis D, Janson C, Malinovschi A
World Allergy Organ J. 2021 May;14(5):100544
Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU.
Estella Á, Vidal-Cortés P, Rodríguez A, Andaluz Ojeda D, Martín-Loeches I, Díaz E, Suberviola B, Gracia Arnillas MP, Catalán González M, Álvarez-Lerma F, Ramírez P, Nuvials X, Borges M, Zaragoza R
Med Intensiva. 2021 Apr 30;
Financial Strain and Health Status Among European Workers: Gender and Welfare State Inequalities.
Artazcoz L, Cortès-Franch I, Escribà-Agüir V, Benavides FG
Front Public Health. 2021;9:616191
Hydrophilic or Lipophilic Statins?
Climent E, Benaiges D, Pedro-Botet J
Front Cardiovasc Med. 2021;8:687585
The FRAILMar Study Protocol: Frailty in Patients With Advanced Chronic Kidney Disease Awaiting Kidney Transplantation. A Randomized Clinical Trial of Multimodal Prehabilitation.
Pérez-Sáez MJ, Morgado-Pérez A, Faura A, Muñoz-Redondo E, Gárriz M, Muns MD, Nogués X, Marco E, Pascual J
Front Med (Lausanne). 2021;8:675049
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions.
Serra SA, Stojakovic P, Amat R, Rubio-Moscardo F, Latorre P, Seisenbacher G, Canadell D, Böttcher R, Aregger M, Moffat J, de Nadal E, Valverde MA, Posas F
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23)
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Thalamocortical Spectral Transmission Relies on Balanced Input Strengths.
Saponati M, Garcia-Ojalvo J, Cataldo E, Mazzoni A
Brain Topogr. 2021 Jun 4;
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Fetal growth trajectories among small for gestational age babies and child neurodevelopment.
Ferguson KK, Sammallahti S, Rosen E, van den Dries M, Pronk A, Spaan S, Guxens M, Tiemeier H, Gaillard R, Jaddoe VWV
Epidemiology. 2021 Jun 3;
Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
Vivori C, Papasaikas P, Stadhouders R, Di Stefano B, Rubio AR, Balaguer CB, Generoso S, Mallol A, Sardina JL, Payer B, Graf T, Valcárcel J
Genome Biol. 2021 Jun 3;22(1):171
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Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study.
Papantoniou K, Castaño-Vinyals G, Espinosa A, Turner MC, Martín-Sánchez V, Casabonne D, Aragonés N, Gómez-Acebo I, Ardanaz E, Jimenez-Moleon JJ, Amiano P, Molina-Barceló A, Alguacil J, Fernández-Tardón G, Huerta JM, Hernández-Segura N, Perez-Gomez B, Llorca J, Vidán-Alli J, Olmedo-Requena R, Gil L, Castañon-López C, Pollan M, Kogevinas M, Moreno V
Sci Rep. 2021 Jun 3;11(1):11822
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Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Brudfors M, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Benavente OR, Bevan S, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Söderholm M, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Bzdok D, Wu O, MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium., Rost NS
Nat Commun. 2021 Jun 2;12(1):3289
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Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people.
Zumel-Marne A, Castaño-Vinyals G, Alguacil J, Villanueva CM, Maule M, Gracia-Lavedan E, Momoli F, Krewski D, Mohipp C, Petridou E, Bouka E, Merletti F, Migliore E, Piro S, Ha M, Mannetje A', Eng A, Aragones N, Cardis E
Environ Res. 2021 Jun 1;:111392
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Exposure to nature and mental health outcomes during COVID-19 lockdown. A comparison between Portugal and Spain.
Ribeiro AI, Triguero-Mas M, Jardim Santos C, Gómez-Nieto A, Cole H, Anguelovski I, Silva FM, Baró F
Environ Int. 2021 May 28;154:106664
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Genetic Predisposition to Alzheimer's Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region.
Ciampa I, Operto G, Falcon C, Minguillon C, Castro de Moura M, Piñeyro D, Esteller M, Molinuevo JL, Guigó R, Navarro A, Gispert JD, Vilor-Tejedor N, For The Alfa Study
Genes (Basel). 2021 May 27;12(6)
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Nigella and Milk Thistle Seed Oils: Potential Cytoprotective Effects against 7B-Hydroxycholesterol-Induced Toxicity on SH-SY5Y Cells.
Hammouda S, Ghzaiel I, Picón-Pagès P, Meddeb W, Khamlaoui W, Hammami S, Muñoz FJ, Hammami M, Zarrouk A
Biomolecules. 2021 May 27;11(6)
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Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries.
Julvez J, López-Vicente M, Warembourg C, Maitre L, Philippat C, Gützkow KB, Guxens M, Evandt J, Andrusaityte S, Burgaleta M, Casas M, Chatzi L, de Castro M, Donaire-González D, Gražulevi?ien? R, Hernandez-Ferrer C, Heude B, Mceachan R, Mon-Williams M, Nieuwenhuijsen M, Robinson O, Sakhi AK, Sebastian-Galles N, Slama R, Sunyer J, Tamayo-Uria I, Thomsen C, Urquiza J, Vafeiadi M, Wright J, Basagaña X, Vrijheid M
Environ Pollut. 2021 May 24;284:117404
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Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy.
Palau V, Nugraha B, Benito D, Pascual J, Emmert MY, Hoerstrup SP, Riera M, Soler MJ
Int J Mol Sci. 2021 May 24;22(11)
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Impact of a Nosocomial COVID-19 Outbreak on a Non-COVID-19 Nephrology Ward during the First Wave of the Pandemic in Spain.
Montero MM, Hidalgo López C, López Montesinos I, Sorli L, Barrufet Gonzalez C, Villar-García J, Güerri-Fernández R, Herranz M, Crespo M, Arenas Jiménez MD, Pascual J, González Juanes C, Horcajada JP
Antibiotics (Basel). 2021 May 22;10(6)
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Consumption of Ultra-Processed Food and Drinks and Chronic Lymphocytic Leukemia in the MCC-Spain Study.
Solans M, Fernández-Barrés S, Romaguera D, Benavente Y, Marcos-Gragera R, Gracia-Lavedan E, Costas L, Robles C, Gonzalez-Barca E, de la Banda E, Alonso E, Aymerich M, Campo E, Llorca J, Fernández-Tardón G, Olmedo-Requena R, Gimeno E, Castaño-Vinyals G, Aragonés N, Kogevinas M, Pollán M, de Sanjose S, Amiano P, Casabonne D
Int J Environ Res Public Health. 2021 May 20;18(10)
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Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6.
Casadó-Llombart S, Velasco-de Andrés M, Català C, Leyton-Pereira A, Lozano F, Bosch E
Int J Mol Sci. 2021 May 18;22(10)
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Prospective Associations between Maternal and Child Diet Quality and Sedentary Behaviors.
Juton C, Lerin C, Homs C, Casas Esteve R, Berruezo P, Cárdenas-Fuentes G, Fíto M, Grau M, Estrada L, Gómez SF, Schröder H
Nutrients. 2021 May 18;13(5)
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Accidental Interruption of the Cold Chain for the Preservation of the Moderna COVID-19 Vaccine.
Grau S, Ferrández O, Martín-García E, Maldonado R
Vaccines (Basel). 2021 May 17;9(5)
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Clinical and Economic Impact of Community-Onset Urinary Tract Infections Caused by ESBL-Producing Klebsiella pneumoniae Requiring Hospitalization in Spain: An Observational Cohort Study.
Rozenkiewicz D, Esteve-Palau E, Arenas-Miras M, Grau S, Duran X, Sorlí L, Montero MM, Horcajada JP
Antibiotics (Basel). 2021 May 15;10(5)
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Risk Factors for Amoxicillin-Clavulanate Resistance in Community-Onset Urinary Tract Infections Caused by Escherichia coli or Klebsiella pneumoniae: The Role of Prior Exposure to Fluoroquinolones.
Martínez-Casanova J, Gómez-Zorrilla S, Prim N, Dal Molin A, Echeverría-Esnal D, Gracia-Arnillas MP, Sendra E, Güerri-Fernández R, Durán-Jordà X, Padilla E, Horcajada JP, Grau S, Proa-Psmar Group OBOT
Antibiotics (Basel). 2021 May 14;10(5)
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Large-scale citizen science provides high-resolution nitrogen dioxide values and health impact while enhancing community knowledge and collective action.
Perelló J, Cigarini A, Vicens J, Bonhoure I, Rojas-Rueda D, Nieuwenhuijsen MJ, Cirach M, Daher C, Targa J, Ripoll A
Sci Total Environ. 2021 May 14;789:147750
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Validation of an Online Version of the Alcohol Use Disorders Identification Test (AUDIT) for Alcohol Screening in Spanish University Students.
