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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.

Hospital del Mar Medical Research Institute (IMIM)


The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 


The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Medicine and Life Sciences at Pompeu Fabra University (MELIS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry.

Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.


The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.


ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.

Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:



⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news

Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza


The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko


The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut


This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet


This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas


The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.

Contact: Dirección de secretaría


This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis


Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop


The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría

Web: (Acceso: Portal PRBB)

BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso


The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro


This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht


The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà


The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals


The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera


This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea


This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger


The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi


Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu


This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade


Scientific publications
(keywords, journal, author,...)

Finding the vulnerable postoperative population: A two-step cluster analysis of the PAIN-OUT registry.

Polanco-García M, Granero R, Gallart L, García-Lopez J, Montes A

Eur J Pain. 2022 Jun 28;

Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndrome.

Martinez de Lagran M, Elizalde-Torrent A, Paredes R, Clotet B, Dierssen M

J Cell Mol Med. 2022 Jun 28;

Latin America And Spain: A Successful Partnership.

Checa MA

JBRA Assist Reprod. 2014 Jun 27;18(2):33

Ecological complexity and the biosphere: the next 30 years.

Solé R, Levin S

Philos Trans R Soc Lond B Biol Sci. 2022 Aug 15;377(1857):20210376

Network-level containment of single-species bioengineering.

Maull V, Solé R

Philos Trans R Soc Lond B Biol Sci. 2022 Aug 15;377(1857):20210396

GATA2 deficiency and MDS/AML: Experimental strategies for disease modelling and future therapeutic prospects.

Kotmayer L, Romero-Moya D, Marin-Bejar O, Kozyra E, Català A, Bigas A, Wlodarski MW, Bödör C, Giorgetti A

Br J Haematol. 2022 Jun 26;

Polyvascular Subclinical Atherosclerosis: Correlation Between Ankle Brachial Index and Carotid Atherosclerosis in a Population-Based Sample.

Vila MDM, Igual L, Remeseiro B, Elosua R, Ramos R, Valdivielso JM, Martí-Lluch R, Marrugat J, Grau M

Angiology. 2022 Jun 25;:33197221110720

Genotypic effects of APOE-Epsilon-4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.

Cacciaglia R, Operto G, Falcón C, de Echavarri-Gómez JMG, Sánchez-Benavides G, Brugulat-Serrat A, Milà-Alomà M, Blennow K, Zetterberg H, Molinuevo JL, Suárez-Calvet M, Gispert JD, ALFA study .

Cereb Cortex. 2022 Jun 27;

Determinants of effective treatment coverage for major depressive disorder in the WHO World Mental Health Surveys.

Vigo DV, Kazdin AE, Sampson NA, Hwang I, Alonso J, Andrade LH, Ayinde O, Borges G, Bruffaerts R, Bunting B, de Girolamo G, Florescu S, Gureje O, Haro JM, Harris MG, Karam EG, Karam G, Kovess-Masfety V, Lee S, Navarro-Mateu F, Posada-Villa J, Scott K, Stagnaro JC, Have MT, Wu CS, Xavier M, Kessler RC

Int J Ment Health Syst. 2022 Jun 23;16(1):29

Essential Role of Enzymatic Activity in the Leishmanicidal Mechanism of the Eosinophil Cationic Protein (RNase 3).

Abengózar MÁ, Fernández-Reyes M, Salazar VA, Torrent M, de la Torre BG, Andreu D, Boix E, Rivas L

ACS Infect Dis. 2022 Jun 22;

CANreduce-SP-adding psychological support to web-based adherence-focused guided self-help for cannabis users: study protocol for a three-arm randomized control trial.

Mestre-Pintó JI, Fonseca F, Schaub MP, Baumgartner C, Alias-Ferri M, Torrens M

Trials. 2022 Jun 22;23(1):524

Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function.

Mayneris-Perxachs J, Arnoriaga-Rodríguez M, Garre-Olmo J, Puig J, Ramos R, Trelis M, Burokas A, Coll C, Zapata-Tona C, Pedraza S, Pérez-Brocal V, Ramió L, Ricart W, Moya A, Jové M, Sol J, Portero-Otin M, Pamplona R, Maldonado R, Fernández-Real JM

ISME J. 2022 Jun 21;

State of the art of enhance recovery after surgery (ERAS) protocols in esophagogastric cancer surgery: the Western experience.

Salvans S, Grande L, Dal Cero M, Pera M

Updates Surg. 2022 Jun 21;

Non-STEMI vs. STEMI Cardiogenic Shock: Clinical Profile and Long-Term Outcomes.

Martínez MJ, Rueda F, Labata C, Oliveras T, Montero S, Ferrer M, El Ouaddi N, Serra J, Lupón J, Bayés-Genís A, García-García C

J Clin Med. 2022 Jun 20;11(12)

Effect of Low-Dose Radiotherapy on the Circulating Levels of Paraoxonase-1-Related Variables and Markers of Inflammation in Patients with COVID-19 Pneumonia.

Rodríguez-Tomàs E, Acosta JC, Torres-Royo L, De Febrer G, Baiges-Gaya G, Castañé H, Jiménez A, Vasco C, Araguas P, Gómez J, Malave B, Árquez M, Calderón D, Piqué B, Algara M, Montero Á, Simó JM, Gabaldó-Barrios X, Sabater S, Camps J, Joven J, Arenas M

Antioxidants (Basel). 2022 Jun 16;11(6)

Impulsive Personality Traits Predicted Weight Loss in Individuals with Type 2 Diabetes after 3 Years of Lifestyle Interventions.

Testa G, Camacho-Barcia L, Gómez-Martínez C, Mora-Maltas B, de la Torre R, Pintó X, Corella D, Granero R, Cuenca-Royo A, Jiménez-Murcia S, Babio N, Fernández-Carrión R, Esteve-Luque V, Forcano L, Ni J, Malcampo M, De Las Heras-Delgado S, Fitó M, Salas-Salvadó J, Fernández-Aranda F

J Clin Med. 2022 Jun 16;11(12)

Attenuation of Muscle Damage, Structural Abnormalities, and Physical Activity in Respiratory and Limb Muscles following Treatment with Rucaparib in Lung Cancer Cachexia Mice.

Pérez-Peiró M, Duran X, Yélamos J, Barreiro E

Cancers (Basel). 2022 Jun 11;14(12)

Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.

Giralt-Steinhauer E, Jiménez-Balado J, Fernández-Pérez I, Rey Álvarez L, Rodríguez-Campello A, Ois Á, Cuadrado-Godia E, Jiménez-Conde J, Roquer J

Int J Mol Sci. 2022 Jun 9;23(12)

[Revisit after discharge from the emergency department in a cohort of patients with COVID-19 pneumonia and analysis based on the healthcare resource used for follow-up. RESALSEVID study].

Albert A, Llorens P, Aguirre A, Martín-Sánchez FJ, Mínguez S, Moreno O, Ferré C, Valls A, Espinosa B, Murillo O, Cirera I, Gil A, Rivera S, Llopis F, Malchair P, Gonzalez Del Castillo J, Jacob J, en representación del grupo de investigadores del estudio RESALSEVID.

J Healthc Qual Res. 2022 Jun 8;

Emergencies associated with shabu - crystal methamphetamine - in a tertiary care hospital.

Supervía A, Ribas N, Sauras R, Rodríguez Campello AM, Pallàs O, López-Vilchez MÁ

Emergencias. 2022 Jun;34(3):235-237

Excess mortality in 2020 in the working-age population of nine Latin American countries.

Benavides FG, Vives A, Zimmerman M, Silva-Peñaherrera M

Rev Panam Salud Publica. 2022;46:e75

Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study.

Torres A, Motos A, ... , Marin-Corral J,, CIBERESUCICOVID Project Investigators

Intensive Care Med. 2022 Jun 21;

Safety and performance of a new burr hole covering device: results of the multicenter cover registry.

Asencio-Cortés C, Villalba G, De Vilalta A, Serrano L, Alvarez Holzapfel MJ, Montes G, Malaga X, Muñoz-Hernandez F, Gabarrós A

J Neurol Surg A Cent Eur Neurosurg. 2022 Jun 23;

Prenatal exposure to multiple organochlorine compounds and childhood body mass index.

Colicino E, Margetaki K, Valvi D, Pedretti NF, Stratakis N, Vafeiadi M, Roumeliotaki T, Kyrtopoulos SA, Kiviranta H, Stephanou EG, Kogevinas M, McConnell R, Berhane KT, Chatzi L, Conti DV

Environ Epidemiol. 2022 Jun;6(3):e201

A long noncoding RNA promotes parasite differentiation in African trypanosomes.

