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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.

Hospital del Mar Medical Research Institute (IMIM)


The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 


The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Inflammatory and Cardiovascular Disorders

This programme expands our knowledge of pathophysiological, inflammatory and genetic mechanisms of cardiovascular, respiratory and bone disorders, as well as other acute and chronic disorders, their diagnosis and treatment. The multidisciplinary team addresses basic biomedical scientific questions arising from clinical cases. This approach should lead to translational research that can be applied to medical care.

Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice.

The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.


The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.


ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.

Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:



⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

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Latest news

Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Montserrat Torà


The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko


The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut


This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet


This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas


The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.

Contact: Dirección de secretaría


Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Dirección de secretaría


The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría

Web: (Acceso: Portal PRBB)

This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis


BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso


The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro


This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht


The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà


The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals


The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera


This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea


This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger


The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi


Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu


This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade


Scientific publications
(keywords, journal, author,...)

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Velten L, Story BA, Hernández-Malmierca P, Raffel S, Leonce DR, Milbank J, Paulsen M, Demir A, Szu-Tu C, Frömel R, Lutz C, Nowak D, Jann JC, Pabst C, Boch T, Hofmann WK, Müller-Tidow C, Trumpp A, Haas S, Steinmetz LM

Nat Commun. 2021 Mar 1;12(1):1366

Economic burden of recurrent Clostridioides difficile infection in adults admitted to Spanish hospitals. A multicentre retrospective observational study.

Bouza E, Cobo J, Rodríguez-Hernández MJ, Salavert M, Horcajada JP, Iribarren JA, Obi E, Lozano V, Maratia S, Cuesta M, Uría E, Limón E

Rev Esp Quimioter. 2021 Feb 23;

Estimating peptide half-life in serum from tunable, sequence-related physicochemical properties.

Cavaco M, Valle J, Flores I, Andreu D, A R B Castanho M

Clin Transl Sci. 2021 Feb 28;

Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey.

Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, Brandão AC, Carfi A, Carmona-Iragui M, Chicoine BA, Ghosh S, Lakhanpaul M, Manso C, Mayer MA, Ortega MDC, de Asua DR, Rebillat AS, Russell LA, Sgandurra G, Valentini D, Sherman SL, Strydom A, T21RS COVID-19 Initiative.

EClinicalMedicine. 2021 Feb 22;:100769

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

Muñoz-Martínez S, Sapena V, Forner A, Nault JC, Sapisochin G, Rimassa L, Sangro B, Bruix J, Sanduzzi-Zamparelli M, Holówko W, El Kassas M, Mocan T, Bouattour M, Merle P, Hoogwater FJH, Alqahtani SA, Reeves HL, Pinato DJ, Giorgakis E, Meyer T, Villadsen GE, Wege H, Salati M, Mínguez B, Di Costanzo GG, Roderburg C, Tacke F, Varela M, Galle PR, Alvares-da-Silva MR, Trojan J, Bridgewater J, Cabibbo G, Toso C, Lachenmayer A, Casadei-Gardini A, Toyoda H, Lüdde T, Villani R, Matilla Peña AM, Guedes Leal CR, Ronzoni M, Delgado M, Perelló C, Pascual S, Lledó JL, Argemi J, Basu B, da Fonseca L, Acevedo J, Siebenhüner AR, Braconi C, Meyers BM, Granito A, Sala M, Rodríguez Lope C, Blaise L, Romero-Gómez M, Piñero F, Gomez D, Mello V, Pinheiro Alves RC, França A, Branco F, Brandi G, Pereira G, Coll S, Guarino M, Benítez C, Anders MM, Bandi JC, Vergara M, Calvo M, Peck-Radosavljevic M, García-Juárez I, Cardinale V, Lozano M, Gambato M, Okolicsanyi S, Arraez DM, Elvevi A, Muñoz AE, Lué A, Iavarone M, Reig M

JHEP Rep. 2021 Feb 23;:100260

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Klionsky DJ, Barreiro E, Munoz-Canoves P, Salazar-Degracia A, Sica V, Zaffagnini G, et al.

Autophagy. 2021 Feb 8;:1-382

Perceived helpfulness of bipolar disorder treatment: Findings from the World Health Organization World Mental Health Surveys.

Nierenberg AA, Harris MG, Kazdin AE, Puac-Polanco V, Sampson N, Vigo DV, Chiu WT, Ziobrowski HN, Alonso J, Altwaijri Y, Borges G, Bunting B, Caldas-de-Almeida JM, Haro JM, Hu CY, Kiejna A, Lee S, McGrath JJ, Navarro-Mateu F, Posada-Villa J, Scott KM, Stagnaro JC, Carmen Viana M, Kessler RC, WHO World Mental Health Survey Collaborators.

Bipolar Disord. 2021 Feb 26;

Ecto-GPR37: a potential biomarker for Parkinson's disease.

Morató X, Garcia-Esparcia P, Argerich J, Llorens F, Zerr I, Paslawski W, Borràs E, Sabidó E, Petäjä-Repo UE, Fernández-Dueñas V, Ferrer I, Svenningsson P, Ciruela F

Transl Neurodegener. 2021 Feb 26;10(1):8

Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome.

Starbuck JM, Llambrich S, Gonzàlez R, Albaigès J, Sarlé A, Wouters J, González A, Sevillano X, Sharpe J, De La Torre R, Dierssen M, Vande Velde G, Martínez-Abadías N

Sci Rep. 2021 Feb 25;11(1):4715

Guidelines for FAIR sharing of preclinical safety and off-target pharmacology data.

Briggs K, Bosc N, Camara T, Diaz C, Drew P, Drewe WC, Kors J, Van Mulligen E, Pastor M, Pognan F, Quintana JR, Sarntivijai S, Steger-Hartmann T

ALTEX. 2021 Feb 25;

Ambient air pollution and the development of overweight and obesity in children: a large longitudinal study.

de Bont J, Díaz Y, de Castro M, Cirach M, Basagaña X, Nieuwenhuijsen M, Duarte-Salles T, Vrijheid M

Int J Obes (Lond). 2021 Feb 24;

Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation.

Arenas EJ, Martínez-Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, Fajardo CA, Gros A, Klein C, Arribas J

Nat Commun. 2021 Feb 23;12(1):1237

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.

Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nielsen SF, Nordestgaard BG, Wiklund F, Tangen CM, Giles GG, Wolk A, Albanes D, Travis RC, Blot WJ, Zheng W, Sanderson M, Stanford JL, Mucci LA, West CML, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Menegaux F, Khaw KT, Park JY, Ingles SA, Maier C, Hamilton RJ, Thibodeau SN, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Penney KL, Huff C, Teixeira MR, Multigner L, Leach RJ, Cannon-Albright L, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Pandha H, Razack A, Newcomb LF, Fowke JH, Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Bush WS, Roobol MJ, Parent MÉ, Hu JJ, Mills IG, Andreassen OA, Dale AM, Seibert TM, UKGPCS collaborators., APCB (Australian Prostate Cancer BioResource)., NC-LA PCaP Investigators., IMPACT Study Steering Committee and Collaborators., Canary PASS Investigators., Profile Study Steering Committee., PRACTICAL Consortium.

Nat Commun. 2021 Feb 23;12(1):1236

Household cleaning and poor asthma control among elderly women.

Dumas O, Bédard A, Marbac M, Sedki M, Temam S, Chanoine S, Severi G, Boutron-Ruault MC, Garcia-Aymerich J, Siroux V, Varraso R, Le Moual N

J Allergy Clin Immunol Pract. 2021 Feb 22;

Factors Associated With the Risk of Developing Moderate to Severe Acute Postoperative Pain After Primary Total Knee Arthroplasty: Results From the PAIN OUT Registry.

García-López J, Polanco-García M, Montes A

J Arthroplasty. 2021 Feb 6;

The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition.

Ros-Rocher N, Pérez-Posada A, Leger MM, Ruiz-Trillo I

Open Biol. 2021 Feb;11(2):200359

Hospital-at-Home Expands Hospital Capacity During COVID-19 Pandemic.

Nogués X, Sánchez-Martinez F, Castells X, Díez-Pérez A, Sabaté RA, Petit I, Brasé A, Horcajada JP, Güerri-Fernández R, Pascual J

J Am Med Dir Assoc. 2021 Jan 31;

High-density lipoprotein functional traits and coronary artery disease in a general population: a case-cohort study.

Sanllorente A, Castañer O, Lassale C, Almanza-Aguilera E, Elosua R, Vila J, Soldado M, Blanchart G, Muñoz-Aguayo D, Subirana I, Marrugat J, Hernáez Á, Fitó M

Eur J Prev Cardiol. 2020 Dec 28;

Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers.

Head SA, Hernandez-Alias X, Yang JS, Ciampi L, Beltran-Sastre V, Torres-Méndez A, Irimia M, Schaefer MH, Serrano L

PLoS Biol. 2021 Feb 23;19(2):e3001138

Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain.

Ramírez-López Á, Pastor A, de la Torre R, La Porta C, Ozaita A, Cabañero D, Maldonado R

Eur J Pain. 2021 Feb 22;

Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion.

Faria M, Prats E, Rosas Ramírez JR, Bellot M, Bedrossiantz J, Pagano M, Valls A, Gomez-Canela C, Porta JM, Mestres J, Garcia-Reyero N, Faggio C, Gómez Oliván LM, Raldua D

Sci Total Environ. 2021 Feb 15;775:145671

Reduced expansion of CD94/NKG2C+ NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.

