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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.


Hospital del Mar Medical Research Institute (IMIM)

Cancer

The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 

Neuroscience

The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry. 


Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.

Radiation

The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.

Other

ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.


Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:

⟶ recercaambanimals.prbb.org

⟶ estabulari-prbb@prbb.org

⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news


Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza
marbiobanc@imim.es

Web:
https://marbiobanc.imim.es

The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko
biocore@crg.eu

Web:
https://biocore.crg.eu

The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut
projectmanager@cnag.crg.eu

Web:
https://www.cnag.crg.eu

This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet
bespinet@parcdesalutmar.cat

Web:
https://www.imim.es/sct/citogen_tica

This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas
oscar.fornas@upf.edu

Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit

The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.

Contact: Dirección de secretaría
ceea@prbb.org

Web:
https://www.prbb.org/ciencia.php#Animalario

This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis
bmspt@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit

Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop
CEIC-PSMAR@imim.es

Web:
https://www.imim.es/comitesetics/ceic/es_index.html

The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría
cbs@prbb.org

Web:
https://www.prbb.org (Acceso: Portal PRBB)

BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso
bibliopro@imim.es

Web:
https://www.bibliopro.org

The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro
helpdesk@ega-archive.org

Web:
https://ega-archive.org

This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht
ngs@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/genomics-unit

The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà
margenomics@imim.es

Web:
https://margenomics.imim.es

The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals
genomica@upf.edu

Web:
https://www.upf.edu/web/sct-genomics/home

The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera
laura.batlle@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0

This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea
aaldea@imim.es

Web:
https://www.imim.es/ofertadeserveis/assajos_clinics

This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger
mif@embl.es

Web:
https://www.embl.es/services/mesoscopic-imaging-facility

The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi
nadia.halidi@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit

Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu
david.andreu@upf.edu

Web:
https://www.upf.edu/web/sct-peptide-synthesis

This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade
eduard.sabido@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit


Scientific publications
(keywords, journal, author,...)

Loss of humoral response 3 months after SARS-CoV-2 vaccination in the CKD spectrum: the multicentric SENCOVAC study.

Quiroga B, Soler MJ, Ortiz A, ... , Crespo M, et. al.

Nephrol Dial Transplant. 2022 Jan 11;

http://www.ncbi.nlm.nih.gov/en...

Addition of Immune Checkpoint Inhibitors to Chemotherapy vs Chemotherapy Alone as First-Line Treatment in Extensive-Stage Small-Cell Lung Carcinoma: A Systematic Review and Meta-Analysis.

Arriola E, González-Cao M, Domine M, De Castro J, Cobo M, Bernabé R, Navarro A, Sullivan I, Trigo JM, Mosquera J, Crama L, Isla D

Oncol Ther. 2022 Jan 15;

http://www.ncbi.nlm.nih.gov/en...

Laparoscopic glissonean pedicle approach: step by step video description of the technique from different centres (with video).

Ielpo B, Giuliani A, Sanchez P, Burdio F, Gastaka M, Di Martino M, Podda M, Lopez-Ben S, Siragusa L, Pellino G, Anselmo A

Updates Surg. 2022 Jan 13;

http://www.ncbi.nlm.nih.gov/en...

Ecological network complexity scales with area.

Galiana N, Lurgi M, Bastazini VAG, Bosch J, Cagnolo L, Cazelles K, Claramunt-López B, Emer C, Fortin MJ, Grass I, Hernández-Castellano C, Jauker F, Leroux SJ, McCann K, McLeod AM, Montoya D, Mulder C, Osorio-Canadas S, Reverté S, Rodrigo A, Steffan-Dewenter I, Traveset A, Valverde S, Vázquez DP, Wood SA, Gravel D, Roslin T, Thuiller W, Montoya JM

Nat Ecol Evol. 2022 Jan 13;

http://www.ncbi.nlm.nih.gov/en...

Co-creating a local environmental epidemiology study: the case of citizen science for investigating air pollution and related health risks in Barcelona, Spain.

Gignac F, Righi V, Toran R, Errandonea LP, Ortiz R, Nieuwenhuijsen M, Creus J, Basagaña X, Balestrini M

Environ Health. 2022 Jan 12;21(1):11

http://www.ncbi.nlm.nih.gov/en...

Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers.

Moncunill G, Aguilar R, Ribes M, Ortega N, Rubio R, Salmerón G, Molina MJ, Vidal M, Barrios D, Mitchell RA, Jiménez A, Castellana C, Hernández-Luis P, Rodó P, Méndez S, Llupià A, Puyol L, Rodrigo Melero N, Carolis C, Mayor A, Izquierdo L, Varela P, Trilla A, Vilella A, Barroso S, Angulo A, Engel P, Tortajada M, García-Basteiro AL, Dobaño C

EBioMedicine. 2022 Jan 11;75:103805

http://www.ncbi.nlm.nih.gov/en...

Prognostic Value of Clinical Staging According to TNM in Patients With SCLC: A Real-World Surveillance Epidemiology and End-Results Database Analysis.

Arriola E, Trigo JM, Sánchez-Gastaldo A, Navarro A, Perez C, Crama L, Ponce-Aix S

JTO Clin Res Rep. 2022 Jan;3(1):100266

http://www.ncbi.nlm.nih.gov/en...

Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells.

La Greca A, Bellora N, Le Dily F, Jara R, Nacht AS, Quilez Oliete J, Villanueva JL, Vidal E, Merino G, Fresno C, Tarifa Reischle I, Vallejo G, Vicent GP, Fernández E, Beato M, Saragüeta P

Elife. 2022 Jan 12;11

http://www.ncbi.nlm.nih.gov/en...

Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1.

Avolio R, Inglés-Ferrándiz M, Ciocia A, Coll O, Bonnin S, Guitart T, Ribó A, Gebauer F

Cell Rep. 2022 Jan 11;38(2):110211

http://www.ncbi.nlm.nih.gov/en...

Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial.

Radosevic A, Quesada R, Serlavos C, Sánchez J, Zugazaga A, Sierra A, Coll S, Busto M, Aguilar G, Flores D, Arce J, Maiques JM, Garcia-Retortillo M, Carrion JA, Visa L, Villamonte M, Pueyo E, Berjano E, Trujillo M, Sánchez-Velázquez P, Grande L, Burdio F

Sci Rep. 2022 Jan 10;12(1):316

http://www.ncbi.nlm.nih.gov/en...

Diagnosis of Genetic White Matter Disorders by Singleton Whole-Exome and Genome Sequencing Using Interactome-Driven Prioritization.

Schlüter A, Rodríguez-Palmero A, Verdura E, Vélez-Santamaría V, Ruiz M, Fourcade S, Planas-Serra L, Martínez JJ, Guilera C, Girós M, Artuch R, Yoldi ME, O'Callaghan M, García-Cazorla A, Armstrong J, Marti I, Rezola EM, Redin C, Mandel JL, Conejo D, Sierra-Córcoles C, Beltran S, Gut M, Vázquez E, Del Toro M, Troncoso M, Pérez-Jurado LA, Gutiérrez-Solana LG, López de Munain A, Casasnovas C, Aguilera-Albesa S, Macaya A, Pujol A, GWMD working group.

Neurology. 2022 Jan 10;

http://www.ncbi.nlm.nih.gov/en...

Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review.

Pisanu C, Severino G, De Toma I, Dierssen M, Fusar-Poli P, Gennarelli M, Lio P, Maffioletti E, Maron E, Mehta D, Minelli A, Potier MC, Serretti A, Stacey D, van Westrhenen R, Xicota L, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network., Baune BT, Squassina A

Eur Neuropsychopharmacol. 2022 Jan 8;55:112-157

http://www.ncbi.nlm.nih.gov/en...

Diagnostic Accuracy and Detection Rate of Glaucoma Screening with Optic Disk Photos, Optical Coherence Tomography Images, and Telemedicine.

Anton A, Nolivos K, Pazos M, Fatti G, Ayala ME, Martínez-Prats E, Peral O, Poposki V, Tsiroukis E, Morilla-Grasa A, Comas M, Castells X

J Clin Med. 2021 Dec 31;11(1)

http://www.ncbi.nlm.nih.gov/en...

ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome.

Martin-Loeches I, Motos A, Menéndez R, Gabarrús A, González J, Fernández-Barat L, Ceccato A, Pérez-Arnal R, García-Gasulla D, Ferrer R, Riera J, Lorente JÁ, Peñuelas Ó, Bermejo-Martin JF, Gonzalo-Calvo D, Rodríguez A, Barbé F, Aguilera L, Amaya-Villar R, Barberà C, Barberán J, Blandino Ortiz A, Bustamante-Munguira E, Caballero J, Carbajales C, Carbonell N, Catalán-González M, Galbán C, Gumucio-Sanguino VD, de la Torre MDC, Díaz E, Gallego E, García Garmendia JL, Garnacho-Montero J, Gómez JM, Jorge García RN, Loza-Vázquez A, Marín-Corral J, Martínez de la Gándara A, Martínez Varela I, Lopez Messa J, Albaiceta GM, Novo MA, Peñasco Y, Ricart P, Urrelo-Cerrón L, Sánchez-Miralles A, Sancho Chinesta S, Socias L, Solé-Violan J, Tamayo Lomas L, Vidal P, Torres A

J Clin Med. 2021 Dec 31;11(1)

http://www.ncbi.nlm.nih.gov/en...

Recent Advances in the Genetic of MALT Lymphomas.

Rodríguez-Sevilla JJ, Salar A

Cancers (Basel). 2021 Dec 30;14(1)

http://www.ncbi.nlm.nih.gov/en...

Prospective Association of Maternal Educational Level with Child's Physical Activity, Screen Time, and Diet Quality.