Guegan F, Rajan KS, Bento F, Pinto-Neves D, Sequeira M, Guminska N, Mroczek S, Dziembowski A, Cohen-Chalamish S, Doniger T, Galili B, Estévez AM, Notredame C, Michaeli S, Figueiredo LM

Sci Adv. 2022 Jun 17;8(24):eabn2706

Brain alterations in the early Alzheimer's continuum with amyloid-Beta, tau, glial and neurodegeneration CSF markers.

Salvadó G, Shekari M, Falcon C, Operto G, Milà-Alomà M, Sánchez-Benavides G, Cacciaglia R, Arenaza-Urquijo E, Niñerola-Baizán A, Perissinotti A, Minguillon C, Fauria K, Kollmorgen G, Suridjan I, Molinuevo JL, Zetterberg H, Blennow K, Suárez-Calvet M, Gispert JD, ALFA Study .

Brain Commun. 2022;4(3):fcac134

PRC2 shields the potency of human stem cells.

Aranda S, Condemi L, Di Croce L

Nat Cell Biol. 2022 Jun 13;

Consensus on the Management of the COPD Patient in the COVID-19 Setting: COPD Forum Working Group.

Rubio MC, López-Campos JL, Alonso JLI, Pitarch DM, Pascual MI, Navarrete BA, Falcones MV, Inglés MJA, López CC, Martínez CJÁ, Ruiz FO, Golpe R, Gomila AF, Guardia SP, Miranda JAR, Peces-Barba G, García-Río F, Muñiz MÁM, Cosío BG

Arch Bronconeumol. 2022 May 18;

Areas of Specific Subspecialization (ACE) in pulmonology.

Gea J, Barrueco M, Martínez C, Jiménez-Ruíz C

Arch Bronconeumol. 2021 Dec;57(12):733-734

Prediction Equations for Maximal Aerobic Capacity on Cycle Ergometer for the Spanish Adult Population.

Puente-Maestú L, Ortega F, Pedro JG, Rodríguez-Nieto MJ, Gómez-Seco J, Gáldiz B, Ojanguren I, Muñoz X, Blanco I, Burgos F, Rodríguez-Chiaradía DA, Gea J, García-Rio F

Arch Bronconeumol. 2021 Jul;57(7):471-478

Bioavailability Study of a Transdermal Patch Formulation of Rivastigmine Compared with Exelon in Healthy Subjects.

Morte A, Vaqué A, Iniesta M, Schug B, Koch C, De la Torre R, Schurad B

Eur J Drug Metab Pharmacokinet. 2022 Jun 13;

Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Pseudomonas aeruginosa Isolates.

Montero MM, Domene-Ochoa S, López-Causapé C, López-Montesinos I, Luque S, Sorlí L, Campillo N, Padilla E, Prim N, Ferrer Alapont L, Grau S, Oliver A, Horcajada JP

Microbiol Spectr. 2022 Jun 13;:e0089222

Malignant lymphoma and occupational exposure to extremely low frequency magnetic fields and electrical shocks: a nested case-control study in a cohort of four Nordic countries.

Jalilian H, Guxens M, Heikkinen S, Pukkala E, Huss A, Eshagh Hossaini SK, Kjærheim K, Vermeulen R

Occup Environ Med. 2022 Jun 13;

Development and external validation of a 1- and 5-year fracture prediction tool based on electronic medical records data: The EPIC risk algorithm.

Tebé C, Pallares N, Reyes C, Carbonell C, Montero-Corominas D, Martín-Merino E, Nogués X, Diez-Perez A, Prieto-Alhambra D, Martinez-Laguna D

Bone. 2022 Jun 9;:116469

Patch test results with the European Baseline Series, 2019/20 - Joint European results of the ESSCAA and the EBSB working groups of the ESCD, and the GEIDACC.

Uter W, Wilkinson SM, Aerts O, Bauer A, Borrego L, Brans R, Buhl T, Dickel H, Dugonik A, Larese Filon F, Mercader Garcìa P, Giménez Arnau A, Patruno C, Pesonen M, Pónyai G, Rustemeyer T, Schubert S, Schuttelaar MA, Simon D, Stingeni L, Valiukeviciené S, Weisshaar E, Werfel T, Gonçalo M, ESSCAA and EBSB ESCD working groups, and the GEIDACC.

Contact Dermatitis. 2022 Jun 9;

Impact of the COVID-19 pandemic on breast cancer screening indicators in a Spanish population-based program: a cohort study.

Bosch G, Posso M, Louro J, Roman M, Porta M, Castells X, Macià F

Elife. 2022 Jun 10;11

Local Functional Connectivity as a Parsimonious Explanation of the Main Frameworks for ADHD in Medication-Naïve Adults.

Marcos-Vidal L, Martínez-García M, Martín de Blas D, Navas-Sánchez FJ, Pretus C, Ramos-Quiroga JA, Richarte V, Vilarroya Ó, Sepulcre J, Desco M, Carmona S

J Atten Disord. 2022 Jun 9;:10870547221101646

A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution.

Grau-Bové X, Navarrete C, Chiva C, Pribasnig T, Antó M, Torruella G, Galindo LJ, Lang BF, Moreira D, López-Garcia P, Ruiz-Trillo I, Schleper C, Sabidó E, Sebé-Pedrós A

Nat Ecol Evol. 2022 Jun 9;

The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions.

Hevia CF, Engel-Pizcueta C, Udina F, Pujades C

Cell Rep. 2022 Jun 7;39(10):110915

Air pollution and health, 20 years later.

Sunyer J, Rivas I

Med Clin (Barc). 2022 Jun 5;

Quality of Life in Older Patients after a Heart Failure Hospitalization: Results from the SENECOR Study.

Luiso D, Herrero-Torrus M, Badosa N, Roqueta C, Ruiz-Bustillo S, Belarte-Tornero LC, Valdivielso-Moré S, Morales RO, Vázquez O, Farré N

J Clin Med. 2022 May 27;11(11)

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.

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Mutat Res Rev Mutat Res. 2022 Jan-Jun;789:108415

The genome sequence of the grizzled skipper, Pyrgus malvae (Linnaeus, 1758).

Hayward A, Vila R, Lohse K, Laetsch D, Darwin Tree of Life Barcoding collective., Wellcome Sanger Institute Tree of Life programme., Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective., Tree of Life Core Informatics collective., Darwin Tree of Life Consortium.

Wellcome Open Res. 2022;7:114

Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study.

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Lancet Reg Health Eur. 2022 Jul;18:100422

Liquid Biopsy for Precision Adjuvant Chemotherapy in Colon Cancer.

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N Engl J Med. 2022 Jun 4;

Characterization of 58 STRs and 94 SNPs with the ForenSeq™ DNA signature prep kit in Mexican-Mestizos from the Monterrey city (Northeast, Mexico).

Aguilar-Velázquez JA, Duran-Salazar MÁ, Córdoba-Mercado MF, Coronado-Avila CE, Salas-Salas O, Martinez-Cortés G, Casals F, Calafell F, Ramos-González B, Rangel-Villalobos H

Mol Biol Rep. 2022 Jun 3;

Therapeutic Drug Monitoring and Prolonged Infusions of Ceftolozane/Tazobactam for MDR/XDR Pseudomonas aeruginosa Infections: An Observational Study.

Navarrete-Rouco ME, Luque S, Sorlí L, Benítez-Cano A, Roberts JA, Grau S

Eur J Drug Metab Pharmacokinet. 2022 Jun 3;

Broad complex and wing development in cockroaches.

Fernandez-Nicolas A, Ventos-Alfonso A, Kamsoi O, Clark-Hachtel C, Tomoyasu Y, Belles X

Insect Biochem Mol Biol. 2022 Jun 1;:103798

Urban environment and health behaviours in children from six European countries.

Fernández-Barrés S, Robinson O, Fossati S, Márquez S, Basagaña X, de Bont J, de Castro M, Donaire-Gonzalez D, Maitre L, Nieuwenhuijsen M, Romaguera D, Urquiza J, Chatzi L, Iakovides M, Vafeiadi M, Grazuleviciene R, Dedele A, Andrusaityte S, Marit Aasvang G, Evandt J, Hjertager Krog N, Lepeule J, Heude B, Wright J, McEachan RRC, Sassi F, Vineis P, Vrijheid M

Environ Int. 2022 May 25;165:107319

Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group.

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Cir Esp (Engl Ed). 2022 Jun 4;

Unicellular-multicellular evolutionary branching driven by resource limitations.

Bonforti A, Solé R

J R Soc Interface. 2022 Jun;19(191):20220018

Exposure to road traffic noise and cognitive development in schoolchildren in Barcelona, Spain: A population-based cohort study.

Foraster M, Esnaola M, López-Vicente M, Rivas I, Álvarez-Pedrerol M, Persavento C, Sebastian-Galles N, Pujol J, Dadvand P, Sunyer J

PLoS Med. 2022 Jun;19(6):e1004001

Diabetes alters the protein secretome of human adipose-derived stem cells and promotes tumorigenesis in hepatic cancer cells.

