Connecting perspectives: from bytes and molecules to organisms and populations
"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".
Jordi Camí, General Director of the PRBB.
The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.
With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.
Hospital del Mar Medical Research Institute (IMIM)
Cancer
The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research
Epidemiology and Public Health
The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.
Biomedical Informatics
This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB).
Neuroscience
The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.
Inflammatory and Cardiovascular Disorders
This programme expands our knowledge of pathophysiological, inflammatory and genetic mechanisms of cardiovascular, respiratory and bone disorders, as well as other acute and chronic disorders, their diagnosis and treatment. The multidisciplinary team addresses basic biomedical scientific questions arising from clinical cases. This approach should lead to translational research that can be applied to medical care.
Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)
Cellular and Molecular Biology
The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.
Molecular Medicine
This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.
Evolutionary Biology and Complex Systems
The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.
Biomedical Informatics
The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.
Genetics and Neuroscience
The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.
Systems Bioengineering
The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.
Transversal Program
Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.
Centre for Genomic Regulation (CRG)
Bioinformatics and Genomics
Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).
Cell and Developmental Biology
The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.
Gene Regulation, Stem Cells and Cancer
The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.
Systems Biology
The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice.
The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.
Barcelona Institute for Global Health (ISGlobal, Mar Campus)
Climate and Health
Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.
Air pollution and urban environment
The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.
Non-communicable diseases and the environment
The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.
Childhood and Environment
This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.
Radiation
The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.
Other
ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.
Institute of Evolutionary Biology (IBE: CSIC-UPF)
Animal Biodiversity and Evolution
The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.
Comparative and Computational Genomics
This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.
Functional Genomics and Evolution
The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.
Population genetics
Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.
Complex Systems
This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.
European Molecular Biology Laboratory (EMBL)
Tissue biology and disease modelling
The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”
Institute of Applied Radiopharmacy of Barcelona (IRAB)
Research and Innovation
The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.
Animal research with the international accreditation from the AAALAC.
The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.
Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.
- Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
- The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
- The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).
For more information on the animal facility and animal experimentation visit:
Animal experimentation courses
The PRBB and Charles River Campus
Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.
The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:
- Euthanasia (Function b)
- Performing procedures (Function c)
- Designing projects and procedures (mice and fish/amphibians) (Function d)
The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.
●Latest news
Shared facilities for high-impact research
"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."
Jordi Camí, General Director of the PRBB
The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.
The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection
Contact: Montserrat Torà
→ marbiobanc@imim.es
The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.
Contact: Julia Ponomarenko
→ biocore@crg.eu
The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.
Contact: Ivo Gut
→ projectmanager@cnag.crg.eu
This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.
Contact: Blanca Espinet
→ bespinet@parcdesalutmar.cat
This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.
Contact: Òscar Fornas
→ oscar.fornas@upf.edu
Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit
The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.
Contact: Dirección de secretaría
→ ceea@prbb.org
Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.
Contact: Dirección de secretaría
→ ceic-imas@imim.es
The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.
Contact: Secretaría
→ cbs@prbb.org
This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.
Contact: Carlo Carolis
→ bmspt@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit
BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.
Contact: Jordi Alonso
→ bibliopro@imim.es
The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.
Contact: Arcadi Navarro
→ helpdesk@ega-archive.org
This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.
Contact: Jochen Hecht
→ ngs@crg.eu
The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.
Contact: Montserrat Torà
→ margenomics@imim.es
The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.
Contact: Ferran Casals
→ genomica@upf.edu
The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.
Contact: Laura Batlle Morera
→ laura.batlle@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0
This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.
Contact: Ana Aldea
→ aaldea@imim.es
This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.
Contact: Jim Swoger
→ mif@embl.es
Web:
https://www.embl.es/services/mesoscopic-imaging-facility
The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.
Contact: Timo Zimmermann
→ timo.zimmermann@crg.es
Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit
Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)
Contact: David Andreu
→ david.andreu@upf.edu
This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.
Contact: Eduard Sabido Aguade
→ eduard.sabido@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit
Quality of life and symptom assessment in paraesophageal hernias: a systematic literature review of reporting standards.
Patel NM, Puri A, Sounderajah V, Ferri L, Griffiths E, Low D, Maynard N, Mueller C, Pera M, van Berge Henegouwen MI, Watson DI, Zaninotto G, Hanna GB, Markar SR, Para-Oesophageal hernia Symptom Tool (POST) Collaborative.
Dis Esophagus. 2021 Jan 13;
Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid.
Lleó A, Núñez-Llaves R, Alcolea D, Chiva C, Balateu-Paños D, Colom-Cadena M, Gomez-Giro G, Muñoz L, Querol-Vilaseca M, Pegueroles J, Rami L, Lladó A, Molinuevo JL, Tainta M, Clarimón J, Spires-Jones T, Blesa R, Fortea J, Martínez-Lage P, Sánchez-Valle R, Sabidó E, Bayés À, Belbin O
Mol Cell Proteomics. 2019 Mar;18(3):546-560
Corrigendum to "Television viewing duration during childhood and long-association with adolescent neuropsychological outcomes" [Prev. Med. Rep. 4 (2016) 447-452.].
O'Connor G, Piñero Casas M, Basagaña X, López Vicente M, Davand P, Torrent M, Martínez-Murciano D, García-Esteban R, Marinelli M, Sunyer J, Julvez J
Prev Med Rep. 2021 Mar;21:101305
Efficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental clinical cases.
Bousquet J, Le Moing V, Blain H, Czarlewski W, Zuberbier T, de la Torre R, Pizarro Lozano N, Reynes J, Bedbrook A, Cristol JP, Cruz AA, Fiocchi A, Haahtela T, Iaccarino G, Klimek L, Kuna P, Melén E, Mullol J, Samolinski B, Valiulis A, Anto JM
World Allergy Organ J. 2021 Jan;14(1):100498
Does cognitive impairment in bipolar disorder impact on a SIMPLe app use?
Bonnín CDM, Solé B, Reinares M, García-Estela A, Samalin L, Martínez-Arán A, Sánchez-Moreno J, Colom F, Vieta E, Hidalgo-Mazzei D
J Affect Disord. 2020 Dec 29;282:488-494
Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age - An exposome-based approach in 5 European cohorts.
Jedynak P, Maitre L, Guxens M, Gützkow KB, Julvez J, López-Vicente M, Sunyer J, Casas M, Chatzi L, Grazuleviciene R, Kampouri M, McEachan R, Mon-Williams M, Tamayo I, Thomsen C, Urquiza J, Vafeiadi M, Wright J, Basagaña X, Vrijheid M, Philippat C
Sci Total Environ. 2020 Dec 15;763:144115
http://www.ncbi.nlm.nih.gov/en...
Two ways to be endemic. Alps and Apennines are different functional refugia during climatic cycles.
Menchetti M, Talavera G, Cini A, Salvati V, Dinca V, Platania L, Bonelli S, Balletto E, Vila R, Dapporto L
Mol Ecol. 2021 Jan 9;
A novel role of MNT as a negative regulator of REL and the NF-KB pathway.
Liaño-Pons J, Lafita-Navarro MC, García-Gaipo L, Colomer C, Rodríguez J, von Kriegsheim A, Hurlin PJ, Ourique F, Delgado MD, Bigas A, Espinosa ML, León J
Oncogenesis. 2021 Jan 8;10(1):5
http://www.ncbi.nlm.nih.gov/en...
Arachidonic acid effect on the allosteric gating mechanism of BK (Slo1) channels associated with the Beta1 subunit.
Martín P, Moncada M, Castillo K, Orsi F, Ducca G, Fernández-Fernández JM, Gonzalez C, Milesi V
Biochim Biophys Acta Biomembr. 2021 Jan 5;:183550
Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes.
Vellino S, Oddou C, Rivier P, Boyault C, Hiriart-Bryant E, Kraut A, Martin R, Coute Y, Knölker HJ, Valverde MA, Albigès-Rizo C, Destaing O
J Cell Biol. 2021 Feb 1;220(2)
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.
van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L, Send TS, Frank J, Jylhävä J, Wang Y, Mishra PP, Colins OF, Corcoran DL, Poulton R, Mill J, Hannon E, Arseneault L, Korhonen T, Vuoksimaa E, Felix JF, Bakermans-Kranenburg MJ, Campbell A, Czamara D, Binder E, Corpeleijn E, Gonzalez JR, Grazuleviciene R, Gutzkow KB, Evandt J, Vafeiadi M, Klein M, van der Meer D, Ligthart L, BIOS Consortium., Kluft C, Davies GE, Hakulinen C, Keltikangas-Järvinen L, Franke B, Freitag CM, Konrad K, Hervas A, Fernández-Rivas A, Vetro A, Raitakari O, Lehtimäki T, Vermeiren R, Strandberg T, Räikkönen K, Snieder H, Witt SH, Deuschle M, Pedersen NL, Hägg S, Sunyer J, Franke L, Kaprio J, Ollikainen M, Moffitt TE, Tiemeier H, van IJzendoorn MH, Relton C, Vrijheid M, Sebert S, Jarvelin MR, Caspi A, Evans KL, McIntosh AM, Bartels M, Boomsma DI
Mol Psychiatry. 2021 Jan 8;
http://www.ncbi.nlm.nih.gov/en...
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.
Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA, Kote-Jarai Z, Muir K, Lophatananon A, UKGPCS collaborators., Schleutker J, Pashayan N, Batra J, APCB BioResource (Australian Prostate Cancer BioResource)., Grönberg H, Walsh EI, Turner EL, Lane A, Martin RM, Neal DE, Donovan JL, Hamdy FC, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A, Albanes D, Haiman CA, Travis RC, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Wiklund F, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Vega A, IMPACT Study Steering Committee and Collaborators., Kogevinas M, Penney KL, Teixeira MR, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, Razack A, Newcomb LF, Canary PASS Investigators., Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Roobol MJ, Zheng W, Profile Study Steering Committee., Mills IG, Andreassen OA, Dale AM, Seibert TM, PRACTICAL Consortium.