Ballester L, Alayo I, Vilagut G, Almenara J, Cebrià AI, Echeburúa E, Gabilondo A, Gili M, Lagares C, Piqueras JA, Roca M, Soto-Sanz V, Blasco MJ, Castellví P, G Forero C, Mortier P, Alonso J, On Behalf Of The Universal Study Group
Int J Environ Res Public Health. 2021 May 14;18(10)
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Schuurs-Hoeijmakers Syndrome (PACS1 Neurodevelopmental Disorder): Seven Novel Patients and a Review.
Tenorio-Castaño J, Morte B, Nevado J, Martinez-Glez V, Santos-Simarro F, García-Miñaúr S, Palomares-Bralo M, Pacio-Míguez M, Gómez B, Arias P, Alcochea A, Carrión J, Arias P, Almoguera B, López-Grondona F, Lorda-Sanchez I, Galán-Gómez E, Valenzuela I, Méndez Perez MP, Cuscó I, Barros F, Pié J, Ramos S, Ramos FJ, Kuechler A, Tizzano E, Ayuso C, Kaiser FJ, Pérez-Jurado LA, Carracedo Á, The ENoD-Ciberer Consortium, The Side Consortium, Lapunzina P
Genes (Basel). 2021 May 13;12(5)
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CACNA1A Mutations Causing Early Onset Ataxia: Profiling Clinical, Dysmorphic and Structural-Functional Findings.
Martínez-Monseny AF, Edo A, Casas-Alba D, Izquierdo-Serra M, Bolasell M, Conejo D, Martorell L, Muchart J, Carrera L, Ortez CI, Nascimento A, Oliva B, Fernández-Fernández JM, Serrano M
Int J Mol Sci. 2021 May 13;22(10)
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Glycolysis Metabolites and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Trial.
Becerra-Tomás N, Ruiz-Canela M, Hernández-Alonso P, Bulló M, Li J, Guasch-Ferré M, Toledo E, Clish CB, Estruch R, Ros E, Fitó M, Lee CH, Pierce K, Arós F, Serra-Majem L, Liang L, Razquin C, Gómez-Gracia E, Martínez-González MA, Hu FB, Corella D, Salas-Salvadó J
Metabolites. 2021 May 11;11(5)
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Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health.
Forner M, Cañas-Arranz R, Defaus S, de León P, Rodríguez-Pulido M, Ganges L, Blanco E, Sobrino F, Andreu D
Vaccines (Basel). 2021 May 8;9(5)
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The Mitochondria-to-Cytosol H2O2 Gradient Is Caused by Peroxiredoxin-Dependent Cytosolic Scavenging.
de Cubas L, Pak VV, Belousov VV, Ayté J, Hidalgo E
Antioxidants (Basel). 2021 May 6;10(5)
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Energy Balance and Risk of Mortality in Spanish Older Adults.
Lassale C, Hernáez Á, Toledo E, Castañer O, Sorlí JV, Salas-Salvadó J, Estruch R, Ros E, Alonso-Gómez ÁM, Lapetra J, Cueto R, Fiol M, Serra-Majem L, Pinto X, Gea A, Corella D, Babio N, Fitó M, Schröder H
Nutrients. 2021 May 4;13(5)
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A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes.
Ramirez J, Prieto G, Olazabal-Herrero A, Borràs E, Fernandez-Vigo E, Alduntzin U, Osinalde N, Beaskoetxea J, Lectez B, Aloria K, Rodriguez JA, Paradela A, Sabidó E, Muñoz J, Corrales F, Arizmendi JM, Mayor U
Int J Mol Sci. 2021 May 3;22(9)
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Workplace interventions to reduce depression and anxiety in small and medium-sized enterprises: A systematic review.
Hogg B, Medina JC, Gardoki-Souto I, Serbanescu I, Moreno-Alcázar A, Cerga-Pashoja A, Coppens E, Tóth MD, Fanaj N, Greiner BA, Holland C, Kõlves K, Maxwell M, Qirjako G, de Winter L, Hegerl U, Pérez-Sola V, Arensman E, Amann BL
J Affect Disord. 2021 May 1;290:378-386
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EpiNano: Detection of m6A RNA Modifications Using Oxford Nanopore Direct RNA Sequencing.
Liu H, Begik O, Novoa EM
Methods Mol Biol. 2021;2298:31-52
The impact of the SARS-CoV-2 pandemic on the ongoing prospective, international, multicentre observational study assessing the preoperative anaemia prevalence in surgical patients (ALICE-trial).
Judd L, Baron DM, Bisbe E, Lasocki S, Metnitz P, Posch M, Raobaikady R, Reichmayr M, Spahn DR, Stoppe C, Zacharowski K, Choorapoikayil S, Meybohm P, ALICE-Study-Group.
Transfus Med. 2021 May 31;
Use of a bioabsorbable mesh in midline laparotomy closure to prevent incisional hernia: randomized controlled trial.
Valverde S, Arbós MA, Quiles MT, Espín E, Sánchez-Garcia JL, Rodrigues V, Pereira JA, Villalobos R, García-Alamino JM, Armengol M, López-Cano M
Hernia. 2021 May 31;
More green, less lonely? A longitudinal cohort study.
Astell-Burt T, Hartig T, Eckermann S, Nieuwenhuijsen M, McMunn A, Frumkin H, Feng X
Int J Epidemiol. 2021 May 31;
Epidemiology and costs of depressive disorder in Spain: the EPICO study.
Vieta E, Alonso J, Pérez-Sola V, Roca M, Hernando T, Sicras-Mainar A, Sicras-Navarro A, Herrera B, Gabilondo A
Eur Neuropsychopharmacol. 2021 May 28;50:93-103
Structural dynamics bridge the gap between the genetic and functional levels of GPCRs.
Torrens-Fontanals M, Stepniewski TM, Gloriam DE, Selent J
Curr Opin Struct Biol. 2021 May 27;69:150-159
Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study.
Hernández-Alonso P, Canudas S, Boughanem H, Toledo E, Sorlí JV, Estruch R, Castañer O, Lapetra J, Alonso-Gómez AM, Gutiérrez-Bedmar M, Fiol M, Serra-Majem L, Pintó X, Ros E, Fernandez-Lazaro CI, Ramirez-Sabio JB, Fitó M, Portu-Zapirain J, Macias-González M, Babio N, Salas-Salvadó J
Eur J Nutr. 2021 May 28;
Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts.
Alemany S, Avella-García C, Liew Z, García-Esteban R, Inoue K, Cadman T, López-Vicente M, González L, Riaño Galán I, Andiarena A, Casas M, Margetaki K, Strandberg-Larsen K, Lawlor DA, El Marroun H, Tiemeier H, Iñiguez C, Tardón A, Santa-Marina L, Júlvez J, Porta D, Chatzi L, Sunyer J
Eur J Epidemiol. 2021 May 28;
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Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer.
Fernández-Rozadilla C, Álvarez-Barona M, Quintana I, López-Novo A, Amigo J, Cameselle-Teijeiro JM, Roman E, Gonzalez D, Llor X, Bujanda L, Bessa X, Jover R, Balaguer F, Castells A, Castellví-Bel S, Capellá G, Carracedo A, Valle L, Ruiz-Ponte C
Sci Rep. 2021 May 27;11(1):11135
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HuConTest: Testing human contamination in great ape samples.
Kuhlwilm M, Fontsere C, Han S, Alvarez-Estape M, Marques-Bonet T
Genome Biol Evol. 2021 May 26;
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Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures.
García-Pérez R, Esteller-Cucala P, Mas G, Lobón I, Di Carlo V, Riera M, Kuhlwilm M, Navarro A, Blancher A, Di Croce L, Gómez-Skarmeta JL, Juan D, Marquès-Bonet T
Nat Commun. 2021 May 25;12(1):3116
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Recognizing obesity as a disease: A true challenge.
Arrieta F, Pedro-Botet J
Rev Clin Esp (Barc). 2021 May 25;
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Financiación e independencia... de Gaceta Sanitaria.
Benavides FG, Comino I
Gac Sanit. 2021 May 24;
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Health care-associated infections in patients with COVID-19 pneumonia in COVID critical care areas.
Marin-Corral J, Pascual-Guardia S, Muñoz-Bermúdez R, Salazar-Degracia A, Climent C, Vilà-Vilardell C, Acer M, Picornell M, Restrepo MI, Masclans JR, Álvarez-Lerma F
Med Intensiva. 2021 Apr 30;
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Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes.