Ejarque M, Sabadell-Basallote J, Benaiges E, Núñez-Roa C, Sabido E, Borras E, Llacer E, Zorzano A, Vendrell J, Fernández-Veledo S

Clin Transl Med. 2022 Jun;12(6):e823

Erratic enteric absorption of dolutegravir in a critically ill patient.

de Antonio-Cuscó M, Parrilla FJ, Knobel Freud H, Echeverría-Esnal D, Castellví Font A, Vázquez A, Masclans JR, Ferrández O, Grau S

Rev Esp Quimioter. 2022 May 30;

Understanding the interplay of membrane trafficking, cell surface mechanics, and stem cell differentiation.

Li JH, Trivedi V, Diz-Muñoz A

Semin Cell Dev Biol. 2022 May 28;

Laparoscopic versus open pancreatoduodenectomy: an individual participant data meta-analysis of randomized controlled trials.

Vissers FL, van Hilst J, Burdío F, Sabnis SC, Busch OR, Dijkgraaf MG, Festen SF, Sanchez-Velázquez P, Senthilnathan P, Palanivelu C, Poves I, Besselink MG, International Minimally Invasive Pancreatic Resection Trialists Group.

HPB (Oxford). 2022 Mar 18;

The Potential of Sewage Sludge to Predict and Evaluate the Human Chemical Exposome.

Gil-Solsona R, Nika MC, Bustamante M, Villanueva CM, Foraster M, Cosin-Tomás M, Alygizakis N, Gómez-Roig MD, Llurba-Olive E, Sunyer J, Thomaidis NS, Dadvand P, Gago-Ferrero P

Environ Sci Technol Lett. 2021 Dec 14;8(12):1077-1084

Study of the Combined Effect of Maternal Tobacco Smoking and Polygenic Risk Scores on Birth Weight and Body Mass Index in Childhood.

Fuentes-Paez G, Escaramís G, Aguilar-Lacasaña S, Andrusaityte S, Brantsæter AL, Casas M, Charles MA, Chatzi L, Lepeule J, Grazuleviciene R, Gützkow KB, Heude B, Maitre L, Ruiz-Arenas C, Sunyer J, Urquiza J, Yang TC, Wright J, Vrijheid M, Vilor-Tejedor N, Bustamante M

Front Genet. 2022;13:867611

205 newly assembled mitogenomes provide mixed evidence for rivers as drivers of speciation for Amazonian primates.

Janiak MC, Silva FE, Beck RMD, de Vries D, Kuderna LFK, Torosin NS, Melin AD, Marquès-Bonet T, Goodhead IB, Messias M, da Silva MNF, Sampaio I, Farias IP, Rossi R, de Melo FR, Valsecchi J, Hrbek T, Boubli JP

Mol Ecol. 2022 May 31;

Development of the ParaOesophageal hernia SympTom (POST) tool.

Puri A, Patel NM, Sounderajah V, Ferri L, Griffiths EA, Low D, Maynard N, Mueller C, Pera M, van Berge Henegouwen MI, Watson DI, Zaninotto G, Hanna GB, Markar SR, POST Collaborative .

Br J Surg. 2022 May 30;

Maternal exposure to air pollution during pregnancy and child's cognitive, language, and motor function: ECLIPSES study.

Iglesias-Vázquez L, Binter AC, Canals J, Hernández-Martínez C, Voltas N, Ambròs A, Fernández-Barrés S, Pérez-Crespo L, Guxens M, Arija V

Environ Res. 2022 May 28;:113501

DIPA-CRISPR is a simple and accessible method for insect gene editing.

Shirai Y, Piulachs MD, Belles X, Daimon T

Cell Rep Methods. 2022 May 23;2(5):100215

Polymers of micro(nano) plastic in household tap water of the Barcelona Metropolitan Area.

Vega-Herrera A, Llorca M, Borrell-Diaz X, Redondo-Hasselerharm PE, Abad E, Villanueva CM, Farré M

Water Res. 2022 May 22;220:118645

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.

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Osteoporos Int. 2022 May 31;

Advances and Pitfalls of Specialized Pain Care through Public and Private Health Care Providers in Catalonia and the Balearic Islands: A Physician's Survey.

Medel J, Serrano A, Batet C, Lorente L, Bella S, Ferrandiz M, Monerris MD, Boada S, Villoria J, Ribera MV, Montes A, Videla S

Pain Res Manag. 2022;2022:4077139

Mental health and COVID-19 in a general population cohort in Spain (COVICAT study).

Goldberg X, Castaño-Vinyals G, Espinosa A, Carreras A, Liutsko L, Sicuri E, Foraster M, O'Callaghan-Gordo C, Dadvand P, Moncunill G, Dobaño C, Cortés B, Pleguezuelos V, Straif K, Garcia-Aymerich J, de Cid R, Cardis E, Kogevinas M

Soc Psychiatry Psychiatr Epidemiol. 2022 May 28;

Native RNA sequencing in fission yeast reveals frequent alternative splicing isoforms.

Montañés JC, Huertas M, Moro SG, Blevins WR, Carmona M, Ayté J, Hidalgo E, Albà MM

Genome Res. 2022 May 26;

Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages.

Arnan C, Ullrich S, Pulido-Quetglas C, Nurtdinov R, Esteban A, Blanco-Fernandez J, Aparicio-Prat E, Johnson R, Pérez-Lluch S, Guigó R

BMC Genomics. 2022 May 26;23(1):402

Best practice standards for circular RNA research.

Nielsen AF, Bindereif A, Bozzoni I, Hanan M, Hansen TB, Irimia M, Kadener S, Kristensen LS, Legnini I, Morlando M, Jarlstad Olesen MT, Pasterkamp RJ, Preibisch S, Rajewsky N, Suenkel C, Kjems J

Nat Methods. 2022 May 26;

Non targeted screening of nitrogen containing disinfection by-products in formation potential tests of river water and subsequent monitoring in tap water samples.

Sanchís J, Redondo-Hasselerharm PE, Villanueva CM, Farré MJ

Chemosphere. 2022 May 24;303(Pt 2):135087

Clinical description and genetic analysis of a novel familial skeletal dysplasia characterized by high bone mass and lucent bone lesions.

Ovejero D, Garcia-Giralt N, Martínez-Gil N, Rabionet R, Balcells S, Grinberg D, Pérez-Jurado L, Nogués X, Foronda IE

Bone. 2022 May 24;:116450

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells.

Bellio C, Emperador M, Castellano P, Gris-Oliver A, Canals F, Sánchez-Pla A, Zamora E, Arribas J, Saura C, Serra V, Tabernero J, Littlefield BA, Villanueva J

Cancers (Basel). 2022 May 23;14(10)

An Abnormal Inflammatory Pattern Associated with Long-Term Non-Progression of HIV Infection Impacts Negatively on Bone Quality.

Soldado-Folgado J, Chillarón JJ, Cañas-Ruano E, Arrieta-Aldea I, González-Mena A, Blasco-Hernando F, Knobel H, Garcia-Giralt N, Güerri-Fernández R

J Clin Med. 2022 May 22;11(10)

Clinical guide to perioperative management for videothoracoscopy lung resection (Section of Cardiac, Vascular and Thoracic Anesthesia, SEDAR; Spanish Society of Thoracic Surgery, SECT; Spanish Society of Physiotherapy).

Granell-Gil M, Murcia-Anaya M, Sevilla S, Martínez-Plumed R, Biosca-Pérez E, Cózar-Bernal F, Garutti I, Gallart L, Ubierna-Ferreras B, Sukia-Zilbeti I, Gálvez-Muñoz C, Delgado-Roel M, Mínguez L, Bermejo S, Valencia O, Real M, Unzueta C, Ferrando C, Sánchez F, González S, Ruiz-Villén C, Lluch A, Hernández A, Hernández-Beslmeisl J, Vives M, Vicente R

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Safety and Efficacy of Crizotinib in Combination with Temozolomide and Radiotherapy in Patients with Newly Diagnosed Glioblastoma: Phase Ib GEINO 1402 Trial.

Martínez-García M, Velasco G, Pineda E, Gil-Gil M, Alameda F, Capellades J, Martín-Soberón MC, López-Valero I, Tovar Ambel E, Foro P, Taus Á, Arumi M, Hernández-Laín A, Sepúlveda-Sánchez JM

Cancers (Basel). 2022 May 12;14(10)

Evolution of Brains and Computers: The Roads Not Taken.

Solé R, Seoane LF

Entropy (Basel). 2022 May 9;24(5)

Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes.

Wang X, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, Golpe R, Menéndez R, Rodríguez-López J, Prados C, Martinez-García MA, Rodriguez JL, de la Rosa D, Qin L, Duran X, Garcia-Ojalvo J, Barreiro E

Biomedicines. 2022 Apr 30;10(5)

Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders.