Prostate Cancer Prostatic Dis. 2021 Jan 8;
High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib.
Barbui T, Vannucchi AM, Alvarez-Larran A, Iurlo A, Masciulli A, Carobbio A, Ghirardi A, Ferrari A, Rossi G, Elli E, Andrade-Campos MM, Kabat MG, Kiladjian JJ, Palandri F, Benevolo G, Garcia-Gutierrez V, Fox ML, Foncillas MA, Morcillo CM, Rumi E, Osorio S, Papadopoulos P, Bonifacio M, Cervantes KSQ, Serrano MS, Carreno-Tarragona G, Sobas MA, Lunghi F, Patriarca A, Elorza BN, Angona A, Mazo EM, Koschmieder S, Ruggeri M, Cuevas B, Hernandez-Boluda JC, Abadia EL, Cirici BX, Guglielmelli P, Garrote M, Cattaneo D, Daffini R, Cavalca F, Bellosillo B, Benajiba L, Curto-Garcia N, Bellini M, Betti S, De Stefano V, Harrison C, Rambaldi A
Leukemia. 2021 Jan 7;
http://www.ncbi.nlm.nih.gov/en...
Chemical and in vitro bioanalytical assessment of drinking water quality in Manhiça, Mozambique.
Villanueva CM, Grau-Pujol B, Evlampidou I, Escola V, Goñi-Irigoyen F, Kuckelkorn J, Grummt T, Arjona L, Lazaro B, Etxeandia A, Ulibarrena E, Nhacolo A, Muñoz J
J Expo Sci Environ Epidemiol. 2021 Jan 7;
Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.
Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wright RO, Annesi-Maesano I, Wright J, Hivert MF, Wright RJ, Zar HJ, Stein DJ, London SJ, Cecil CAM, Tiemeier H, Lahti J
Mol Psychiatry. 2021 Jan 7;
Epidemiology of Dog Bite Incidents in Chile: Factors Related to the Patterns of Human-Dog Relationship.
Barrios CL, Bustos-López C, Pavletic C, Parra A, Vidal M, Bowen J, Fatjó J
Animals (Basel). 2021 Jan 6;11(1)
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Breast density, benign breast disease, and risk of breast cancer over time.
Román M, Louro J, Posso M, Alcántara R, Peñalva L, Sala M, Del Riego J, Prieto M, Vidal C, Sánchez M, Bargalló X, Tusquets I, Castells X
Eur Radiol. 2021 Jan 6;
CLL-like monoclonal B cell lymphocytosis displays an increased inflammatory signature that is reduced in early stage chronic lymphocytic leukemia.
Blanco G, Puiggros A, Sherry B, Nonell L, Calvo X, Puigdecanet E, Chiu PY, Kieso Y, Ferrer G, Palacios F, Arnal M, Rodríguez-Rivera M, Gimeno E, Abella E, Rai KR, Abrisqueta P, Bosch F, Calon A, Ferrer A, Chiorazzi N, Espinet B
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SPServer: split-statistical potentials for the analysis of protein structures and protein-protein interactions.
Aguirre-Plans J, Meseguer A, Molina-Fernandez R, Marín-López MA, Jumde G, Casanova K, Bonet J, Fornes O, Fernandez-Fuentes N, Oliva B
BMC Bioinformatics. 2021 Jan 6;22(1):4
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Prenatal metal mixtures and child blood pressure in the Rhea mother-child cohort in Greece.
Howe CG, Margetaki K, Vafeiadi M, Roumeliotaki T, Karachaliou M, Kogevinas M, McConnell R, Eckel SP, Conti DV, Kippler M, Farzan SF, Chatzi L
Environ Health. 2021 Jan 6;20(1):1
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Reliability of transcutaneous bilirubin determination based on skin color determined by a neonatal skin color scale of our own.
Maya-Enero S, Candel-Pau J, Garcia-Garcia J, Duran-Jordà X, López-Vílchez MÁ
Eur J Pediatr. 2021 Jan 6;
Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts.
Martínez-Gil N, Roca-Ayats N, Cozar M, Garcia-Giralt N, Ovejero D, Nogués X, Grinberg D, Balcells S
Int J Mol Sci. 2021 Jan 6;22(2)
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Reply to Anirban P. Mitra, Tanner Miest, and Colin P.N. Dinney's Words of Wisdom re: Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non-Muscle-Invasive Bladder Cancer. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.10.020.
Perera-Bel J, Bellmunt J
Eur Urol. 2021 Jan 5;
Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts.
Lertxundi N, Molinuevo A, Valvi D, Gorostiaga A, Balluerka N, Shivappa N, Hebert J, Navarrete-Muñoz EM, Vioque J, Tardón A, Vrijheid M, Roumeliotaki T, Koutra K, Chatzi L, Ibarluzea J
Eur Child Adolesc Psychiatry. 2021 Jan 4;
A RAC-GEF network critical for early intestinal tumourigenesis.
Pickering KA, Gilroy K, Cassidy JW, Fey SK, Najumudeen AK, Zeiger LB, Vincent DF, Gay DM, Johansson J, Fordham RP, Miller B, Clark W, Hedley A, Unal EB, Kiel C, McGhee E, Machesky LM, Nixon C, Johnsson AE, Bain M, Strathdee D, van Hoof SR, Medema JP, Anderson KI, Brachmann SM, Stucke VM, Malliri A, Drysdale M, Turner M, Serrano L, Myant K, Campbell AD, Sansom OJ
Nat Commun. 2021 Jan 4;12(1):56
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
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Nat Genet. 2021 Jan;53(1):65-75
A Woman with Gradually Enlarging Brownish Confluent Papules on the Left Thigh: A Quiz.
Altemir A, Canal-Garcia E, Pujol RM
Acta Derm Venereol. 2020 Dec 22;
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Repository of proposed pathways and protein-protein interaction networks in age-related macular degeneration.
Pool FM, Kiel C, Serrano L, Luthert PJ
NPJ Aging Mech Dis. 2020 Jan 7;6(1):2
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The demise of a wonder: Evolutionary history and conservation assessments of the Wonder Gecko Teratoscincus keyserlingii (Gekkota, Sphaerodactylidae) in Arabia.
Tamar K, Els J, Kornilios P, Soorae P, Tarroso P, Thanou E, Pereira J, Shah JN, Elhassan EEM, Aguhob JC, Badaam SF, Eltayeb MM, Pusey R, Papenfuss TJ, Macey JR, Carranza S
PLoS One. 2021;16(1):e0244150
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Correction: Do birthrates contribute to sickness absence differences in women? A cohort study in Catalonia, Spain, 2012-2014.
March AN, Villar R, Ubalde-Lopez M, Benavides FG, Serra L
PLoS One. 2021;16(1):e0245332
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New Algorithms Improving PML Risk Stratification in MS Patients Treated With Natalizumab.
Toboso I, Tejeda-Velarde A, Alvarez-Lafuente R, Arroyo R, Hegen H, Deisenhammer F, Sainz de la Maza S, Alvarez-Cermeño JC, Izquierdo G, Paramo D, Oliva P, Casanova B, Agüera-Morales E, Franciotta D, Gastaldi M, Fernández O, Urbaneja P, Garcia-Dominguez JM, Romero F, Laroni A, Uccelli A, Perez-Sempere A, Saiz A, Blanco Y, Galimberti D, Scarpini E, Espejo C, Montalban X, Rasche L, Paul F, González I, Álvarez E, Ramo C, Caminero AB, Aladro Y, Calles C, Eguía P, Belenguer-Benavides A, Ramió-Torrentà L, Quintana E, Martínez-Rodríguez JE, Oterino A, López de Silanes C, Casanova LI, Landete L, Frederiksen J, Bsteh G, Mulero P, Comabella M, Hernández MA, Espiño M, Prieto JM, Pérez D, Otano M, Padilla F, García-Merino JA, Navarro L, Muriel A, Frossard LC, Villar LM
Front Neurol. 2020;11:579438
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Thirty-day suicidal thoughts and behaviors among hospital workers during the first wave of the Spain COVID-19 outbreak.
Mortier P, Vilagut G, Ferrer M, Serra C, de Dios Molina J, López-Fresneña N, Puig T, Pelayo-Terán JM, Pijoan JI, Emparanza JI, Espuga M, Plana N, González-Pinto A, Ortí-Lucas RM, de Salázar AM, Rius C, Aragonès E, Del Cura-González I, Aragón-Peña A, Campos M, Parellada M, Pérez-Zapata A, Forjaz MJ, Sanz F, Haro JM, Vieta E, Pérez-Solà V, Kessler RC, Bruffaerts R, Alonso J, MINDCOVID Working Group.
Depress Anxiety. 2021 Jan 4;
Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response.
von Locquenghien M, Rozalén C, Celià-Terrassa T
J Clin Invest. 2021 Jan 4;131(1)
Risk of breast cancer two years after a benign biopsy depends on the mammographic feature prompting recall.
Vernet-Tomás M, Louro J, Román M, Saladié F, Posso M, Prieto M, Vázquez I, Baré M, Peñalva L, Vidal C, Bargalló X, Sánchez M, Ferrer J, A Espinàs J, Quintana MJ, Rodríguez-Arana A, Castells X, BELE study group.
Maturitas. 2021 Feb;144:53-59
Application of ultrasound for muscle assessment in sarcopenia: 2020 SARCUS update.