Cárdenas-Fuentes G, Homs C, Ramírez-Contreras C, Juton C, Casas-Esteve R, Grau M, Aguilar-Palacio I, Fitó M, Gomez SF, Schröder H

Nutrients. 2021 Dec 30;14(1)

http://www.ncbi.nlm.nih.gov/en...

Endothelial ADAM17 Expression in the Progression of Kidney Injury in an Obese Mouse Model of Pre-Diabetes.

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Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy.

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Genome Biol Evol. 2022 Jan 6;

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Initiation of the Primate Genome Project.

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Proc Natl Acad Sci U S A. 2022 Jan 11;119(2)

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Study of risk factors for healthcare-associated infections in acute cardiac patients using categorical principal component analysis (CATPCA).

Renes Carreño E, Escribá Bárcena A, Catalán González M, Álvarez Lerma F, Palomar Martínez M, Nuvials Casals X, Jaén Herreros F, Montejo González JC

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Noninvasive Prediction of Outcomes in Autoimmune Hepatitis-Related Cirrhosis.

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PlayMolecule Glimpse: Understanding Protein-Ligand Property Predictions with Interpretable Neural Networks.

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Uncovering the impacts of alternative splicing on the proteome with current omics techniques.

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Wiley Interdiscip Rev RNA. 2022 Jan 3;:e1707

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Frailty in kidney transplant candidates: a comparison between physical frailty phenotype and FRAIL scales.

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Establishing a Cell-Free Transcription-Translation Platform for Cutibacterium acnes to Prototype Engineered Metabolic and Synthetic Biology.

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New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia.

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BMJ Open. 2021 Dec 31;11(12):e052897

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Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study.

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Regulation of insulin-like peptide expression in adult Blattella germanica females.

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Insect Biochem Mol Biol. 2021 Dec 30;:103706

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Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis.

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Environ Pollut. 2021 Dec 29;:118765

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Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol.

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Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 29;:110508

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DNA Damage Protection for Enhanced Bacterial Survival Under Simulated Low Earth Orbit Environmental Conditions in Escherichia coli.

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Guidelines for diagnosis, prevention and treatment of hand eczema.

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Contact Dermatitis. 2021 Dec 30;

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The COVID-19 pandemic as a starting point to accelerate improvements in health in our cities through better urban and transport planning.

Nieuwenhuijsen MJ, Hahad O, Münzel T

Environ Sci Pollut Res Int. 2021 Dec 29;

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Transposable element variants and their potential adaptive impact in urban populations of the malaria vector Anopheles coluzzii.

Vargas-Chavez C, Longo Pendy NM, Nsango SE, Aguilera L, Ayala D, González J

Genome Res. 2021 Dec 29;

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Cutaneous Involvement of Angioimmunoblastic T-Cell Lymphoma Masquerading as B-Cell Reactive Lymphoid Hyperplasia.

Pesqué D, Marcantonio O, Vázquez I, Papaleo N, Sánchez-González B, Gallardo F, Colomo L, Pujol RM

Am J Dermatopathol. 2021 Dec 28;

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Transition Therapy: Tackling the Ecology of Tumor Phenotypic Plasticity.

Aguadé-Gorgorió G, Kauffman S, Solé R

Bull Math Biol. 2021 Dec 27;84(1):24

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Correction to: Origins, admixture and founder lineages in European Roma.

Martínez-Cruz B, Mendizabal I, Harmant C, de Pablo R, Ioana M, Angelicheva D, Kouvatsi A, Makukh H, Netea MG, Pamjav H, Zalán A, Tournev I, Marushiakova E, Popov V, Bertranpetit J, Kalaydjieva L, Quintana-Murci L, Comas D, and the Genographic Consortium.

Eur J Hum Genet. 2021 Dec 24;

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Pustular frontal fibrosing alopecia: a new variant within the folliculitis decalvans and lichen planopilaris phenotypic spectrum?

Lobato-Berezo A, González-Farré M, Pujol RM

Br J Dermatol. 2021 Dec 23;

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Predicting disease variants using biodiversity and machine learning.

Arnedo-Pac C, Lopez-Bigas N, Muiños F

Nat Biotechnol. 2021 Dec 23;

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Ecological specialization, rather than the island effect, explains morphological diversification in an ancient radiation of geckos.

Tejero-Cicuéndez H, Simó-Riudalbas M, Menéndez I, Carranza S

Proc Biol Sci. 2021 Dec 22;288(1965):20211821

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Prenatal exposure to phthalates and phenols and preclinical vascular health during early adolescence.

Montazeri P, Fossati S, Warembourg C, Casas M, Clemente DBP, Garcia-Esteban R, Nawrot TS, Vrijheid M

Int J Hyg Environ Health. 2021 Dec 21;240:113909

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Postural effect of vestibular galvanic stimulation in patients with Parkinson's disease and camptocormia: Case series.

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Rehabilitacion (Madr). 2021 Dec 20;

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Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease.

Barrios V, Chowen JA, Martín-Rivada Á, Guerra-Cantera S, Pozo J, Yakar S, Rosenfeld RG, Pérez-Jurado LA, Suárez J, Argente J

Cells. 2021 Dec 18;10(12)

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Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells.

Peralta-Garcia A, Torrens-Fontanals M, Stepniewski TM, Grau-Expósito J, Perea D, Ayinampudi V, Waldhoer M, Zimmermann M, Buzón MJ, Genescà M, Selent J

Int J Mol Sci. 2021 Dec 18;22(24)

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Myocardial Injury as a Prognostic Factor in Mid- and Long-Term Follow-Up of COVID-19 Survivors.

Izquierdo A, Mojón D, Bardají A, Carrasquer A, Calvo-Fernández A, Carreras-Mora J, Giralt T, Pérez-Fernández S, Farré N, Soler C, Solà-Richarte C, Cabero P, Vaquerizo B, Marrugat J, Ribas N

J Clin Med. 2021 Dec 16;10(24)

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Modification of High-Density Lipoprotein Functions by Diet and Other Lifestyle Changes: A Systematic Review of Randomized Controlled Trials.

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J Clin Med. 2021 Dec 15;10(24)

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Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome.

White AE, de-Dios T, Carrión P, Bonora GL, Llovera L, Cilli E, Lizano E, Khabdulina MK, Tleugabulov DT, Olalde I, Marquès-Bonet T, Balloux F, Pettener D, van Dorp L, Luiselli D, Lalueza-Fox C

Biology (Basel). 2021 Dec 14;10(12)

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Targeted Therapy Modulates the Secretome of Cancer-Associated Fibroblasts to Induce Resistance in HER2-Positive Breast Cancer.

Luque M, Sanz-Álvarez M, Santamaría A, Zazo S, Cristóbal I, de la Fuente L, Mínguez P, Eroles P, Rovira A, Albanell J, Madoz-Gúrpide J, Rojo F

Int J Mol Sci. 2021 Dec 10;22(24)

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Transdiagnostic Perspective of Impulsivity and Compulsivity in Obesity: From Cognitive Profile to Self-Reported Dimensions in Clinical Samples with and without Diabetes.

Testa G, Mora-Maltas B, Camacho-Barcia L, Granero R, Lucas I, Agüera Z, Jiménez-Murcia S, Baños R, Bertaina-Anglade V, Botella C, Bulló M, Casanueva FF, Dalsgaard S, Fernández-Real JM, Franke B, Frühbeck G, Fitó M, Gómez-Martínez C, Pintó X, Poelmans G, Tinahones FJ, Torre R, Salas-Salvadó J, Serra-Majem L, Vos S, Wimberley T, Fernández-Aranda F

Nutrients. 2021 Dec 10;13(12)

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Chronic urticaria patients are interested in apps to monitor their disease activity and control: A UCARE CURICT analysis.

Cherrez-Ojeda I, Vanegas E, Cherrez A, Felix M, Weller K, Magerl M, Maurer RR, Mata VL, Kasperska-Zajac A, Sikora A, Fomina D, Kovalkova E, Godse K, Rao ND, Khoshkhui M, Rastgoo S, Criado RFJ, Abuzakouk M, Grandon D, Van Doorn MBA, Rodrigues Valle SO, De Souza Lima EM, Thomsen SF, Ramón GD, Matos Benavides EE, Bauer A, Giménez-Arnau AM, Kocatürk E, Guillet C, Larco JI, Zhao ZT, Makris M, Ritchie C, Xepapadaki P, Ensina LF, Cherrez S, Maurer M

Clin Transl Allergy. 2021 Dec;11(10):e12089

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xDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System in Colorectal Cancer.

Bustos A, Payá A, Torrubia A, Jover R, Llor X, Bessa X, Castells A, Carracedo Á, Alenda C

Biomolecules. 2021 Nov 29;11(12)

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Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview.

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Environ Epidemiol. 2021 Oct;5(5):e166

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Interplay between DNA and RNA Modifications: A Constantly Evolving Process.

Fico A, Di Croce L, Matarazzo MR

Epigenomes. 2020 Nov 23;4(4)

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Mediterranean, DASH, and MIND Dietary Patterns and Cognitive Function: The 2-Year Longitudinal Changes in an Older Spanish Cohort.

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Front Aging Neurosci. 2021;13:782067

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NFAT5 Controls the Integrity of Epidermis.

Muhammad K, Xavier D, Klein-Hessling S, Azeem M, Rauschenberger T, Murti K, Avots A, Goebeler M, Klein M, Bopp T, Sielaff M, Tenzer S, Möckel S, Aramburu J, López-Rodríguez C, Kerstan A, Serfling E

Front Immunol. 2021;12:780727

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Follow-up care over 12 months of patients with prostate cancer in Spain: A multicenter prospective cohort study.

Bonfill X, Martinez-Zapata MJ, Vernooij RW, Sánchez MJ, Morales-Suárez-Varela M, Emparanza JI, Ferrer M, Pijoan JI, Palou J, Madrid E, Abraira V, Zamora J, EMPARO-CU study group.