Flores-López M, García-Marchena N, Araos P, Requena-Ocaña N, Porras-Perales O, Torres-Galván S, Suarez J, Pizarro N, de la Torre R, Rubio G, Ruiz-Ruiz JJ, Rodríguez de Fonseca F, Serrano A, Pavón-Morón FJ

Brain Sci. 2022 Apr 30;12(5)

New Psychoactive Substances Consumption in Opioid-Use Disorder Patients.

Alías-Ferri M, Pellegrini M, Marchei E, Pacifici R, Rotolo MC, Pichini S, Pérez-Mañá C, Papaseit E, Muga R, Fonseca F, Torrens M, Farré M

Biology (Basel). 2022 Apr 22;11(5)

Real-World Evidence of Daratumumab Monotherapy in Relapsed/Refractory Multiple Myeloma Patients and Efficacy on Soft-Tissue Plasmacytomas.

Moreno DF, Clapés V, Soler JA, González-Montes Y, Gironella M, Motlló C, Granell M, Abella E, García-Pintos M, García-Guiñón A, Cabezudo E, Bladé J, Rosiñol L

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Cost Analysis of the Use of Voriconazole, Posaconazole and Micafungin in the Primary Prophylaxis of Invasive Fungal Infections in Recipients of Allogeneic Hematopoietic Stem Cell Transplants.

Grau S, Solano C, García-Vidal C, Jarque I, Barrueta JA, Peral C, Rodríguez I, Rubio-Rodríguez D, Rubio-Terrés C

J Health Econ Outcomes Res. 2016;3(2):153-161

A set point in the selection of the alfabetaTCR T cell repertoire imposed by pre-TCR signaling strength.

Bovolenta ER, García-Cuesta EM, Horndler L, Ponomarenko J, Schamel WW, Mellado M, Castro M, Abia D, van Santen HM

Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2201907119

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk.

Ali M, Sung YJ, Wang F, Fernández MV, Morris JC, Fagan AM, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleó A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, et. al.

PLoS One. 2022;17(5):e0267298

Full spectrum cytometry improves the resolution of highly autofluorescent biological samples: Identification of myeloid cells in regenerating skeletal muscles.

Kharraz Y, Lukesova V, Serrano AL, Davison A, Muñoz-Cánoves P

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p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.

Solé L, Lobo-Jarne T, Álvarez-Villanueva D, Alonso-Marañón J, Guillén Y, Guix M, Sangrador I, Rozalén C, Vert A, Barbachano A, Lop J, Salido M, Bellosillo B, García-Romero R, Garrido M, González J, Martínez-Iniesta M, López-Arribillaga E, Salazar R, Montagut C, Torres F, Iglesias M, Celià-Terrassa T, Muñoz A, Villanueva A, Bigas A, Espinosa L

Nat Commun. 2022 May 23;13(1):2866

Polycomb complexes in MLL-AF9-related leukemias.

Sparavier A, Di Croce L

Curr Opin Genet Dev. 2022 May 21;75:101920

Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells.

Severino J, Bauer M, Mattimoe T, Arecco N, Cozzuto L, Lorden P, Hamada N, Nosaka Y, Nagaoka SI, Audergon P, Tarruell A, Heyn H, Hayashi K, Saitou M, Payer B

EMBO J. 2022 May 23;:e109457

Patterns of change of multisite pain over one year of follow-up and related risk factors.

Ntani G, Coggon D, Felli VE, Harari F, Barrero LH, Felknor SA, Rojas M, Serra C, Bonzini M, Merisalu E, Habib RR, Sadeghian F, Wickremasinghe AR, Matsudaira K, Nyantumbu-Mkhize B, Kelsall HL, Harcombe H, Walker-Bone K

Eur J Pain. 2022 May 22;

Fostering interest in surgery in medical students: The experience of the Gimbernat Surgical Association.

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Reliability and Validation of the Child Eating Behavior Questionnaire in 3- to 6-Year-Old Spanish Children.

Jimeno-Martínez A, Maneschy I, Moreno LA, Bueno-Lozano G, De Miguel-Etayo P, Flores-Rojas K, Jurado-Castro JM, de Lamas C, Vázquez-Cobela R, Martinez-Lacruz R, Portoles O, Martínez JA, Navas-Carretero S, Schröder H, Fitó M, Babio N, Salas-Salvadó J, Leis R, Gil-Campos M, Rupérez AI

Front Psychol. 2022;13:705912

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer.

Adam-Artigues A, Arenas EJ, Martínez-Sabadell A, Brasó-Maristany F, Cervera R, Tormo E, Hernando C, Martínez MT, Carbonell-Asins J, Simón S, Poveda J, Moragón S, Zazo S, Martínez D, Rovira A, Burgués O, Rojo F, Albanell J, Bermejo B, Lluch A, Prat A, Arribas J, Eroles P, Cejalvo JM

Sci Adv. 2022 May 20;8(20):eabk2746

Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors.

Willis JR, Saus E, Iraola-Guzmán S, Ksiezopolska E, Cozzuto L, Bejarano LA, Andreu-Somavilla N, Alloza-Trabado M, Blanco A, Puig-Sola A, Broglio E, Carolis C, Ponomarenko J, Hecht J, Gabaldón T

NPJ Biofilms Microbiomes. 2022 May 19;8(1):38

Intra-plaque calcium and its relation with the progression of carotid atheromatous disease.

Miralles M, Arrébola M, Lago A, Brugger S, Lara R, Medina P, Clará A, Plana E

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Cost-effectiveness Analysis of Peripherally Inserted Central Catheters Versus Central Venous Catheters for in-Hospital Parenteral Nutrition.

Comas M, Domingo L, Jansana A, Lafuente E, Civit A, García-Pérez L, Lasso de la Vega C, Cots F, Sala M, Castells X

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Association of physical activity with high-density lipoprotein functionality in a population-based cohort: the REGICOR study.

Viadas R, Toloba A, Fernández I, Sayols-Baixeras S, Hernáez Á, Schroeder H, Dégano IR, Lassale C, Marrugat J, Elosua R

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Association of ambient and household air pollution with lung function in young adults in an peri-urban area of South-India: A cross-sectional study.

Ranzani OT, Bhogadi S, Milà C, Kulkarni B, Balakrishnan K, Sambandam S, Garcia-Aymerich J, Marshall JD, Kinra S, Tonne C

Environ Int. 2022 May 11;165:107290

GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer.

Rodríguez De Dios N, Navarro-Martin A, Cigarral C, Chicas-Sett R, García R, Garcia V, Gonzalez JA, Gonzalo S, Murcia-Mejía M, Robaina R, Sotoca A, Vallejo C, Valtueña G, Couñago F

World J Clin Oncol. 2022 Apr 24;13(4):237-266

Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain.

Cabañero D, Álvarez-Pérez B, Martín-García E, Maldonado R

Bio Protoc. 2022 Mar 5;12(5):e4348

Correction to: SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021).

Capdevila J, Gómez MA, Guillot M, Páez D, Pericay C, Safont MJ, Tarazona N, Vera R, Vidal J, Sastre J

Clin Transl Oncol. 2022 May 20;

Recovering the genomes hidden in museum wet collections.

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Mol Ecol Resour. 2022 May 16;

Maternal occupational exposure to chemicals and child cognitive function.

Ish J, Symanski E, Gimeno Ruiz de Porras D, Casas M, Delclos GL, Guxens M, Ibarluzea JM, Iñiguez C, Lertxundi A, Rebagliato M, Swartz MD, Whitworth KW

Pediatr Res. 2022 May 16;

Exposure to traffic-related air pollution and noise during pregnancy and childhood, and functional brain connectivity in preadolescents.

Pérez-Crespo L, Kusters MSW, López-Vicente M, Lubczynska MJ, Foraster M, White T, Hoek G, Tiemeier H, Muetzel RL, Guxens M

Environ Int. 2022 May 5;164:107275

Ein zweijähriges Mädchen mit bläulich-erythematösem Tumor an der Schulter.

Tormo-Mainar S, March-Rodríguez A, Gonzàlez-Farré M, Pujol RM

J Dtsch Dermatol Ges. 2022 May;20(5):703-706

Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry.

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United European Gastroenterol J. 2022 May 16;

Arginine catabolism metabolites and atrial fibrillation or heart failure risk: two case-control studies within the PREDIMED trial.

Goni L, Razquin C, Toledo E, Guasch-Ferré M, Clish CB, Babio N, Wittenbecher C, Atzeni A, Li J, Liang L, Dennis C, Alonso-Gómez Á, Fitó M, Corella D, Gómez-Gracia E, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Arós F, Salas-Salvadó J, Hu FB, Martínez-González MA, Ruiz-Canela M

Am J Clin Nutr. 2022 May 16;

Antibodies to SARS-CoV-2 in patients with primary immunodeficiencies treated with nonspecific immunoglobulins.