Puiggros A, Blanco G, Muntasell A, Rodríguez-Rivera M, Nonell L, Altadill M, Puigdecanet E, Arnal M, Calvo X, Gimeno E, Abella E, Abrisqueta P, Bosch F, Yélamos J, Ferrer A, López-Botet M, Espinet B

Int J Lab Hematol. 2021 Feb 22;

Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent.

Collij LE, Salvadó G, Shekari M, Alves IL, Reimand J, Wink AM, Zwan M, Niñerola-Baizán A, Perissinotti A, Scheltens P, Ikonomovic MD, Smith APL, Farrar G, Molinuevo JL, Barkhof F, Buckley CJ, van Berckel BNM, Gispert JD, ALFA study., AMYPAD consortium.

Eur J Nucl Med Mol Imaging. 2021 Feb 22;

Obstructive Sleep Apnea Syndrome as a Trigger of Cardiac Arrhythmias.

Martí-Almor J, Jiménez-López J, Casteigt B, Conejos J, Valles E, Farré N, Flor MF

Curr Cardiol Rep. 2021 Feb 20;23(3):20

A Gender Perspective of Addictive Disorders.

Fonseca F, Robles-Martínez M, Tirado-Muñoz J, Alías-Ferri M, Mestre-Pintó JI, Coratu AM, Torrens M

Curr Addict Rep. 2021 Feb 16;:1-11

Swine T-Cells and Specific Antibodies Evoked by Peptide Dendrimers Displaying Different FMDV T-Cell Epitopes.

de León P, Cañas-Arranz R, Defaus S, Torres E, Forner M, Bustos MJ, Revilla C, Dominguez J, Andreu D, Blanco E, Sobrino F

Front Immunol. 2020;11:621537

Subclinical Atherosclerosis and Brain Metabolism in Middle-Aged Individuals: The PESA Study.

Cortes-Canteli M, Gispert JD, Salvadó G, Toribio-Fernandez R, Tristão-Pereira C, Falcon C, Oliva B, Mendiguren J, Fernandez-Friera L, Sanz J, Garcia-Ruiz JM, Fernandez-Ortiz A, Sanchez-Gonzalez J, Ibanez B, Molinuevo JL, Fuster V

J Am Coll Cardiol. 2021 Feb 23;77(7):888-898

Complete genomic characterization of a new KLRC2 allele, NKG2C*03.

Asenjo J, Muntasell A, López-Botet M, Moraru M, Vilches C

HLA. 2021 Feb 20;

Predictors of Metachronous Risk Polyps After Index Colonoscopy.

Carot L, Navarro G, Naranjo-Hans D, Iglesias-Coma M, Dalmases A, Fernández L, Seoane A, Buron A, Bellosillo B, Bessa X, Andreu M, Alvarez-Urturi C

Clin Transl Gastroenterol. 2021 Feb 18;12(2):e00304

The longitudinal association of eating behaviour and ADHD symptoms in school age children: a follow-up study in the RHEA cohort.

Leventakou V, Herle M, Kampouri M, Margetaki K, Vafeiadi M, Kogevinas M, Chatzi L, Micali N

Eur Child Adolesc Psychiatry. 2021 Feb 18;

Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease.

Grau-Rivera O, Navalpotro-Gomez I, Sánchez-Benavides G, Suárez-Calvet M, Milà-Alomà M, Arenaza-Urquijo EM, Salvadó G, Sala-Vila A, Shekari M, González-de-Echávarri JM, Minguillón C, Niñerola-Baizán A, Perissinotti A, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Gispert JD, Molinuevo JL, ALFA Study.

Alzheimers Res Ther. 2021 Feb 17;13(1):46

Neuropsychiatric involvement in systemic lupus erythematosus: A review.

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Autoimmun Rev. 2021 Feb 17;:102780

Reduction in new cardiac electronic device implantations in Catalonia during COVID-19.

Arbelo E, Angera I, Trucco E, Rivas-Gándara N, Guerra JM, Bisbal F, Jáuregui-Abularach M, Vallés E, Martin G, Sbraga F, Tolosana JM, Linhart M, Francisco-Pascual J, Montiel-Serrano J, Pereferrer D, Menéndez-Ramírez D, Jiménez J, Elamrani A, Borrás R, Dallaglio PD, Benito E, Santos-Ortega A, Rodríguez-Font E, Sarrias A, González-Matos CE, Martí-Almor J, Cabrera S, Mont L

Europace. 2021 Feb 17;

DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.

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Mol Cell. 2021 Feb 10;

Kidney transplant after a COVID-19.

Pascual J

Nefrologia. 2021 Jan 9;

Transitioning from a coronary to a critical cardiovascular care unit: trends over the past three decades.

Ferrer M, García-García C, El Ouaddi N, Rueda F, Serra J, Oliveras T, Labata C, Dégano IR, Montero S, De Diego O, Elosúa R, Lupón J, Bayes-Genis A

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Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19.

Bousquet J, Czarlewski W, Zuberbier T, Mullol J, Blain H, Cristol JP, De La Torre R, Pizarro Lozano N, Le Moing V, Bedbrook A, Agache I, Akdis CA, Canonica GW, Cruz AA, Fiocchi A, Fonseca JA, Fonseca S, Gemicioglu B, Haahtela T, Iaccarino G, Ivancevich JC, Jutel M, Klimek L, Kraxner H, Kuna P, Larenas-Linnemann DE, Martineau A, Melén E, Okamoto Y, Papadopoulos NG, Pfaar O, Regateiro FS, Reynes J, Rolland Y, Rouadi PW, Samolinski B, Sheikh A, Toppila-Salmi S, Valiulis A, Choi HJ, Kim HJ, Anto JM

Int Arch Allergy Immunol. 2021 Feb 10;:1-15

The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS.

Orkin JD, Montague MJ, Tejada-Martinez D, de Manuel M, Del Campo J, Cheves Hernandez S, Di Fiore A, Fontsere C, Hodgson JA, Janiak MC, Kuderna LFK, Lizano E, Martin MP, Niimura Y, Perry GH, Valverde CS, Tang J, Warren WC, de Magalhães JP, Kawamura S, Marquès-Bonet T, Krawetz R, Melin AD

Proc Natl Acad Sci U S A. 2021 Feb 16;118(7)

Long-term risks after kidney donation: How do we inform potential donors? A survey from descartes and EKITA transplantation working groups.

Mjøen G, Maggiore U, Kessaris N, Kimenai D, Watschinger B, Mariat C, Sever MS, Crespo M, Peruzzi L, Spasovski G, Sørensen SS, Heemann U, Pascual J, Viklicky O, Courtney AE, Hadaya K, Wagner L, Nistor I, Hadjianastassiou V, Durlik M, Helanterä I, Oberbauer R, Oniscu G, Hilbrands L, Abramowicz D, European Renal Association-European Dialysis Transplant Association (ERA-EDTA) Developing Education Science and Care for Renal Transplantation in European States (DESCARTES) working group and the European Society of Organ Transplantation (ESOT) European Kidney Transplant Association (EKITA) – Collaborators are in the Appendix.

Nephrol Dial Transplant. 2021 Feb 15;

Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies.

Dobaño C, Santano R, Jiménez A, Vidal M, Chi J, Melero NR, Popovic M, López-Aladid R, Fernández-Barat L, Tortajada M, Carmona-Torre F, Reina G, Torres A, Mayor A, Carolis C, García-Basteiro AL, Aguilar R, Moncunill G, Izquierdo L

Transl Res. 2021 Feb 12;

Smoking modifies pancreatic cancer risk loci on 2q21.3.

Mocci E, Kundu P, Wheeler W, Arslan AA, Beane Freeman LE, Bracci PM, Brennan P, Canzian F, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Le Marchand L, Neale RE, Shu XO, Visvanathan K, White E, Zheng W, Albanes D, Andreotti G, Babic A, Bamlet WR, Berndt SI, Blackford AL, Bueno-de-Mesquita B, Buring JE, Campa D, Chanock SJ, Childs EJ, Duell EJ, Fuchs CS, Gaziano JM, Giovannucci EL, Goggins MG, Hartge P, Hassan MM, Holly EA, Hoover RN, Hung RJ, Kurtz RC, Lee IM, Malats N, Milne RL, Ng K, Oberg AL, Panico S, Peters U, Porta M, Rabe KG, Riboli E, Rothman N, Scelo G, Sesso HD, Silverman DT, Stevens VL, Strobel O, Thompson IM, Tjonneland A, Trichopoulou A, Van Den Eeden SK, Wactawski-Wende J, Wentzensen N, Wilkens LR, Yu H, Yuan F, Zeleniuch-Jacquotte A, Amundadottir LT, Li D, Jacobs EJ, Petersen GM, Wolpin BM, Risch HA, Kraft P, Chatterjee N, Klein AP, Stolzenberg-Solomon RZ

Cancer Res. 2021 Feb 11;

Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome.

Atzeni A, Galié S, Muralidharan J, Babio N, Tinahones FJ, Vioque J, Corella D, Castañer O, Vidal J, Moreno-Indias I, Torres-Collado L, Fernández-Carrión R, Fitó M, Olbeyra R, Martínez-González MA, Bulló M, Salas-Salvadó J

Microorganisms. 2021 Feb 10;9(2)

A Transdisciplinary Approach to Recovering Natural and Cultural Landscape and Place Identification: A Case Study of Can Moritz Spring (Rubí, Spain).

Cervera M, Bell S, Muñoz F, Mishra HS, Fleming LE, Grellier J, Carrasco-Turigas G, Nieuwenhuijsen MJ, Vert C, Gascon M

Int J Environ Res Public Health. 2021 Feb 10;18(4)

Improvement of Arterial Stiffness One Month after Bariatric Surgery and Potential Mechanisms.