Medicine (Baltimore). 2021 Nov 24;100(47):e27801

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Large-scale migration into Britain during the Middle to Late Bronze Age.

Patterson N, Isakov M, Booth T, ... , Lalueza-Fox C, et. al.

Nature. 2021 Dec 22;

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Description of an intervention to prevent pressure-induced skin lesions caused by personal protective equipment (PPE) during the care of patients with COVID-19.

Chercoles López I, Terradas R, Lasso de Vega Panillo C, Garcimartín Cerezo P, García Zaldívar L, Giménez Arnau AM

Arch Prev Riesgos Labor. 2021 Jul 15;24(3):252-262

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Genomics Reveal Admixture and Unexpected Patterns of Diversity in a Parapatric Pair of Butterflies.

Tahami MS, Dinca V, Lee KM, Vila R, Joshi M, Heikkilä M, Dapporto L, Schmid S, Huemer P, Mutanen M

Genes (Basel). 2021 Dec 17;12(12)

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Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression.

Gallego-Landin I, García-Baos A, Castro-Zavala A, Valverde O

Front Pharmacol. 2021;12:762738

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Development and validation of combined symptom-medication scores for allergic rhinitis.

Sousa-Pinto B, Filipe Azevedo L, Jutel M, Agache I, Canonica GW, Czarlewsk W, Papadopoulos NG, Bergmann KC, Devillier P, Laune D, Klimek L, Anto A, Anto JM, Eklund P, Almeida R, Bedbrook A, Bosnic-Anticevich S, Brough HA, Brussino L, Cardona V, Casale T, Cecchi L, Charpin D, Chivato T, Costa EM, Cruz AA, Dramburg S, Durham SR, De Feo G, Gerth van Wijk R, Fokkens WJ, Gemicioglu B, Haahtela T, Illario M, Ivancevich JC, Kvedariene V, Kuna P, Larenas-Linnemann DE, Makris M, Mathieu-Dupas E, Melén E, Morais-Almeida M, Mösges R, Mullol J, Nadeau KC, Pham-Thi N, O'Hehir R, Regateiro FS, Reitsma S, Samolinski B, Sheikh A, Stellato C, Todo-Bom A, Tomazic PV, Toppila-Salmi S, Valero A, Valiulis A, Ventura MT, Wallace D, Waserman S, Yorgancioglu A, De Vries G, van Eerd M, Zieglmayer P, Zuberbier T, Pfaar O, Almeida Fonseca J, Bousquet J

Allergy. 2021 Dec 21;

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Genetic data from the extinct giant rat from Tenerife (Canary Islands) points to a recent divergence from mainland relatives.

Renom P, de-Dios T, Civit S, Llovera L, Sánchez-Gracia A, Lizano E, Rando JC, Marquès-Bonet T, Kergoat GJ, Casanovas-Vilar I, Lalueza-Fox C

Biol Lett. 2021 Dec;17(12):20210533

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Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches.

Castells-Garcia A, Ed-Daoui I, González-Almela E, Vicario C, Ottestrom J, Lakadamyali M, Neguembor MV, Cosma MP

Nucleic Acids Res. 2021 Dec 21;

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Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients.

Torres A, Motos A, Riera J, Fernández-Barat L, Ceccato A, Pérez-Arnal R, García-Gasulla D, Peñuelas O, Lorente JA, Rodriguez A, de Gonzalo-Calvo D, Almansa R, Gabarrús A, Menéndez R, Bermejo-Martin JF, Ferrer R, Amaya Villar R, Añón JM, Barberà C, Barberán J, Blandino Ortiz A, Bustamante-Munguira E, Caballero J, Carbajales C, Carbonell N, Catalán-González M, Galbán C, Gumucio-Sanguino VD, de la Torre MDC, Díaz E, Estella Á, Gallego E, García Garmendia JL, Garnacho-Montero J, Gómez JM, Huerta A, Jorge García RN, Loza-Vázquez A, Marin-Corral J, Martínez de la Gándara A, Martínez Varela I, López Messa J, M Albaiceta G, Novo MA, Peñasco Y, Pozo-Laderas JC, Ricart P, Salvador-Adell I, Sánchez-Miralles A, Sancho Chinesta S, Socias L, Solé-Violan J, Suares Sipmann F, Tamayo Lomas L, Trenado J, Barbé F, CIBERESUCICOVID Project (COV20/00110, ISCIII).

Crit Care. 2021 Dec 17;25(1):435

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Erratum to "In Memoriam". [YMCD 45/10 (October 2020) 100657].

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Curr Probl Cardiol. 2021 Dec 15;:101030

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In the literature: December 2021.

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ESMO Open. 2021 Dec 14;7(1):100352

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Cell Lineage Infidelity in PDAC Progression and Therapy Resistance.

Malinova A, Veghini L, Real FX, Corbo V

Front Cell Dev Biol. 2021;9:795251

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The genetic scenario of Mercheros: an under-represented group within the Iberian Peninsula.

Flores-Bello A, Font-Porterias N, Aizpurua-Iraola J, Duarri-Redondo S, Comas D

BMC Genomics. 2021 Dec 15;22(1):897

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Sculpting with stem cells: how models of embryo development take shape.

Veenvliet JV, Lenne PF, Turner DA, Nachman I, Trivedi V

Development. 2021 Dec 15;148(24)

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Association between magnesium in drinking water and atrial fibrillation incidence: a nationwide population-based cohort study, 2002-2015.

Wodschow K, Villanueva CM, Larsen ML, Gislason G, Schullehner J, Hansen B, Ersbøll AK

Environ Health. 2021 Dec 15;20(1):126

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Returning to work after a sickness absence due to cancer: a cohort study of salaried workers in Catalonia (Spain).

Ayala-Garcia A, Serra L, Hernando-Rodriguez JC, Benavides FG

Sci Rep. 2021 Dec 14;11(1):23953

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Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency.

Akin L, Rizzoti K, Gregory LC, Corredor B, Le Quesne Stabej P, Williams H, Buonocore F, Mouilleron S, Capra V, McGlacken-Byrne SM, Martos-Moreno GÁ, Azmanov DN, Kendirci M, Kurtoglu S, Suntharalingham JP, Galichet C, Gustincich S, Tasic V, Achermann JC, Accogli A, Filipovska A, Tuilpakov A, Maghnie M, Gucev Z, Gonen ZB, Pérez-Jurado LA, Robinson I, Lovell-Badge R, Argente J, Dattani MT

Genet Med. 2021 Nov 30;

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Impact of Non-Persistence on Healthcare Resource Utilization and Costs in Patients With Immune-Mediated Rheumatic Diseases Initiating Subcutaneous TNF-Alpha Inhibitors: A Before-and-After Study.

Carballo N, Garcia-Alzórriz E, Ferrández O, Navarrete-Rouco ME, Durán-Jordà X, Pérez-García C, Monfort J, Cots F, Grau S

Front Pharmacol. 2021;12:752879

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Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body.

Dhandapani L, Salzer MC, Duran JM, Zaffagnini G, De Guirior C, Martínez-Zamora MA, Böke E

J Cell Sci. 2021 Dec 13;

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Ivermectin: a pathway out of the pandemic or another dead end?

Echeverría-Esnal D, Grau S

Expert Rev Anti Infect Ther. 2021 Dec 13;:1-3

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Randomized phase II study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2-advanced breast cancer: GEICAM/2014-12 (FLIPPER).

Albanell J, Martínez MT, Ramos M, O'Connor M, de la Cruz-Merino L, Santaballa A, Martínez-Jañez N, Moreno F, Fernández I, Alarcón J, Virizuela JA, de la Haba-Rodríguez J, Sánchez-Rovira P, González-Cortijo L, Margelí M, Sánchez-Muñoz A, Antón A, Casas M, Bezares S, Rojo F

Eur J Cancer. 2021 Dec 10;161:26-37

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Sex-Specific Effects of Synbiotic Exposure in Mice on Addictive-Like Behavioral Alterations Induced by Chronic Alcohol Intake Are Associated With Changes in Specific Gut Bacterial Taxa and Brain Tryptophan Metabolism.

Pizarro N, Kossatz E, González P, Gamero A, Veza E, Fernández C, Gabaldón T, de la Torre R, Robledo P

Front Nutr. 2021;8:750333

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Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD.

Casas-Recasens S, Mendoza N, López-Giraldo A, Garcia T, Cosio BG, Pascual-Guardia S, Acosta-Castro A, Borras-Santos A, Gea J, Garrabou G, Agusti A, Faner R

Front Med (Lausanne). 2021;8:761767

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Impact of and Reasons for Not Performing Exercise Training After an Acute Coronary Syndrome in the Setting of an Interdisciplinary Cardiac Rehabilitation Program: Results From a Risk-Op- Acute Coronary Syndrome Ambispective Registry.

Cabrera-Aguilera I, Ivern C, Badosa N, Marco E, Salas-Medina L, Mojón D, Vicente M, Llagostera M, Farré N, Ruiz-Bustillo S

Front Physiol. 2021;12:768199

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Feasibility of Imaging-Guided Adrenalectomy in Young Patients With Primary Aldosteronism.

Rossi GP, Crimì F, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Naruse M, Deinum J, Kool LS, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, Rump LC, Vonend O, Willenberg HS, Fuller PJ, Yang J, Chee NYN, Magill SB, Shafigullina Z, Quinkler M, Oliveras A, Wu VC, Kratka Z, Barbiero G, Battistel M, Seccia TM

Hypertension. 2022 Jan;79(1):187-195

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Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems.

van den Dries MA, Ferguson KK, Keil AP, Pronk A, Spaan S, Ghassabian A, Santos S, Jaddoe VWV, Trasande L, Tiemeier H, Guxens M

Environ Sci Technol. 2021 Dec 8;

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Primary biliary cholangitis and SARS-CoV-2 infection: incidence, susceptibility and outcomes.