Heerlein K, Perugi G, Otte C, Frodl T, Degraeve G, Hagedoorn W, Oliveira-Maia AJ, Perez Sola V, Rathod S, Rosso G, Sierra P, Malynn S, Morrens J, Verrijcken C, Gonzalez B, Young AH
J Affect Disord. 2021 Apr 1;290:334-344
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Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity.
Mendonça DA, Bakker M, Cruz-Oliveira C, Neves V, Jiménez MA, Defaus S, Cavaco M, Veiga AS, Cadima-Couto I, Castanho MARB, Andreu D, Todorovski T
Bioconjug Chem. 2021 May 25;
NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment.
Lunazzi G, Buxadé M, Riera-Borrull M, Higuera L, Bonnin S, Huerga Encabo H, Gaggero S, Reyes-Garau D, Company C, Cozzuto L, Ponomarenko J, Aramburu J, López-Rodríguez C
J Immunol. 2021 May 24;
What lessons can we learn? Clinical and epidemiological retrospective analysis of 267 patients with urticaria in a Brazilian tertiary center.
Criado RFJ, Criado PR, Baldavira N, Cardial D, Gimenez-Arnau AM, Machado Filho CD
An Bras Dermatol. 2021 May 21;
Second GHEP-ISFG exercise for DVI: "DNA-led" victims' identification in a simulated air crash.
Vullo CM, Catelli L, Ibarra Rodriguez AA, Papaioannou A, Merino JCÁ, Lopez-Parra AM, Gaviria A, Baeza-Richer C, Romanini C, González-Moya E, Casals F, Calafell F, Berardi G, Iannacone GC, Vicuña Giraldo GC, Zorba GK, Boschi I, Olarte JV, Ruiz Gomez JE, Acierno JP, Soto ML, Miranda MV, García King MD, Marrucci MA, Porto MJ, Piñero MH, Aler M, Stephenson Ojea MM, Navarrete SC, Toscanini U, Saragoni VG, Bozzo W, Posada Posada YC, Bajunovic Z, Solla LP, Parsons T
Forensic Sci Int Genet. 2021 May 19;53:102527
Comment on: Meta-analysis and Systematic Review of the Use of a Prosthetic Mesh for Prevention of Parastomal Hernia.
López-Cano M, Pereira JA, García-Alamino JM
Ann Surg. 2021 May 24;
Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts.
Bazal P, Gea A, Navarro AM, Salas-Salvadó J, Corella D, Alonso-Gómez A, Fitó M, Muñoz-Bravo C, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Rekondo J, Muñoz MA, Basora J, Sorlí JV, Toledo E, Martínez-González MA, Ruiz-Canela M
Eur J Prev Cardiol. 2021 May 22;28(6):648-657
DNA barcodes combined with multi-locus data of representative taxa can generate reliable higher-level phylogenies.
Talavera G, Lukhtanov V, Pierce NE, Vila R
Syst Biol. 2021 May 22;
Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study.
Muralidharan J, Moreno-Indias I, Bulló M, Lopez JV, Corella D, Castañer O, Vidal J, Atzeni A, Fernandez-García JC, Torres-Collado L, Fernández-Carrión R, Fito M, Olbeyra R, Gomez-Perez AM, Galiè S, Bernal-López MR, Martinez-Gonzalez MA, Salas-Salvadó J, Tinahones FJ
Am J Clin Nutr. 2021 May 21;
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The relationship between residential proximity to outdoor play spaces and children's mental and behavioral health: the importance of neighborhood socio-economic characteristics.
Pérez-Del-Pulgar C, Anguelovski I, Cole HVS, de Bont J, Connolly J, Baró F, Díaz Y, Fontán-Vela M, Duarte-Salles T, Triguero-Mas M
Environ Res. 2021 May 21;:111326
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties.
Phillips HRP, Bach EM, Bartz MLC, Bennett JM, Beugnon R, Briones MJI, Brown GG, Ferlian O, Gongalsky KB, Guerra CA, König-Ries B, Krebs JJ, Orgiazzi A, Ramirez KS, Russell DJ, Schwarz B, Wall DH, Brose U, Decaëns T, Lavelle P, Loreau M, Mathieu J, Mulder C, van der Putten WH, Rillig MC, Thakur MP, de Vries FT, Wardle DA, Ammer C, Ammer S, Arai M, Ayuke FO, Baker GH, Baretta D, Barkusky D, Beauséjour R, Bedano JC, Birkhofer K, Blanchart E, Blossey B, Bolger T, Bradley RL, Brossard M, Burtis JC, Capowiez Y, Cavagnaro TR, Choi A, Clause J, Cluzeau D, Coors A, Crotty FV, Crumsey JM, Dávalos A, Cosín DJD, Dobson AM, Domínguez A, Duhour AE, van Eekeren N, Emmerling C, Falco LB, Fernández R, Fonte SJ, Fragoso C, Franco ALC, Fusilero A, Geraskina AP, Gholami S, González G, Gundale MJ, López MG, Hackenberger BK, Hackenberger DK, Hernández LM, Hirth JR, Hishi T, Holdsworth AR, Holmstrup M, Hopfensperger KN, Lwanga EH, Huhta V, Hurisso TT, Iannone BV 3rd, Iordache M, Irmler U, Ivask M, Jesús JB, Johnson-Maynard JL, Joschko M, Kaneko N, Kanianska R, Keith AM, Kernecker ML, Koné AW, Kooch Y, Kukkonen ST, Lalthanzara H, Lammel DR, Lebedev IM, Le Cadre E, Lincoln NK, López-Hernández D, Loss SR, Marichal R, Matula R, Minamiya Y, Moos JH, Moreno G, Morón-Ríos A, Motohiro H, Muys B, Neirynck J, Norgrove L, Novo M, Nuutinen V, Nuzzo V, Mujeeb Rahman P, Pansu J, Paudel S, Pérès G, Pérez-Camacho L, Ponge JF, Prietzel J, Rapoport IB, Rashid MI, Rebollo S, Rodríguez MÁ, Roth AM, Rousseau GX, Rozen A, Sayad E, van Schaik L, Scharenbroch B, Schirrmann M, Schmidt O, Schröder B, Seeber J, Shashkov MP, Singh J, Smith SM, Steinwandter M, Szlavecz K, Talavera JA, Trigo D, Tsukamoto J, Uribe-López S, de Valença AW, Virto I, Wackett AA, Warren MW, Webster ER, Wehr NH, Whalen JK, Wironen MB, Wolters V, Wu P, Zenkova IV, Zhang W, Cameron EK, Eisenhauer N
Sci Data. 2021 May 21;8(1):136
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Candidate allergens to be included in the spanish standard series based on the data of the spanish registry of contact dermatitis.
Hernández-Fernández CP, Mercader-García P, Silvestre Salvador JF, Sánchez Pérez J, Fernández Redondo V, Miquel Miquel FJ, Ortiz de Frutos FJ, Gatica Ortega ME, Mora V, Giménez Arnau AM, Zaragoza Ninet V, González Pérez R, Sanz Sánchez T, Pastor Nieto MA, Serra Baldrich E, Córdoba Guijarro S, Heras Mendaza F, Ruiz González I, Rodríguez Serna M, Hervella Garcés M, Gallego Descalzo MA, García Doval I, Borrego L
Actas Dermosifiliogr. 2021 May 21;
Bottlenecks in the Acute Stroke Care System during the COVID-19 Pandemic in Catalonia.
Ramos-Pachón A, García-Tornel Á, Millán M, Ribó M, Amaro S, Cardona P, Martí-Fàbregas J, Roquer J, Silva Y, Ustrell X, Purroy F, Gómez-Choco M, Zaragoza-Brunet J, Cánovas D, Krupinski J, Sala NM, Palomeras E, Cocho D, Redondo L, Repullo C, Sanjurjo E, Carrión D, López M, Almendros MC, Barceló M, Monedero J, Catena E, Rybyeba M, Diaz G, Jiménez-Fàbrega X, Solà S, Hidalgo V, Pueyo MJ, Pérez de la Ossa N, Urra X, Catalan Stroke Code and Reperfusion Consortium (Cat-SCR).
Cerebrovasc Dis. 2021 May 21;:1-9
Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer.
Woolston A, Barber LJ, Griffiths B, Pich O, Lopez-Bigas N, Matthews N, Rao S, Watkins D, Chau I, Starling N, Cunningham D, Gerlinger M
Nat Ecol Evol. 2021 May 20;
Saving time in the radiotherapy procedures for COVID-19 pneumonia treatment. A single-institution experience.