Oliveras A, Galceran I, Goday A, Vázquez S, Sans L, Riera M, Benaiges D, Pascual J

J Clin Med. 2021 Feb 10;10(4)

Cooperative epithelial phagocytosis enables error correction in the early embryo.

Hoijman E, Häkkinen HM, Tolosa-Ramon Q, Jiménez-Delgado S, Wyatt C, Miret-Cuesta M, Irimia M, Callan-Jones A, Wieser S, Ruprecht V

Nature. 2021 Feb 10;

Cell memory of epithelial-mesenchymal plasticity in cancer.

Berenguer J, Celià-Terrassa T

Curr Opin Cell Biol. 2021 Feb 9;69:103-110

Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection.

Vogel-González M, Talló-Parra M, Herrera-Fernández V, Pérez-Vilaró G, Chillón M, Nogués X, Gómez-Zorrilla S, López-Montesinos I, Arnau-Barrés I, Sorli-Redó ML, Horcajada JP, García-Giralt N, Pascual J, Díez J, Vicente R, Güerri-Fernández R

Nutrients. 2021 Feb 9;13(2)

Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19.

Barbui T, De Stefano V, Alvarez-Larran A, Iurlo A, Masciulli A, Carobbio A, Ghirardi A, Ferrari A, Cancelli V, Elli EM, Andrade-Campos MM, Kabat MG, Kiladjian JJ, Palandri F, Benevolo G, Garcia-Gutierrez V, Fox ML, Foncillas MA, Morcillo CM, Rumi E, Osorio S, Papadopoulos P, Bonifacio M, Cervantes KSQ, Serrano MS, Carreno-Tarragona G, Sobas MA, Lunghi F, Patriarca A, Elorza BN, Angona A, Mazo EM, Koschmieder S, Carli G, Cuevas B, Hernandez-Boluda JC, Abadia EL, Cirici BX, Guglielmelli P, Garrote M, Cattaneo D, Daffini R, Cavalca F, Bellosillo B, Benajiba L, Curto-Garcia N, Bellini M, Betti S, Harrison C, Rambaldi A, Vannucchi AM

Blood Cancer J. 2021 Feb 4;11(2):21

Incidence of pulmonary embolism in patients with non-invasive respiratory support during COVID-19 outbreak.

González-García JG, Pascual-Guardia S, Aguilar Colindres RJ, Ausín Herrero P, Alvarado Miranda M, Arita Guevara M, Badenes Bonet D, Bellido Calduch S, Caguana Vélez OA, Cumpli Gargallo C, Dominguez-Alvarez M, Gea J, Grau N, Khilzi K, Martínez-Llorens J, Sánchez Ortiz M, Sánchez-Font A, Sancho-Muñoz A, Parrilla-Gómez FJ, Marín Corral J, Pérez Terán P, Rodríguez-Sevilla JJ, Chalela R, Rodríguez-Chiaradia D

Respir Med. 2021 Feb 4;178:106325

Variation in predicted COVID-19 risk among lemurs and lorises.

Melin AD, Orkin JD, Janiak MC, Valenzuela A, Kuderna L, Marrone F, Ramangason H, Horvath JE, Roos C, Kitchener AC, Khor CC, Lim WK, Lee JGH, Tan P, Umapathy G, Raveendran M, Harris RA, Gut I, Gut M, Lizano E, Nadler T, Zinner D, Johnson SE, Jarvis ED, Fedrigo O, Wu D, Zhang G, Farh KK, Rogers J, Marques-Bonet T, Navarro A, Juan D, Arora PS, Higham JP

bioRxiv. 2021 Feb 3;

From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities.

Hernáez Á, Jaramillo S, García-Borrego A, Espejo-Calvo JA, Covas MI, Blanchart G, de la Torre R, Carrasco-Pancorbo A, Mesa MD, Fernández-Prior MÁ, Castañer O, Fitó M

Antioxidants (Basel). 2021 Jan 30;10(2)

Evolution of Antimicrobial Consumption During the First Wave of COVID-19 Pandemic.

Grau S, Echeverria-Esnal D, Gómez-Zorrilla S, Navarrete-Rouco ME, Masclans JR, Espona M, Gracia-Arnillas MP, Duran X, Comas M, Horcajada JP, Ferrández O

Antibiotics (Basel). 2021 Jan 29;10(2)

Characterization of nuclear mitochondrial insertions in the whole genomes of primates.

Dayama G, Zhou W, Prado-Martinez J, Marques-Bonet T, Mills RE

NAR Genom Bioinform. 2020 Dec;2(4):lqaa089

A fully integrated machine learning scan of selection in the chimpanzee genome.

Nye J, Mondal M, Bertranpetit J, Laayouni H

NAR Genom Bioinform. 2020 Sep;2(3):lqaa061

On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF.

Meseguer A, Årman F, Fornes O, Molina-Fernández R, Bonet J, Fernandez-Fuentes N, Oliva B

NAR Genom Bioinform. 2020 Sep;2(3):lqaa046

First Person Account COVID 19 Delirium in a Doctor: When Death Stalks the Mind.

Arumi A, Bulbena-Cabre A, Bulbena A

Front Psychiatry. 2021;12:626648

The Immunobiogram, a Novel In Vitro Assay to Evaluate Treatment Resistance in Patients Receiving Immunosuppressive Therapy.

Portoles JM, Jimenez C, Janeiro D, Lopez-Oliva MO, Ortega-Carrion A, Blanquez D, Arribas L, Gomez C, Diez T, Pascual J, Portero I

Front Immunol. 2020;11:618202

Efficacy and safety of oral fosfomycin for asymptomatic bacteriuria in kidney transplant recipients: Results from a Spanish multicenter cohort.

Ruiz-Ruigómez M, Fernández-Ruiz M, Silva JT, Vidal E, Origüen J, Calvo-Cano A, Luna-Huerta E, Merino E, Hernández D, Jironda-Gallegos C, Escudero-Sánchez R, Gioia F, Moreno A, Roca C, Cordero E, Janeiro D, Sánchez-Sobrino B, Montero MM, Redondo D, Candel FJ, Pérez-Flores I, Armiñanzas C, González-Rico C, Fariñas MC, Rodrigo E, Loeches B, López-Oliva MO, Montejo M, Lauzurica R, Horcajada JP, Pascual J, Andrés A, Aguado JM, López-Medrano F, REIPI, REDinREN, and GESITRA-IC/SEIMC.

Antimicrob Agents Chemother. 2021 Feb 8;

Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study.

Fernández-Castillejo S, Pedret A, Catalán Ú, Valls RM, Farràs M, Rubió L, Castañer O, Macià A, Fitó M, Motilva MJ, Covas MI, Giera M, Remaley AT, Solà R

Mol Nutr Food Res. 2021 Feb 9;:e2001192

miR-24-3p regulates CDX2 during intestinalization of cardiac-type epithelium in a human model of Barrett's esophagus.

Gil-Gómez G, Fassan M, Nonell L, Garrido M, Climent M, Anglada R, Iglesias M, Guzzardo V, Borga C, Grande L, de Bolós C, Pera M

Dis Esophagus. 2021 Feb 9;

Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity.

Ruiz de Azua I, Martin-Garcia E, Domingo-Rodriguez L, Aparisi Rey A, Pascual Cuadrado D, Islami L, Turunen P, Remmers F, Lutz B, Maldonado R

Neuropsychopharmacology. 2021 Feb 8;

A Loading Micafungin Dose in Critically Ill Patients Undergoing Continuous Veno-Venous Hemofiltration or Continuous Veno-Venous Hemodiafiltration: A Population Pharmacokinetic Analysis.

Garbez N, Mbatchi LC, Maseda E, Luque S, Grau S, Wallis SC, Muller L, Lipman J, Roberts JA, Lefrant JY, Roger C

Ther Drug Monit. 2021 Feb 8;

Effect of an Intensive Weight-Loss Lifestyle Intervention on Kidney Function: A Randomized Controlled Trial.

Díaz-López A, Becerra-Tomás N, Ruiz V, Toledo E, Babio N, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Cano Ibañez N, Delgado-Rodríguez M, Matía-Martín P, Daimiel L, de Paz JA, Vidal J, Vázquez C, Ruiz-Canela M, Bulló M, Sorlí JV, Goday A, Fiol M, García-de-la-Hera M, Tojal Sierra L, Pérez-Farinós N, Zulet MÁ, Sánchez-Villegas A, Sacanella E, Fernández-García JC, Santos-Lozano JM, Gimenez-Gracia M, Del Mar Bibiloni M, Diez-Espino J, Ortega-Azorin C, Castañer O, Morey M, Torres-Collado L, Sorto Sanchez C, Muñoz MÁ, Ros E, Martinez-Gonzalez MA, Salas-Salvadó J, PREDIMED-Plus Investigators.

Am J Nephrol. 2021 Feb 8;:1-14

LDL Cholesterol Reduction Variability with Different Types and Doses of Statins in Monotherapy or Combined with Ezetimibe. Results from the Spanish Arteriosclerosis Society Dyslipidaemia Registry.

Climent E, Bea AM, Benaiges D, Brea-Hernando Á, Pintó X, Suárez-Tembra M, Perea V, Plana N, Blanco-Vaca F, Pedro-Botet J, Dyslipidaemia Registry of the Spanish Atherosclerosis Society.

Cardiovasc Drugs Ther. 2021 Feb 8;

Pathways linking biodiversity to human health: A conceptual framework.

Marselle MR, Hartig T, Cox DTC, de Bell S, Knapp S, Lindley S, Triguero-Mas M, Böhning-Gaese K, Braubach M, Cook PA, de Vries S, Heintz-Buschart A, Hofmann M, Irvine KN, Kabisch N, Kolek F, Kraemer R, Markevych I, Martens D, Müller R, Nieuwenhuijsen M, Potts JM, Stadler J, Walton S, Warber SL, Bonn A

Environ Int. 2021 Feb 6;150:106420

Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy.