Ampuero J, Lucena A, Hernández-Guerra M, Moreno-Moraleda I, Arenas J, Conde I, Muñoz L, Canillas L, Fernandez E, Quiñones R, Simon MA, Gómez-Dominguez E, Gutierrez ML, Fernandez-Rodriguez C, Domper-Arnal MJ, Jorquera F, Garcia-Buey ML, Garcia-Retortillo M, Morillas R, Berenguer M, Casado M, Morales-Arraez D, Sousa JM, Molina E

Gut. 2021 Dec 7;

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Population histories and genomic diversity of South American natives.

Castro E Silva MA, Ferraz T, Couto-Silva CM, Lemes RB, Nunes K, Comas D, Hünemeier T

Mol Biol Evol. 2021 Dec 7;

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Atypical, but Not Typical, Antipsychotic Drugs Reduce Hypersynchronized Prefrontal-Hippocampal Circuits during Psychosis-Like States in Mice: Contribution of 5-HT2A and 5-HT1A Receptors.

Delgado-Sallent C, Nebot P, Gener T, Fath AB, Timplalexi M, Puig MV

Cereb Cortex. 2021 Dec 7;

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Impact of residential greenness on myocardial infarction in population with diabetes: A sex-dependent association?

Ponjoan A, Blanch J, Alves-Cabratosa L, Martí-Lluch R, Comas-Cufí M, Cirach M, Nieuwenhuijsen M, Garcia-Gil MDM, Ramos R

Environ Res. 2021 Dec 6;:112449

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Recent advances in T-cell lymphoid neoplasms.

Bigas A, Rodriguez-Sevilla JJ, Espinosa L, Gallardo F

Exp Hematol. 2021 Dec 5;

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Mapping the neural systems driving breathing at the transition to unconsciousness.

Pujol J, Blanco-Hinojo L, Ortiz H, Gallart L, Moltó L, Martínez-Vilavella G, Vilà E, Pacreu S, Adalid I, Deus J, Pérez-Sola V, Fernández-Candil J

Neuroimage. 2021 Dec 4;:118779

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Redefining the Role of ADAM17 in Renal Proximal Tubular Cells and Its Implications in an Obese Mouse Model of Pre-Diabetes.

Palau V, Villanueva S, Jarrín J, Benito D, Márquez E, Rodríguez E, Soler MJ, Oliveras A, Gimeno J, Sans L, Crespo M, Pascual J, Barrios C, Riera M

Int J Mol Sci. 2021 Dec 3;22(23)

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A forensic population database in El Salvador: 58 STRs and 94 SNPs.

Casals F, Rasal R, Anglada R, Tormo M, Bonet N, Rivas N, Vásquez P, Calafell F

Forensic Sci Int Genet. 2021 Dec 1;57:102646

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Evolution of a histone variant involved in compartmental regulation of NAD metabolism.

Guberovic I, Hurtado-Bagès S, Rivera-Casas C, Knobloch G, Malinverni R, Valero V, Leger MM, García J, Basquin J, Gómez de Cedrón M, Frigolé-Vivas M, Cheema MS, Pérez A, Ausió J, Ramírez de Molina A, Salvatella X, Ruiz-Trillo I, Eirin-Lopez JM, Ladurner AG, Buschbeck M

Nat Struct Mol Biol. 2021 Dec;28(12):1009-1019

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Oral Antibiotic Prophylaxis Lowers Surgical Site Infection in Elective Colorectal Surgery: Results of a Pragmatic Cohort Study in Catalonia.

Badia JM, Flores-Yelamos M, Vázquez A, Arroyo-García N, Puig-Asensio M, Parés D, Pera M, López-Contreras J, Limón E, Pujol M, Members Of The VINCat Colorectal Surveillance Team

J Clin Med. 2021 Nov 29;10(23)

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Impact of DNA Damage Response-Targeted Therapies on the Immune Response to Tumours.

Lutfi N, Galindo-Campos MA, Yélamos J

Cancers (Basel). 2021 Nov 29;13(23)

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Dual Disorders in the Consultation Liaison Addiction Service: Gender Perspective and Quality of Life.

Ferrer-Farré T, Dinamarca F, Mestre-Pintó JI, Fonseca F, Torrens M

J Clin Med. 2021 Nov 26;10(23)

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Upfront primary tumour resection and survival in synchronous metastatic colorectal cancer according to primary tumour location and RAS status: Pooled analysis of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD).

Benavides M, Gómez-España A, García-Alfonso P, González CG, Viéitez JM, Rivera F, Safont MJ, Abad A, Sastre J, Valladares-Ayerbes M, Carrato A, González-Flores E, Robles L, Salud A, Alonso-Orduña V, Montagut C, Asensio E, Díaz-Rubio E, Aranda E, Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD).

Eur J Surg Oncol. 2021 Nov 25;

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Suicide-related thoughts and behavior and suicide death trends during the COVID-19 in the general population of Catalonia, Spain.

Pérez V, Elices M, Vilagut G, Vieta E, Blanch J, Laborda-Serrano E, Prat B, Colom F, Palao D, Alonso J

Eur Neuropsychopharmacol. 2021 Nov 19;56:4-12

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Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study.

Wang G, Hallberg J, Charalampopoulos D, Sanahuja MC, Breyer-Kohansal R, Langhammer A, Granell R, Vonk JM, Mian A, Olvera N, Laustsen LM, Rönmark E, Abellan A, Agusti A, Arshad SH, Bergström A, Boezen HM, Breyer MK, Burghuber O, Bolund AC, Custovic A, Devereux G, Donaldson GC, Duijts L, Esplugues A, Faner R, Ballester F, Garcia-Aymerich J, Gehring U, Haider S, Hartl S, Backman H, Holloway JW, Koppelman GH, Lertxundi A, Holmen TL, Lowe L, Mensink-Bout SM, Murray CS, Roberts G, Hedman L, Schlünssen V, Sigsgaard T, Simpson A, Sunyer J, Torrent M, Turner S, Van den Berge M, Vermeulen RCH, Vikjord SAA, Wedzicha JA, Maitland van der Zee AH, Melén E

ERJ Open Res. 2021 Oct;7(4)

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The protective gene dose effect of the APOE Epsilon-2 allele on gray matter volume in cognitively unimpaired individuals.

Salvadó G, Ferreira D, Operto G, Cumplido-Mayoral I, Arenaza-Urquijo EM, Cacciaglia R, Falcon C, Vilor-Tejedor N, Minguillon C, Groot C, van der Flier WM, Barkhof F, Scheltens P, Ossenkoppele R, Kern S, Zettergren A, Skoog I, Hort J, Stomrud E, van Westen D, Hansson O, Molinuevo JL, Wahlund LO, Westman E, Gispert JD, ALFA study†, BioFINDER, ADNI.

Alzheimers Dement. 2021 Dec 8;

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Prediction of Protein-Protein Binding Affinities from Unbound Protein Structures.

Meseguer A, Bota P, Fernández-Fuentes N, Oliva B

Methods Mol Biol. 2022;2385:335-351

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Urban Climate Policy and Action through a Health Lens-An Untapped Opportunity.

de Nazelle A, Roscoe CJ, Roca-Barcelo A, Sebag G, Weinmayr G, Dora C, Ebi KL, Nieuwenhuijsen MJ, Negev M

Int J Environ Res Public Health. 2021 Nov 27;18(23)

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Informal employment and poor self-perceived health in Latin America and the Caribbean: a gender-based comparison between countries and welfare states in a pooled analysis of 176,786 workers.

Utzet M, Botías F, Silva-Peñaherrera M, Tobías A, Benavides FG

Global Health. 2021 Dec 5;17(1):140

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A sustainable development goal framework to guide multisectoral action on NAFLD through a societal approach.

Lazarus JV, Mark HE, Colombo M, Demaio S, Dillon JF, George J, Hagström H, Hocking S, Lee N, Nieuwenhuijsen MJ, Rinella ME, Romero-Gomez M, Soriano JB, Schattenberg JM, Tacke F, Tsochatzis EA, Valenti L, Zelber-Sagi S, Ashworth Dirac M, Huang TT

Aliment Pharmacol Ther. 2021 Dec 5;

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Quality of life and disease experience in patients with heart failure with reduced ejection fraction in Spain: a mixed-methods study.

Rubio R, Palacios B, Varela L, Fernández R, Camargo Correa S, Estupiñan MF, Calvo E, José N, Ruiz Muñoz M, Yun S, Jiménez-Marrero S, Alcoberro L, Garay A, Moliner P, Sánchez-Fernández L, Soria Gómez MT, Hidalgo E, Enjuanes C, Calero-Molina E, Rueda Y, San Saturnino M, Garcimartín P, López-Ibor JV, Segovia-Cubero J, Comin-Colet J

BMJ Open. 2021 Dec 3;11(12):e053216

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Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study.

López Montesinos I, Gómez-Zorrilla S, Palacios-Baena ZR, Prim N, Echeverria-Esnal D, Gracia MP, Montero MM, Durán-Jordà X, Sendra E, Sorli L, Guerri-Fernandez R, Padilla E, Grau S, Horcajada JP, PROA PSMAR group.

Infect Dis Ther. 2021 Dec 3;

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Sex specific associations between in utero exposure to persistent organic pollutants and allergy-related outcomes in childhood: The Rhea Mother-Child Cohort (Crete, Greece).

Margetaki K, Alexaki M, Vittorakis E, Roumeliotaki T, Leventakou V, Bempi V, Chalkiadaki G, Kyrtopoulos SA, Rantakokko P, Kiviranta H, Stephanou EG, Kogevinas M, Chatzi L, Vafeiadi M

J Dev Orig Health Dis. 2021 Dec 3;:1-9

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Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.

Park S, Supek F, Lehner B

Nat Commun. 2021 Dec 3;12(1):7051

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Technical validation of real-world monitoring of gait: a multicentric observational study.