Eguía J, Caballero-Rabasco MA, Cos ML, Grau S, Mellibovsky L, Villegas E, Blasco F, Lemus A, Crespo M, Padilla E, Gimeno R

Immunology. 2022 May 15;

Secondhand tobacco smoke and functional impairments in older adults living in the community.

Craciun OM, Ortolá R, Pascual JA, Pérez-Ortuño R, Galán Labaca I, Banegas JR, Rodríguez Artalejo F, García-Esquinas E

Nicotine Tob Res. 2022 May 15;

Short-term NO2 exposure and cognitive and mental health: A panel study based on a citizen science project in Barcelona, Spain.

Gignac F, Righi V, Toran R, Paz Errandonea L, Ortiz R, Mijling B, Naranjo A, Nieuwenhuijsen M, Creus J, Basagaña X

Environ Int. 2022 May 10;164:107284

Therapeutic drug monitoring of colistin in plasma and cerebrospinal fluid in meningoventriculitis caused by a carbapenem-resistant Enterobacter cloacae.

Acín P, Luque S, Sorli L, Grau S

Enferm Infecc Microbiol Clin (Engl Ed). 2022 May;40(5):277-278

Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases.

Bullich G, Matalonga L, Pujadas M, Papakonstantinou A, Piscia D, Tonda R, Artuch R, Gallano P, Garrabou G, González JR, Grinberg D, Guitart M, Laurie S, Lázaro C, Luengo C, Martí R, Milà M, Ovelleiro D, Parra G, Pujol A, Tizzano E, Macaya A, Palau F, Ribes A, Pérez-Jurado LA, Beltran S, Undiagnosed Rare Disease Program of Catalonia (URD-Cat) Consortium.

J Mol Diagn. 2022 May;24(5):529-542

Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study.

Atzeni A, Bastiaanssen TFS, Cryan JF, Tinahones FJ, Vioque J, Corella D, Fitó M, Vidal J, Moreno-Indias I, Gómez-Pérez AM, Torres-Collado L, Coltell O, Castañer O, Bulló M, Salas-Salvadó J

Front Endocrinol (Lausanne). 2022;13:804455

Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke?.

Frid P, Xu H, Mitchell BD, Drake M, Wasselius J, Gaynor B, Ryan K, Giese AK, Schirmer M, Donahue KL, Irie R, Bouts MJRJ, McIntosh EC, Mocking SJT, Dalca AV, Giralt-Steinhauer E, Holmegaard L, Jood K, Roquer J, Cole JW, McArdle PF, Broderick JP, Jimenez-Conde J,

J Stroke Cerebrovasc Dis. 2022 May 13;31(8):106546

What next? Expanding our view of city planning and global health, and implementing and monitoring evidence-informed policy.

Giles-Corti B, Moudon AV, Lowe M, Cerin E, Boeing G, Frumkin H, Salvo D, Foster S, Kleeman A, Bekessy S, de Sá TH, Nieuwenhuijsen M, Higgs C, Hinckson E, Adlakha D, Arundel J, Liu S, Oyeyemi AL, Nitvimol K, Sallis JF

Lancet Glob Health. 2022 Jun;10(6):e919-e926

Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease.

Visser PJ, Reus LM, Gobom J, Jansen I, Dicks E, van der Lee SJ, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuevo JL, Engelborghs S, Freund-Levi Y, Froelich L, Sleegers K, Dobricic V, Lovestone S, Streffer J, Vos SJB, Bos I, ADNI., Smit AB, Blennow K, Scheltens P, Teunissen CE, Bertram L, Zetterberg H, Tijms BM

Mol Neurodegener. 2022 May 13;17(1):37

IBRORS-MCL study: a Spanish retrospective and observational study of relapsed/refractory mantle-cell lymphoma treated with ibrutinib in routine clinical practice.

Sancho JM, Marín-Niebla A, Fernández S, Capote FJ, Cañigral C, Grande C, Donato E, Zeberio I, Puerta JM, Rivas A, Pérez-Ceballos E, Vale A, Martín García-Sancho A, Salar A, González-Barca E, Teruel A, Pastoriza C, Conde-Royo D, Sánchez-García J, Barrenetxea C, Arranz R, Hernández-Rivas JÁ, Ramírez MJ, Jiménez A, Rubio-Azpeitia E

Int J Hematol. 2022 May 13;

Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes.

Vicencio J, Sánchez-Bolaños C, Moreno-Sánchez I, Brena D, Vejnar CE, Kukhtar D, Ruiz-López M, Cots-Ponjoan M, Rubio A, Melero NR, Crespo-Cuadrado J, Carolis C, Pérez-Pulido AJ, Giráldez AJ, Kleinstiver BP, Cerón J, Moreno-Mateos MA

Nat Commun. 2022 May 12;13(1):2601

The early-life exposome modulates the effect of polymorphic inversions on DNA methylation.

Carreras-Gallo N, Cáceres A, Balagué-Dobón L, Ruiz-Arenas C, Andrusaityte S, Carracedo Á, Casas M, Chatzi L, Grazuleviciene R, Gutzkow KB, Lepeule J, Maitre L, Nieuwenhuijsen M, Slama R, Stratakis N, Thomsen C, Urquiza J, Wright J, Yang T, Escaramís G, Bustamante M, Vrijheid M, Pérez-Jurado LA, González JR

Commun Biol. 2022 May 12;5(1):455

Impact of cerebral blood flow and amyloid load on SUVR bias.

Heeman F, Yaqub M, Hendriks J, van Berckel BNM, Collij LE, Gray KR, Manber R, Wolz R, Garibotto V, Wimberley C, Ritchie C, Barkhof F, Gispert JD, Vállez García D, Lopes Alves I, Lammertsma AA, AMYPAD Consortium.

EJNMMI Res. 2022 May 12;12(1):29

Evaluation of a single-shot of a high-density viscoelastic solution of hyaluronic acid in patients with symptomatic primary knee osteoarthritis: the no-dolor study.

Calvet J, Khorsandi D, Tío L, Monfort J

BMC Musculoskelet Disord. 2022 May 11;23(1):442

Efficacy of niraparib by time of surgery and postoperative residual disease status: A post hoc analysis of patients in the PRIMA/ENGOT-OV26/GOG-3012 study.

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Gynecol Oncol. 2022 May 9;

The LP07 and LLC pre-clinical models of lung cancer present divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting.

Belcher DJ, de la Rosa Guitart M, Hain B, Kim HG, Waning D, Barreiro E, Nader GA

FASEB J. 2022 May;36 Suppl 1

Dose dependent effects of green tea extracts in the skeletal development of a Down syndrome mouse model.

Martínez Abadías N, Llambrich S, González R, Albaigès JM, Wouters J, Roldán J, Salassa S, Van Bulck V, Wouters K, Callaerts-Vegh Z, Sharpe J, Dierssen M, Vande Velde G

FASEB J. 2022 May;36 Suppl 1

Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage.

Matute-Blanch C, Brito V, Midaglia L, Villar LM, Garcia-Diaz Barriga G, Guzman de la Fuente A, Borrás E, Fernández-García S, Calvo-Barreiro L, Miguez A, Costa-Frossard L, Pinteac R, Sabidó E, Alberch J, Fitzgerald DC, Montalban X, Comabella M

Clin Transl Med. 2022 May;12(5):e837

Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non-redundant chemokine signaling.

Eiger DS, Smith J, Shi T, Stepniewski TM, Honeycutt C, Boldizsar N, Gardner J, Tsai CF, Nicora C, Moghieb A, Kawakami K, Choi I, Smith R, Inoue A, Selent J, Jacobs J, Rajagopal S

FASEB J. 2022 May;36 Suppl 1

Multi-organ Involvement in Non-pulmonary Sarcoidosis.

Vílchez-Oya F, Meraz-Ostíz JA, Carrión-Barberà I, Gonzàlez-Farré M, Carrión JA, Salman-Monte TC

Reumatol Clin (Engl Ed). 2022 May;18(5):309-311

Short-Term Mortality in Patients with Heart Failure at the End-of-Life Stages: Hades Study.

Muñoz MA, Calero E, Duran J, Navas E, Alonso S, Argemí N, Casademunt M, Furió P, Casajuana E, Torralba N, Farre N, Abellana R, Verdú-Rotellar JM, On Behalf Of Hades Study

J Clin Med. 2022 Apr 19;11(9)

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.

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Nat Genet. 2022 May;54(5):560-572

Comparison of rhinitis treatments using MASK-air® data and considering the Minimal Important Difference.

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Allergy. 2022 May 14;

Socioeconomic Status and Prognosis of Patients With ST-Elevation Myocardial Infarction Managed by the Emergency-Intervention "Codi IAM" Network.

Tizón-Marcos H, Vaquerizo B, Ferré JM, Farré N, Lidón RM, Garcia-Picart J, Regueiro A, Ariza A, Carrillo X, Duran X, Poirier P, Cladellas M, Camps-Vilaró A, Ribas N, Cubero-Gallego H, Marrugat J

Front Cardiovasc Med. 2022;9:847982

Auricular Transcutaneous Vagus Nerve Stimulation Acutely Modulates Brain Connectivity in Mice.