Linares J, Marín-Jiménez JA, Badia-Ramentol J, Calon A

Front Cell Dev Biol. 2020;8:621070

Effects of Environmental Factors on Severity and Mortality of COVID-19.

Kifer D, Bugada D, Villar-Garcia J, Gudelj I, Menni C, Sudre C, Vuckovic F, Ugrina I, Lorini LF, Posso M, Bettinelli S, Ughi N, Maloberti A, Epis O, Giannattasio C, Rossetti C, Kalogjera L, Peršec J, Ollivere L, Ollivere BJ, Yan H, Cai T, Aithal GP, Steves CJ, Kantele A, Kajova M, Vapalahti O, Sajantila A, Wojtowicz R, Wierzba W, Krol Z, Zaczynski A, Zycinska K, Postula M, Lukšic I, Civljak R, Markotic A, Brachmann J, Markl A, Mahnkopf C, Murray B, Ourselin S, Valdes AM, Horcajada JP, Castells X, Pascual J, Allegri M, Primorac D, Spector TD, Barrios C, Lauc G

Front Med (Lausanne). 2020;7:607786

Assessing Autophagy in Muscle Stem Cells.

Campanario S, Ramírez-Pardo I, Hong X, Isern J, Muñoz-Cánoves P

Front Cell Dev Biol. 2020;8:620409

Accidental extubation in prone position: Report of two cases and proposal of an algorithm for airway management.

Bosch L, Pacreu S, Castelltort L, Gallart L

Eur J Anaesthesiol. 2021 Mar 1;38(3):319-322

PACIFIC: a lightweight deep-learning classifier of SARS-CoV-2 and co-infecting RNA viruses.

Acera Mateos P, Balboa RF, Easteal S, Eyras E, Patel HR

Sci Rep. 2021 Feb 5;11(1):3209

Antimyeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis.

Rodríguez E, Latzke B, Sierra M, Romera AM, Siedel D, Agraz I, Soler MJ, García-Carro C, Draibe J, de la Prada FJ, Villacorta J, Buxeda A, Sierra-Ochoa A, Lozano I, Durán X, Barrios C, Pascual J, Spanish Group for the Study of Glomerular Diseases (GLOSEN).

Nephrol Dial Transplant. 2021 Feb 3;

Frequency of sensitisation to the individual fragrances of Fragrance Mix I and II according to the factors included in the MOAHLFA index.

Sánchez-Pujol MJ, Docampo-Simón A, Mercader P, González-Pérez R, Hervella-Garcés M, Sanz-Sánchez T, Córdoba S, Sánchez-Pérez J, Heras-Mendaza F, Giménez-Arnau AM, Gatica-Ortega ME, Pastor-Nieto MA, Zaragoza V, Carrascosa JM, García-Bravo B, Ruiz-González I, Borrego L, Sánchez-Pedreño P, de Frutos JO, Armario-Hita JC, García-Gavín J, Fernández-Redondo V, Serra E, Silvestre JF

Contact Dermatitis. 2021 Feb 3;

Interplay between Humoral and CLA+ T Cell Response against Candida albicans in Psoriasis.

de Jesús-Gil C, Sans-de San Nicolàs L, Ruiz-Romeu E, Ferran M, Soria-Martínez L, García-Jiménez I, Chiriac A, Casanova-Seuma JM, Fernández-Armenteros JM, Owens S, Celada A, Howell MD, Pujol RM, Santamaria-Babí LF

Int J Mol Sci. 2021 Feb 3;22(4)

Benchmarking the performance of Pool-seq SNP callers using simulated and real sequencing data.

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Mol Ecol Resour. 2021 Feb 3;

Habitat preference and diversification rates in a speciose lineage of diving beetles.

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Mol Phylogenet Evol. 2021 Feb 2;:107087

Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease.

Dávalos-Yerovi V, Marco E, Sánchez-Rodríguez D, Duran X, Meza-Valderrama D, Rodríguez DA, Muñoz E, Tejero-Sánchez M, Muns MD, Guillén-Solà A, Duarte E

Nutrients. 2021 Jan 26;13(2)

EAACI Biologicals Guidelines-dupilumab for children and adults with moderate-to-severe atopic dermatitis.

Agache I, Akdis C, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong PY, O'Mahony L, Schwarze J, Warner A, Werfel T, Palomares O, Jutel M

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Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics.

Heerlein K, Young AH, Otte C, Frodl T, Degraeve G, Hagedoorn W, Oliveira-Maia AJ, Perez Sola V, Rathod S, Rosso G, Sierra P, Morrens J, Van Dooren G, Gali Y, Perugi G

J Affect Disord. 2020 Nov 30;283:115-122

Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome.

Garrido-Martín D, Borsari B, Calvo M, Reverter F, Guigó R

Nat Commun. 2021 Feb 1;12(1):727

Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans.

Papaseit E, Olesti E, Pérez-Mañá C, Torrens M, Fonseca F, Grifell M, Ventura M, de la Torre R, Farré M

Pharmaceuticals (Basel). 2021 Jan 28;14(2)

Do Pregnancy-Induced Brain Changes Reverse? The Brain of a Mother Six Years after Parturition.

Martínez-García M, Paternina-Die M, Barba-Müller E, Martín de Blas D, Beumala L, Cortizo R, Pozzobon C, Marcos-Vidal L, Fernández-Pena A, Picado M, Belmonte-Padilla E, Massó-Rodriguez A, Ballesteros A, Desco M, Vilarroya Ó, Hoekzema E, Carmona S

Brain Sci. 2021 Jan 28;11(2)

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.

López de Maturana E, Rodríguez JA, Alonso L, Lao O, Molina-Montes E, Martín-Antoniano IA, Gómez-Rubio P, Lawlor R, Carrato A, Hidalgo M, Iglesias M, Molero X, Löhr M, Michalski C, Perea J, O'Rorke M, Barberà VM, Tardón A, Farré A, Muñoz-Bellvís L, Crnogorac-Jurcevic T, Domínguez-Muñoz E, Gress T, Greenhalf W, Sharp L, Arnes L, Cecchini L, Balsells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Márquez M, Mora J, O'Driscoll D, Scarpa A, Ye W, Yu J, PanGenEU Investigators., García-Closas M, Kogevinas M, Rothman N, Silverman DT, SBC/EPICURO Investigators., Albanes D, Arslan AA, Beane-Freeman L, Bracci PM, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Du M, Gallinger S, Gaziano JM, Goodman PJ, Gunter M, LeMarchand L, Li D, Neale RE, Peters U, Petersen GM, Risch HA, Sánchez MJ, Shu XO, Thornquist MD, Visvanathan K, Zheng W, Chanock SJ, Easton D, Wolpin BM, Stolzenberg-Solomon RZ, Klein AP, Amundadottir LT, Marti-Renom MA, Real FX, Malats N

Genome Med. 2021 Feb 1;13(1):15

The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer's disease mutations.

Seuma M, Faure A, Badia M, Lehner B, Bolognesi B

Elife. 2021 Feb 1;10

Environment and the COVID-19 pandemic.

Sunyer J, Dadvand P, Foraster M, Gilliland F, Nawrot T

Environ Res. 2021 Jan 29;:110819

Suicidality among healthcare professionals during the first COVID19 wave.

Bruffaerts R, Voorspoels W, Jansen L, Kessler RC, Mortier P, Vilagut G, De Vocht J, Alonso J

J Affect Disord. 2021 Jan 11;283:66-70

Differential associations of APOE-epsilon2 and APOE-epsilon4 alleles with PET-measured amyloid-Beta and tau deposition in older individuals without dementia.

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High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib.

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Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.

Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wright RO, Annesi-Maesano I, Wright J, Hivert MF, Wright RJ, Zar HJ, Stein DJ, London SJ, Cecil CAM, Tiemeier H, Lahti J

Mol Psychiatry. 2021 Jan 7;

Epidemiology of Dog Bite Incidents in Chile: Factors Related to the Patterns of Human-Dog Relationship.

Barrios CL, Bustos-López C, Pavletic C, Parra A, Vidal M, Bowen J, Fatjó J

Animals (Basel). 2021 Jan 6;11(1)

Breast density, benign breast disease, and risk of breast cancer over time.

Román M, Louro J, Posso M, Alcántara R, Peñalva L, Sala M, Del Riego J, Prieto M, Vidal C, Sánchez M, Bargalló X, Tusquets I, Castells X

Eur Radiol. 2021 Jan 6;

CLL-like monoclonal B cell lymphocytosis displays an increased inflammatory signature that is reduced in early stage chronic lymphocytic leukemia.

Blanco G, Puiggros A, Sherry B, Nonell L, Calvo X, Puigdecanet E, Chiu PY, Kieso Y, Ferrer G, Palacios F, Arnal M, Rodríguez-Rivera M, Gimeno E, Abella E, Rai KR, Abrisqueta P, Bosch F, Calon A, Ferrer A, Chiorazzi N, Espinet B

Exp Hematol. 2021 Jan 6;

SPServer: split-statistical potentials for the analysis of protein structures and protein-protein interactions.

Aguirre-Plans J, Meseguer A, Molina-Fernandez R, Marín-López MA, Jumde G, Casanova K, Bonet J, Fornes O, Fernandez-Fuentes N, Oliva B

BMC Bioinformatics. 2021 Jan 6;22(1):4

Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece.