Bonet M, Vázquez S, García E, Visus M, Jové D, Ripol O, Solé C, Gutiérrez L, Morales-Rull JL, Montero Á, Algara M, Arenas M, Mira M
Clin Transl Oncol. 2021 May 19;
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Quality standards in proteomics research facilities: Common standards and quality procedures are essential for proteomics facilities and their users.
Chiva C, Mendes Maia T, Panse C, Stejskal K, Douché T, Matondo M, Loew D, Helm D, Rettel M, Mechtler K, Impens F, Nanni P, Shevchenko A, Sabidó E
EMBO Rep. 2021 May 19;:e52626
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The relationship between self-care, long-term mortality, and heart failure hospitalization: insights from a real-world cohort study.
Calero-Molina E, Hidalgo E, Rosenfeld L, Verdú-Rotellar JM, Verdú-Soriano J, Garay A, Alcoberro L, Jimenez-Marrero S, Garcimartin P, Yun S, Guerrero C, Moliner P, Delso C, Alcober L, Enjuanes C, Comin-Colet J
Eur J Cardiovasc Nurs. 2021 May 19;
Evolutionary Cell Type Mapping with Single-Cell Genomics.
Tanay A, Sebé-Pedrós A
Trends Genet. 2021 May 18;
The transcription factor code: a beacon for histone methyltransferase docking.
Torcal Garcia G, Graf T
Trends Cell Biol. 2021 May 17;
Multi-organ Involvement in Non-pulmonary Sarcoidosis.
Vílchez-Oya F, Meraz-Ostíz JA, Carrión-Barberà I, Gonzàlez-Farré M, Carrión JA, Salman-Monte TC
Reumatol Clin. 2021 May 15;
Lung cancer patients with COVID-19 in Spain: GRAVID study.
Provencio M, Mazarico Gallego JM, Calles A, Antoñanzas M, Pangua C, Mielgo Rubio X, Nadal E, Castro RL, López-Martín A, Del Barco E, Dómine M, Franco F, Diz P, Sandoval C, Girona ES, Sullivan I, Sala MÁ, Ledo GG, Cucurull M, Mosquera J, Martínez M, Chara LE, Arriola E, Herrera BE, Jarabo JR, Álvarez RÁ, Baena J, Cao MG
Lung Cancer. 2021 May 14;
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Natural outdoor environments' health effects in gentrifying neighborhoods: Disruptive green landscapes for underprivileged neighborhood residents.
Triguero-Mas M, Anguelovski I, García-Lamarca M, Argüelles L, Perez-Del-Pulgar C, Shokry G, Connolly JJT, Cole HVS
Soc Sci Med. 2021 May 5;279:113964
Familial combined hyperlipidaemia/polygenic mixed hyperlipidaemia.
Pedro-Botet J, Climent E, Gabarró N, Millán J
Clin Investig Arterioscler. 2021 May;33 Suppl 2:43-49
Glyphosate Exposure during Pregnancy and Preterm Birth (More Research Is Needed).
Kogevinas M
Environ Health Perspect. 2021 May;129(5):51301
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Sex differences in cancer risk and outcomes after kidney transplantation.
Buxeda A, Redondo-Pachón D, Pérez-Sáez MJ, Crespo M, Pascual J
Transplant Rev (Orlando). 2021 May 1;35(3):100625
From safety and industrial hygiene to occupational safety and health: 50 years of occupational risk prevention in Spain.
Castejón E, Benavides FG
Arch Prev Riesgos Labor. 2021 Apr 15;24(2):12-16
Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study.
Martínez E, Garin O, Pardo Y, Fernández P, Guix B, Gutiérrez C, Boladeras A, Ferrer F, Hernández T, Ayala A, Egiguren M, Fernández G, Muñoz V, Macías V, Pera J, Pont À, Ferrer M, Guedea F, Multicentric Spanish Group of Clinically Localized Prostate Cancer., Multicentric Spanish Group of Clincally Localized Prostate Cancer: Montse Ferrer, Àngels Pont, Olatz Garin, Yolanda Pardo, Jordi Alonso, Mónica Ávila, Víctor Zamora, Ferran Guedea, Montse Ventura, Cristina Gutiérrez, Ferran Ferrer, Ana Boladeras, José Francisco Suárez, Manel Castells, Xavier Bonet, Pastor S, Carmen Bonet, Gemma Sancho, Javier Ponce de León, Joan Palou, Belén de Paula, Alai Goñi, Pablo Fernández, Ismael Herruzo, Asunción Hervás, Alfredo Ramos, Víctor Macías, Josep Solé, Marta Bonet, Alfonso Mariño, Patricia Cabrera, Maria José Ortiz.
J Contemp Brachytherapy. 2021 Feb;13(1):1-11
Medicolegal aspects of teledermatology.
Arimany-Manso J, Pujol RM, García-Patos V, Saigí U, Martin-Fumadó C
Actas Dermosifiliogr. 2020 Dec;111(10):815-821
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Patch Testing During the COVID-19 Pandemic: Recommendations of the AEDV's Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC).
Carrascosa JM, Pastor-Nieto MA, Ruiz-González I, Silvestre JF, Borrego L, Gatica-Ortega ME, Giménez-Arnau AM
Actas Dermosifiliogr. 2020 Oct;111(8):650-654
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COVID-19 and Pulmonology in the XXI century: Challenge or Opportunity?
Barreiro E, Jiménez C, García de Pedro J, Ramírez Prieto MT
Arch Bronconeumol. 2020 Jul;56(7):411-412
Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition.
Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, Hor CN, Ossowski S
Front Mol Neurosci. 2021;14:664912
Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study.
Kocatürk E, Al-Ahmad M, Krause K, Gimenez-Arnau A, Thomsen SF, Conlon N, Marsland A, Savk E, Criado RF, Danilycheva I, Fomina D, Godse K, Khoshkhui M, Gelincik A, Degirmentepe EN, Demir S, Ensina LF, Kasperska-Zajac A, Rudenko M, Valle S, Medina I, Bauer A, Zhao Z, Staubach P, Bouillet L, Su Küçük Ö, Ates C, Maurer M
Allergy. 2021 May 22;
Mouse Models of Muscle Fibrosis.
Serrano AL, Muñoz-Cánoves P
Methods Mol Biol. 2021;2299:357-370
MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation.
Bisceglie L, Hopp AK, Gunasekera K, Wright RH, Le Dily F, Vidal E, Dall'Agnese A, Caputo L, Nicoletti C, Puri PL, Beato M, Hottiger MO
iScience. 2021 May 21;24(5):102432
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Heart healthy cities: genetics loads the gun but the environment pulls the trigger.
Münzel T, Sørensen M, Lelieveld J, Hahad O, Al-Kindi S, Nieuwenhuijsen M, Giles-Corti B, Daiber A, Rajagopalan S
Eur Heart J. 2021 May 18;
Impact of uORFs in mediating regulation of translation in stress conditions.
Moro SG, Hermans C, Ruiz-Orera J, Albà MM
BMC Mol Cell Biol. 2021 May 16;22(1):29
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Associations of traffic-related air pollution and greenery with academic outcomes among primary schoolchildren.
Claesen JLA, Wheeler AJ, Klabbers G, Gonzalez DD, Molina MA, Tham R, Nieuwenhuijsen M, Carver A
Environ Res. 2021 May 14;:111325
Short-term effect of air pollution on attention function in adolescents (ATENC!Ó): A randomized controlled trial in high schools in Barcelona, Spain.
Gignac F, Barrera-Gómez J, Persavento C, Solé C, Tena È, López-Vicente M, Foraster M, Amato F, Alastuey A, Querol X, Llavador H, Apesteguia J, Júlvez J, Couso D, Sunyer J, Basagaña X
Environ Int. 2021 May 14;156:106614
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Health care-associated infections in patients with COVID-19 pneumonia in COVID critical care areas.
Marin-Corral J, Pascual-Guardia S, Muñoz-Bermúdez R, Salazar-Degracia A, Climent C, Vilà C, Acer M, Picornell M, Restrepo MI, Masclans JR, Álvarez-Lerma F
Med Intensiva. 2021 Apr 30;
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Manejo de las complicaciones infecciosas asociadas con la infección por coronavirus en pacientes graves ingresados en UCI.
Estella Á, Vidal-Cortés P, Rodriguez A, Ojeda DA, Martin-Loeches I, Díaz E, Suberviola B, Arnillas MPG, González MC, Álvarez-Lerma F, Ramirez P, Nuvials X, Sa MB, Zaragoza R
Med Intensiva. 2021 Apr 30;
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Comorbidities and Mortality in Patients With COVID-19 Aged 60 Years and Older in a University Hospital in Spain.