Brambilla-Pisoni C, Muñoz-Moreno E, Gallego-Amaro I, Maldonado R, Ivorra A, Soria G, Ozaita A

Front Cell Neurosci. 2022;16:856855

A Feasibility Study of Patients with Major Depression and Substance Use Disorders: Vortioxetine as Maintenance Treatment.

Basurte-Villamor I, Vega P, Roncero C, Martínez-Raga J, Grau-López L, Aguilar L, Torrens M, Szerman N

Neuropsychiatr Dis Treat. 2022;18:965-976

Does the patient-assisted compression mode affect the mammography quality? A within-woman randomized controlled trial.

Perez-Leon D, Posso M, Louro J, Ejarque B, Arranz M, Arenas N, Maiques J, Martínez J, Maciá F, Román M, Rodríguez-Arana A, Castells X, Alcántara R

Eur Radiol. 2022 May 10;

Comparison of technical parameters and women's experience between self-compression and standard compression modes in mammography screening: a single-blind randomized clinical trial.

Arenas N, Alcantara R, Posso M, Louro J, Perez-Leon D, Ejarque B, Arranz M, Maiques J, Castells X, Macià F, Román M, Rodríguez-Arana A

Eur Radiol. 2022 May 10;

Disinfection By-Products in Drinking Water and Bladder Cancer: Evaluation of Risk Modification by Common Genetic Polymorphisms in Two Case-Control Studies.

Beane Freeman LE, Kogevinas M, Cantor KP, Villanueva CM, Prokunina-Olsson L, Florez-Vargas O, Figueroa JD, Ward MH, Koutros S, Baris D, Garcia-Closas M, Schwenn M, Johnson A, Serra C, Tardon A, Garcia-Closas R, Carrato A, Malats N, Karagas MR, Rothman N, Silverman DT

Environ Health Perspect. 2022 May;130(5):57006

The genome sequence of the large tortoiseshell, Nymphalis polychloros (Linnaeus, 1758).

Lohse K, Laetsch D, Vila R, Darwin Tree of Life Barcoding collective., Wellcome Sanger Institute Tree of Life programme., Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective., Tree of Life Core Informatics collective., Darwin Tree of Life Consortium.

Wellcome Open Res. 2021;6:238

Patterns and correlates of patient-reported helpfulness of treatment for common mental and substance use disorders in the WHO World Mental Health Surveys.

Kessler RC, Kazdin AE, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Altwaijri YA, Andrade LH, Benjet C, Bharat C, Borges G, Bruffaerts R, Bunting B, de Almeida JMC, Cardoso G, Chiu WT, Cía A, Ciutan M, Degenhardt L, de Girolamo G, de Jonge P, de Vries YA, Florescu S, Gureje O, Haro JM, Harris MG, Hu C, Karam AN, Karam EG, Karam G, Kawakami N, Kiejna A, Kovess-Masfety V, Lee S, Makanjuola V, McGrath JJ, Medina-Mora ME, Moskalewicz J, Navarro-Mateu F, Nierenberg AA, Nishi D, Ojagbemi A, Oladeji BD, O'Neill S, Posada-Villa J, Puac-Polanco V, Rapsey C, Ruscio AM, Sampson NA, Scott KM, Slade T, Stagnaro JC, Stein DJ, Tachimori H, Ten Have M, Torres Y, Viana MC, Vigo DV, Williams DR, Wojtyniak B, Xavier M, Zarkov Z, Ziobrowski HN, WHO World Mental Health Survey collaborators.

World Psychiatry. 2022 Jun;21(2):272-286

Erratic spatiotemporal vegetation growth anomalies drive population outbreaks in a trans-Saharan insect migrant.

López-Mañas R, Pascual-Díaz JP, García-Berro A, Bahleman F, Reich MS, Pokorny L, Bataille CP, Vila R, Domingo-Marimon C, Talavera G

Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2121249119

Study protocol comparing the ethical, psychological and socio-economic impact of personalised breast cancer screening to that of standard screening in the "My Personal Breast Screening" (MyPeBS) randomised clinical trial.

Roux A, Cholerton R, Sicsic J, Moumjid N, French DP, Giorgi Rossi P, Balleyguier C, Guindy M, Gilbert FJ, Burrion JB, Castells X, Ritchie D, Keatley D, Baron C, Delaloge S, de Montgolfier S

BMC Cancer. 2022 May 6;22(1):507

Radiofrequency-assisted transection of the pancreas vs stapler in distal pancreatectomy: a propensity score matched cohort analysis.

Pueyo-Périz E, Téllez-Marquès C, Radosevic A, Morató O, Visa L, Ilzarbe L, Berjano E, de Vicente E, Poves I, Ielpo B, Grande L, Burdío F, Sánchez-Velázquez P

Sci Rep. 2022 May 6;12(1):7486

Evaluating the potential of polygenic risk score to improve colorectal cancer screening.

Arnau-Collell C, Díez-Villanueva A, Bellosillo B, Augé JM, Muñoz J, Guinó E, Moreira L, Serradesanferm A, Pozo À, Torà-Rocamora I, Bonjoch L, Ibáñez-Sanz G, Obón-Santacana M, Moratalla-Navarro F, Sanz-Pamplona R, Márquez Márquez C, Rueda Miret R, Pérez Berbegal R, Piquer Velasco G, Hernández Rodríguez C, Consortium C, Grau J, Castells A, Borràs JM, Bessa X, Moreno V, Castellví-Bel S

Cancer Epidemiol Biomarkers Prev. 2022 May 5;

Arrested coalescence of multicellular aggregates.

Oriola D, Marin-Riera M, Anlas K, Gritti N, Sanaki-Matsumiya M, Aalderink G, Ebisuya M, Sharpe J, Trivedi V

Soft Matter. 2022 May 5;

Heterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up.

Manouchehri M, Cea-Soriano L, Franch-Nadal J, Ruiz A, Goday A, Villanueva R, Diez-Espino J, Mata-Cases M, Giraldez-García C, Regidor E, PREDAPS Study Group.

Sci Rep. 2022 May 5;12(1):7373

Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.

Alfano R, Plusquin M, Robinson O, Brescianini S, Chatzi L, Keski-Rahkonen P, Handakas E, Maitre L, Nawrot T, Robinot N, Roumeliotaki T, Sassi F, Scalbert A, Vrijheid M, Vineis P, Richiardi L, Zugna D

Int J Obes (Lond). 2022 May 4;

Microbiota alterations in proline metabolism impact depression.

Mayneris-Perxachs J, Castells-Nobau A, Arnoriaga-Rodríguez M, Martin M, de la Vega-Correa L, Zapata C, Burokas A, Blasco G, Coll C, Escrichs A, Biarnés C, Moreno-Navarrete JM, Puig J, Garre-Olmo J, Ramos R, Pedraza S, Brugada R, Vilanova JC, Serena J, Gich J, Ramió-Torrentà L, Pérez-Brocal V, Moya A, Pamplona R, Sol J, Jové M, Ricart W, Portero-Otin M, Deco G, Maldonado R, Fernández-Real JM

Cell Metab. 2022 May 3;34(5):681-701.e10

Localized electrical stimulation triggers cell-type-specific proliferation in biofilms.

Comerci CJ, Gillman AL, Galera-Laporta L, Gutierrez E, Groisman A, Larkin JW, Garcia-Ojalvo J, Süel GM

Cell Syst. 2022 May 2;

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.

Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J, Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Muñoz-Cánoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby M, Cornall RJ, Mulder J, Uhlén M, Esteban MA, Li Y, Liu L, Xu X, Wang J

Cell. 2022 Apr 22;

Nursing Home Workers' Mental Health During the COVID-19 Pandemic in France.

Husky MM, Villeneuve R, Teguo MT, Alonso J, Bruffaerts R, Swendsen J, Amieva H

J Am Med Dir Assoc. 2022 Apr 7;

Consensus on the definition of disease control and response assessment in chronic urticaria.

Giménez-Arnau AM, Jáuregui I, Silvestre-Salvador JF, Valero A, Ferrer M, Sastre J, Ortiz de Frutos FJ, Labrador-Horrillo M, Bartra J, Miquel Miquel J

J Investig Allergol Clin Immunol. 2022 May 2;:0

Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units.