Howe CG, Margetaki K, Vafeiadi M, Roumeliotaki T, Karachaliou M, Kogevinas M, McConnell R, Eckel SP, Conti DV, Kippler M, Farzan SF, Chatzi L

Environ Health. 2021 Jan 6;20(1):1

Reliability of transcutaneous bilirubin determination based on skin color determined by a neonatal skin color scale of our own.

Maya-Enero S, Candel-Pau J, Garcia-Garcia J, Duran-Jordà X, López-Vílchez MÁ

Eur J Pediatr. 2021 Jan 6;

Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts.

Martínez-Gil N, Roca-Ayats N, Cozar M, Garcia-Giralt N, Ovejero D, Nogués X, Grinberg D, Balcells S

Int J Mol Sci. 2021 Jan 6;22(2)

Reply to Anirban P. Mitra, Tanner Miest, and Colin P.N. Dinney's Words of Wisdom re: Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non-Muscle-Invasive Bladder Cancer. Eur Urol. In press.

Perera-Bel J, Bellmunt J

Eur Urol. 2021 Jan 5;

Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts.

Lertxundi N, Molinuevo A, Valvi D, Gorostiaga A, Balluerka N, Shivappa N, Hebert J, Navarrete-Muñoz EM, Vioque J, Tardón A, Vrijheid M, Roumeliotaki T, Koutra K, Chatzi L, Ibarluzea J

Eur Child Adolesc Psychiatry. 2021 Jan 4;

A RAC-GEF network critical for early intestinal tumourigenesis.

Pickering KA, Gilroy K, Cassidy JW, Fey SK, Najumudeen AK, Zeiger LB, Vincent DF, Gay DM, Johansson J, Fordham RP, Miller B, Clark W, Hedley A, Unal EB, Kiel C, McGhee E, Machesky LM, Nixon C, Johnsson AE, Bain M, Strathdee D, van Hoof SR, Medema JP, Anderson KI, Brachmann SM, Stucke VM, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell AD, Sansom OJ

Nat Commun. 2021 Jan 4;12(1):56

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM Jr, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA

Nat Genet. 2021 Jan;53(1):65-75

A Woman with Gradually Enlarging Brownish Confluent Papules on the Left Thigh: A Quiz.

Altemir A, Canal-Garcia E, Pujol RM

Acta Derm Venereol. 2020 Dec 22;

Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration.

Pool FM, Kiel C, Serrano L, Luthert PJ

NPJ Aging Mech Dis. 2020 Jan 7;6(1):2

The demise of a wonder: Evolutionary history and conservation assessments of the Wonder Gecko Teratoscincus keyserlingii (Gekkota, Sphaerodactylidae) in Arabia.

Tamar K, Els J, Kornilios P, Soorae P, Tarroso P, Thanou E, Pereira J, Shah JN, Elhassan EEM, Aguhob JC, Badaam SF, Eltayeb MM, Pusey R, Papenfuss TJ, Macey JR, Carranza S

PLoS One. 2021;16(1):e0244150

Correction: Do birthrates contribute to sickness absence differences in women? A cohort study in Catalonia, Spain, 2012-2014.

March AN, Villar R, Ubalde-Lopez M, Benavides FG, Serra L

PLoS One. 2021;16(1):e0245332

New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab.

Toboso I, Tejeda-Velarde A, Alvarez-Lafuente R, Arroyo R, Hegen H, Deisenhammer F, Sainz de la Maza S, Alvarez-Cermeño JC, Izquierdo G, Paramo D, Oliva P, Casanova B, Agüera-Morales E, Franciotta D, Gastaldi M, Fernández O, Urbaneja P, Garcia-Dominguez JM, Romero F, Laroni A, Uccelli A, Perez-Sempere A, Saiz A, Blanco Y, Galimberti D, Scarpini E, Espejo C, Montalban X, Rasche L, Paul F, González I, Álvarez E, Ramo C, Caminero AB, Aladro Y, Calles C, Eguía P, Belenguer-Benavides A, Ramió-Torrentà L, Quintana E, Martínez-Rodríguez JE, Oterino A, López de Silanes C, Casanova LI, Landete L, Frederiksen J, Bsteh G, Mulero P, Comabella M, Hernández MA, Espiño M, Prieto JM, Pérez D, Otano M, Padilla F, García-Merino JA, Navarro L, Muriel A, Frossard LC, Villar LM

Front Neurol. 2020;11:579438

Thirty-day suicidal thoughts and behaviors among hospital workers during the first wave of the Spain COVID-19 outbreak.

Mortier P, Vilagut G, Ferrer M, Serra C, de Dios Molina J, López-Fresneña N, Puig T, Pelayo-Terán JM, Pijoan JI, Emparanza JI, Espuga M, Plana N, González-Pinto A, Ortí-Lucas RM, de Salázar AM, Rius C, Aragonès E, Del Cura-González I, Aragón-Peña A, Campos M, Parellada M, Pérez-Zapata A, Forjaz MJ, Sanz F, Haro JM, Vieta E, Pérez-Solà V, Kessler RC, Bruffaerts R, Alonso J, MINDCOVID Working Group.

Depress Anxiety. 2021 Jan 4;

Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response.

von Locquenghien M, Rozalén C, Celià-Terrassa T

J Clin Invest. 2021 Jan 4;131(1)

Risk of breast cancer two years after a benign biopsy depends on the mammographic feature prompting recall.

Vernet-Tomás M, Louro J, Román M, Saladié F, Posso M, Prieto M, Vázquez I, Baré M, Peñalva L, Vidal C, Bargalló X, Sánchez M, Ferrer J, A Espinàs J, Quintana MJ, Rodríguez-Arana A, Castells X, BELE study group.

Maturitas. 2021 Feb;144:53-59

Application of ultrasound for muscle assessment in sarcopenia: 2020 SARCUS update.

Perkisas S, Bastijns S, Baudry S, Bauer J, Beaudart C, Beckwée D, Cruz-Jentoft A, Gasowski J, Hobbelen H, Jager-Wittenaar H, Kasiukiewicz A, Landi F, Malek M, Marco E, Martone AM, de Miguel AM, Piotrowicz K, Sanchez E, Sanchez-Rodriguez D, Scafoglieri A, Vandewoude M, Verhoeven V, Wojszel ZB, De Cock AM

Eur Geriatr Med. 2021 Jan 2;

Data for a city-level health impact assessment of urban transport in Mauritius.

Thondoo M, Rojas-Rueda D, de Vries D, Naraynen N, Nieuwenhuijsen MJ, Gupta J

Data Brief. 2021 Feb;34:106658

Smartphone App for monitoring Asthma in children and adolescents.

Mayoral K, Garin O, Caballero-Rabasco MA, Praena-Crespo M, Bercedo A, Hernandez G, Castillo J, Lizano Barrantes C, Pardo Y, Ferrer M, ARCA group.

Qual Life Res. 2021 Jan 2;

Spatial sequestration of misfolded proteins as an active chaperone-mediated process during heat stress.

Boronat S, Cabrera M, Hidalgo E

Curr Genet. 2021 Jan 1;

Comparative Effectiveness Research in Localized Prostate Cancer: a 10-Year follow-up Cohort Study.

Garin O, Suárez JF, Guedea F, Pont À, Pardo Y, Goñi A, Mariño A, Hervás A, Herruzo I, Cabrera P, Sancho G, Ponce de León J, Macías V, Gutierrez C, Castells M, Ferrer M, Multicentric Spanish Group of Clinically Localized Prostate Cancer.

Int J Radiat Oncol Biol Phys. 2020 Dec 31;

Effects of COVID-19 Home Confinement on Mental Health in Individuals with Increased Risk of Alzheimer's Disease.

Soldevila-Domenech N, Forcano L, Boronat A, Lorenzo T, Piera I, Puig-Pijoan A, Mateus J, González de Echevarri Gómez JM, Knezevic I, Soteras A, Fauria K, Pizarro N, Molinuevo JL, de la Torre R, PENSA Study Group. From IMIM: ., From BBRC: .

J Alzheimers Dis. 2020 Dec 31;

Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease.

Guasch-Ferré M, Hernández-Alonso P, Drouin-Chartier JP, Ruiz-Canela M, Razquin C, Toledo E, Li J, Dennis C, Wittenbecher C, Corella D, Estruch R, Fitó M, Ros E, Babio N, Bhupathiraju SN, Clish CB, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J

J Nutr. 2020 Dec 31;

Safety of oral bisphosphonates in moderate-to-severe chronic kidney disease: a bi-national cohort analysis.

Robinson DE, Ali MS, Pallares N, Tebé C, Elhussein L, Abrahamsen B, Arden NK, Ben-Shlomo Y, Caskey FJ, Cooper C, Dedman D, Delmestri A, Judge A, Pérez-Sáez MJ, Pascual J, Nogues X, Diez-Perez A, Strauss VY, Javaid MK, Prieto-Alhambra D

J Bone Miner Res. 2020 Dec 29;

Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus.

Almanza-Aguilera E, Hernáez Á, Corella D, Sanllorente A, Ros E, Portolés O, Valussi J, Estruch R, Coltell O, Subirana I, Canudas S, Razquin C, Blanchart G, Nonell L, Fitó M, Castañer O

J Clin Med. 2020 Dec 29;10(1)

Quality of urban green spaces influences residents' use of these spaces, physical activity, and overweight/obesity.

Knobel P, Maneja R, Bartoll X, Alonso L, Bauwelinck M, Valentin A, Zijlema W, Borrell C, Nieuwenhuijsen M, Dadvand P

Environ Pollut. 2020 Dec 29;271:116393

Toward a correct measure of third-hand exposure.