Posso M, Comas M, Román M, Domingo L, Louro J, González C, Sala M, Anglès A, Cirera I, Cots F, Frías VM, Gea J, Güerri-Fernández R, Masclans JR, Noguès X, Vázquez O, Villar-García J, Horcajada JP, Pascual J, Castells X
Arch Bronconeumol. 2020 Nov;56(11):756-758
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Pulmonary Embolism in Patients With Covid-19 Pneumonia: The Utility of D-dimer.
Rodriguez-Sevilla JJ, Rodó-Pin A, Espallargas I, Villar-García J, Molina L, Pérez Terán P, Vázquez Sanchez A, Masclans JR, Jiménez C, Millan Segovia R, Zuccarino F, Salar A, Rodriguez-Chiaradía DA
Arch Bronconeumol. 2020 Nov;56(11):758-759
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E93-depleted adult insects preserve the prothoracic gland and molt again.
Kamsoi O, Belles X
Development. 2020 Jan 1;
Polycomb Factor PHF19 Controls Cell Growth and Differentiation Toward Erythroid Pathway in Chronic Myeloid Leukemia Cells.
García-Montolio M, Ballaré C, Blanco E, Gutiérrez A, Aranda S, Gómez A, Kok CH, Yeung DT, Hughes TP, Vizán P, Di Croce L
Front Cell Dev Biol. 2021;9:655201
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Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries.
Fonseca F, Lenahan W, Dart RC, Papaseit E, Dargan PI, Wood DM, Guareschi M, Maremmani I, Auriacombe M, Farré M, Scherbaum N, Torrens M
Front Psychiatry. 2021;12:676224
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, ..., Kogevinas M, et al.
Nat Genet. 2021 May 17;
Características y factores de gravedad de las reacciones de anafilaxia atendidas en un servicio de urgencias.
Belloso P, Supervía A, Del Baño F, Bosch L, Pallàs O, Escolano F
Emergencias. 2021 Jun;33(3):241-243
Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
Kapla J, Rodriguez Espigares I, Ballante F, Selent J, Carlsson J
PLoS Comput Biol. 2021 May 13;17(5):e1008936
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Novel Dent Disease 1 cellular models reveal biological processes underlying ClC-5 loss-of-function.
Durán M, Burballa C, Cantero-Recasens G, Butnaru CM, Malhotra V, Ariceta G, Sarró E, Meseguer A
Hum Mol Genet. 2021 May 13;
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Quantitative profiling of pseudouridylation dynamics in native RNAs with nanopore sequencing.
Begik O, Lucas MC, Pryszcz LP, Ramirez JM, Medina R, Milenkovic I, Cruciani S, Liu H, Vieira HGS, Sas-Chen A, Mattick JS, Schwartz S, Novoa EM
Nat Biotechnol. 2021 May 13;
Effects of chronic intermittent hypobaric hypoxia on prostate-specific antigen (PSA) in Chilean miners.
Alcantara-Zapata DE, Bangdiwala SI, Jiménez D, Kogevinas M, Marchetti N, Nazzal C
Occup Environ Med. 2021 May 11;
Differences between the child and adult brain in the local functional structure of the cerebral cortex.
Pujol J, Blanco-Hinojo L, Macia D, Martínez-Vilavella G, Deus J, Pérez-Sola V, Cardoner N, Soriano-Mas C, Sunyer J
Neuroimage. 2021 May 10;:118150
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Influence of age on treatment and prognosis of invasive cervical cancer.
Mancebo G, Miralpeix E, Solé-Sedeño JM, Tió G, Rodrigo-Calvo T, Lloveras B, Alameda F
Eur J Obstet Gynecol Reprod Biol. 2021 May 1;262:68-72
Social mobility and healthy behaviours from a gender perspective in the Spanish multicase-control study (MCC-Spain).
Pinto-Carbó M, Peiró-Pérez R, Molina-Barceló A, Vanaclocha-Espi M, Alguacil J, Castaño-Vinyals G, O'Callaghan-Gordo C, Gràcia-Lavedan E, Pérez-Gómez B, Lope V, Aragonés N, Molina AJ, Fernández-Villa T, Gil-Majuelo L, Amiano P, Dierssen-Sotos T, Gómez-Acebo I, Guevara M, Moreno-Iribas C, Obón-Santacana M, Rodríguez-Suárez MM, Salcedo-Bellido I, Delgado-Parrilla A, Marcos-Gragera R, Chirlaque MD, Kogevinas M, Pollán M, Salas D
PLoS One. 2021;16(5):e0251447
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The Pleistocene species pump past its prime: evidence from European butterfly sister species.
Ebdon S, Laetsch DR, Dapporto L, Hayward A, Ritchie MG, Dinca V, Vila R, Lohse K
Mol Ecol. 2021 May 15;
Patient-reported outcomes after oesophagectomy in the multicentre LASER study.
Markar SR, Sounderajah V, Johar A, Zaninotto G, Castoro C, Lagergren P, Elliott JA, Gisbertz SS, Mariette C, Alfieri R, Huddy J, Pinto E, Scarpa M, Klevebro F, Sunde B, Murphy CF, Greene C, Ravi N, Piessen G, Brenkman H, Ruurda J, van Hillegersberg R, Lagarde SM, Wijnhoven BP, Pera M, Roigg J, Castro S, Matthijsen R, Findlay J, Antonowicz S, Maynard N, McCormack O, Ariyarathenam A, Sanders G, Cheong E, Jaunoo S, Allum W, van Lanschot J, Nilsson M, Reynolds JV, van Berge Henegouwen MI, Hanna GB
Br J Surg. 2021 May 11;
Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states.
Li KC, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn JW, Goldmann U, Sedlyarov V, Bensimon A, Schick S, Lin JG, Gürtl B, Reil D, Klavins K, Kubicek S, Sdelci S, Superti-Furga G
Nat Metab. 2021 May 10;
A cost-utility analysis of increasing percutaneous coronary intervention use in elderly patients with acute coronary syndromes in six European countries.
Forné C, Subirana I, Blanch J, Ferrieres J, Azevedo A, Meisinger C, Farmakis D, Tavazzi L, Davoli M, Ramos R, Brosa M, Marrugat J, Dégano IR, EUROTRACS Investigators.
Eur J Prev Cardiol. 2021 May 8;28(4):408-417
Therapeutic targets in the treatment of dyslipidaemias: From statins to PCSK9 inhibitors. Unmet needs.
López-Miranda J, Pedro-Botet J
Clin Investig Arterioscler. 2021 May;33 Suppl 1:46-52
Amyloid-B positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume.
Sánchez-Benavides G, Suárez-Calvet M, Milà-Alomà M, Arenaza-Urquijo EM, Grau-Rivera O, Operto G, Gispert JD, Vilor-Tejedor N, Sala-Vila A, Crous-Bou M, González-de-Echávarri JM, Minguillon C, Fauria K, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Molinuevo JL, ALFA Study.
Neurobiol Aging. 2021 Mar 6;104:24-31
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Diagnostic Value of Genotypic Analysis in Primary Cutaneous Lymphomas using Standardized BIOMED-2 Polymerase Chain Reaction Protocols: Experience in Daily Clinical Practice.
López Aventín D, Gallardo F, Colomo L, Moragón E, Vela MC, Jordà XD, Bellosillo B, Pujol RM
Acta Derm Venereol. 2021 May 6;
Position statement: The need for EU legislation to require disclosure and labelling of the composition of medical devices.
Herman A, Uter W, Rustemeyer T, Matura M, Aalto-Korte K, Duus Johansen J, Gonçalo M, White IR, Balato A, Giménez Arnau AM, Brockow K, Mortz CG, Mahler V, Goossens A, ESCD, EECDRG, EADV Contact Dermatitis Task Force, EAACI.
J Eur Acad Dermatol Venereol. 2021 May 6;
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Validation of a targeted next-generation sequencing panel for tumor mutation burden analysis: results from the Onconetwork Immuno-Oncology Consortium.
Fenizia F, Alborelli I, Costa JL, Vollbrecht C, Bellosillo B, Dinjens W, Endris V, Heydt C, Leonards K, Merkelback-Bruse S, Pfarr N, van Marion R, Allen C, Chaudhary R, Gottimukkala R, Hyland F, Wong-Ho E, Jermann P, Machado JC, Hummel M, Stenzinger A, Normanno N
J Mol Diagn. 2021 May 5;
Syphilitic paronychia: a diagnostic challenge.
Marcantonio O, López-Castillo D, Pujol RM, Martin-Ezquerra G
Sex Transm Infect. 2021 May 5;
Prevalence and variability of current depressive disorder in 27 European countries: a population-based study.