Perkisas S, Bastijns S, Baudry S, Bauer J, Beaudart C, Beckwée D, Cruz-Jentoft A, Gasowski J, Hobbelen H, Jager-Wittenaar H, Kasiukiewicz A, Landi F, Malek M, Marco E, Martone AM, de Miguel AM, Piotrowicz K, Sanchez E, Sanchez-Rodriguez D, Scafoglieri A, Vandewoude M, Verhoeven V, Wojszel ZB, De Cock AM
Eur Geriatr Med. 2021 Jan 2;
Data for a city-level health impact assessment of urban transport in Mauritius.
Thondoo M, Rojas-Rueda D, de Vries D, Naraynen N, Nieuwenhuijsen MJ, Gupta J
Data Brief. 2021 Feb;34:106658
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Smartphone App for monitoring Asthma in children and adolescents.
Mayoral K, Garin O, Caballero-Rabasco MA, Praena-Crespo M, Bercedo A, Hernandez G, Castillo J, Lizano Barrantes C, Pardo Y, Ferrer M, ARCA group.
Qual Life Res. 2021 Jan 2;
Spatial sequestration of misfolded proteins as an active chaperone-mediated process during heat stress.
Boronat S, Cabrera M, Hidalgo E
Curr Genet. 2021 Jan 1;
Comparative Effectiveness Research in Localized Prostate Cancer: a 10-Year follow-up Cohort Study.
Garin O, Suárez JF, Guedea F, Pont À, Pardo Y, Goñi A, Mariño A, Hervás A, Herruzo I, Cabrera P, Sancho G, Ponce de León J, Macías V, Gutierrez C, Castells M, Ferrer M, Multicentric Spanish Group of Clinically Localized Prostate Cancer.
Int J Radiat Oncol Biol Phys. 2020 Dec 31;
Effects of COVID-19 Home Confinement on Mental Health in Individuals with Increased Risk of Alzheimer's Disease.
Soldevila-Domenech N, Forcano L, Boronat A, Lorenzo T, Piera I, Puig-Pijoan A, Mateus J, González de Echevarri Gómez JM, Knezevic I, Soteras A, Fauria K, Pizarro N, Molinuevo JL, de la Torre R, PENSA Study Group. From IMIM: ., From BBRC: .
J Alzheimers Dis. 2020 Dec 31;
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Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease.
Guasch-Ferré M, Hernández-Alonso P, Drouin-Chartier JP, Ruiz-Canela M, Razquin C, Toledo E, Li J, Dennis C, Wittenbecher C, Corella D, Estruch R, Fitó M, Ros E, Babio N, Bhupathiraju SN, Clish CB, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J
J Nutr. 2020 Dec 31;
Safety of oral bisphosphonates in moderate-to-severe chronic kidney disease: a bi-national cohort analysis.
Robinson DE, Ali MS, Pallares N, Tebé C, Elhussein L, Abrahamsen B, Arden NK, Ben-Shlomo Y, Caskey FJ, Cooper C, Dedman D, Delmestri A, Judge A, Pérez-Sáez MJ, Pascual J, Nogues X, Diez-Perez A, Strauss VY, Javaid MK, Prieto-Alhambra D
J Bone Miner Res. 2020 Dec 29;
Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus.
Almanza-Aguilera E, Hernáez Á, Corella D, Sanllorente A, Ros E, Portolés O, Valussi J, Estruch R, Coltell O, Subirana I, Canudas S, Razquin C, Blanchart G, Nonell L, Fitó M, Castañer O
J Clin Med. 2020 Dec 29;10(1)
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Quality of urban green spaces influences residents' use of these spaces, physical activity, and overweight/obesity.
Knobel P, Maneja R, Bartoll X, Alonso L, Bauwelinck M, Valentin A, Zijlema W, Borrell C, Nieuwenhuijsen M, Dadvand P
Environ Pollut. 2020 Dec 29;271:116393
Toward a correct measure of third-hand exposure.
Lidón-Moyano C, Fu M, Perez-Ortuño R, Ballbè M, Garcia E, Martín-Sánchez JC, Pascual JA, Fernández E, Martínez-Sánchez JM
Environ Res. 2020 Dec 29;:110686
Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.
Alcalá-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, Golbano A, Crespí-Vázquez K, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Narita M, Pérez-Navarro E
EMBO Mol Med. 2020 Dec 28;:e12105
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Benchmarking of Single-Virus Genomics: a new tool for uncovering the virosphere.
Garcia-Heredia I, Bhattacharjee AS, Fornas O, Gomez ML, Martínez JM, Martinez-Garcia M
Environ Microbiol. 2020 Dec 28;
Generative Models for Molecular Design.
Merz KM Jr, De Fabritiis G, Wei GW
J Chem Inf Model. 2020 Dec 28;60(12):5635-5636
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bsAS, an antisense long non-coding RNA, essential for correct wing development through regulation of blistered/DSRF isoform usage.
Pérez-Lluch S, Klein CC, Breschi A, Ruiz-Romero M, Abad A, Palumbo E, Bekish L, Arnan C, Guigó R
PLoS Genet. 2020 Dec 28;16(12):e1009245
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Intraoperative Bacterial Contamination and Activity of Different Antimicrobial Prophylaxis Regimens in Primary Knee and Hip Replacement.
Rivera A, Sánchez A, Luque S, Mur I, Puig L, Crusi X, González JC, Sorlí L, González A, Horcajada JP, Navarro F, Benito N
Antibiotics (Basel). 2020 Dec 27;10(1)
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Dietary Constituents: Relationship with Breast Cancer Prognostic (MCC-SPAIN Follow-Up).
Dierssen-Sotos T, Gómez-Acebo I, Gutiérrez-Ruiz N, Aragonés N, Amiano P, Molina de la Torre AJ, Guevara M, Alonso-Molero J, Obon-Santacana M, Fernández-Tardón G, Molina-Barceló A, Alguacil J, Marcos-Gragera R, Rodríguez-Cundín P, Castaño-Vinyals G, Canseco Fernandez R, Castilla J, Molinuevo A, Pérez-Gómez B, Kogevinas M, Pollán M, Llorca J
Int J Environ Res Public Health. 2020 Dec 24;18(1)
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Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates.
Aguiar L, Pinheiro M, Neves AR, Vale N, Defaus S, Andreu D, Reis S, Gomes P
Membranes (Basel). 2020 Dec 22;11(1)
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Temperature, rainfall and wind variables underlie environmental adaptation in natural populations of Drosophila melanogaster.
Bogaerts-Márquez M, Guirao-Rico S, Gautier M, González J
Mol Ecol. 2020 Dec 22;
A Specialized Therapeutic Approach to Chronic Urticaria Patient's Refractory to H1-Antihistamines Improves the Burden of the Disease. The Spanish AWARE Experience.
Gimenez-Arnau A, Bartra J, Ferrer M, Jauregui I, Borbujo J, Figueras I, Muñoz-Bellido FJ, Pedraz J, Serra-Baldrich E, Tejedor-Alonso MA, Velasco M, Terradas P, Labrador M
J Investig Allergol Clin Immunol. 2020 Dec 21;:0
Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance: A randomized controlled trial.
Seoane A, Font X, Pérez JC, Pérez R, Enriquez CF, Parrilla M, Riu F, Dedeu JM, Barranco LE, Duran X, Ibáñez IA, Álvarez MA
World J Gastroenterol. 2020 Dec 21;26(47):7568-7583
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Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites.
Frigola J, Sabarinathan R, Gonzalez-Perez A, Lopez-Bigas N
Nucleic Acids Res. 2020 Dec 21;
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The Tryptophan System in Cocaine-Induced Depression.
Fonseca F, Mestre-Pintó JI, Gómez-Gómez À, Martinez-Sanvisens D, Rodríguez-Minguela R, Papaseit E, Pérez-Mañá C, Langohr K, Valverde O, Pozo ÓJ, Farré M, Torrens M, On Behalf Of Neurodep Group
J Clin Med. 2020 Dec 19;9(12)
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Air pollution, physical activity and health: A mapping review of the evidence.
Tainio M, Jovanovic Andersen Z, Nieuwenhuijsen MJ, Hu L, de Nazelle A, An R, Garcia LMT, Goenka S, Zapata-Diomedi B, Bull F, Sá TH
Environ Int. 2020 Dec 19;147:105954
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Evaluating Behavioral and Linguistic Changes During Drug Treatment for Depression Using Tweets in Spanish: Pairwise Comparison Study.
Leis A, Ronzano F, Mayer MA, Furlong LI, Sanz F
J Med Internet Res. 2020 Dec 18;22(12):e20920
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Consequences of canceling elective invasive cardiac procedures during Covid-19 outbreak.
Moreno R, Díez JL, Diarte JA, Macaya F, de la Torrre Hernández JM, Rodríguez-Leor O, Trillo R, Alonso-Briales J, Amat-Santos I, Romaguera R, Díaz JF, Vaquerizo B, Ojeda S, Cruz-González I, Morena-Salas D, Pérez de Prado A, Sarnago F, Portero P, Gutierrez-Barrios A, Alfonso F, Bosch E, Pinar E, Ruiz-Arroyo JR, Ruiz-Quevedo V, Jiménez-Mazuecos J, Lozano F, Rumoroso JR, Novo E, Irazusta FJ, García Del Blanco B, Moreu J, Ballesteros-Pradas SM, Frutos A, Villa M, Alegría-Barrero E, Lázaro R, Paredes E
Catheter Cardiovasc Interv. 2020 Dec 17;
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Cognitive effects of low dose of ionizing radiation - Lessons learned and research gaps from epidemiological and biological studies.
Pasqual E, Boussin F, Bazyka D, Nordenskjold A, Yamada M, Ozasa K, Pazzaglia S, Roy L, Thierry-Chef I, de Vathaire F, Benotmane MA, Cardis E
Environ Int. 2020 Dec 17;147:106295
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Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma.
García-Colmenero L, González J, Sandoval J, Guillén Y, Diaz-Lagares A, Andrades E, Iglesias A, Nonell L, Pujol RM, Bigas A, Espinosa L, Gallardo F
Cells. 2020 Dec 15;9(12)
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Shared DNA methylation signatures in childhood allergy: the MeDALL study.