Mazzà C, Alcock L, Aminian K, Becker C, Bertuletti S, Bonci T, Brown P, Brozgol M, Buckley E, Carsin AE, Caruso M, Caulfield B, Cereatti A, Chiari L, Chynkiamis N, Ciravegna F, Del Din S, Eskofier B, Evers J, Garcia Aymerich J, Gazit E, Hansen C, Hausdorff JM, Helbostad JL, Hiden H, Hume E, Paraschiv-Ionescu A, Ireson N, Keogh A, Kirk C, Kluge F, Koch S, Küderle A, Lanfranchi V, Maetzler W, Micó-Amigo ME, Mueller A, Neatrour I, Niessen M, Palmerini L, Pluimgraaff L, Reggi L, Salis F, Schwickert L, Scott K, Sharrack B, Sillen H, Singleton D, Soltani A, Taraldsen K, Ullrich M, Van Gelder L, Vereijken B, Vogiatzis I, Warmerdam E, Yarnall A, Rochester L

BMJ Open. 2021 Dec 2;11(12):e050785

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Changes in health-related quality of life after orthognathic surgery: a multicenter study.

Duarte V, Zaror C, Villanueva J, Werlinger F, Vidal C, Solé P, O Ryan JA, Requena R, Dallaserra M, Rojas R, Burgos M, Ferrer M

Clin Oral Investig. 2021 Dec 2;

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Aproximación al coste de enfermedades profesionales atendidas en siete hospitales en España.

Benavides FG, Palma-Vasquez C, Ramada JM, Carreras R, Del Campo MT, Taboada I, Diego C, Castañón J, Orpella X, Serra C

Gac Sanit. 2021 Dec 2;

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The EHA Research Roadmap: Normal Hematopoiesis.

Jaffredo T, Balduini A, Bigas A, Bernardi R, Bonnet D, Canque B, Charbord P, Cumano A, Delwel R, Durand C, Fibbe W, Forrester L, de Franceschi L, Ghevaert C, Gjertsen B, Gottgens B, Graf T, Heidenreich O, Hermine O, Higgs D, Kleanthous M, Klump H, Kouskoff V, Krause D, Lacaud G, Celso CL, Martens JHA, Méndez-Ferrer S, Menendez P, Oostendorp R, Philipsen S, Porse B, Raaijmakers M, Robin C, Stunnenberg H, Theilgaard-Mönch K, Touw I, Vainchenker W, Corrons JV, Yvernogeau L, Schuringa JJ

Hemasphere. 2021 Dec;5(12):e669

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Bioavailability of once-daily tacrolimus formulations used in clinical practice in the management of De Novo kidney transplant recipients: the better study.

Rivera CF, Rodríguez MC, Poveda JL, Pascual J, Crespo M, Gomez G, Pelegrin SC, Paul J, Lauzurica R, Mir MP, Moreso F, Perelló M, Andres A, González E, Fernandez A, Mendiluce A, Carbajo BF, Fructuoso AS, Calvo N, Suarez A, Blanco GB, Osuna A, Fuentes MCR, Melilli E, Perez NM, Ramos A, Fernández B, López V, Domingo H

Clin Transplant. 2021 Dec 1;:e14550

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Premature Mortality of 2050 High Bike Use Scenarios in 17 Countries.

Egiguren J, Nieuwenhuijsen MJ, Rojas-Rueda D

Environ Health Perspect. 2021 Dec;129(12):127002

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Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial.

Gonzalez-Cao M, Mayo de Las Casas C, Oramas J, Berciano-Guerrero MA, de la Cruz L, Cerezuela P, Arance A, Muñoz-Couselo E, Espinosa E, Puertolas T, Diaz Beveridge R, Ochenduszko S, Villanueva MJ, Basterretxea L, Bellido L, Rodriguez D, Campos B, Montagut C, Drozdowskyj A, Molina MA, Lopez-Martin JA, Berrocal A

Nat Commun. 2021 Dec 1;12(1):7008

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Transcriptome analysis in LRRK2 and idiopathic Parkinson's disease at different glucose levels.

Fernández-Santiago R, Esteve-Codina A, Fernández M, Valldeoriola F, Sanchez-Gómez A, Muñoz E, Compta Y, Tolosa E, Ezquerra M, Martí MJ

NPJ Parkinsons Dis. 2021 Dec 1;7(1):109

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Associations between parameters of peripheral quantitative computed tomography and bone material strength index.

Holloway-Kew KL, Rufus-Membere P, Anderson KB, Tembo MC, Sui SX, Hyde NK, Diez-Perez A, Kotowicz MA, Pasco JA

Bone. 2021 Nov 29;155:116268

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The Effectiveness of Mindfulness-Based Cognitive Therapy in Primary Care and the Role of Depression Severity and Treatment Attendance.

Elices M, Pérez-Sola V, Pérez-Aranda A, Colom F, Polo M, Martín-López LM, Gárriz M

Mindfulness (N Y). 2021 Nov 29;:1-11

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The Tetragnatha kauaiensis genome sheds light on the origins of genomic novelty in spiders.

Cerca J, Armstrong EE, Vizueta J, Fernández R, Dimitrov D, Petersen B, Prost S, Rozas J, Petrov D, Gillespie RG

Genome Biol Evol. 2021 Nov 26;

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Corrigendum to: Diagnostic radiological examinations and risk of intracranial tumours in adults-findings from the interphone study.

Auvinen A, Cardis E, Blettner M, Moissonnier M, Sadetzki S, Giles G, Johansen C, Swerdlow A, Cook A, Fleming S, Berg-Beckhoff G, Iavarone I, Parent ME, Woodward A, Tynes T, McBride M, Krewski D, Feychting M, Takebayashi T, Armstrong B, Hours M, Siemiatycki J, Lagorio S, Larsen SB, Schoemaker M, Klaeboe L, Lönn S, Schüz J, and the INTERPHONE study group.

Int J Epidemiol. 2021 Nov 25;

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A set of accessible enhancers enables the initial response of breast cancer cells to physiological progestin concentrations.

Zaurin R, Ferrari R, Nacht AS, Carbonell J, Le Dily F, Font-Mateu J, de Llobet Cucalon LI, Vidal E, Lioutas A, Beato M, Vicent GP

Nucleic Acids Res. 2021 Nov 25;

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.

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Biol Psychiatry. 2021 Sep 9;

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Risk factors for systemic reactions in typical cold urticaria: results from the COLD-CE study.

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Allergy. 2021 Dec 4;

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Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review.

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Lyonnais S, Sadiq SK, Lorca-Oró C, Dufau L, Nieto-Marquez S, Escribà T, Gabrielli N, Tan X, Ouizougun-Oubari M, Okoronkwo J, Reboud-Ravaux M, Gatell JM, Marquet R, Paillart JC, Meyerhans A, Tisné C, Gorelick RJ, Mirambeau G

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Microorganisms. 2021 Nov 11;9(11)

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Pharmaceutics. 2021 Nov 4;13(11)

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Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort.

Xu J, Green R, Kim M, Lord J, Ebshiana A, Westwood S, Baird AL, Nevado-Holgado AJ, Shi L, Hye A, Snowden SG, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck EE, Engelborghs S, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey FRJ, Alcolea D, Lleó A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Proitsi P, Legido-Quigley C, On Behalf Of The European Medical Information Framework Consortium

Biomedicines. 2021 Nov 3;9(11)

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Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study.

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Cells. 2021 Oct 28;10(11)

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Antioxidants (Basel). 2021 Oct 25;10(11)

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Antibiotics (Basel). 2021 Oct 24;10(11)

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Ambient Air Pollution in Relation to SARS-CoV-2 Infection, Antibody Response, and COVID-19 Disease: A Cohort Study in Catalonia, Spain (COVICAT Study).

Kogevinas M, Castaño-Vinyals G, Karachaliou M, Espinosa A, de Cid R, Garcia-Aymerich J, Carreras A, Cortés B, Pleguezuelos V, Jiménez A, Vidal M, O'Callaghan-Gordo C, Cirach M, Santano R, Barrios D, Puyol L, Rubio R, Izquierdo L, Nieuwenhuijsen M, Dadvand P, Aguilar R, Moncunill G, Dobaño C, Tonne C

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Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates.

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Stroke. 2021 Nov 16;:STROKEAHA121036257

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Multimorbidity patterns of chronic conditions and geriatric syndromes in older patients from the MoPIM multicentre cohort study.

Baré M, Herranz S, Roso-Llorach A, Jordana R, Violán C, Lleal M, Roura-Poch P, Arellano M, Estrada R, Nazco GJ, MoPIM study group.

BMJ Open. 2021 Nov 15;11(11):e049334

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Acute-to-Chronic Glycemic Ratio as a Predictor of COVID-19 Severity and Mortality.

Ramon J, Llauradó G, Güerri R, Climent E, Ballesta S, Benaiges D, López-Montesinos I, Navarro H, Fernández N, Carrera MJ, Mauricio D, Flores-Le Roux JA, Chillarón JJ

Diabetes Care. 2021 Nov 15;

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Perceived helpfulness of treatment for alcohol use disorders: Findings from the World Mental Health Surveys.

Degenhardt L, Bharat C, Chiu WT, Harris MG, Kazdin AE, Vigo DV, Sampson NA, Alonso J, Andrade LH, Bruffaerts R, Bunting B, Cardoso G, de Girolamo G, Florescu S, Gureje O, Haro JM, Hu C, Karam AN, Karam EG, Kovess-Masfety V, Lee S, Makanjuola V, McGrath JJ, Medina-Mora ME, Moskalewicz J, Navarro-Mateu F, Posada-Villa J, Rapsey C, Stagnaro JC, Tachimori H, Ten Have M, Torres Y, Williams DR, Zarkov Z, Kessler RC, WHO World Mental Health Survey collaborators, The WHO World Mental Health Survey collaborators are Sergio Aguilar-Gaxiola.