Arias-de la Torre J, Vilagut G, Ronaldson A, Serrano-Blanco A, Martín V, Peters M, Valderas JM, Dregan A, Alonso J
Lancet Public Health. 2021 May 4;
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Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.
Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E
Neuromolecular Med. 2021 May 4;
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The genomic basis of evolutionary differentiation among honey bees.
Fouks B, Brand P, Nguyen HN, Herman J, Camara F, Ence D, Hagen D, Hoff KJ, Nachweide S, Romoth L, Walden KK, Guigo R, Stanke M, Narzisi G, Yandell M, Robertson HM, Koeniger N, Chantawannakul P, Schatz MC, Worley KC, Robinson GE, Elsik CG, Rueppell O
Genome Res. 2021 May 4;
Cardiovascular disease: still far from being beaten.
Marrugat J, Camps-Vilaró A, Tizón-Marcos H
Rev Esp Cardiol (Engl Ed). 2021 May 1;
Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients.
Marín-Corral J, Rodríguez-Morató J, Gomez-Gomez A, Pascual-Guardia S, Muñoz-Bermúdez R, Salazar-Degracia A, Pérez-Terán P, Restrepo MI, Khymenets O, Haro N, Masclans JR, Pozo OJ
Int J Mol Sci. 2021 Apr 30;22(9)
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Trends in Prevalence of Diabetes among Twin Pregnancies and Perinatal Outcomes in Catalonia between 2006 and 2015: The DIAGESTCAT Study.
Gortazar L, Flores-Le Roux JA, Benaiges D, Sarsanedas E, Navarro H, Payà A, Mañé L, Pedro-Botet J, Goday A
J Clin Med. 2021 Apr 30;10(9)
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Phenotypic and Functional Consequences of PLT Binding to Monocytes and Its Association with Clinical Features in SLE.
Mariscal A, Zamora C, Magallares B, Salman-Monte TC, Ortiz MÀ, Díaz-Torné C, Castellví I, Corominas H, Vidal S
Int J Mol Sci. 2021 Apr 29;22(9)
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A stony coral cell atlas illuminates the molecular and cellular basis of coral symbiosis, calcification, and immunity.
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Clinical case report: endoluminal thermal ablation of main pancreatic duct for patients at high risk of postoperative pancreatic fistula after pancreaticoduodenectomy.
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Int J Hyperthermia. 2021;38(1):755-759
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STAR Protoc. 2021 Jun 18;2(2):100451
On the use of direct-coupling analysis with a reduced alphabet of amino acids combined with super-secondary structure motifs for protein fold prediction.
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NAR Genom Bioinform. 2021 Jun;3(2):lqab027
Evaluation of data quality in the Spanish EURECCA Esophagogastric Cancer Registry.
Cero MD, Rodríguez-Santiago J, Miró M, Castro S, Miranda C, Santamaría M, Gobbini Y, Garsot E, Pujadas M, Luna A, Momblán D, Balagué C, Aldeano A, Olona C, Molinas J, Pulido L, Sánchez-Cano JJ, Güell M, Salazar D, Gimeno M, Grande L, Pera M, Spanish EURECCA Esophagogastric Cancer Group.
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Perceived helpfulness of treatment for specific phobia: Findings from the World Mental Health Surveys.
de Vries YA, Harris MG, Vigo D, Chiu WT, Sampson NA, Al-Hamzawi A, Alonso J, Andrade LH, Benjet C, Bruffaerts R, Bunting B, Caldas de Almeida JM, de Girolamo G, Florescu S, Gureje O, Haro JM, Hu C, Karam EG, Kawakami N, Kovess-Masfety V, Lee S, Moskalewicz J, Navarro-Mateu F, Ojagbemi A, Posada-Villa J, Scott K, Torres Y, Zarkov Z, Nierenberg A, Kessler RC, de Jonge P, WHO World Mental Health Survey collaborators.
J Affect Disord. 2021 Apr 20;288:199-209
Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study.
Glenn AJ, Hernández-Alonso P, Kendall CWC, Martínez-González MÁ, Corella D, Fitó M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Celada SR, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Mas-Fontao S, Daimiel L, Ros E, Jenkins DJA, Toledo E, Sorlí JV, Castañer O, Abete I, Rodriguez AM, Barceló OF, Oncina-Canovas A, Konieczna J, Garcia-Rios A, Casas R, Gómez-Pérez AM, Santos-Lozano JM, Vazquez-Ruiz Z, Portolés O, Schröder H, Zulet MA, Eguaras S, Lete IS, Zomeño MD, Sievenpiper JL, Salas-Salvadó J
Clin Nutr. 2021 Mar 18;40(5):2825-2836
The effect of physical activity on asthma incidence over 10 years: population-based study.
Russell MA, Dharmage S, Fuertes E, Marcon A, Carsin AE, Pascual Erquicia S, Heinrich J, Johannessen A, Abramson MJ, Amaral AFS, Cerveri I, Demoly P, Garcia-Larsen V, Jarvis D, Martinez-Moratalla J, Nowak D, Palacios-Gomez L, Squillacioti G, Raza W, Emtner M, Garcia-Aymerich J
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The Value of Companion Dogs as a Source of Social Support for Their Owners: Findings From a Pre-pandemic Representative Sample and a Convenience Sample Obtained During the COVID-19 Lockdown in Spain.
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Front Psychiatry. 2021;12:622060
Management and Quality Control of Large Neuroimaging Datasets: Developments From the BarcelonaBeta Brain Research Center.
Huguet J, Falcon C, Fusté D, Girona S, Vicente D, Molinuevo JL, Gispert JD, Operto G, ALFA Study.
Front Neurosci. 2021;15:633438
A multiplex antigen microarray for simultaneous IgG and IgM detection against SARS-CoV-2 reveals higher seroprevalence than reported.
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Single human oocyte transcriptome analysis reveals distinct maturation stage-dependent pathways impacted by age.
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Sci Rep. 2021 Apr 27;11(1):9076
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Exercise Training-Induced Extracellular Matrix Protein Adaptation in Locomotor Muscles: A Systematic Review.
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Cells. 2021 Apr 26;10(5)
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Proteomic Studies on the Management of High-Grade Serous Ovarian Cancer Patients: A Mini-Review.
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Cancers (Basel). 2021 Apr 25;13(9)
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Dopamine D2 Receptor Agonist Binding Kinetics-Role of a Conserved Serine Residue.
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Int J Mol Sci. 2021 Apr 15;22(8)
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Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry and High-Sensitivity Gas Chromatography-Mass Spectrometry Screening of Classic Drugs and New Psychoactive Substances and Metabolites in Urine of Consumers.
Marchei E, Ferri MA, Torrens M, Farré M, Pacifici R, Pichini S, Pellegrini M
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Analysis of Personality Traits in Patients with Hodgkin Lymphoma.
Roso-Bas F, Alonso-Llobregat MD, Bento L, Sanchez-Gonzalez B, Herraez I, Garcia-Dilla P, Vallespir C, Rado F, Rodriguez R, Garcia-Pallarols F, Aguirre I, Bargay J, Sampol A, Salar A, Gutierrez A
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Clinical Characteristics and Degree of Glycemic and Cardiovascular Risk Factor Control in Patients with Type 1 Diabetes in Catalonia (Spain).
Gimenez-Perez G, Franch-Nadal J, Ortega E, Mata-Cases M, Goday A, Real J, Rodriguez A, Vlacho B, Mauricio D
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Environmental and individual exposure to secondhand aerosol of electronic cigarettes in confined spaces: Results from the TackSHS Project†.
Amalia B, Fu M, Tigova O, Ballbè M, Castellano Y, Semple S, Clancy L, Vardavas C, López MJ, Cortés N, Pérez-Ortuño R, Pascual JA, Fernández E
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Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.
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Associations between green/blue spaces and mental health across 18 countries.
White MP, Elliott LR, Grellier J, Economou T, Bell S, Bratman GN, Cirach M, Gascon M, Lima ML, Lõhmus M, Nieuwenhuijsen M, Ojala A, Roiko A, Schultz PW, van den Bosch M, Fleming LE
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Zootaxa. 2021 Apr 13;4953(1):zootaxa.4953.1.1
Lower risk of adverse perinatal outcomes in natural versus artificial frozen-thawed embryo transfer cycles: a systematic review and meta-analysis.
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Can routine Primary Care Records Help in Detecting Suicide Risk? A Population-Based Case-Control Study in Barcelona.
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"Black nails" as a sign of hypertrophic osteoarthropathy.
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DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study.
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Mortality, falls and fracture risk are positively associated with frailty: a SIDIAP cohort study of 890,000 patients.