Xu CJ, Gruzieva O, Qi C, Esplugues A, Gehring U, Bergström A, Mason D, Chatzi L, Porta D, Lodrup Carlsen KC, Baïz N, Madore AM, Alenius H, van Rijkom B, Jankipersadsing SA, van der Vlies P, Kull I, van Hage M, Bustamante M, Lertxundi A, Torrent M, Santorelli G, Fantini MP, Hovland V, Pesce G, BIOS Consortium., Fyhrquist N, Laatikainen T, Nawijn MC, Li Y, Wijmenga C, Netea MG, Bousquet J, Anto JM, Laprise C, Haahtela T, Annesi-Maesano I, Carlsen KH, Gori D, Kogevinas M, Wright J, Söderhäll C, Vonk JM, Sunyer J, Melén E, Koppelman GH
J Allergy Clin Immunol. 2020 Dec 15;
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Frailty and kidney transplant candidates.
Pérez-Sáez MJ, Gutiérrez-Dalmau Á, Moreso F, Rodríguez Mañas L, Pascual J
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Substance use during pregnancy and personality dimensions.
Imaz ML, Navinés R, Gelabert E, Fonseca F, Gutierrez-Zotes A, Guillamat R, Langohr K, Canellas F, Gornemann I, Costas J, Mayoral F, Valles V, De Diego Y, Roca M, Iborra JL, Gratacos M, Vilella E, García-Esteve L, Sanjuan J, Torrens M, Martin-Santos Laffon R
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Functional Assessment of Coding and Regulatory Variants From the DKK1 Locus.
Martínez-Gil N, Roca-Ayats N, Atalay N, Pineda-Moncusí M, Garcia-Giralt N, Van Hul W, Boudin E, Ovejero D, Mellibovsky L, Nogués X, Díez-Pérez A, Grinberg D, Balcells S
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Generation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering Williams-Beuren syndrome (7q11.23 deletion).
Kuebler B, Aran B, Flores R, Pérez-Jurado LA, Veiga A, Corominas R, Cuscó I
Stem Cell Res. 2020 Dec;49:102087
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Dietary Quality and Dietary Inflammatory Potential During Pregnancy and Offspring Emotional and Behavioral Symptoms in Childhood: An Individual Participant Data Meta-analysis of Four European Cohorts.
Polanska K, Kaluzny P, Aubert AM, Bernard JY, Duijts L, El Marroun H, Hanke W, Hébert JR, Heude B, Jankowska A, Mancano G, Mensink-Bout SM, Relton C, Shivappa N, Suderman M, Trafalska E, Wesolowska E, Garcia-Esteban R, Guxens M, Casas M, Phillips CM
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Gastruloids: Embryonic Organoids from Mouse Embryonic Stem Cells to Study Patterning and Development in Early Mammalian Embryos.
Anlas K, Baillie-Benson P, Arató K, Turner DA, Trivedi V
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Spices to Control COVID-19 Symptoms: Yes, but Not Only….
Bousquet J, Czarlewski W, Zuberbier T, Mullol J, Blain H, Cristol JP, De La Torre R, Le Moing V, Pizarro Lozano N, Bedbrook A, Agache I, Akdis CA, Canonica GW, Cruz AA, Fiocchi A, Fonseca JA, Fonseca S, Gemicioglu B, Haahtela T, Iaccarino G, Ivancevich JC, Jutel M, Klimek L, Kuna P, Larenas-Linnemann DE, Melén E, Okamoto Y, Papadopoulos NG, Pfaar O, Reynes J, Rolland Y, Rouadi PW, Samolinski B, Sheikh A, Toppila-Salmi S, Valiulis A, Choi HJ, Kim HJ, Anto JM
Int Arch Allergy Immunol. 2020 Dec 22;:1-7
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Comparative Analysis of Different Definitions of Amyloid-Beta Positivity to Detect Early Downstream Pathophysiological Alterations in Preclinical Alzheimer.
Milà-Alomà M, Salvadó G, Shekari M, Grau-Rivera O, Sala-Vila A, Sánchez-Benavides G, Arenaza-Urquijo EM, González-de-Echávarri JM, Simon M, Kollmorgen G, Zetterberg H, Blennow K, Gispert JD, Suárez-Calvet M, Molinuevo JL
J Prev Alzheimers Dis. 2021;8(1):68-77
Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD.
Coca A, Burballa C, Centellas-Pérez FJ, Pérez-Sáez MJ, Bustamante-Munguira E, Ortega A, Dueñas C, Arenas MD, Pérez-Martínez J, Ruiz G, Crespo M, Llamas F, Bustamante-Munguira J, Pascual J
Front Med (Lausanne). 2020;7:615312
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Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium.
Ronkainen J, Heiskala A, Vehmeijer FOL, Lowry E, Caramaschi D, Estrada Gutiérrez G, Heiss JA, Hummel N, Keikkala E, Kvist T, Kupsco A, Melton PE, Pesce G, Soomro MH, Vives-Usano M, Baiz N, Binder E, Czamara D, Guxens M, Mustaniemi S, London SJ, Rauschert S, Vääräsmäki M, Vrijheid M, Ziegler AG, Annesi-Maesano I, Bustamante M, Huang RC, Hummel S, Just AC, Kajantie E, Lahti J, Lawlor D, Räikkönen K, Järvelin MR, Felix JF, Sebert S
Epigenetics. 2020 Dec 17;
Effect of bariatric surgery on cardiac structure and function in obese patients: Role of the renin-angiotensin system.
Oliveras A, Molina L, Goday A, Sans L, Riera M, Vazquez S, Benaiges D, Granados AM, Ramon JM, Pascual J
J Clin Hypertens (Greenwich). 2020 Dec 17;
Editorial: Human-Nature Interactions: Perspectives on Conceptual and Methodological Issues.
MacIntyre TE, Beckmann J, Calogiuri G, Donnell AA, Jones MV, Madan CR, Rogerson M, Brick NE, Nieuwenhuijsen M, Gidlow CJ
Front Psychol. 2020;11:607888
Effects of COVID-19 Pandemic Confinement in Patients With Cognitive Impairment.
Barguilla A, Fernández-Lebrero A, Estragués-Gázquez I, García-Escobar G, Navalpotro-Gómez I, Manero RM, Puente-Periz V, Roquer J, Puig-Pijoan A
Front Neurol. 2020;11:589901
Editorial: New Trends of Substance Abuse: Looking for New Psychotropic Effects of Chem Sex Drugs, Cognitive Enhancers, and New Psychoactive Substances.
Pichini S, Di Trana A, Torrens M, Scherbaum N, Zaami S
Front Psychiatry. 2020;11:612192
LoxTnSeq: random transposon insertions combined with cre/lox recombination and counterselection to generate large random genome reductions.
Shaw D, Miravet-Verde S, Piñero-Lambea C, Serrano L, Lluch-Senar M
Microb Biotechnol. 2020 Dec 16;
mRNA spindle localization and mitotic translational regulation by CPEB1 and CPEB4.
Pascual R, Segura-Morales C, Omerzu M, Bellora N, Belloc E, Castellazzi CL, Reina O, Eyras E, Maurice MM, Millanes-Romero A, Méndez R
RNA. 2020 Dec 15;
Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury.
Butragueño-Laiseca L, Troconiz IF, Grau S, Campillo N, García X, Padilla B, Fernández SN, Santiago MJ
Antibiotics (Basel). 2020 Dec 10;9(12)
Annotation of Full-Length Long Noncoding RNAs with Capture Long-Read Sequencing (CLS).
Carbonell Sala S, Uszczynska-Ratajczak B, Lagarde J, Johnson R, Guigó R
Methods Mol Biol. 2021;2254:133-159
Editorial: Proteomics as a Tool for Biomarker and Drug Target Discovery: Improving the Diagnosis and Treatment of Neurodegenerative Diseases.
Belbin O, Lehmann S, Sabidó E, Hirtz C
Front Aging Neurosci. 2020;12:232
Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome.
Heitsch L, Ibanez L, Carrera C, Binkley MM, Strbian D, Tatlisumak T, Bustamante A, Ribó M, Molina C, Dávalos A, López-Cancio E, Muñoz-Narbona L, Soriano-Tárraga C, Giralt-Steinhauer E, Obach V, Slowik A, Pera J, Lapicka-Bodzioch K, Derbisz J, Sobrino T, Castillo J, Campos F, Rodríguez-Castro E, Arias-Rivas S, Segura T, Serrano-Heras G, Vives-Bauza C, Díaz-Navarro R, Tur S, Jimenez C, Martí-Fàbregas J, Delgado-Mederos R, Arenillas J, Krupinski J, Cullell N, Torres-Aguila NP, Muiño E, Cárcel-Márquez J, Moniche F, Cabezas JA, Ford AL, Dhar R, Roquer J, Khatri P, Jiménez-Conde J, Fernandez-Cadenas I, Montaner J, Rosand J, Cruchaga C, Lee JM, International Stroke Genetics Consortium.
Stroke. 2021 Jan;52(1):132-141
Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein.
Cadima-Couto I, Tauzin A, Freire JM, Figueira TN, Silva RDM, Pérez-Peinado C, Cunha-Santos C, Bártolo I, Taveira N, Gano L, Correia JDG, Goncalves J, Mammano F, Andreu D, Castanho MARB, Veiga AS
ACS Infect Dis. 2020 Dec 15;
Green Infrastructure and Health.
Nieuwenhuijsen MJ
Annu Rev Public Health. 2020 Dec 11;
Corrigendum to "Time association between hepatitis C therapy and hepatocellular carcinoma emergence in cirrhosis: Relevance of non-characterized nodules" [J Hepatol (2019) 874-884].