Lidón-Moyano C, Fu M, Perez-Ortuño R, Ballbè M, Garcia E, Martín-Sánchez JC, Pascual JA, Fernández E, Martínez-Sánchez JM

Environ Res. 2020 Dec 29;:110686

Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.

Alcalá-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, Golbano A, Crespí-Vázquez K, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Narita M, Pérez-Navarro E

EMBO Mol Med. 2020 Dec 28;:e12105

Benchmarking of Single-Virus Genomics: a new tool for uncovering the virosphere.

Garcia-Heredia I, Bhattacharjee AS, Fornas O, Gomez ML, Martínez JM, Martinez-Garcia M

Environ Microbiol. 2020 Dec 28;

Generative Models for Molecular Design.

Merz KM Jr, De Fabritiis G, Wei GW

J Chem Inf Model. 2020 Dec 28;60(12):5635-5636

bsAS, an antisense long non-coding RNA, essential for correct wing development through regulation of blistered/DSRF isoform usage.

Pérez-Lluch S, Klein CC, Breschi A, Ruiz-Romero M, Abad A, Palumbo E, Bekish L, Arnan C, Guigó R

PLoS Genet. 2020 Dec 28;16(12):e1009245

Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement.

Rivera A, Sánchez A, Luque S, Mur I, Puig L, Crusi X, González JC, Sorlí L, González A, Horcajada JP, Navarro F, Benito N

Antibiotics (Basel). 2020 Dec 27;10(1)

Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up).

Dierssen-Sotos T, Gómez-Acebo I, Gutiérrez-Ruiz N, Aragonés N, Amiano P, Molina de la Torre AJ, Guevara M, Alonso-Molero J, Obon-Santacana M, Fernández-Tardón G, Molina-Barceló A, Alguacil J, Marcos-Gragera R, Rodríguez-Cundín P, Castaño-Vinyals G, Canseco Fernandez R, Castilla J, Molinuevo A, Pérez-Gómez B, Kogevinas M, Pollán M, Llorca J

Int J Environ Res Public Health. 2020 Dec 24;18(1)

Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates.

Aguiar L, Pinheiro M, Neves AR, Vale N, Defaus S, Andreu D, Reis S, Gomes P

Membranes (Basel). 2020 Dec 22;11(1)

Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster.

Bogaerts-Márquez M, Guirao-Rico S, Gautier M, González J

Mol Ecol. 2020 Dec 22;

A Specialized Therapeutic Approach to Chronic Urticaria Patient's Refractory to H1-Antihistamines Improves the Burden of the Disease. The Spanish AWARE Experience.

Gimenez-Arnau A, Bartra J, Ferrer M, Jauregui I, Borbujo J, Figueras I, Muñoz-Bellido FJ, Pedraz J, Serra-Baldrich E, Tejedor-Alonso MA, Velasco M, Terradas P, Labrador M

J Investig Allergol Clin Immunol. 2020 Dec 21;:0

Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance: A randomized controlled trial.

Seoane A, Font X, Pérez JC, Pérez R, Enriquez CF, Parrilla M, Riu F, Dedeu JM, Barranco LE, Duran X, Ibáñez IA, Álvarez MA

World J Gastroenterol. 2020 Dec 21;26(47):7568-7583

Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites.

Frigola J, Sabarinathan R, Gonzalez-Perez A, Lopez-Bigas N

Nucleic Acids Res. 2020 Dec 21;

The Tryptophan System in Cocaine-Induced Depression.

Fonseca F, Mestre-Pintó JI, Gómez-Gómez À, Martinez-Sanvisens D, Rodríguez-Minguela R, Papaseit E, Pérez-Mañá C, Langohr K, Valverde O, Pozo ÓJ, Farré M, Torrens M, On Behalf Of Neurodep Group

J Clin Med. 2020 Dec 19;9(12)

Air pollution, physical activity and health: A mapping review of the evidence.

Tainio M, Jovanovic Andersen Z, Nieuwenhuijsen MJ, Hu L, de Nazelle A, An R, Garcia LMT, Goenka S, Zapata-Diomedi B, Bull F, Sá TH

Environ Int. 2020 Dec 19;147:105954

Evaluating Behavioral and Linguistic Changes During Drug Treatment for Depression Using Tweets in Spanish: Pairwise Comparison Study.

Leis A, Ronzano F, Mayer MA, Furlong LI, Sanz F

J Med Internet Res. 2020 Dec 18;22(12):e20920

Consequences of canceling elective invasive cardiac procedures during Covid-19 outbreak.

Moreno R, Díez JL, Diarte JA, Macaya F, de la Torrre Hernández JM, Rodríguez-Leor O, Trillo R, Alonso-Briales J, Amat-Santos I, Romaguera R, Díaz JF, Vaquerizo B, Ojeda S, Cruz-González I, Morena-Salas D, Pérez de Prado A, Sarnago F, Portero P, Gutierrez-Barrios A, Alfonso F, Bosch E, Pinar E, Ruiz-Arroyo JR, Ruiz-Quevedo V, Jiménez-Mazuecos J, Lozano F, Rumoroso JR, Novo E, Irazusta FJ, García Del Blanco B, Moreu J, Ballesteros-Pradas SM, Frutos A, Villa M, Alegría-Barrero E, Lázaro R, Paredes E

Catheter Cardiovasc Interv. 2020 Dec 17;

Cognitive effects of low dose of ionizing radiation - Lessons learned and research gaps from epidemiological and biological studies.

Pasqual E, Boussin F, Bazyka D, Nordenskjold A, Yamada M, Ozasa K, Pazzaglia S, Roy L, Thierry-Chef I, de Vathaire F, Benotmane MA, Cardis E

Environ Int. 2020 Dec 17;147:106295

Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma.

García-Colmenero L, González J, Sandoval J, Guillén Y, Diaz-Lagares A, Andrades E, Iglesias A, Nonell L, Pujol RM, Bigas A, Espinosa L, Gallardo F

Cells. 2020 Dec 15;9(12)

Shared DNA methylation signatures in childhood allergy: the MeDALL study.

Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G, BIOS Consortium., Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH

J Allergy Clin Immunol. 2020 Dec 15;

Frailty and kidney transplant candidates.

Pérez-Sáez MJ, Gutiérrez-Dalmau Á, Moreso F, Rodríguez Mañas L, Pascual J

Nefrologia. 2020 Dec 15;

Substance use during pregnancy and personality dimensions.

Imaz ML, Navinés R, Gelabert E, Fonseca F, Gutierrez-Zotes A, Guillamat R, Langohr K, Canellas F, Gornemann I, Costas J, Mayoral F, Valles V, De Diego Y, Roca M, Iborra JL, Gratacos M, Vilella E, García-Esteve L, Sanjuan J, Torrens M, Martin-Santos Laffon R

Adicciones. 2020 Dec 2;0(0):1433

Functional Assessment of Coding and Regulatory Variants From the DKK1 Locus.

Martínez-Gil N, Roca-Ayats N, Atalay N, Pineda-Moncusí M, Garcia-Giralt N, Van Hul W, Boudin E, Ovejero D, Mellibovsky L, Nogués X, Díez-Pérez A, Grinberg D, Balcells S

JBMR Plus. 2020 Dec;4(12):e10423

Generation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering Williams-Beuren syndrome (7q11.23 deletion).

Kuebler B, Aran B, Flores R, Pérez-Jurado LA, Veiga A, Corominas R, Cuscó I

Stem Cell Res. 2020 Dec;49:102087

Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohorts.

Polanska K, Kaluzny P, Aubert AM, Bernard JY, Duijts L, El Marroun H, Hanke W, Hébert JR, Heude B, Jankowska A, Mancano G, Mensink-Bout SM, Relton C, Shivappa N, Suderman M, Trafalska E, Wesolowska E, Garcia-Esteban R, Guxens M, Casas M, Phillips CM

Biol Psychiatry. 2020 Oct 24;

Gastruloids: Embryonic Organoids from Mouse Embryonic Stem Cells to Study Patterning and Development in Early Mammalian Embryos.

Anlas K, Baillie-Benson P, Arató K, Turner DA, Trivedi V

Methods Mol Biol. 2021;2258:131-147

Spices to Control COVID-19 Symptoms: Yes, but Not Only….

Bousquet J, Czarlewski W, Zuberbier T, Mullol J, Blain H, Cristol JP, De La Torre R, Le Moing V, Pizarro Lozano N, Bedbrook A, Agache I, Akdis CA, Canonica GW, Cruz AA, Fiocchi A, Fonseca JA, Fonseca S, Gemicioglu B, Haahtela T, Iaccarino G, Ivancevich JC, Jutel M, Klimek L, Kuna P, Larenas-Linnemann DE, Melén E, Okamoto Y, Papadopoulos NG, Pfaar O, Reynes J, Rolland Y, Rouadi PW, Samolinski B, Sheikh A, Toppila-Salmi S, Valiulis A, Choi HJ, Kim HJ, Anto JM

Int Arch Allergy Immunol. 2020 Dec 22;:1-7

Comparative Analysis of Different Definitions of Amyloid-Beta Positivity to Detect Early Downstream Pathophysiological Alterations in Preclinical Alzheimer.

Milà-Alomà M, Salvadó G, Shekari M, Grau-Rivera O, Sala-Vila A, Sánchez-Benavides G, Arenaza-Urquijo EM, González-de-Echávarri JM, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Gispert JD, Suárez-Calvet M, Molinuevo JL

J Prev Alzheimers Dis. 2021;8(1):68-77

Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD.

Coca A, Burballa C, Centellas-Pérez FJ, Pérez-Sáez MJ, Bustamante-Munguira E, Ortega A, Dueñas C, Arenas MD, Pérez-Martínez J, Ruiz G, Crespo M, Llamas F, Bustamante-Munguira J, Pascual J

Front Med (Lausanne). 2020;7:615312

Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium.