Torres A, Motos A, Ceccato A, Bermejo-Martin J, de Gonzalo-Calvo D, Pérez R, Barroso M, Pascual IZ, Gonzalez J, Fernández-Barat L, Ferrer R, Riera J, García-Gasulla D, Peñuelas O, Lorente JÁ, Almansa R, Menéndez R, Kiarostami K, Canseco J, Villar RA, Añón JM, Mariño AB, Barberà C, Barberán J, Ortiz AB, Boado MV, Bustamante-Munguira E, Caballero J, Cantón-Bulnes ML, Pérez CC, Carbonell N, Catalán-González M, de Frutos R, Franco N, Galbán C, Gumucio-Sanguino VD, Torre MDC, Díaz E, Estella Á, Gallego E, Garmendia JLG, Gómez JM, Huerta A, García RNJ, Loza-Vázquez A, Marin-Corral J, Delgado MCM, Gándara AM, Varela IM, Messa JL, Albaiceta GM, Nieto M, Novo MA, Peñasco Y, Pérez-García F, Pozo-Laderas JC, Ricart P, Sagredo V, Sánchez-Miralles Á, Chinesta SS, Serra-Fortuny M, Socias L, Solé-Violan J, Suárez-Sipmann F, Lomas LT, Trenado J, Úbeda A, Valdivia LJ, Vidal P, Barbé F, CIBERESUCICOVID Project (COV20/00110, ISCIII).

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Variability in Phelan-McDermid Syndrome in a Cohort of 210 Individuals.

Nevado J, García-Miñaúr S, Palomares-Bralo M, Vallespín E, Guillén-Navarro E, Rosell J, Bel-Fenellós C, Mori MÁ, Milá M, Del Campo M, Barrúz P, Santos-Simarro F, Obregón G, Orellana C, Pachajoa H, Tenorio JA, Galán E, Cigudosa JC, Moresco A, Saleme C, Castillo S, Gabau E, Pérez-Jurado L, Barcia A, Martín MS, Mansilla E, Vallcorba I, García-Murillo P, Cammarata-Scalisi F, Gonçalves Pereira N, Blanco-Lago R, Serrano M, Ortigoza-Escobar JD, Gener B, Seidel VA, Tirado P, Lapunzina P, Spanish PMS Working Group.

Front Genet. 2022;13:652454

Human herpesvirus diversity is altered in HLA class I binding peptides.

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Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2123248119

Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1.

Ten-Blanco M, Flores Á, Pereda-Pérez I, Piscitelli F, Izquierdo-Luengo C, Cristino L, Romero J, Hillard CJ, Maldonado R, Di Marzo V, Berrendero F

Biomed Pharmacother. 2022 May;149:112925

Mental impact of Covid-19 among Spanish healthcare workers. A large longitudinal survey.

Alonso J, Vilagut G, Alayo I, Ferrer M, Amigo F, Aragón-Peña A, Aragonès E, Campos M, Del Cura-González I, Urreta I, Espuga M, González Pinto A, Haro JM, López Fresneña N, Martínez de Salázar A, Molina JD, Ortí Lucas RM, Parellada M, Pelayo-Terán JM, Pérez Zapata A, Pijoan JI, Plana N, Puig MT, Rius C, Rodriguez-Blazquez C, Sanz F, Serra C, Kessler RC, Bruffaerts R, Vieta E, Pérez-Solá V, Mortier P, MINDCOVID Working group.

Epidemiol Psychiatr Sci. 2022 Apr 29;31:e28

Seasonal changes in membrane structure and excitability in retinal neurons of goldfish (Carassius auratus) under constant environmental conditions.

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J Exp Biol. 2022 Apr 29;

Periodic formation of epithelial somites from human pluripotent stem cells.

Sanaki-Matsumiya M, Matsuda M, Gritti N, Nakaki F, Sharpe J, Trivedi V, Ebisuya M

Nat Commun. 2022 Apr 28;13(1):2325

Circulating microRNA profiling is altered in the acute respiratory distress syndrome related to SARS-CoV-2 infection.

Garcia-Giralt N, Du J, Marin-Corral J, Bódalo-Torruella M, Blasco-Hernando F, Muñoz-Bermúdez R, Clarós M, Nonell L, Perera-Bel J, Fernandez-González M, Nogues X, Sorli-Redó L, Güerri-Fernández R

Sci Rep. 2022 Apr 28;12(1):6929

Tension hones body segmentation around the clock.

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Nature. 2022 Apr 27;

The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians.

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PLoS Biol. 2022 Apr 27;20(4):e3001615

Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS.

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Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes.

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Nature. 2022 Apr 26;

Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year.

Domínguez-López I, Arancibia-Riveros C, Casas R, Tresserra-Rimbau A, Razquin C, Martínez-González MÁ, Hu FB, Ros E, Fitó M, Estruch R, López-Sabater MC, Lamuela-Raventós RM

Biomed Pharmacother. 2022 Apr 25;150:113028

Loss of Arid1a and Pten in pancreatic ductal cells induces intraductal tubulopapillary neoplasm via the YAP/TAZ pathway.

Fukunaga Y, Fukuda A, Omatsu M, Namikawa M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Ferrer J, Tsuruyama T, Masui T, Hatano E, Seno H

Gastroenterology. 2022 Apr 25;

Usefulness of telemedicine-based heart failure monitoring according to 'eHealth literacy' domains: Insights from the iCOR randomized controlled trial.

Yun S, Enjuanes C, Calero-Molina E, Hidalgo E, José-Bazán N, Ruiz M, Verdú-Rotellar JM, Garcimartín P, Jiménez-Marrero S, Garay A, Ras M, Ramos R, Pons-Riverola A, Moliner P, Corbella X, Comín-Colet J

Eur J Intern Med. 2022 Apr 25;

Waiting time from identification to recognition an occupational disease in Spain.

Pelegrí A, Serra C, Ramada JM, Palma-Vásquez C, Benavides FG

Gac Sanit. 2022 Apr 24;

Ceftaroline removal during plasmapheresis.

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Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150.000 European children.

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Need for Conversion Reduces the Benefits of Laparoscopic Approach for Adhesive Small Bowel Obstruction. A Propensity-Score Matching Analysis.

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Kidney transplantation reduces the risk of chronic limb threatening ischemia and amputation among patients with end-stage renal disease on hemodialysis.

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Pascal R, Crovetto F, Casas I, Youssef L, Trilla C, Larroya M, Cahuana A, Boada D, Foraster M, Llurba E, Sunyer J, Crispi F, Gratacos E, Gómez-Roig MD

J Clin Med. 2022 Apr 15;11(8)

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Cardiac Tomography and Cardiac Magnetic Resonance to Predict the Absence of Intracardiac Thrombus in Anticoagulated Patients Undergoing Atrial Fibrillation Ablation.

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Eur J Breast Health. 2022 Apr;18(2):182-189

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide-Porphyrin Conjugates.

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Presentation of the UNIA FORUM on Workplace Safety and Health "Telework, reality and regulation: from protection to the health of workers". La Rábida, Huelva (Spain), November 2021.

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An interventional nationwide surveillance program lowers postoperative infection rates in elective colorectal surgery. A cohort study (2008-2019).

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Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans.

Guimier A, Pontual L, Braddock SR, Torti E, Pérez-Jurado LA, Muñoz-Cabello P, Arumí M, Monaghan KG, Lee H, Wang LK, Pluym ID, Lynch SA, Stals K, Ellard S, Muller C, Houyel L, Cohen L, Lyonnet S, Bajolle F, Amiel J, Gordon CT

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Expression of Huntingtin and TDP-43 Derivatives in Fission Yeast Can Cause Both Beneficial and Toxic Effects.

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Cytogenetics in Chronic Lymphocytic Leukemia: ERIC Perspectives and Recommendations.

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Genetic Analysis in a Familial Case With High Bone Mineral Density Suggests Additive Effects at Two Loci.

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Randomized Controlled Trial Comparing a Multidisciplinary Intervention by a Geriatrician and a Cardiologist to Usual Care after a Heart Failure Hospitalization in Older Patients: The SENECOR Study.

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Minardi D, Ryder D, Del Campo J, Garcia Fonseca V, Kerr R, Mortensen S, Pallavicini A, Bass D

Mol Ecol Resour. 2022 Feb;22(2):664-678

Selection still shapes our genome.

Lao O

Nat Hum Behav. 2021 Dec;5(12):1600-1601

Fine-scale population structure in five rural populations from the Spanish Eastern Pyrenees using high-coverage whole-genome sequence data.

Maceda I, Álvarez MM, Athanasiadis G, Tonda R, Camps J, Beltran S, Camps A, Fàbrega J, Felisart J, Grané J, Remón JL, Serra J, Moral P, Lao O

Eur J Hum Genet. 2021 Oct;29(10):1557-1565

Characterization of new cristamonad species from kalotermitid termites including a novel genus, Runanympha.

Singh RA, Boscaro V, James ER, Karnkowska A, Kolisko M, Gavelis GS, Okamoto N, Del Campo J, Fiorito R, Hehenberger E, Irwin NAT, Mathur V, Scheffrahn RH, Keeling PJ

Sci Rep. 2021 Mar 31;11(1):7270

Exploring the Contribution to ADHD of Genes Involved in Mendelian Disorders Presenting with Hyperactivity and/or Inattention.