Mariño Z, Darnell A, Lens S, Sapena V, Díaz A, Belmonte E, Perelló C, Calleja JL, Varela M, Rodriguez M, Rodriguez de Lope C, Llerena S, Torras X, Gallego A, Sala M, Morillas RM, Minguez B, Llaneras J, Coll S, Carrion JA, Iñarrairaegui M, Sangro B, Vilana R, Sole M, Ayuso C, Ríos J, Forns X, Bruix J, Reig M
J Hepatol. 2020 Dec 11;
Protein quality control and regulated proteolysis in the genome-reduced organism Mycoplasma pneumoniae.
Burgos R, Weber M, Martinez S, Lluch-Senar M, Serrano L
Mol Syst Biol. 2020 Dec;16(12):e9530
Food Resource Sharing of Alder Leaf Beetle Specialists (Coleoptera: Chrysomelidae) as Potential Insect-Plant Interface for Horizontal Transmission of Endosymbionts.
Cardoso A, Gómez-Zurita J
Environ Entomol. 2020 Dec 14;49(6):1402-1414
Differential Binding of Sarilumab and Tocilizumab to IL-6R-alfa and Effects of Receptor Occupancy on Clinical Parameters.
Xu C, Rafique A, Potocky T, Paccaly A, Nolain P, Lu Q, Iglesias-Rodriguez M, John GS, Nivens MC, Kanamaluru V, Fairhurst J, Ishii T, Maldonado R, Choy E, Emery P
J Clin Pharmacol. 2020 Dec 12;
Mental Health Impact of the First Wave of COVID-19 Pandemic on Spanish Healthcare Workers: a Large Cross-sectional Survey.
Alonso J, Vilagut G, Mortier P, Ferrer M, Alayo I, Aragón-Peña A, Aragonès E, Campos M, Cura-González ID, Emparanza JI, Espuga M, Forjaz MJ, González-Pinto A, Haro JM, López-Fresneña N, Salázar ADM, Molina JD, Ortí-Lucas RM, Parellada M, Pelayo-Terán JM, Pérez-Zapata A, Pijoan JI, Plana N, Puig MT, Rius C, Rodríguez-Blázquez C, Sanz F, Serra C, Kessler RC, Bruffaerts R, Vieta E, Pérez-Solà V, MINDCOVID Working group.
Rev Psiquiatr Salud Ment. 2020 Dec 10;
The ecology of cancer differentiation therapy.
Solé R, Aguadé-Gorgorió G
J Theor Biol. 2020 Dec 9;:110552
Hepatitis B surface antigen and hepatitis B core-related antigen kinetics after adding pegylated-interferon to nucleos(t)ids analogues in hepatitis B e antigen-negative patients.
Broquetas T, Garcia-Retortillo M, Micó M, Canillas L, Puigvehí M, Cañete N, Coll S, Viu A, Hernandez JJ, Bessa X, Carrión JA
World J Hepatol. 2020 Nov 27;12(11):1076-1088
Targeted metabolomics in formalin-fixed paraffin-embedded tissue specimens: Liquid chromatography-tandem mass spectrometry determination of acidic metabolites in cancer research.
Gomez-Gomez A, Sabbaghi M, Haro N, Albanell J, Menéndez S, González M, Gil-Gómez G, Rovira A, Pozo OJ
Talanta. 2021 Feb 1;223(Pt 2):121740
DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches.
Ventós-Alfonso A, Ylla G, Montañes JC, Belles X
iScience. 2020 Dec 18;23(12):101778
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Metabolic Syndrome Features and Excess Weight Were Inversely Associated with Nut Consumption after 1-Year Follow-Up in the PREDIMED-Plus Study.
Julibert A, Del Mar Bibiloni M, Gallardo-Alfaro L, Abbate M, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Cano-Ibañez N, Martín-Sánchez V, Pintó X, Gaforio JJ, Matía-Martín P, Vidal J, Vázquez C, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Notario-Barandiaran L, Colom A, Garcia-Rios A, Castro-Barquero S, Bernal R, Santos-Lozano JM, Fernández-Lázaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari J, Canudas S, Goday A, Tur JA, PREDIMED-PLUS investigators .
J Nutr. 2020 Dec 10;150(12):3161-3170
Treatment of allergic rhinitis during and outside the pollen season using mobile technology. A MASK study.
Bédard A, Basagaña X, Anto JM, Garcia-Aymerich J, Devillier P, Arnavielhe S, Bedbrook A, Onorato GL, Czarlewski W, Murray R, Almeida R, Fonseca JA, Correia da Sousa J, Costa E, Morais-Almeida M, Todo-Bom A, Cecchi L, De Feo G, Illario M, Menditto E, Monti R, Stellato C, Ventura MT, Annesi-Maesano I, Bosse I, Fontaine JF, Pham-Thi N, Thibaudon M, Schmid-Grendelmeier P, Spertini F, Chavannes NH, Fokkens WJ, Reitsma S, Dubakiene R, Emuzyte R, Kvedariene V, Valiulis A, Kuna P, Samolinski B, Klimek L, Mösges R, Pfaar O, Shamai S, Roller-Wirnsberger RE, Tomazic PV, Ryan D, Sheikh A, Haahtela T, Toppila-Salmi S, Valovirta E, Cardona V, Mullol J, Valero A, Makris M, Papadopoulos NG, Prokopakis EP, Psarros F, Bachert C, Hellings PW, Pugin B, Bindslev-Jensen C, Eller E, Kull I, Melén E, Wickman M, De Vries G, van Eerd M, Agache I, Ansotegui IJ, Bosnic-Anticevich S, Cruz AA, Casale T, Ivancevich JC, Larenas-Linnemann DE, Sofiev M, Wallace D, Waserman S, Yorgancioglu A, Laune D, Bousquet J, MASK study group.
Clin Transl Allergy. 2020 Dec 9;10(1):62
Plasma Metabolomic Profiles of Glycemic Index, Glycemic Load, and Carbohydrate Quality Index in the PREDIMED Study.
Bulló M, Papandreou C, Ruiz-Canela M, Guasch-Ferré M, Li J, Hernández-Alonso P, Toledo E, Liang L, Razquin C, Corella D, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Serra-Majem L, Clish CB, Becerra-Tomás N, Martínez-González MA, Hu FB, Salas-Salvadó J
J Nutr. 2020 Dec 9;
Non-occupational protein contact dermatitis induced by mango fruit.
Pesqué D, Canal-Garcia E, Rozas-Muñoz E, Pujol RM, Giménez-Arnau AM
Contact Dermatitis. 2020 Dec 9;
U-Shaped Association between Dietary Acid Load and Risk of Osteoporotic Fractures in 2 Populations at High Cardiovascular Risk.
García-Gavilán JF, Martínez A, Konieczna J, Mico-Perez R, García-Arellano A, Basora J, Barrubés L, Goday A, Canudas S, Salas-Salvadó J, Bulló M
J Nutr. 2020 Dec 9;
Missense variant contribution to USP9X-female syndrome.
Jolly LA, Parnell E, Gardner AE, Corbett MA, Pérez-Jurado LA, Shaw M, Lesca G, Keegan C, Schneider MC, Griffin E, Maier F, Kiss C, Guerin A, Crosby K, Rosenbaum K, Tanpaiboon P, Whalen S, Keren B, McCarrier J, Basel D, Sadedin S, White SM, Delatycki MB, Kleefstra T, Küry S, Brusco A, Sukarova-Angelovska E, Trajkova S, Yoon S, Wood SA, Piper M, Penzes P, Gecz J
NPJ Genom Med. 2020 Dec 9;5(1):53
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The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.
Arumugam K, Shin W, Schiavone V, Vlahos L, Tu X, Carnevali D, Kesner J, Paull EO, Romo N, Subramaniam P, Worley J, Tan X, Califano A, Cosma MP
Cell Rep. 2020 Dec 8;33(10):108474
A call for urgent action to safeguard our Planet and our health in line with the Helsinki Declaration.
Halonen JI, Erhola M, Furman E, Haahtela T, Jousilahti P, Barouki R, Bergman Å, Billo NE, Fuller R, Haines A, Kogevinas M, Kolossa-Gehring M, Krauze K, Lanki T, Vicente JL, Messerli P, Nieuwenhuijsen M, Paloniemi R, Peters A, Posch KH, Timonen P, Vermeulen R, Virtanen SM, Bousquet J, Antó JM
Environ Res. 2020 Dec 8;:110600
Validation of an Asbestos Exposure Questionnaire (QEAS-7) for Clinical Practice.
Ferrer J, Granados G, Hernández S, Cruz MJ, Sampol J, Álvarez Simón D, Ramada JM
Int J Environ Res Public Health. 2020 Dec 8;17(24)
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The Suicide Prevention and Intervention Study (SURVIVE): study protocol for a Spanish multisite cohort study with nested randomized-controlled trials.
Pérez V, Elices M, Toll A, Bobes J, López-Solà C, Díaz-Marsá M, Grande I, López-Peña P, Rodríguez-Vega B, Ruiz-Veguilla M, de la Torre-Luque A, SURVIVE Group.
Rev Psiquiatr Salud Ment. 2020 Dec 7;
Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies.
Bousquet J, Cristol JP, Czarlewski W, Anto JM, Martineau A, Haahtela T, Fonseca SC, Iaccarino G, Blain H, Fiocchi A, Canonica GW, Fonseca JA, Vidal A, Choi HJ, Kim HJ, Le Moing V, Reynes J, Sheikh A, Akdis CA, Zuberbier T, ARIA group.
Clin Transl Allergy. 2020 Dec 3;10(1):58
Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic.
Sousa-Pinto B, Heffler E, Antó A, Czarlewski W, Bedbrook A, Gemicioglu B, Canonica GW, Antó JM, Fonseca JA, Bousquet J
Clin Transl Allergy. 2020 Nov 2;10(1):47
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Population history of North Africa based on modern and ancient genomes.