Ronkainen J, Heiskala A, Vehmeijer FOL, Lowry E, Caramaschi D, Estrada Gutiérrez G, Heiss JA, Hummel N, Keikkala E, Kvist T, Kupsco A, Melton PE, Pesce G, Soomro MH, Vives-Usano M, Baiz N, Binder E, Czamara D, Guxens M, Mustaniemi S, London SJ, Rauschert S, Vääräsmäki M, Vrijheid M, Ziegler AG, Annesi-Maesano I, Bustamante M, Huang RC, Hummel S, Just AC, Kajantie E, Lahti J, Lawlor D, Räikkönen K, Järvelin MR, Felix JF, Sebert S

Epigenetics. 2020 Dec 17;

Effect of bariatric surgery on cardiac structure and function in obese patients: Role of the renin-angiotensin system.

Oliveras A, Molina L, Goday A, Sans L, Riera M, Vazquez S, Benaiges D, Granados AM, Ramon JM, Pascual J

J Clin Hypertens (Greenwich). 2020 Dec 17;

Editorial: Human-Nature Interactions: Perspectives on Conceptual and Methodological Issues.

MacIntyre TE, Beckmann J, Calogiuri G, Donnell AA, Jones MV, Madan CR, Rogerson M, Brick NE, Nieuwenhuijsen M, Gidlow CJ

Front Psychol. 2020;11:607888

Effects of COVID-19 Pandemic Confinement in Patients With Cognitive Impairment.

Barguilla A, Fernández-Lebrero A, Estragués-Gázquez I, García-Escobar G, Navalpotro-Gómez I, Manero RM, Puente-Periz V, Roquer J, Puig-Pijoan A

Front Neurol. 2020;11:589901

Editorial: New Trends of Substance Abuse: Looking for New Psychotropic Effects of Chem Sex Drugs, Cognitive Enhancers, and New Psychoactive Substances.

Pichini S, Di Trana A, Torrens M, Scherbaum N, Zaami S

Front Psychiatry. 2020;11:612192

LoxTnSeq: random transposon insertions combined with cre/lox recombination and counterselection to generate large random genome reductions.

Shaw D, Miravet-Verde S, Piñero-Lambea C, Serrano L, Lluch-Senar M

Microb Biotechnol. 2020 Dec 16;

mRNA spindle localization and mitotic translational regulation by CPEB1 and CPEB4.

Pascual R, Segura-Morales C, Omerzu M, Bellora N, Belloc E, Castellazzi CL, Reina O, Eyras E, Maurice MM, Millanes-Romero A, Méndez R

RNA. 2020 Dec 15;

Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury.

Butragueño-Laiseca L, Troconiz IF, Grau S, Campillo N, García X, Padilla B, Fernández SN, Santiago MJ

Antibiotics (Basel). 2020 Dec 10;9(12)

Annotation of Full-Length Long Noncoding RNAs with Capture Long-Read Sequencing (CLS).

Carbonell Sala S, Uszczynska-Ratajczak B, Lagarde J, Johnson R, Guigó R

Methods Mol Biol. 2021;2254:133-159

Editorial: Proteomics as a Tool for Biomarker and Drug Target Discovery: Improving the Diagnosis and Treatment of Neurodegenerative Diseases.

Belbin O, Lehmann S, Sabidó E, Hirtz C

Front Aging Neurosci. 2020;12:232

Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome.

Heitsch L, Ibanez L, Carrera C, Binkley MM, Strbian D, Tatlisumak T, Bustamante A, Ribó M, Molina C, Dávalos A, López-Cancio E, Muñoz-Narbona L, Soriano-Tárraga C, Giralt-Steinhauer E, Obach V, Slowik A, Pera J, Lapicka-Bodzioch K, Derbisz J, Sobrino T, Castillo J, Campos F, Rodríguez-Castro E, Arias-Rivas S, Segura T, Serrano-Heras G, Vives-Bauza C, Díaz-Navarro R, Tur S, Jimenez C, Martí-Fàbregas J, Delgado-Mederos R, Arenillas J, Krupinski J, Cullell N, Torres-Aguila NP, Muiño E, Cárcel-Márquez J, Moniche F, Cabezas JA, Ford AL, Dhar R, Roquer J, Khatri P, Jiménez-Conde J, Fernandez-Cadenas I, Montaner J, Rosand J, Cruchaga C, Lee JM, International Stroke Genetics Consortium.

Stroke. 2021 Jan;52(1):132-141

Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein.

Cadima-Couto I, Tauzin A, Freire JM, Figueira TN, Silva RDM, Pérez-Peinado C, Cunha-Santos C, Bártolo I, Taveira N, Gano L, Correia JDG, Goncalves J, Mammano F, Andreu D, Castanho MARB, Veiga AS

ACS Infect Dis. 2020 Dec 15;

Green Infrastructure and Health.

Nieuwenhuijsen MJ

Annu Rev Public Health. 2020 Dec 11;

Corrigendum to "Time association between hepatitis C therapy and hepatocellular carcinoma emergence in cirrhosis: Relevance of non-characterized nodules" [J Hepatol (2019) 874-884].

Mariño Z, Darnell A, Lens S, Sapena V, Díaz A, Belmonte E, Perelló C, Calleja JL, Varela M, Rodriguez M, Rodriguez de Lope C, Llerena S, Torras X, Gallego A, Sala M, Morillas RM, Minguez B, Llaneras J, Coll S, Carrion JA, Iñarrairaegui M, Sangro B, Vilana R, Sole M, Ayuso C, Ríos J, Forns X, Bruix J, Reig M

J Hepatol. 2020 Dec 11;

Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae.

Burgos R, Weber M, Martinez S, Lluch-Senar M, Serrano L

Mol Syst Biol. 2020 Dec;16(12):e9530

Food Resource Sharing of Alder Leaf Beetle Specialists (Coleoptera: Chrysomelidae) as Potential Insect-Plant Interface for Horizontal Transmission of Endosymbionts.

Cardoso A, Gómez-Zurita J

Environ Entomol. 2020 Dec 14;49(6):1402-1414

Differential Binding of Sarilumab and Tocilizumab to IL-6R-alfa and Effects of Receptor Occupancy on Clinical Parameters.

Xu C, Rafique A, Potocky T, Paccaly A, Nolain P, Lu Q, Iglesias-Rodriguez M, John GS, Nivens MC, Kanamaluru V, Fairhurst J, Ishii T, Maldonado R, Choy E, Emery P

J Clin Pharmacol. 2020 Dec 12;

Mental Health Impact of the First Wave of COVID-19 Pandemic on Spanish Healthcare Workers: a Large Cross-sectional Survey.

Alonso J, Vilagut G, Mortier P, Ferrer M, Alayo I, Aragón-Peña A, Aragonès E, Campos M, Cura-González ID, Emparanza JI, Espuga M, Forjaz MJ, González-Pinto A, Haro JM, López-Fresneña N, Salázar ADM, Molina JD, Ortí-Lucas RM, Parellada M, Pelayo-Terán JM, Pérez-Zapata A, Pijoan JI, Plana N, Puig MT, Rius C, Rodríguez-Blázquez C, Sanz F, Serra C, Kessler RC, Bruffaerts R, Vieta E, Pérez-Solà V, MINDCOVID Working group.

Rev Psiquiatr Salud Ment. 2020 Dec 10;

The ecology of cancer differentiation therapy.

Solé R, Aguadé-Gorgorió G

J Theor Biol. 2020 Dec 9;:110552

Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients.

Broquetas T, Garcia-Retortillo M, Micó M, Canillas L, Puigvehí M, Cañete N, Coll S, Viu A, Hernandez JJ, Bessa X, Carrión JA

World J Hepatol. 2020 Nov 27;12(11):1076-1088

Targeted metabolomics in formalin-fixed paraffin-embedded tissue specimens: Liquid chromatography-tandem mass spectrometry determination of acidic metabolites in cancer research.

Gomez-Gomez A, Sabbaghi M, Haro N, Albanell J, Menéndez S, González M, Gil-Gómez G, Rovira A, Pozo OJ

Talanta. 2021 Feb 1;223(Pt 2):121740

DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches.

Ventós-Alfonso A, Ylla G, Montañes JC, Belles X

iScience. 2020 Dec 18;23(12):101778

Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study.

Julibert A, Del Mar Bibiloni M, Gallardo-Alfaro L, Abbate M, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Cano-Ibañez N, Martín-Sánchez V, Pintó X, Gaforio JJ, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Notario-Barandiaran L, Colom A, Garcia-Rios A, Castro-Barquero S, Bernal R, Santos-Lozano JM, Fernández-Lázaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari J, Canudas S, Goday A, Tur JA, PREDIMED-PLUS investigators .

J Nutr. 2020 Dec 10;150(12):3161-3170

Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study.

Bédard A, Basagaña X, Anto JM, Garcia-Aymerich J, Devillier P, Arnavielhe S, Bedbrook A, Onorato GL, Czarlewski W, Murray R, Almeida R, Fonseca JA, Correia da Sousa J, Costa E, Morais-Almeida M, Todo-Bom A, Cecchi L, De Feo G, Illario M, Menditto E, Monti R, Stellato C, Ventura MT, Annesi-Maesano I, Bosse I, Fontaine JF, Pham-Thi N, Thibaudon M, Schmid-Grendelmeier P, Spertini F, Chavannes NH, Fokkens WJ, Reitsma S, Dubakiene R, Emuzyte R, Kvedariene V, Valiulis A, Kuna P, Samolinski B, Klimek L, Mösges R, Pfaar O, Shamai S, Roller-Wirnsberger RE, Tomazic PV, Ryan D, Sheikh A, Haahtela T, Toppila-Salmi S, Valovirta E, Cardona V, Mullol J, Valero A, Makris M, Papadopoulos NG, Prokopakis EP, Psarros F, Bachert C, Hellings PW, Pugin B, Bindslev-Jensen C, Eller E, Kull I, Melén E, Wickman M, De Vries G, van Eerd M, Agache I, Ansotegui IJ, Bosnic-Anticevich S, Cruz AA, Casale T, Ivancevich JC, Larenas-Linnemann DE, Sofiev M, Wallace D, Waserman S, Yorgancioglu A, Laune D, Bousquet J, MASK study group.