Drug Alcohol Depend. 2021 Nov 1;229(Pt B):109158

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Relevance of myocardial injury biomarkers to the prognosis of COVID-19 patients. Response.

Calvo-Fernández A, Marrugat J, Vaquerizo B

Rev Esp Cardiol (Engl Ed). 2021 Oct 19;

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The Proteomic Signature of Recombinant Growth Hormone in Recreational Athletes.

Esefeld M, Pastor A, de la Torre R, Barroso O, Aikin R, Sarwath H, Engelke R, Schmidt F, Suhre K

J Endocr Soc. 2021 Dec 1;5(12):bvab156

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Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study.

Pedret A, Fernández-Castillejo S, Valls RM, Catalán Ú, Rubió L, Romeu M, Macià A, de Las Hazas MCL, Farràs M, Giralt M, Mosele JI, Martín-Peláez S, Remaley AT, Covas MI, Fitó M, Motilva MJ, Solà R

Mol Nutr Food Res. 2021 Nov 14;:e2170061

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Sustained safety and efficacy of ligelizumab in patients with chronic spontaneous urticaria: A one-year extension study.

Maurer M, Giménez-Arnau A, Bernstein JA, Chu CY, Danilycheva I, Hide M, Makris M, Metz M, Savic S, Sitz K, Soong W, Staubach P, Sussman G, Barve A, Burciu A, Hua E, Janocha R, Severin T

Allergy. 2021 Nov 13;

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Cohort description: Measures of early-life behaviour and later psychopathology in the LifeCycle Project - EU Child Cohort Network.

Nader JL, López-Vicente M, Julvez J, Guxens M, Cadman T, Elhakeem A, Järvelin MR, Rautio N, Miettunen J, El Marroun H, Melchior M, Heude B, Charles MA, Yang TC, McEachan RRC, Wright J, Polanska K, Carson J, Lin A, Rauschert S, Huang RC, Popovic M, Richiardi L, Corpeleijn E, Cardol M, Mikkola TM, Eriksson JG, Salika T, Inskip H, Vinther JL, Strandberg-Larsen K, Gürlich K, Grote V, Koletzko B, Vafeiadi M, Sunyer J, Jaddoe VWV, Harris JR

J Epidemiol. 2021 Nov 13;

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SARS-CoV-2 could be spread through hospital medication dispensed to patients: A prospective observational study.

Grau S, Ferrández O, Echeverría-Esnal D, Maldonado R, Puig B, Ramirez A, Canal M, Montero A, González C, Herranz M, Masclans JR, Horcajada JP, Padilla E

Medicine (Baltimore). 2021 Nov 12;100(45):e27592

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Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model.

Montero MM, Domene-Ochoa S, López-Causapé C, Luque S, Sorlí L, Campillo N, Padilla E, Prim N, Ferrer-Alapont L, Angulo-Brunet A, Grau S, Oliver A, Horcajada JP

Sci Rep. 2021 Nov 12;11(1):22178

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Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.

Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi VL

Obes Rev. 2021 Nov 12;:e13383

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Previous disorders and depression outcomes in individuals with 12-month major depressive disorder in the World Mental Health surveys.

Roest AM, de Vries YA, Al-Hamzawi A, Alonso J, Ayinde OO, Bruffaerts R, Bunting B, Caldas de Almeida JM, de Girolamo G, Degenhardt L, Florescu S, Gureje O, Haro JM, Hu C, Karam EG, Kiejna A, Kovess-Masfety V, Lee S, McGrath JJ, Medina-Mora ME, Navarro-Mateu F, Nishi D, Piazza M, Posada-Villa J, Scott KM, Stagnaro JC, Stein DJ, Torres Y, Viana MC, Zarkov Z, Kessler RC, de Jonge P, WHO World Mental Health Survey collaborators.

Epidemiol Psychiatr Sci. 2021 Nov 11;30:e70

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Dose of furosemide before admission predicts diuretic efficiency and long-term prognosis in acute heart failure.

Blázquez-Bermejo Z, Farré N, Caravaca Perez P, Llagostera M, Morán-Fernández L, Fort A, de Juan Bagudá J, García-Cosio MD, Ruiz-Bustillo S, Delgado JF

ESC Heart Fail. 2021 Nov 11;

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A conserved expression signature predicts growth rate and reveals cell & lineage-specific differences.

Jiang Z, Generoso SF, Badia M, Payer B, Carey LB

PLoS Comput Biol. 2021 Nov 11;17(11):e1009582

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SCoV2-MD: a database for the dynamics of the SARS-CoV-2 proteome and variant impact predictions.

Torrens-Fontanals M, Peralta-García A, Talarico C, Guixà-González R, Giorgino T, Selent J

Nucleic Acids Res. 2021 Nov 11;

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Influence of PACE score and conduction disturbances in the incidence of early new onset atrial fibrillation after typical atrial flutter ablation.

Vallès E, Martí-Almor J, Grau N, Casteigt B, Benito B, Cabrera S, Alcalde O, Benito E, Bas D, Conejos J, Cabero P, Soler C, Duran X, Fan R, Jimenez J

J Cardiol. 2021 Nov 10;

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Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type.

Solà-Porta E, Redondo-Pachón D, Arias-Cabrales C, Navazo D, Buxeda A, Burballa C, Crespo M, García-Retortillo M, Pascual J, Pérez-Sáez MJ

J Clin Med. 2021 Nov 4;10(21)

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Health impacts of the new WHO air quality guidelines in European cities.

Khomenko S, Cirach M, Pereira-Barboza E, Mueller N, Barrera-Gómez J, Rojas-Rueda D, de Hoogh K, Hoek G, Nieuwenhuijsen M

Lancet Planet Health. 2021 Nov;5(11):e764

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COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey.

Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L, Sherman SL, Strydom A, Bargagna S, Brandão AC, Costa ACS, Feany PT, Chicoine BA, Ghosh S, Rebillat AS, Sgandurra G, Valentini D, Rohrer TR, Levin J, Lakhanpaul M, On Behalf Of The Trisomy Research Society Covid-Initiative Study Group

J Clin Med. 2021 Oct 31;10(21)

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Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection.

Arnau-Barrés I, Pascual-Dapena A, López-Montesinos I, Gómez-Zorrilla S, Sorlí L, Herrero M, Nogués X, Navarro-Valls C, Ibarra B, Canchucaja L, da Costa Venancio E, Blasco-Hernando F, Cruz J, Vázquez O, Miralles R, García-Giralt N, Güerri-Fernández R

J Clin Med. 2021 Oct 31;10(21)

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A Collection of Designed Peptides to Target SARS-CoV-2 Spike RBD-ACE2 Interaction.

Fernandez-Fuentes N, Molina R, Oliva B

Int J Mol Sci. 2021 Oct 27;22(21)

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Effects of Albumin on Survival after a Hepatic Encephalopathy Episode: Randomized Double-Blind Trial and Meta-Analysis.

Ventura-Cots M, Simón-Talero M, Poca M, Ariza X, Masnou H, Sanchez J, Llop E, Cañete N, Martín-Llahí M, Amador A, Martínez J, Clemente-Sanchez A, Puente A, Torrens M, Alvarado-Tapias E, Napoleone L, Miquel-Planas M, Ardèvol A, Casas Rodrigo M, Calleja JL, Solé C, Soriano G, Genescà J

J Clin Med. 2021 Oct 23;10(21)

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Relationship between the Risk of Gastric Cancer and Adherence to the Mediterranean Diet According to Different Estimators. MCC-Spain Study.

Álvarez-Álvarez L, Vitelli-Storelli F, Rubín-García M, Aragonés N, Ardanaz E, Castaño-Vinyals G, Obón-Santacana M, Dierssen-Sotos T, Salas-Trejo D, Tardón A, Moleón JJJ, Alguacil J, Chirlaque MD, Pérez-Gómez B, Pollán M, Kogevinas M, Martín V

Cancers (Basel). 2021 Oct 21;13(21)

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Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study.

Gómez-Martínez C, Babio N, Júlvez J, Becerra-Tomás N, Martínez-González MÁ, Corella D, Castañer O, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Dalsgaard S, Sayón-Orea C, Sorlí JV, de la Torre R, Abete I, Tojal-Sierra L, Barón-López FJ, Fernández-Brufal N, Konieczna J, García-Ríos A, Sacanella E, Bernal-López MR, Santos-Lozano JM, Razquin C, Alvarez-Sala A, Goday A, Zulet MA, Vaquero-Luna J, Diez-Espino J, Cuenca-Royo A, Fernández-Aranda F, Bulló M, Salas-Salvadó J

Front Endocrinol (Lausanne). 2021;12:754347

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Human CLA+ Memory T Cell and Cytokines in Psoriasis.

de Jesús-Gil C, Sans-de San Nicolàs L, García-Jiménez I, Ferran M, Pujol RM, Santamaria-Babí LF

Front Med (Lausanne). 2021;8:731911

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Mood Disturbances, Anxiety, and Impact on Quality of Life in Patients Admitted to Epilepsy Monitoring Units.

Rocamora R, Chavarría B, Pérez E, Pérez-Enríquez C, Barguilla A, Panadés-de Oliveira L, Principe A, Zucca R

Front Neurol. 2021;12:761239

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Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let's MAMBO!

Vilor-Tejedor N, Garrido-Martín D, Rodriguez-Fernandez B, Lamballais S, Guigó R, Gispert JD

Comput Struct Biotechnol J. 2021;19:5800-5810

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Developing an App to Screen for Dual Disorders: A Tool for Improving Treatment Services in Mexico.

Marín-Navarrete R, Torrens M, Toledo-Fernández A, Mestre-Pinto JI, Sánchez-Domínguez R, Pérez-Lopez A, Saracco-Alvarez R, Madrigal-De León EÁ, Szerman N

Front Psychiatry. 2021;12:697598

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ADHD Comorbidity Structure and Impairment: Results of the WHO World Mental Health Surveys International College Student Project (WMH-ICS).