Lucas-Sánchez M, Serradell JM, Comas D
Hum Mol Genet. 2020 Dec 8;
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Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease.
Castañer O, Pintó X, Subirana I, Amor AJ, Ros E, Hernáez Á, Martínez-González MÁ, Corella D, Salas-Salvadó J, Estruch R, Lapetra J, Gómez-Gracia E, Alonso-Gomez AM, Fiol M, Serra-Majem L, Corbella E, Benaiges D, Sorli JV, Ruiz-Canela M, Babió N, Sierra LT, Ortega E, Fitó M
J Am Coll Cardiol. 2020 Dec 8;76(23):2712-2724
RNA-protein interactions: Central players in coordination of regulatory networks.
Armaos A, Zacco E, Sanchez de Groot N, Tartaglia GG
Bioessays. 2020 Dec 7;:e2000118
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Lox'd in translation: contradictions in the nomenclature surrounding common lox-site mutants and their implications in experiments.
Shaw D, Serrano L, Lluch-Senar M
Microbiology (Reading). 2020 Dec 7;
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In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species.
Delgado Blanco J, Hernandez-Alias X, Cianferoni D, Serrano L
PLoS Comput Biol. 2020 Dec 7;16(12):e1008450
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Burden of Psoriasis in Catalonia: Epidemiology, Associated Comorbidities, Health Care Utilization, and Sick Leave.
Puig L, Ferrándiz C, Pujol RM, Vela E, Albertí-Casas C, Comellas M, Blanch C
Actas Dermosifiliogr. 2020 Dec 5;
Urinary metabolite quantitative trait loci in children and their interaction with dietary factors.
Calvo-Serra B, Maitre L, Lau CE, Siskos AP, Gützhow KB, Andrusaityte S, Casas M, Cadiou S, Chatzi L, González JR, Grazuleviciene R, McEachan R, Slama R, Vafeiadi M, Wright J, Coen M, Vrijheid M, Keun HC, Escaramís G, Bustamante M
Hum Mol Genet. 2020 Dec 5;
Autosomal genetics and Y-chromosome haplogroup L1b-M317 reveal Mount Lebanon Maronites as a persistently non-emigrating population.
Platt DE, Artinian H, Mouzaya F, Khalil W, Kamar FG, Matisoo-Smith E, Calafell F, Taleb NN, Zalloua P
Eur J Hum Genet. 2020 Dec 4;
Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in healthy adults.
van Nunen E, Hoek G, Tsai MY, Probst-Hensch N, Imboden M, Jeong A, Naccarati A, Tarallo S, Raffaele D, Nieuwenhuijsen M, Vlaanderen J, Gulliver J, Amaral AFS, Vineis P, Vermeulen R
Environ Res. 2020 Dec 4;:110579
Towards understanding the origin of animal development.
Ruiz-Trillo I, de Mendoza A
Development. 2020 Dec 3;147(23)
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COSMIN Risk of Bias tool to assess the quality of studies on reliability or measurement error of outcome measurement instruments: a Delphi study.
Mokkink LB, Boers M, van der Vleuten CPM, Bouter LM, Alonso J, Patrick DL, de Vet HCW, Terwee CB
BMC Med Res Methodol. 2020 Dec 3;20(1):293
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Allergic rhinitis.
Bousquet J, Anto JM, Bachert C, Baiardini I, Bosnic-Anticevich S, Walter Canonica G, Melén E, Palomares O, Scadding GK, Togias A, Toppila-Salmi S
Nat Rev Dis Primers. 2020 Dec 3;6(1):95
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GENCODE 2021.
Frankish A, Diekhans M, Jungreis I, Lagarde J, Loveland JE, Mudge JM, Sisu C, Wright JC, Armstrong J, Barnes I, Berry A, Bignell A, Boix C, Carbonell Sala S, Cunningham F, Di Domenico T, Donaldson S, Fiddes IT, García Girón C, Gonzalez JM, Grego T, Hardy M, Hourlier T, Howe KL, Hunt T, Izuogu OG, Johnson R, Martin FJ, Martínez L, Mohanan S, Muir P, Navarro FCP, Parker A, Pei B, Pozo F, Riera FC, Ruffier M, Schmitt BM, Stapleton E, Suner MM, Sycheva I, Uszczynska-Ratajczak B, Wolf MY, Xu J, Yang YT, Yates A, Zerbino D, Zhang Y, Choudhary JS, Gerstein M, Guigó R, Hubbard TJP, Kellis M, Paten B, Tress ML, Flicek P
Nucleic Acids Res. 2020 Dec 3;
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Radiofrequency Echographic multi spectrometry (REMS) for the diagnosis of osteoporosis in a European multicenter clinical context.
Cortet B, Dennison E, Diez-Perez A, Locquet M, Muratore M, Nogués X, Crespo DO, Quarta E, Brandi ML
Bone. 2020 Dec 2;:115786
Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population.
Walsh S, Izquierdo-Serra M, Acosta S, Edo A, Lloret M, Moret R, Bosch E, Oliva B, Bertranpetit J, Fernández-Fernández JM
Sci Rep. 2020 Dec 2;10(1):20999
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Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study.
Hinchliffe A, Kogevinas M, Pérez-Gómez B, Ardanaz E, Amiano P, Marcos-Delgado A, Castaño-Vinyals G, Llorca J, Moreno V, Alguacil J, Fernandez-Tardon G, Salas-Trejo D, Marcos-Gragera R, Aragonés N, Guevara M, Gil L, Martín V, Benavente Y, Gomez-Acebo I, Santibañez M, Ángel Alba M, García AM, Pollán M, Turner MC
Cancer Epidemiol Biomarkers Prev. 2020 Dec 2;
To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.
Supek F, Lehner B, Lindeboom RGH
Trends Genet. 2020 Dec 2;
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma With Secondary Cutaneous Involvement: A Diagnostic Challenge.
Olmos-Alpiste F, Vázquez I, Gallardo F, Sánchez-Gonzalez B, Colomo L, Pujol RM
Am J Dermatopathol. 2020 Dec 1;
The chaperonin CCT controls T cell receptor-driven 3D configuration of centrioles.
Martin-Cofreces NB, Chichon FJ, Calvo E, Torralba D, Bustos-Moran E, Dosil SG, Rojas-Gomez A, Bonzon-Kulichenko E, Lopez JA, Otón J, Sorrentino A, Zabala JC, Vernos I, Vazquez J, Valpuesta JM, Sanchez-Madrid F
Sci Adv. 2020 Dec;6(49)
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Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression.
Martín-Sánchez A, García-Baos A, Castro-Zavala A, Alegre-Zurano L, Valverde O
Neuropharmacology. 2020 Nov 30;:108416
The SHAMISEN Recommendations on preparedness and health surveillance of populations affected by a radiation accident.
Liutsko L, Oughton D, Sarukhan A, Cardis E, SHAMISEN Consortium.
Environ Int. 2020 Nov 30;146:106278
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Improved postoperative outcomes and reduced transfusion rates after implementation of a Patient Blood Management program in gastric cancer surgery.
Osorio J, Jericó C, Miranda C, Santamaría M, Artigau E, Galofré G, Garsot E, Luna A, Puértolas N, Aldeano A, Olona C, Molinas J, Feliu J, Videla S, Tebe C, Pera M
Eur J Surg Oncol. 2020 Nov 27;
Rethinking Intellectual Disability from Neuro- to Astro-Pathology.
Fernández-Blanco Á, Dierssen M
Int J Mol Sci. 2020 Nov 27;21(23)
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Exome-wide rare variant analysis in familial essential tremor.
Diez-Fairen M, Houle G, Ortega-Cubero S, Bandres-Ciga S, Alvarez I, Carcel M, Ibañez L, Fernandez MV, Budde JP, Trotta JR, Tonda R, Chong JX, Bamshad MJ, Nickerson DA, University of Washington Center for Mendelian Genomics (UWCMG)., Aguilar M, Tartari JP, Gironell A, García-Martín E, Agundez JA, Alonso-Navarro H, Jimenez-Jimenez FJ, Fernandez M, Valldeoriola F, Marti MJ, Tolosa E, Coria F, Pastor MA, Vilariño-Güell C, Rajput A, Dion PA, Cruchaga C, Rouleau GA, Pastor P
Parkinsonism Relat Disord. 2020 Nov 24;82:109-116
The Chemokine Receptors Ccr5 and Cxcr6 Enhance Migration of Mesenchymal Stem Cells into the Degenerating Retina.
Pesaresi M, Bonilla-Pons SA, Sebastian-Perez R, Di Vicino U, Alcoverro-Bertran M, Michael R, Cosma MP
Mol Ther. 2020 Nov 10;
Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data.
García Castillo E, Alonso Pérez T, Ancochea J, Pastor Sanz MT, Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramírez-García Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, de-Torres JP, Celli BR, Marín JM, Ter Riet G, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Vikjord SAA, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío BG, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, López-Campos JL, Carrasco L, Soriano JB
ERJ Open Res. 2020 Oct;6(4)
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The global impact of the COVID-19 pandemic on the management and course of chronic urticaria.