Clin Transl Allergy. 2020 Dec 9;10(1):62

Plasma Metabolomic Profiles of Glycemic Index, Glycemic Load, and Carbohydrate Quality Index in the PREDIMED Study.

Bulló M, Papandreou C, Ruiz-Canela M, Guasch-Ferré M, Li J, Hernández-Alonso P, Toledo E, Liang L, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Serra-Majem L, Clish CB, Becerra-Tomás N, Martínez-González MA, Hu FB, Salas-Salvadó J

J Nutr. 2020 Dec 9;

Non-occupational protein contact dermatitis induced by mango fruit.

Pesqué D, Canal-Garcia E, Rozas-Muñoz E, Pujol RM, Giménez-Arnau AM

Contact Dermatitis. 2020 Dec 9;

U-Shaped Association between Dietary Acid Load and Risk of Osteoporotic Fractures in 2 Populations at High Cardiovascular Risk.

García-Gavilán JF, Martínez A, Konieczna J, Mico-Perez R, García-Arellano A, Basora J, Barrubés L, Goday A, Canudas S, Salas-Salvadó J, Bulló M

J Nutr. 2020 Dec 9;

Missense variant contribution to USP9X-female syndrome.

Jolly LA, Parnell E, Gardner AE, Corbett MA, Pérez-Jurado LA, Shaw M, Lesca G, Keegan C, Schneider MC, Griffin E, Maier F, Kiss C, Guerin A, Crosby K, Rosenbaum K, Tanpaiboon P, Whalen S, Keren B, McCarrier J, Basel D, Sadedin S, White SM, Delatycki MB, Kleefstra T, Küry S, Brusco A, Sukarova-Angelovska E, Trajkova S, Yoon S, Wood SA, Piper M, Penzes P, Gecz J

NPJ Genom Med. 2020 Dec 9;5(1):53

The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.

Arumugam K, Shin W, Schiavone V, Vlahos L, Tu X, Carnevali D, Kesner J, Paull EO, Romo N, Subramaniam P, Worley J, Tan X, Califano A, Cosma MP

Cell Rep. 2020 Dec 8;33(10):108474

A call for urgent action to safeguard our Planet and our health in line with the Helsinki Declaration.

Halonen JI, Erhola M, Furman E, Haahtela T, Jousilahti P, Barouki R, Bergman Å, Billo NE, Fuller R, Haines A, Kogevinas M, Kolossa-Gehring M, Krauze K, Lanki T, Vicente JL, Messerli P, Nieuwenhuijsen M, Paloniemi R, Peters A, Posch KH, Timonen P, Vermeulen R, Virtanen SM, Bousquet J, Antó JM

Environ Res. 2020 Dec 8;:110600

Validation of an Asbestos Exposure Questionnaire (QEAS-7) for Clinical Practice.

Ferrer J, Granados G, Hernández S, Cruz MJ, Sampol J, Álvarez Simón D, Ramada JM

Int J Environ Res Public Health. 2020 Dec 8;17(24)

The Suicide Prevention and Intervention Study (SURVIVE): study protocol for a Spanish multisite cohort study with nested randomized-controlled trials.

Pérez V, Elices M, Toll A, Bobes J, López-Solà C, Díaz-Marsá M, Grande I, López-Peña P, Rodríguez-Vega B, Ruiz-Veguilla M, de la Torre-Luque A, SURVIVE Group.

Rev Psiquiatr Salud Ment. 2020 Dec 7;

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies.

Bousquet J, Cristol JP, Czarlewski W, Anto JM, Martineau A, Haahtela T, Fonseca SC, Iaccarino G, Blain H, Fiocchi A, Canonica GW, Fonseca JA, Vidal A, Choi HJ, Kim HJ, Le Moing V, Reynes J, Sheikh A, Akdis CA, Zuberbier T, ARIA group.

Clin Transl Allergy. 2020 Dec 3;10(1):58

Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic.

Sousa-Pinto B, Heffler E, Antó A, Czarlewski W, Bedbrook A, Gemicioglu B, Canonica GW, Antó JM, Fonseca JA, Bousquet J

Clin Transl Allergy. 2020 Nov 2;10(1):47

Population history of North Africa based on modern and ancient genomes.

Lucas-Sánchez M, Serradell JM, Comas D

Hum Mol Genet. 2020 Dec 8;

Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease.

Castañer O, Pintó X, Subirana I, Amor AJ, Ros E, Hernáez Á, Martínez-González MÁ, Corella D, Salas-Salvadó J, Estruch R, Lapetra J, Gómez-Gracia E, Alonso-Gomez AM, Fiol M, Serra-Majem L, Corbella E, Benaiges D, Sorli JV, Ruiz-Canela M, Babió N, Sierra LT, Ortega E, Fitó M

J Am Coll Cardiol. 2020 Dec 8;76(23):2712-2724

RNA-protein interactions: Central players in coordination of regulatory networks.

Armaos A, Zacco E, Sanchez de Groot N, Tartaglia GG

Bioessays. 2020 Dec 7;:e2000118

Lox'd in translation: contradictions in the nomenclature surrounding common lox-site mutants and their implications in experiments.

Shaw D, Serrano L, Lluch-Senar M

Microbiology (Reading). 2020 Dec 7;

In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species.

Delgado Blanco J, Hernandez-Alias X, Cianferoni D, Serrano L

PLoS Comput Biol. 2020 Dec 7;16(12):e1008450

Burden of Psoriasis in Catalonia: Epidemiology, Associated Comorbidities, Health Care Utilization, and Sick Leave.

Puig L, Ferrándiz C, Pujol RM, Vela E, Albertí-Casas C, Comellas M, Blanch C

Actas Dermosifiliogr. 2020 Dec 5;

Urinary metabolite quantitative trait loci in children and their interaction with dietary factors.

Calvo-Serra B, Maitre L, Lau CE, Siskos AP, Gützhow KB, Andrusaityte S, Casas M, Cadiou S, Chatzi L, González JR, Grazuleviciene R, McEachan R, Slama R, Vafeiadi M, Wright J, Coen M, Vrijheid M, Keun HC, Escaramís G, Bustamante M

Hum Mol Genet. 2020 Dec 5;

Autosomal genetics and Y-chromosome haplogroup L1b-M317 reveal Mount Lebanon Maronites as a persistently non-emigrating population.

Platt DE, Artinian H, Mouzaya F, Khalil W, Kamar FG, Matisoo-Smith E, Calafell F, Taleb NN, Zalloua P

Eur J Hum Genet. 2020 Dec 4;

Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in healthy adults.

van Nunen E, Hoek G, Tsai MY, Probst-Hensch N, Imboden M, Jeong A, Naccarati A, Tarallo S, Raffaele D, Nieuwenhuijsen M, Vlaanderen J, Gulliver J, Amaral AFS, Vineis P, Vermeulen R

Environ Res. 2020 Dec 4;:110579

Towards understanding the origin of animal development.

Ruiz-Trillo I, de Mendoza A

Development. 2020 Dec 3;147(23)

COSMIN Risk of Bias tool to assess the quality of studies on reliability or measurement error of outcome measurement instruments: a Delphi study.

Mokkink LB, Boers M, van der Vleuten CPM, Bouter LM, Alonso J, Patrick DL, de Vet HCW, Terwee CB

BMC Med Res Methodol. 2020 Dec 3;20(1):293

Allergic rhinitis.

Bousquet J, Anto JM, Bachert C, Baiardini I, Bosnic-Anticevich S, Walter Canonica G, Melén E, Palomares O, Scadding GK, Togias A, Toppila-Salmi S

Nat Rev Dis Primers. 2020 Dec 3;6(1):95


Frankish A, Diekhans M, Jungreis I, Lagarde J, Loveland JE, Mudge JM, Sisu C, Wright JC, Armstrong J, Barnes I, Berry A, Bignell A, Boix C, Carbonell Sala S, Cunningham F, Di Domenico T, Donaldson S, Fiddes IT, García Girón C, Gonzalez JM, Grego T, Hardy M, Hourlier T, Howe KL, Hunt T, Izuogu OG, Johnson R, Martin FJ, Martínez L, Mohanan S, Muir P, Navarro FCP, Parker A, Pei B, Pozo F, Riera FC, Ruffier M, Schmitt BM, Stapleton E, Suner MM, Sycheva I, Uszczynska-Ratajczak B, Wolf MY, Xu J, Yang YT, Yates A, Zerbino D, Zhang Y, Choudhary JS, Gerstein M, Guigó R, Hubbard TJP, Kellis M, Paten B, Tress ML, Flicek P

Nucleic Acids Res. 2020 Dec 3;

Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:

Latest news


Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar


UPF Business Shuttle and Innovation Unit


Technology and Business Development Office at the CRG


Analysis and Global Development at ISGlobal


EMBLEM Technology Transfer


  • The following start-ups have been created within the PRBB environment:


Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.



Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.



qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.



ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.



Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.



World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.


Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.


MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.



A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.


Latest news