Mak ADP, Lee S, Sampson NA, Albor Y, Alonso J, Auerbach RP, Baumeister H, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Gutierrez-Garcia RA, Hasking P, Lapsley C, Lochner C, Kessler RC

J Atten Disord. 2021 Nov 10;:10870547211057275

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Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis.

Colomé N, Abian J, Aloria K, Arizmendi JM, Barceló-Batllori S, Braga-Lagache S, Burlet-Schiltz O, Carrascal M, Casal JI, Chicano-Gálvez E, Chiva C, Clemente LF, Elortza F, Estanyol JM, Fernandez-Irigoyen J, Fernández-Puente P, Fidalgo MJ, Froment C, Fuentes M, Fuentes-Almagro C, Gay M, Hainard A, Heller M, Hernández ML, Ibarrola N, Iloro I, Kieselbach T, Lario A, Locard-Paulet M, Marina-Ramírez A, Martín L, Morato-López E, Muñoz J, Navajas R, Odena MA, Odriozola L, de Oliveira E, Paradela A, Pasquarello C, de Los Rios V, Ruiz-Romero C, Sabidó E, Sánchez Del Pino M, Sancho J, Santamaría E, Schaeffer-Reiss C, Schneider J, de la Torre C, Valero ML, Vilaseca M, Wu S, Wu L, Ximénez de Embún P, Canals F, Corrales FJ, ProteoRed-ISCIII., EuPA.

J Proteomics. 2021 Nov 7;251:104409

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Textbook outcome and survival after gastric cancer resection with curative intent: A population-based analysis.

Dal Cero M, Román M, Grande L, Yarnoz C, Estremiana F, Gantxegi A, Codony C, Gobbini Y, Garsot E, Momblan D, González-Duaigües M, Luna A, Pérez N, Aldeano A, Fernández S, Olona C, Hermoso J, Pulido L, Sánchez-Cano JJ, Güell M, Salazar D, Gimeno M, Pera M, Spanish EURECCA Esophagogastric Cancer Group.

Eur J Surg Oncol. 2021 Nov 2;

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PHQ-8 scores and estimation of depression prevalence - Author's reply.

Arias-de la Torre J, Vilagut G, Ronaldson A, Serrano-Blanco A, Alonso J

Lancet Public Health. 2021 Nov;6(11):e794

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Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents.

Cabré-Riera A, van Wel L, Liorni I, Koopman-Verhoeff ME, Imaz L, Ibarluzea J, Huss A, Wiart J, Vermeulen R, Joseph W, Capstick M, Vrijheid M, Cardis E, Röösli M, Eeftens M, Thielens A, Tiemeier H, Guxens M

Environ Res. 2021 Oct 29;:112291

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Corrigendum to "Linezolid vs glycopeptides in the treatment of glycopeptide-susceptible Enterococcus faecium bacteraemia: A propensity score matched comparative study" [International Journal of Antimicrobial Agents, Volume 54, Issue 5 (2019) 572-578].

Echeverria-Esnal D, Sorli L, Prim N, Conde-Estévez D, Mateu-De Antonio J, Martin-Ontiyuelo C, Horcajada JP, Grau S

Int J Antimicrob Agents. 2021 Oct 28;:106455

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Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial.

Badenes-Bonet D, Cejudo P, Rodó-Pin A, Martín-Ontiyuelo C, Chalela R, Rodríguez-Portal JA, Vázquez-Sánchez R, Gea J, Duran X, Caguana OA, Rodriguez-Chiaradia DA, Balcells E

BMC Pulm Med. 2021 Nov 8;21(1):355

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Single-Cell Transcriptional Changes In Neurodegenerative Diseases.

Ahmadi A, Gispert JD, Navarro A, Vilor-Tejedor N, Sadeghi I

Neuroscience. 2021 Nov 5;

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Recommendations for pharmacotranscriptomic profiling of drug response in CNS disorders.

Xicota L, De Toma I, Maffioletti E, Pisanu C, Squassina A, Baune BT, Potier MC, Stacey D, Dierssen M, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Thematic Workgroup.

Eur Neuropsychopharmacol. 2021 Nov 4;54:41-53

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Cost-effectiveness evaluation of the use of PCSK9 inhibitors.

Civeira F, Pedro-Botet J

Endocrinol Diabetes Nutr (Engl Ed). 2021 Jun-Jul;68(6):369-371

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From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation.

Ghose R, Aranguren-Ibáñez Á, Arecco N, Balboa D, Bataller M, Beltran S, Benisty H, Bénard A, Bernardo E, Carbonell Sala S, Casals E, Ciampi L, Condemi L, Corvó A, Cosín-Tomás M, Cuenca-Ardura M, Duran Serrano JM, Espejo Díaz MI, Fernandez Callejo M, Gañez-Zapater A, Garcia-Castellanos R, Garrido R, Henkin G, Hermoso Pulido T, Hernandez-Alias X, Herrero Vicente J, Ingham M, Lim WM, Llonch S, Marmesat Bertoli E, Miguel-Escalada I, Montero-Blay A, Navarrete Hernández C, Neguembor MV, Ní Chárthaigh RA, Pardo-Lorente N, Pascual-Reguant L, Pérez-Lluch S, Perza R, Pesaresi M, Picó Amador D, Pifarré P, Piscia D, Plana-Carmona M, Ponomarenko J, Radusky L, Rivero E, Rogalska M, Torcal Garcia G, Wojnacki J

F1000Res. 2020;9:1336

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Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain.

Karachaliou M, Moncunill G, Espinosa A, Castaño-Vinyals G, Jiménez A, Vidal M, Santano R, Barrios D, Puyol L, Carreras A, Mayer L, Rubio R, Cortés B, Pleguezuelos V, O'Callaghan-Gordo C, Fossati S, Rivas I, Casabonne D, Vrijheid M, Izquierdo L, Aguilar R, Basagaña X, Garcia-Aymerich J, de Cid R, Dobaño C, Kogevinas M

Sci Rep. 2021 Nov 3;11(1):21571

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Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.

Salat-Canela C, Carmona M, Martín-García R, Pérez P, Ayté J, Hidalgo E

Cell Rep. 2021 Nov 2;37(5):109951

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Determinants of mechanical restraint in an acute psychiatric care unit.

El-Abidi K, Moreno-Poyato AR, Toll Privat A, Corcoles Martinez D, Aceña-Domínguez R, Pérez-Solà V, Mané A

World J Psychiatry. 2021 Oct 19;11(10):854-863

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P-tau235: a novel biomarker for staging preclinical Alzheimer's disease.

Lantero-Rodriguez J, Snellman A, Benedet AL, Milà-Alomà M, Camporesi E, Montoliu-Gaya L, Ashton NJ, Vrillon A, Karikari TK, Gispert JD, Salvadó G, Shekari M, Toomey CE, Lashley TL, Zetterberg H, Suárez-Calvet M, Brinkmalm G, Rosa Neto P, Blennow K

EMBO Mol Med. 2021 Nov 2;:e15098

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Txikispora philomaios n. sp., n. g., a Micro-Eukaryotic Pathogen of Amphipods, Reveals Parasitism and Hidden Diversity in Class Filasterea.

Urrutia A, Mitsi K, Foster R, Ross S, Carr M, Ward GM, van Aerle R, Marigomez I, Leger MM, Ruiz-Trillo I, Feist SW, Bass D

J Eukaryot Microbiol. 2021 Nov 2;:e12875

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linus: Conveniently explore, share, and present large-scale biological trajectory data in a web browser.

Waschke J, Hlawitschka M, Anlas K, Trivedi V, Roeder I, Huisken J, Scherf N

PLoS Comput Biol. 2021 Nov 1;17(11):e1009503

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COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.

Chatzikonstantinou T, Kapetanakis A, Scarfò L, Karakatsoulis G, Allsup D, Cabrero AA, Andres M, Antic D, Baile M, Baliakas P, Bron D, Capasso A, Chatzileontiadou S, Cordoba R, Correa JG, Cuéllar-García C, De Paoli L, De Paolis MR, Del Poeta G, Demosthenous C, Dimou M, Donaldson D, Doubek M, Efstathopoulou M, Eichhorst B, El-Ashwah S, Enrico A, Espinet B, Farina L, Ferrari A, Foglietta M, Frederiksen H, Fürstenau M, García-Marco JA, García-Serra R, Gentile M, Gimeno E, Glenthøj A, Gomes da Silva M, Gutwein O, Hakobyan YK, Herishanu Y, Hernández-Rivas JÁ, Herold T, Innocenti I, Itchaki G, Jaksic O, Janssens A, Kalashnikova OB, Kalicinska E, Karlsson LK, Kater AP, Kersting S, Labrador J, Lad D, Laurenti L, Levin MD, Lista E, Lopez-Garcia A, Malerba L, Marasca R, Marchetti M, Marquet J, Mattsson M, Mauro FR, Milosevic I, Mirás F, Morawska M, Motta M, Munir T, Murru R, Niemann CU, Rodrigues RN, Olivieri J, Orsucci L, Papaioannou M, Pavlovsky MA, Piskunova I, Popov VM, Quaglia FM, Quaresmini G, Qvist K, Reda G, Rigolin GM, Ruchlemer R, Saghumyan G, Shrestha A, Šimkovic M, Špacek M, Sportoletti P, Stanca O, Stavroyianni N, Tadmor T, Te Raa D, Tonino SH, Trentin L, Van Der Spek E, van Gelder M, van Kampen R, Varettoni M, Visentin A, Vitale C, Wasik-Szczepanek E, Wróbel T, San Segundo LY, Yassin M, Coscia M, Rambaldi A, Montserrat E, Foà R, Cuneo A, Stamatopoulos K, Ghia P

Leukemia. 2021 Nov 1;

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A Standard Set of Value-Based Patient-Centered Outcomes and Measures of Overall Health in Adults.