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Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects.
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The EU Child Cohort Network's core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables.
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Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy.
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A novel approach to improve detection of glucocorticoid doping in sport with new guidance for physicians prescribing for athletes.
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Long-term results of a randomized partial irradiation trial compared to whole breast irradiation in the early stage and low-risk breast cancer patients after conservative surgery.
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Validation of the Spanish version of the Low Vision Quality of Life Questionnaire.
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Adapting the environmental risk transition theory for urban health inequities: An observational study examining complex environmental riskscapes in seven neighborhoods in Global North cities.
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Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project.
Carrizosa C, Murcia M, Ballesteros V, Costa O, Manzano-Salgado CB, Ibarluzea J, Iñiguez C, Casas M, Andiarena A, Llop S, Lertxundi A, Schettgen T, Sunyer J, Ballester F, Vrijheid M, Lopez-Espinosa MJ
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Integration of the ICD-11 and DSM-5 Dimensional Systems for Personality Disorders Into a Unified Taxonomy With Non-overlapping Traits.
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Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging.
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Absence of Relevant Clinical Effects of SARS-COV-2 on the Affinity of Hemoglobin for O2 in Patients with COVID-19.
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Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial.
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Psychother Psychosom. 2021 Apr 19;:1-10
Therapeutic drug monitoring of colistin in plasma and cerebrospinal fluid in meningoventriculitis caused by a carbapenem-resistant Enterobacter cloacae.
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Enferm Infecc Microbiol Clin. 2021 Apr 15;
Epigenome-wide association study of COVID-19 severity with respiratory failure.
Castro de Moura M, Davalos V, Planas-Serra L, Alvarez-Errico D, Arribas C, Ruiz M, Aguilera-Albesa S, Troya J, Valencia-Ramos J, Vélez-Santamaria V, Rodríguez-Palmero A, Villar-Garcia J, Horcajada JP, Albu S, Casasnovas C, Rull A, Reverte L, Dietl B, Dalmau D, Arranz MJ, Llucià-Carol L, Planas AM, Pérez-Tur J, Fernandez-Cadenas I, Villares P, Tenorio J, Colobran R, Martin-Nalda A, Soler-Palacin P, Vidal F, Pujol A, Esteller M
EBioMedicine. 2021 Apr 14;:103339
Effects of COVID -19 pandemic and lockdown on people with multiple system atrophy participating in a therapeutic education program.
Cámara A, Compta Y, Pérez-Soriano A, Montagut N, Baixauli M, Maragall L, Ludeña E, Lopez de Los Reyes JC, Peri-Cusi L, Fernández N, Villote S, Ahuir M, Grau A, Caballol N, Buongiorno M, Pont-Sunyer C, Puente V, Giraldo DM, de Fabregues O, Garrido A, Navarro-Otano J, Painous C, Sánchez-Gómez A, Muñoz E, Zaro I, Obiang D, Valldeoriola F, Lombraña M, Martí MJ
Parkinsonism Relat Disord. 2021 Mar 29;86:78-80
Functional and Pathological Roles of AHCY.
Vizán P, Di Croce L, Aranda S
Front Cell Dev Biol. 2021;9:654344
The copy number variation and stroke (CaNVAS) risk and outcome study.
Cole JW, Adigun T, Akinyemi R, Akpa OM, Bell S, Chen B, Jimenez Conde J, Lazcano Dobao U, Fernandez I, Fornage M, Gallego-Fabrega C, Jern C, Krawczak M, Lindgren A, Markus HS, Melander O, Owolabi M, Schlicht K, Söderholm M, Srinivasasainagendra V, Soriano Tárraga C, Stenman M, Tiwari H, Corasaniti M, Fecteau N, Guizzardi B, Lopez H, Nguyen K, Gaynor B, O'Connor T, Stine OC, Kittner SJ, McArdle P, Mitchell BD, Xu H, Grond-Ginsbach C
PLoS One. 2021;16(4):e0248791
Realizing the actual magnitudes of aortic diameter and cardiac output: a multisensory learning approach.
Farré N, Almendros I, Otero J, Navajas D, Farré R
Adv Physiol Educ. 2021 Jun 1;45(2):322-326
http://www.ncbi.nlm.nih.gov/en...
Dysfunctional Brain Reward System in Child Obesity.
Pujol J, Blanco-Hinojo L, Martínez-Vilavella G, Deus J, Pérez-Sola V, Sunyer J
Cereb Cortex. 2021 Apr 16;
The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories.
Marcon A, Locatelli F, Dharmage SC, Svanes C, Heinrich J, Leynaert B, Burney P, Corsico A, Caliskan G, Calciano L, Gislason T, Janson C, Jarvis D, Jõgi R, Lytras T, Malinovschi A, Probst-Hensch N, Toren K, Casas L, Verlato G, Garcia-Aymerich J, Accordini S, Ageing Lungs in European Cohorts (ALEC) study.
Eur Respir J. 2021 Apr 16;
Copy number variation underlies complex phenotypes in domestic dog breeds and other canids.
Serres-Armero A, Davis BW, Povolotskaya IS, Morcillo-Suarez C, Plassais J, Juan D, Ostrander EA, Marques-Bonet T
Genome Res. 2021 Apr 16;
Conserved long-range base pairings are associated with pre-mRNA processing of human genes.
Kalmykova S, Kalinina M, Denisov S, Mironov A, Skvortsov D, Guigó R, Pervouchine D
Nat Commun. 2021 Apr 16;12(1):2300
http://www.ncbi.nlm.nih.gov/en...
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Lindskrog SV, Prip F, Lamy P, Taber A, Groeneveld CS, Birkenkamp-Demtröder K, Jensen JB, Strandgaard T, Nordentoft I, Christensen E, Sokac M, Birkbak NJ, Maretty L, Hermann GG, Petersen AC, Weyerer V, Grimm MO, Horstmann M, Sjödahl G, Höglund M, Steiniche T, Mogensen K, de Reyniès A, Nawroth R, Jordan B, Lin X, Dragicevic D, Ward DG, Goel A, Hurst CD, Raman JD, Warrick JI, Segersten U, Sikic D, van Kessel KEM, Maurer T, Meeks JJ, DeGraff DJ, Bryan RT, Knowles MA, Simic T, Hartmann A, Zwarthoff EC, Malmström PU, Malats N, Real FX, Dyrskjøt L
Nat Commun. 2021 Apr 16;12(1):2301
http://www.ncbi.nlm.nih.gov/en...
Ancient and modern mitogenomes from Central Argentina: new insights into population continuity, temporal depth and migration in South America.
García A, Nores R, Motti JMB, Pauro M, Luisi P, Bravi CM, Fabra M, Gosling AL, Kardailsky O, Boocock J, Solé-Morata N, Matisoo-Smith EA, Comas D, Demarchi DA
Hum Mol Genet. 2021 Apr 15;
Smelling in the dark: phylogenomic insights into the chemosensory system of a subterranean beetle.
Balart-García P, Cieslak A, Escuer P, Rozas J, Ribera I, Fernández R
Mol Ecol. 2021 Apr 15;
Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene.
Akerman I, Maestro MA, De Franco E, Grau V, Flanagan S, García-Hurtado J, Mittler G, Ravassard P, Piemonti L, Ellard S, Hattersley AT, Ferrer J
Cell Rep. 2021 Apr 13;35(2):108981
[Long-term cognitive and functional status in survivors of an aneurysmal subarachnoid hemorrhage: Analysis of a retrospective cohort].
Neira N, Leiva N, Vílchez-Oya F, Salas LA, Boza R, Guillén-Solà A, Duarte E
Rehabilitacion (Madr). 2021 Apr 12;
ECG patterns of typical and atypical advanced interatrial block: prevalence and clinical relevance.
Elosua R, Escobar-Robledo LA, Massó-van Roessel A, Martínez-Sellés M, Baranchuk A, Bayés-de-Luna A
Rev Esp Cardiol (Engl Ed). 2021 Apr 12;
Epigenetic association studies at birth and the origin of lung function development.
Cosín-Tomás M, Bustamante M, Sunyer J
Eur Respir J. 2021 Apr;57(4)
Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study.
De la Rosa Carrillo D, Martínez-García MÁ, Barreiro E, Tabernero Huguet E, Costa Sola R, García-Clemente MM, Celorrio Jiménez N, Rodríguez Pons L, Calero Acuña C, Rodríguez Hermosa JL, Golpe R, Dacal Quintas R, Sánchez-Cuéllar S, Torres Arroyo I, Blanco Aparicio M, Almadana Pacheco V, Miravitlles M, 'Study group on the effectiveness of inhaled antibiotic treatment in COPD'., Members of the 'Study group on the effectiveness of inhaled antibiotic treatment in COPD'.