Fernàndez-Castillo N, Cabana-Domínguez J, Kappel DB, Torrico B, Weber H, Lesch KP, Lao O, Reif A, Cormand B

Genes (Basel). 2021 Dec 30;13(1)

Analysis of the Batch Effect Due to Sequencing Center in Population Statistics Quantifying Rare Events in the 1000 Genomes Project.

Maceda I, Lao O

Genes (Basel). 2021 Dec 24;13(1)

The genomic history of the Aegean palatial civilizations.

Clemente F, Unterländer M, Dolgova O, Amorim CEG, Coroado-Santos F, Neuenschwander S, Ganiatsou E, Cruz Dávalos DI, Anchieri L, Michaud F, Winkelbach L, Blöcher J, Arizmendi Cárdenas YO, Sousa da Mota B, Kalliga E, Souleles A, Kontopoulos I, Karamitrou-Mentessidi G, Philaniotou O, Sampson A, Theodorou D, Tsipopoulou M, Akamatis I, Halstead P, Kotsakis K, Urem-Kotsou D, Panagiotopoulos D, Ziota C, Triantaphyllou S, Delaneau O, Jensen JD, Moreno-Mayar JV, Burger J, Sousa VC, Lao O, Malaspinas AS, Papageorgopoulou C

Cell. 2021 May 13;184(10):2565-2586.e21

Personalized antimicrobial therapy in critical and elderly patients.

Grau S, De Antonio-Cuscó M, Ortonobes-Roig S, Los-Arcos I, Jiménez MJ, Soy D

Farm Hosp. 2021 Dec 22;45(7):64-76

Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates: a randomized clinical trial.

Maya-Enero S, Fàbregas-Mitjans M, Llufriu-Marquès RM, Candel-Pau J, Garcia-Garcia J, López-Vílchez MÁ

World J Pediatr. 2022 Apr 4;

New Synthetic Opioids Use among Patients in Treatment for an Opioid Use Disorder in Barcelona.

Alías-Ferri M, Marchei E, Pacifici R, Pichini S, Pellegrini M, Pérez-Mañá C, Papaseit E, Muga R, Fonseca F, Farré M, Torrens M

Eur Addict Res. 2022 Apr 4;:1-8

Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk.

Valle-Hita C, Díaz-López A, Becerra-Tomás N, Martínez-González MA, García VR, Corella D, Goday A, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Cano-Ibáñez N, Tur JA, Rubín-García M, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Fontao SM, Daimiel L, Ros E, Toledo E, Sorlí JV, Roca C, Abete I, Moreno-Rodriguez A, Crespo-Oliva E, Candela-García I, Morey M, Garcia-Rios A, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Diez-Espino J, Ortega-Azorín C, Comas M, Zulet MA, Sorto-Sanchez C, Ruiz-Canela M, Fitó M, Salas-Salvadó J, Babio N

Eur J Nutr. 2022 Apr 2;

Muscle is a stage, and cells and factors are merely players.

Roman W, Muñoz-Cánoves P

Trends Cell Biol. 2022 Apr 1;

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.

Jami ES, Hammerschlag AR, Ip HF, Allegrini AG, Benyamin B, Border R, Diemer EW, Jiang C, Karhunen V, Lu Y, Lu Q, Mallard TT, Mishra PP, Nolte IM, Palviainen T, Peterson RE, Sallis HM, Shabalin AA, Tate AE, Thiering E, Vilor-Tejedor N, Wang C, Zhou A, Adkins DE, Alemany S, Ask H, Chen Q, Corley RP, Ehli EA, Evans LM, Havdahl A, Hagenbeek FA, Hakulinen C, Henders AK, Hottenga JJ, Korhonen T, Mamun A, Marrington S, Neumann A, Rimfeld K, Rivadeneira F, Silberg JL, van Beijsterveldt CE, Vuoksimaa E, Whipp AM, Xiaoran T, Andreassen OA, Boomsma DI, Brown SA, Burt SA, Copeland W, Dick DM, Harden KP, Harris KM, Hartman CA, Heinrich J, Hewitt JK, Hopfer C, Hypponen E, Jarvelin MR, Kaprio J, Keltikangas-Järvinen L, Klump KL, Krauter K, Kuja-Halkola R, Larsson H, Lehtimäki T, Lichtenstein P, Lundström S, Maes HH, Magnus P, Munafò MR, Najman JM, Njølstad PR, Oldehinkel AJ, Pennell CE, Plomin R, Reichborn-Kjennerud T, Reynolds C, Rose RJ, Smolen A, Snieder H, Stallings M, Standl M, Sunyer J, Tiemeier H, Wadsworth SJ, Wall TL, Whitehouse AJO, Williams GM, Ystrøm E, Nivard MG, Bartels M, Middeldorp CM

J Am Acad Child Adolesc Psychiatry. 2022 Mar 30;

Impacts of changes in environmental exposures and health behaviours due to the COVID-19 pandemic on cardiovascular and mental health: A comparison of Barcelona, Vienna, and Stockholm.

Koch S, Khomenko S, Cirach M, Ubalde-Lopez M, Baclet S, Daher C, Hidalgo L, Lõhmus M, Rizzuto D, Rumpler R, Susilo Y, Venkataraman S, Wegener S, Wellenius GA, Woodcock J, Nieuwenhuijsen M

Environ Pollut. 2022 Mar 29;:119124

In Silico Approaches In Carcinogenicity Hazard Assessment: Current Status and Future Needs.

Tice RR, Bassan A, Amberg A, Anger LT, Beal MA, Bellion P, Benigni R, Birmingham J, Brigo A, Bringezu F, Ceriani L, Crooks I, Cross K, Elespuru R, Faulkner DM, Fortin MC, Fowler P, Frericks M, Gerets HHJ, Jahnke GD, Jones DR, Kruhlak NL, Lo Piparo E, Lopez-Belmonte J, Luniwal A, Luu A, Madia F, Manganelli S, Manickam B, Mestres J, Mihalchik-Burhans AL, Neilson L, Pandiri A, Pavan M, Rider CV, Rooney JP, Trejo-Martin A, Watanabe-Sailor KH, White AT, Woolley D, Myatt GJ

Comput Toxicol. 2021 Nov;20

Respiratory physiotherapy in Lady Windermere syndrome: The missing link?

Balañá Corberó A, Domínguez-Álvarez M, Barreiro E

Arch Bronconeumol. 2020 Oct;56(10):619-620

Statistically Significant or Clinically Important?

Santibáñez M, García-Rivero JL, Barreiro E

Arch Bronconeumol. 2020 Oct;56(10):615-616

Descriptive Study of the Effect of Methodology in the Measurement of Sniff Nasal Inspiratory Pressure (SNIP) in a Healthy Population.

Balañá Corberó A, Admetllo M, Sancho-Muñoz A, Alvarado M, Gea J, Ausin P, Martínez Llorens J

Arch Bronconeumol. 2020 Jun;56(6):398-399

Endoscopic Diagnosis of Small Cell Lung Carcinoma and Follicular Thyroid Cancer.

Bellido-Calduch S, Martín-Ontiyuelo C, Pijuan L, Puig de Dou J, Suárez-Piñera M, Curull V, Sánchez-Font A

Arch Bronconeumol. 2020 May;56(5):328-329

BDNF and Cortisol in the Diagnosis of Cocaine-Induced Depression.

Fonseca F, Mestre-Pinto JI, Rodríguez-Minguela R, Papaseit E, Pérez-Mañá C, Langohr K, Barbuti M, Farré M, Torrens M, NEURODEP GROUP.

Front Psychiatry. 2022;13:836771

A high-quality, long-read genome assembly of the endangered ring-tailed lemur (Lemur catta).

Palmada-Flores M, Orkin JD, Haase B, Mountcastle J, Bertelsen MF, Fedrigo O, Kuderna LFK, Jarvis ED, Marques-Bonet T

Gigascience. 2022 Apr 1;11

Author Correction: Understanding signatures of positive natural selection in human zinc transporter genes.

Roca-Umbert A, Caro-Consuegra R, Londono-Correa D, Rodriguez-Lozano GF, Vicente R, Bosch E

Sci Rep. 2022 Mar 30;12(1):5378

Setting the European environment and health research agenda -under-researched areas and solution-oriented research.

Huss A, Peters A, Zhao T, Barouki R, Kogevinas M, Vermeulen R, Matthies-Wiesler F

Environ Int. 2022 Mar 28;163:107202

Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:

Latest news


Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar


UPF Business Shuttle and Innovation Unit


Technology and Business Development Office at the CRG


Analysis and Global Development at ISGlobal


EMBLEM Technology Transfer


  • The following start-ups have been created within the PRBB environment:


Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.



Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.



qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.



ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.



Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.



World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.


Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.


MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.



A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.


Integra Therapeutics

Integra Therapeutics, a spin-off company from MELIS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.


Latest news