Kocatürk E, Salman A, Cherrez-Ojeda I, Ricardo Criado P, Peter J, Comert-Ozer E, Abuzakouk M, Câmara Agondi R, Al-Ahmad M, Altrichter S, Arnaout R, Karla Arruda L, Asero R, Bauer A, Ben-Shoshan M, Bernstein JA, Bizjak M, Boccon-Gibod I, Bonnekoh H, Bouillet L, Brzoza Z, Busse P, Campos RA, Carne E, Conlon N, Criado RF, de Souza Lima EM, Demir S, Dissemond J, Dogan Günaydin S, Dorofeeva I, Felipe Ensina L, Ertas R, Mariel Ferrucci S, Figueras-Nart I, Fomina D, Franken SM, Fukunaga A, Giménez-Arnau AM, Godse K, Gonçalo M, Gotua M, Grattan C, Guillet C, Inomata N, Jakob T, Karakaya G, Kasperska-Zajac A, Katelaris CH, Košnik M, Krasowska D, Kulthanan K, Sendhil Kumaran M, Lang C, Ignacio Larco-Sousa J, Lazaridou E, Anika Leslie T, Lippert U, Calderón Llosa O, Makris M, Marsland A, Medina IV, Meshkova R, Bastos Palitot E, Parisi CAS, Pickert J, Ramon GD, Rodríguez-Gonzalez M, Rosario N, Rudenko M, Rutkowski K, Sánchez J, Schliemann S, Enis Sekerel B, Serpa FS, Serra-Baldrich E, Song Z, Soria A, Staevska M, Staubach P, Tagka A, Takahagi S, Francis Thomsen S, Treudler R, Vadasz Z, Oliveira Rodrigues Valle S, Van Doorn MBA, Vestergaard C, Wagner N, Wang D, Wang L, Wedi B, Xepapadaki P, Yücel E, Zalewska-Janowska A, Zhao Z, Zuberbier T, Maurer M
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Navarrete-Muñoz EM, Vioque J, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Matía-Martín P, Daimiel L, Sánchez VM, Vidal J, de Cos Blanco AI, Ros E, Diez-Espino J, Babio N, Fernandez-Carrion R, Castañer O, Colom A, Compañ-Gabucio L, Lete IS, Crespo-Oliva E, Abete I, Tomaino L, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Sarasa I, Gámez JM, Garcia-Rios JMA, Martín-Pelaez S, Ruiz-Canela M, Díaz-López A, Martinez-Lacruz R, Zomeño MD, Rayó E, Sellés CG, Canudas S, Goday A, García-de-la-Hera M
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Seoane LF, Solé R
Entropy (Basel). 2020 Jan 31;22(2)
Markers of myocardial injury in the prediction of short-term COVID-19 prognosis.
Calvo-Fernández A, Izquierdo A, Subirana I, Farré N, Vila J, Durán X, García-Guimaraes M, Valdivielso S, Cabero P, Soler C, García-Ribas C, Rodríguez C, Llagostera M, Mojón D, Vicente M, Solé-González E, Sánchez-Carpintero A, Tevar C, Marrugat J, Vaquerizo B
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Multiple Sequence Alignment Computation Using the T-Coffee Regressive Algorithm Implementation.
Garriga E, Di Tommaso P, Magis C, Erb I, Mansouri L, Baltzis A, Floden E, Notredame C
Methods Mol Biol. 2021;2231:89-97
An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders.
Scott J, Colom F, Young A, Bellivier F, Etain B
Int J Bipolar Disord. 2020 Dec 1;8(1):37
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.
Papandreou C, Bulló M, Hernández-Alonso P, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Alonso-Gómez A, Fiol M, Santos-Lozano JM, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J
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Correction: Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study.
Pasqual E, Turner MC, Gracia-Lavedan E, Casabonne D, Benavente Y, Thierry-Chef I, Maynadié M, Cocco P, Staines A, Foretova L, Nieters A, Boffetta P, Brennan P, Cardis E, de Sanjose S
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Derivation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering 7q11.23 microduplication syndrome.
Kuebler B, Aran B, Flores R, Pérez-Jurado LA, Veiga A, Cuscó I, Corominas R
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Optimizing Behavioral Paradigms to Facilitate Development of New Treatments for Anhedonia and Reward Processing Deficits in Schizophrenia and Major Depressive Disorder: Study Protocol.
Bilderbeck AC, Raslescu A, Hernaus D, Hayen A, Umbricht D, Pemberton D, Tiller J, Søgaard B, Sambeth A, van Amelsvoort T, Reif A, Papazisis G, Pérez V, Elices M, Maurice D, Bertaina-Anglade V, Dawson GR, Pollentier S
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Corrigendum to: Analysis of multicentre epidemiological studies: contrasting fixed or random effects modelling and meta-analysis.
Basagaña X, Pedersen M, Barrera-Gómez J, Gehring U, Giorgis-Allemand L, Hoek G, Stafoggia M, Nieuwenhuijsen MJ, Brunekreef B, Slama R
Int J Epidemiol. 2020 Nov 28;
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Factors that Influence Treatment Delay for Patients with Breast Cancer.
Padilla-Ruiz M, Zarcos-Pedrinaci I, Rivas-Ruiz F, Téllez T, García-Gutiérrez S, González N, Rivero A, Sarasqueta C, Serrano-Aguilar P, Castells X, Quintana JM, Sala M, Redondo M, REDISSEC-CaMISS Group., Castells X, Comas M, Domingo L, Macià F, Roman M, Romero A, Sala M, Barata T, de la Lastra ID, de la Vega M, Bare M, Torà N, Ferrer J, Castanyer F, Carmona C, García S, Martín M, González N, Orive M, Valverde MA, Saez A, Barredo I, de Toro M, Ferreiro J, Quintana JM, Pérez J, Rivero A, Valcárcel C, Padilla M, Redondo M, Téllez T, Zarcos I, Churruca C, Perales A, Recio J, Ruiz I, Sarasqueta C, Urraca JM, Michelena MJ, Moreno J, Mallabiabarrena G, Cobos P, Otero B, Gorostiaga J, Troya I
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Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence.
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On the use of digital subtraction angiography in SEEG surgical planning to prevent collisions with vessels.
Delgado-Martínez I, Serrano L, Higueras-Esteban A, Vivas E, Rocamora R, González Ballester MA, Serra L, Conesa G
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Olfactory Neuroepithelium Cells from Cannabis Users Display Alterations to the Cytoskeleton and to Markers of Adhesion, Proliferation and Apoptosis.
Delgado-Sequera A, Hidalgo-Figueroa M, Barrera-Conde M, Duran-Ruiz MC, Castro C, Fernández-Avilés C, de la Torre R, Sánchez-Gomar I, Pérez V, Geribaldi-Doldán N, Robledo P, Berrocoso E
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Publisher Correction: Conservative route to genome compaction in a miniature annelid.
Martín-Durán JM, Vellutini BC, Marlétaz F, Cetrangolo V, Cvetesic N, Thiel D, Henriet S, Grau-Bové X, Carrillo-Baltodano AM, Gu W, Kerbl A, Marquez Y, Bekkouche N, Chourrout D, Gómez-Skarmeta JL, Irimia M, Lenhard B, Worsaae K, Hejnol A
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Genome Med. 2020 Nov 25;12(1):105
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Radiofrequency Electromagnetic Fields from Mobile Communication: Description of Modeled Dose in Brain Regions and the Body in European Children and Adolescents.
Birks LE, Van Wel L, Liorni I, Pierotti L, Guxens M, Huss A, Foerster M, Capstick M, Eeftens M, El Marroun H, Estarlich M, Gallastegi M, Safont LG, Joseph W, Santa-Marina L, Thielens A, Torrent M, Vrijkotte T, Wiart J, Röösli M, Cardis E, Vermeulen R, Vrijheid M
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Nat Rev Genet. 2020 Nov 24;
The COVID-19 pandemic and global environmental change: Emerging research needs.
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A multicenter, observational study of pain and functional impairment in individuals with major depressive disorder in partial remission: the DESIRE study.
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Sentís I, Gonzalez S, Genescà E, García-Hernández V, Muiños F, Gonzalez C, López-Arribillaga E, Gonzalez J, Fernandez-Ibarrondo L, Mularoni L, Espinosa L, Bellosillo B, Ribera JM, Bigas A, Gonzalez-Perez A, Lopez-Bigas N
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Extended Connectivity Interaction Features: Improving Binding Affinity Prediction Through Chemical Description.
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MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data.
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The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.
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Lessons from individuals with Down syndrome during COVID-19.
Del Carmen Ortega M, Borrel JM, de Jesús Bermejo T, González-Lamuño D, Manso C, de la Torre R, Mayer MA, de Asúa DR, Dierssen M, Spanish Trisomy 21 Research Society COVID-19 Taskforce.
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Swimming through the sands of the Sahara and Arabian deserts: Phylogeny of sandfish skinks (Scincidae, Scincus) reveals a recent and rapid diversification.
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Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study.
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The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization.
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Two-Step Digital Follow-up of Patients at High Risk for Melanoma: A Retrospective Analysis of 152 Patients.
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Neumann A, Walton E, Alemany S, Cecil C, González JR, Jima DD, Lahti J, Tuominen ST, Barker ED, Binder E, Caramaschi D, Carracedo Á, Czamara D, Evandt J, Felix JF, Fuemmeler BF, Gutzkow KB, Hoyo C, Julvez J, Kajantie E, Laivuori H, Maguire R, Maitre L, Murphy SK, Murcia M, Villa PM, Sharp G, Sunyer J, Raikkönen K, Bakermans-Kranenburg M, IJzendoorn MV, Guxens M, Relton CL, Tiemeier H
Transl Psychiatry. 2020 Nov 12;10(1):398
Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD.
Tang J, Curull V, Wang X, Ampurdanés C, Duran X, Pijuan L, Rodríguez-Fuster A, Aguiló R, Yélamos J, Barreiro E
Cancers (Basel). 2020 Nov 11;12(11)
Numbers Game and Immune Geography as Determinants of Coronavirus Pathogenicity.
Bocharov G, Casella V, Argilaguet J, Grebennikov D, Güerri-Fernandez R, Ludewig B, Meyerhans A
Front Cell Infect Microbiol. 2020;10:559209
Inflammatory Response of Ischemic Tolerance in Circulating Plasma: Preconditioning-Induced by Transient Ischemic Attack (TIA) Phenomena in Acute Ischemia Patients (AIS).