Arch Bronconeumol. 2021 Mar 19;
Mental well-being of the general population: direct and indirect effects of socioeconomic, relational and health factors.
Soldevila-Domenech N, Forero CG, Alayo I, Capella J, Colom J, Malmusi D, Mompart A, Mortier P, Puértolas B, Sánchez N, Schiaffino A, Vilagut G, Alonso J
Qual Life Res. 2021 Apr 13;
A GATA6-centred gene regulatory network involving HNFs and Delta-Np63 controls plasticity and immune escape in pancreatic cancer.
Kloesch B, Ionasz V, Paliwal S, Hruschka N, Martinez de Villarreal J, Öllinger R, Mueller S, Dienes HP, Schindl M, Gruber ES, Stift J, Herndler-Brandstetter D, Lomberk GA, Seidler B, Saur D, Rad R, Urrutia RA, Real FX, Martinelli P
Gut. 2021 Apr 12;
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Young K, Eudy E, Bell R, Loberg MA, Stearns T, Sharma D, Velten L, Haas S, Filippi MD, Trowbridge JJ
Cell Stem Cell. 2021 Apr 7;
Survey of Anesthesiologists on Topical Vasoconstrictors and Intravenous Tranexamic Acid for Endoscopic Sinus Surgery.
Feng M, Lao VF, Choby G, Bolton PB, Marino MJ, Weingarten TN, Humphreys IM, Dhillon SK, Choi BY, Fernandez RA, Mehter NS, Chen PG
Ann Otol Rhinol Laryngol. 2021 Apr 12;:34894211005940
A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images.
Bucci M, Savitcheva I, Farrar G, Salvadó G, Collij L, Doré V, Gispert JD, Gunn R, Hanseeuw B, Hansson O, Shekari M, Lhommel R, Molinuevo JL, Rowe C, Sur C, Whittington A, Buckley C, Nordberg A
Eur J Nucl Med Mol Imaging. 2021 Apr 12;
Inversions and genomic differentiation after secondary contact: when drift contributes to maintenance, not loss, of differentiation.
Rafajlovi? M, Rambla J, Feder JL, Navarro A, Faria R
Evolution. 2021 Apr 12;
Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice.
Martin M, Gutiérrez-Martos M, Cabrera R, Langohr K, Maldonado R, Farre M, de la Torre R
Psychopharmacology (Berl). 2021 Apr 11;
Evaluation of the Density Spectral Array in the Wada test: report of six cases.
Pacreu S, Vilà E, Moltó L, Rocamora R, Fernández-Candil JL
Braz J Anesthesiol. 2021 Apr 8;
Geographic variation in acclimation responses of thermal tolerance in South African diving beetles (Dytiscidae: Coleoptera).
Hidalgo-Galiana A, Ribera I, Terblanche JS
Comp Biochem Physiol A Mol Integr Physiol. 2021 Apr 8;:110955
Falls Predict Acute Hospitalization in Parkinson's Disease.
Santos García D, de Deus Fonticoba T, Cores C, Castro ES, Hernández Vara J, Jesús S, Mir P, Cosgaya M, Martí MJ, Pastor P, Cabo I, Seijo M, Legarda I, Vives B, Caballol N, Rúiz Martínez J, Croitoru I, Cubo E, Miranda J, Alonso Losada MG, Labandeira C, López Ariztegui N, Morales-Casado M, González Aramburu I, Infante J, Escalante S, Bernardo N, Blázquez Estrada M, Menéndez González M, Caldentey JG, Borrué C, Vela L, Catalán MJ, Gómez Mayordomo V, Kurtis M, Prieto C, Ordás C, Nogueira V, López Manzanares L, Ávila Rivera MA, Puente V, García Moreno JM, Solano Vila B, Álvarez Sauco M, Carrillo Padilla F, Carlos Martínez Castrillo J, Sánchez Alonso P, Gastón I, Kulisevsky J, Valero C, de Fábregues O, González Ardura J, López Díaz LM, Martinez-Martin P, COPPADIS Study Group.
J Parkinsons Dis. 2021 Apr 7;
Activation of final complement components after kidney transplantation as a marker of delayed graft function severity.
Arias-Cabrales CE, Riera M, Pérez-Sáez MJ, Gimeno J, Benito D, Redondo D, Burballa C, Crespo M, Pascual J, Rodríguez E
Clin Kidney J. 2021 Apr;14(4):1190-1196
Kidney transplantation outcomes from elderly donors after circulatory death: a comparison with elderly brain-dead donors.
Buxeda A, Velis G, Arias-Cabrales C, Zapatero A, Burballa C, Redondo-Pachón D, Mir M, Crespo M, Pascual J, Pérez-Sáez MJ
Clin Kidney J. 2021 Apr;14(4):1181-1189
Reply: Usefulness of Circulating Triglycerides and Estimated Remnant Cholesterol as Predictors of Cardiovascular Risk.
Castañer O, Ros E, Pintó X, Ortega E, Fito M
J Am Coll Cardiol. 2021 Apr 13;77(14):1841-1843
DNA methylation and gene expression integration in cardiovascular disease.
Palou-Márquez G, Subirana I, Nonell L, Fernández-Sanlés A, Elosua R
Clin Epigenetics. 2021 Apr 9;13(1):75
http://www.ncbi.nlm.nih.gov/en...
Publisher Correction: MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension.
Canut MI, Villa O, Kudsieh B, Mattlin H, Banchs I, González JR, Armengol L, Casaroli-Marano RP
Sci Rep. 2021 Apr 9;11(1):8237
http://www.ncbi.nlm.nih.gov/en...
Do individuals with autoimmune disease have increased risk of subclinical carotid atherosclerosis and stiffness?
Vila MDM, Remeseiro B, Igual L, Elosua R, Ramos R, Valdivielso JM, Martí-Lluch R, Marrugat J, Grau M
Hypertens Res. 2021 Apr 8;
Defining Minor Intracerebral Hemorrhage.
Gómez-González A, Lazcano U, Vivanco-Hidalgo RM, Prats-Sánchez L, Guisado-Alonso D, Delgado-Mederos R, Camps-Renom P, Martínez Domeño A, Cuadrado-Godia E, Giralt Steinhauer E, Jiménez-Conde J, Soriano-Tárraga C, Avellaneda-Gómez C, Rodríguez-Campello A, Martí-Fábregas J, Ois A, Roquer J
Cerebrovasc Dis. 2021 Apr 8;:1-8
ACME dissociation: a versatile cell fixation-dissociation method for single-cell transcriptomics.
García-Castro H, Kenny NJ, Iglesias M, Álvarez-Campos P, Mason V, Elek A, Schönauer A, Sleight VA, Neiro J, Aboobaker A, Permanyer J, Irimia M, Sebé-Pedrós A, Solana J
Genome Biol. 2021 Apr 8;22(1):89
http://www.ncbi.nlm.nih.gov/en...
CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.
Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ
Oncogene. 2021 Apr 8;
Impact of the subcutaneous formulations of trastuzumab and rituximab on efficiency and resource optimization in Spanish hospitals: H-Excelencia study.
Abad-Sazatornil MR, Arenaza A, Bayo J, García Mata J, Guinea De Castro JM, León J, Letellez J, Reguero V, Martínez Chamorro C, Salar A
BMC Health Serv Res. 2021 Apr 8;21(1):320
Top quality research with the utmost integrity
The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.
At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:
- The PRBB Code of Good Scientific Practices, approved by all the centres.
- An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
- Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.
To learn more about the code, the working group on good scientific practices and the various activities organised, visit:
More information
Contact
●Latest news
Patents and companies
- The following links allow you to explore the technology on offer in the park’s centres:
Technology at the IMIM-Hospital del Mar
UPF Business Shuttle and Innovation Unit
Technology and Business Development Office at the CRG
Analysis and Global Development at ISGlobal
EMBLEM Technology Transfer
- The following start-ups have been created within the PRBB environment:
Acellera
Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.
→ https://www.acellera.comChemotargets
Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.
→ http://www.chemotargets.com/qGenomics
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qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.
→ https://qgenomics.comZeClinics
ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.
→ http://www.zeclinics.comMicroomics
Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.
→ http://www.microomics.euFlomics
World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.
→ http://www.flomics.comBioinspired Materials
This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.
→ http://biom.techMedBioinformatics Solutions
MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.
→ http://www.disgenetplus.com/medbioinformatics/Pulmobiotics
A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.
→ https://www.pulmobio.com/●Latest news