Gangannagaripalli J, Albagli A, Myers SN, Whittaker S, Joseph A, Clarke A, Matkin L, Alonso J, Byock I, van den Berg M, Canfield C, Chaplin J, Dapueto J, de Almedia Fleck MP, Sidey-Gibbons C, Hazelzet J, Hess R, Immonen K, Joyner S, Katz C, Kerrigan C, Lam C, Lunn J, McKenzie F, Roeves A, Stowell C, Switaj T, Tinsley M, Zimlichman E, Valderas JM

Patient. 2021 Nov 1;

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Mapping the Patient-Oriented Prostate Utility Scale From the Expanded Prostate Cancer Index Composite and the Short-Form Health Surveys.

Zamora V, Garin O, Pardo Y, Pont À, Gutiérrez C, Cabrera P, Gómez-Veiga F, Pijoan JI, Litwin MS, Ferrer M, Multicentric Spanish Group of Clinically Localized Prostate Cancer.

Value Health. 2021 Nov;24(11):1676-1685

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The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission.

Carrillo-Garcia J, Herrera-Fernández V, Serra SA, Rubio-Moscardo F, Vogel-Gonzalez M, Doñate-Macian P, Hevia CF, Pujades C, Valverde MA

Sci Adv. 2021 Oct 29;7(44):eabi7785

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The insecticides permethrin and chlorpyriphos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells.

Rodriguez-Cortez VC, Navarrete-Meneses MP, Molina O, Velasco-Hernandez T, Gonzalez J, Romecin P, Gutierrez-Aguera F, Roca-Ho H, Vinyoles M, Kowarz E, Marin P, Rodriguez-Perales S, Gomez-Marin C, Perez-Vera P, Cortes-Ledesma F, Bigas A, Terron A, Bueno C, Menendez P

Haematologica. 2021 Oct 28;

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DeepMP: a deep learning tool to detect DNA base modifications on Nanopore sequencing data.

Bonet J, Chen M, Dabad M, Heath S, Gonzalez-Perez A, Lopez-Bigas N, Lagergren J

Bioinformatics. 2021 Oct 28;

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Gentrification pathways and their health impacts on historically marginalized residents in Europe and North America: Global qualitative evidence from 14 cities.

Anguelovski I, Cole HVS, O'Neill E, Baró F, Kotsila P, Sekulova F, Pérez Del Pulgar C, Shokry G, García-Lamarca M, Argüelles L, Connolly JJ, Honey-Rosés J, López-Gay A, Fontán-Vela M, Matheney A, Oscilowicz E, Binet A, Triguero-Mas M

Health Place. 2021 Oct 27;72:102698

http://www.ncbi.nlm.nih.gov/en...

Environmental noise exposure and emotional, aggressive, and attention-deficit/hyperactivity disorder-related symptoms in children from two European birth cohorts.

Essers E, Pérez-Crespo L, Foraster M, Ambrós A, Tiemeier H, Guxens M

Environ Int. 2021 Oct 27;158:106946

http://www.ncbi.nlm.nih.gov/en...

Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.

Hümmer S, Borao S, Guerra-Moreno A, Cozzuto L, Hidalgo E, Ayté J

Cell Rep. 2021 Oct 26;37(4):109893

http://www.ncbi.nlm.nih.gov/en...

Whole-exome analysis in Tunisian Imazighen and Arabs shows the impact of demography in functional variation.

Lucas-Sánchez M, Font-Porterias N, Calafell F, Fadhlaoui-Zid K, Comas D

Sci Rep. 2021 Oct 26;11(1):21125

http://www.ncbi.nlm.nih.gov/en...

Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.

Arc-Chagnaud C, Salvador-Pascual A, Garcia-Dominguez E, Olaso-Gonzalez G, Correas AG, Serna E, Brioche T, Chopard A, Fernandez-Marcos PJ, Serrano M, Serrano AL, Muñoz-Cánoves P, Sebastiá V, Viña J, Gomez-Cabrera MC

J Cachexia Sarcopenia Muscle. 2021 Oct 26;

http://www.ncbi.nlm.nih.gov/en...

Soundtrack of life: an fMRI study.

Falcon C, Navarro-Plaza MC, Gramunt N, Arenaza-Urquijo EM, Grau-Rivera O, Cacciaglia R, González-de-Echavarria JM, Sánchez-Benavides G, Operto G, Knezevic I, Molinuevo JL, Gispert JD

Behav Brain Res. 2021 Oct 25;:113634

http://www.ncbi.nlm.nih.gov/en...

Absence of relevant clinical effects of SARS-COV-2 on the affinity of hemoglobin for O2 in patients with COVID-19.

Pascual-Guàrdia S, Ferrer A, Díaz Ó, Caguana AO, Tejedor E, Bellido-Calduch S, Rodríguez-Chiaradia DA, Gea J

Arch Bronconeumol. 2021 Oct 23;

http://www.ncbi.nlm.nih.gov/en...

Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias.

Pumarega J, Camargo J, Gasull M, Olshan AF, Soliman A, Chen Y, Richardson D, Alguacil J, Poole C, Trasande L, Porta M, PANKRAS II Study Group.

Expo Health. 2021 Oct 22;:1-13

http://www.ncbi.nlm.nih.gov/en...

Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution.

García Pastor A, López-Cancio Martínez E, Rodríguez-Yáñez M, Alonso de Leciñana M, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Fuentes B, Freijo MM, Gomis M, Gómez Choco M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Segura T, Serena J, Vivancos-Mora J, Roquer J, Ad hoc committee of the Spanish Society of Neurology's Cerebrovascular Disease Study Group.

Neurologia (Engl Ed). 2021 Jun;36(5):377-387

http://www.ncbi.nlm.nih.gov/en...

Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test.

Grau-Guinea L, Pérez Enríquez C, García-Escobar G, Arrondo Elizarán C, Pereira Cutiño B, Florido Santiago M, Piqué Candini J, Planas A, Paez M, Peña Casanova J, Sánchez-Benavides G

Neurologia (Engl Ed). 2021 Jun;36(5):353-360

http://www.ncbi.nlm.nih.gov/en...

Harmonisation and Between-Country Differences of the Lifetime of Experiences Questionnaire in Older Adults.

Ourry V, Marchant NL, Schild AK, Coll-Padros N, Klimecki OM, Krolak-Salmon P, Goldet K, Reyrolle L, Bachelet R, Sannemann L, Meiberth D, Demnitz-King H, Whitfield T, Botton M, Lebahar J, Gonneaud J, de Flores R, Molinuevo JL, Jessen F, Vivien D, de la Sayette V, Valenzuela MJ, Rauchs G, Wirth M, Chételat G, Arenaza-Urquijo EM, Medit-Ageing Research Group.

Front Aging Neurosci. 2021;13:740005

http://www.ncbi.nlm.nih.gov/en...

Retreatment with Hyaluronic Acid Viscosupplementation in Knee Osteoarthritis: Agreement between EUROVISCO Guidelines and Current Medical Practice.

Henrotin Y, Tits C, Paul J, Gramme P, Helleputte T, Migliore A, Richette P, Chevalier X, Monfort J, Diracoglu D, Bard H, Jerosch J, Baron D, Raghu R, Conrozier T

Cartilage. 2021 Oct 25;:19476035211053827

http://www.ncbi.nlm.nih.gov/en...

Development of a Dendrimeric Peptide-Based Approach for the Differentiation of Animals Vaccinated with FlagT4G against Classical Swine Fever from Infected Pigs.

Bohórquez JA, Defaus S, Rosell R, Pérez-Simó M, Alberch M, Gladue DP, Borca MV, Andreu D, Ganges L

Viruses. 2021 Oct 2;13(10)

http://www.ncbi.nlm.nih.gov/en...

An overview of the efficacy and safety of everolimus in adult solid organ transplant recipients.

Tedesco-Silva H, Saliba F, Barten MJ, De Simone P, Potena L, Gottlieb J, Gawai A, Bernhardt P, Pascual J

Transplant Rev (Orlando). 2021 Sep 24;:100655

http://www.ncbi.nlm.nih.gov/en...

Acute stress and alcohol exposure during adolescence result in an anxious phenotype in adulthood: Role of altered glutamate/endocannabinoid transmission mechanisms.

Sánchez-Marín L, Flores-López M, Pastor A, Gavito AL, Suárez J, de la Torre R, Pavón FJ, de Fonseca FR, Serrano A

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Oct 22;:110460

http://www.ncbi.nlm.nih.gov/en...

CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice.

Luján MÁ, Alegre-Zurano L, Martín-Sánchez A, Cantacorps L, Valverde O

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Oct 21;:110462

http://www.ncbi.nlm.nih.gov/en...


Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:


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Innovation

Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar

→ https://www.imim.es/en_dareaestrategica.html

UPF Business Shuttle and Innovation Unit

→ www.upf.edu/web/innovacio

Technology and Business Development Office at the CRG

→ https://tbdo.crg.eu

Analysis and Global Development at ISGlobal

→ www.isglobal.org/es/policy-and-development

EMBLEM Technology Transfer

→ https://embl-em.de

  • The following start-ups have been created within the PRBB environment:

Acellera

Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.

→ https://www.acellera.com

Chemotargets

Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.

→ http://www.chemotargets.com/

qGenomics

qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.

→ https://qgenomics.com

ZeClinics

ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.

→ http://www.zeclinics.com

Microomics

Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.

→ http://www.microomics.eu

Flomics

World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.

→ http://www.flomics.com

Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.

→ http://biom.tech

MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.

→ http://www.disgenetplus.com/medbioinformatics/

Pulmobiotics

A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.

→ https://www.pulmobio.com/

Integra Therapeutics

Integra Therapeutics, a spin-off company from DCEXS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.

→ https://integra-tx.com/

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