Colàs-Campàs L, Farre J, Mauri-Capdevila G, Molina-Seguín J, Aymerich N, Ois Á, Roquer J, Tur S, García-Carreira MDC, Martí-Fàbregas J, Cruz-Culebras A, Segura T, Arque G, Purroy F
Front Neurol. 2020;11:552470
Incomplete Sterility of Chromosomal Hybrids: Implications for Karyotype Evolution and Homoploid Hybrid Speciation.
Lukhtanov VA, Dinca V, Friberg M, Vila R, Wiklund C
Front Genet. 2020;11:583827
SARS-CoV-2 seroprevalence and antibody kinetics among health care workers in a Spanish hospital after three months of follow-up.
Moncunill G, Mayor A, Santano R, Jiménez A, Vidal M, Tortajada M, Sanz S, Méndez S, Llupià A, Aguilar R, Alonso S, Barrios D, Carolis C, Cisteró P, Chóliz E, Cruz A, Fochs S, Jairoce C, Hecht J, Lamoglia M, Martínez MJ, Moreno J, Mitchell RA, Ortega N, Pey N, Puyol L, Ribes M, Rosell N, Figueroa-Romero A, Sotomayor P, Torres S, Williams S, Barroso S, Vilella A, Trilla A, Varela P, Dobaño C, Garcia-Basteiro AL
J Infect Dis. 2020 Nov 11;
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Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels.
Indacochea A, Guerrero S, Ure Ntildea M, Araujo F, Coll O, LLeonart ME, Gebauer F
RNA. 2020 Nov 10;
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Antibiofilm Activity on Candida albicans and Mechanism of Action on Biomembrane Models of the Antimicrobial Peptide Ctn[15-34].
Aguiar FLL, Santos NC, de Paula Cavalcante CS, Andreu D, Baptista GR, Gonçalves S
Int J Mol Sci. 2020 Nov 6;21(21)
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The Presence of Human Herpesvirus 6 in the Brain in Health and Disease.
Santpere G, Telford M, Andrés-Benito P, Navarro A, Ferrer I
Biomolecules. 2020 Nov 6;10(11)
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An international survey on the impact of COVID-19 in individuals with Down syndrome.
Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, Brandão AC, Carfi A, Carmona-Iragui M, Chicoine BA, Ghosh S, Lakhanpaul M, Manso C, Mayer MA, Del Carmen Ortega M, de Asua DR, Rebillat AS, Russell LA, Sgandurra G, Valentini D, Sherman SL, Strydom A
medRxiv. 2020 Nov 5;
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Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke.
Ibanez L, Heitsch L, Carrera C, Farias FHG, Dhar R, Budde J, Bergmann K, Bradley J, Harari O, Phuah CL, Lemmens R, Oliveira Souza AAV, Moniche F, Cabezas-Juan A, Arenillas JF, Krupinksi J, Cullell N, Torres-Aguila N, Muiño E, Cárcel-Márquez J, Marti-Fabregas J, Delgado-Mederos R, Marin-Bueno R, Hornick A, Vives-Bauza C, Navarro RD, Tur S, Jimenez C, Obach V, Segura T, Serrano-Heras G, Chung JW, Roquer J, Soriano-Tarraga C, Giralt-Steinhauer E, Mola-Caminal M, Pera J, Lapicka-Bodzioch K, Derbisz J, Davalos A, Lopez-Cancio E, Muñoz L, Tatlisumak T, Molina C, Ribo M, Bustamante A, Sobrino T, Castillo-Sanchez J, Campos F, Rodriguez-Castro E, Arias-Rivas S, Rodríguez-Yáñez M, Herbosa C, Ford AL, Arauz A, Lopes-Cendes I, Lowenkopf T, Barboza MA, Amini H, Stamova B, Ander BP, Sharp FR, Kim GM, Bang OY, Jimenez-Conde J, Slowik A, Stribian D, Tsai EA, Burkly LC, Montaner J, Fernandez-Cadenas I, Lee JM, Cruchaga C
medRxiv. 2020 Nov 3;
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Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.
Visser PJ, Reus LM, Gobom J, Jansen I, Dicks E, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuevo JL, Engelborghs S, Freund-Levi Y, Froelich L, Sleegers K, Dobricic V, Hong S, Lovestone S, Streffer J, Vos SJB, Bos I, Smit AB, Blennow K, Scheltens P, Teunissen CE, Bertram L, Zetterberg H, Tijms BM
medRxiv. 2020 Nov 3;
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Composition of the immunoglobulin G glycome associates with the severity of COVID-19.
Petrovic T, Alves I, Bugada D, Pascual J, Vuckovic F, Skelin A, Gaifem J, Villar-Garcia J, Vicente MM, Fernandes A, Dias AM, Kurolt IC, Markotic A, Primorac D, Soares A, Malheiro L, Trbojevic-Akmacic I, Abreu M, Sarmento E Castro R, Bettinelli S, Callegaro A, Arosio M, Sangiorgio L, Lorini LF, Castells X, Horcajada JP, Pinho SS, Allegri M, Barrios C, Lauc G
Glycobiology. 2020 Nov 10;
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Prediction Equations for Maximal Aerobic Capacity on Cycle Ergometer for the Spanish Adult Population.
Puente-Maestú L, Ortega F, Pedro JG, Rodríguez-Nieto MJ, Gómez-Seco J, Gáldiz B, Ojanguren I, Muñoz X, Blanco I, Burgos F, Rodríguez-Chiaradía DA, Gea J, García-Rio F
Arch Bronconeumol. 2020 Oct 10;
A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research.
Zahoránszky-Kohalmi G, Siramshetty VB, Kumar P, Gurumurthy M, Grillo B, Mathew B, Metaxatos D, Backus M, Mierzwa T, Simon R, Grishagin I, Brovold L, Mathé EA, Hall MD, Michael SG, Godfrey AG, Mestres J, Jensen LJ, Oprea TI
bioRxiv. 2020 Nov 5;
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The Value of Mouse Models of Rare Diseases: A Spanish Experience.
Murillo-Cuesta S, Artuch R, Asensio F, de la Villa P, Dierssen M, Enríquez JA, Fillat C, Fourcade S, Ibáñez B, Montoliu L, Oliver E, Pujol A, Salido E, Vallejo M, Varela-Nieto I
Front Genet. 2020;11:583932
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Massive gene presence-absence variation shapes an open pan-genome in the Mediterranean mussel.
Gerdol M, Moreira R, Cruz F, Gómez-Garrido J, Vlasova A, Rosani U, Venier P, Naranjo-Ortiz MA, Murgarella M, Greco S, Balseiro P, Corvelo A, Frias L, Gut M, Gabaldón T, Pallavicini A, Canchaya C, Novoa B, Alioto TS, Posada D, Figueras A
Genome Biol. 2020 Nov 10;21(1):275
Transdiagnostic development of internalizing psychopathology throughout the life course up to age 45: a World Mental Health Surveys report.
de Vries YA, Al-Hamzawi A, Alonso J, Andrade LH, Benjet C, Bruffaerts R, Bunting B, de Girolamo G, Florescu S, Gureje O, Haro JM, Karam A, Karam EG, Kawakami N, Kovess-Masfety V, Lee S, Mneimneh Z, Navarro-Mateu F, Ojagbemi A, Posada-Villa J, Scott K, Stagnaro JC, Torres Y, Xavier M, Zarkov ZN, Kessler RC, de Jonge P, WHO World Mental Health Survey collaborators.
Psychol Med. 2020 Nov 10;:1-10
Practice Parameters for Diagnosing and Managing Iodinated Contrast Media Hypersensitivity.
Torres MJ, Trautmann A, Böhm I, Scherer K, Barbaud A, Bavbek S, Bonadonna P, Cernadas J, Chiriac A, Gaeta F, Gimenez-Arnau AM, Kang H, Moreno E, Brockow K
Allergy. 2020 Nov 10;
A physical mechanism of TANGO1-mediated bulky cargo export.
Raote I, Chabanon M, Walani N, Arroyo M, Garcia-Parajo MF, Malhotra V, Campelo F
Elife. 2020 Nov 10;9
The changing chromatome as a driver of disease: A panoramic view from different methodologies.
Espejo I, Di Croce L, Aranda S
Bioessays. 2020 Nov 9;:e2000203
Ectopic activation of GABAB receptors inhibits neurogenesis and metamorphosis in the cnidarian Nematostella vectensis.
Levy S, Brekhman V, Bakhman A, Malik A, Sebé-Pedrós A, Kosloff M, Lotan T
Nat Ecol Evol. 2020 Nov 9;
Elimination profiles of prednisone and prednisolone after different administration routes: evaluation of the reporting level and washout periods to ensure safe therapeutic administrations.
Coll S, Monfort N, Alechaga É, Matabosch X, Pozo OJ, Pérez-Mañá C, Ventura R
Drug Test Anal. 2020 Nov 8;
Lessons learned from Chernobyl and Fukushima on thyroid cancer screening and recommendations in case of a future nuclear accident.
Cléro E, Ostroumova E, Demoury C, Grosche B, Kesminiene A, Liutsko L, Motreff Y, Oughton D, Pirard P, Rogel A, Van Nieuwenhuyse A, Laurier D, Cardis E
Environ Int. 2020 Nov 7;146:106230
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A patients' view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study.
Vitaloni M, Botto-van Bemden A, Sciortino R, Carné X, Quintero M, Santos-Moreno P, Espinosa R, Rillo O, Monfort J, de Abajo F, Oswald E, Matucci M, du Souich P, Möller I, Romera Baures M, Vinci A, Scotton D, Bibas M, Eakin G, Verges J
BMC Musculoskelet Disord. 2020 Nov 7;21(1):727
Results from an 18 country cross-sectional study examining experiences of nature for people with common mental health disorders.
Tester-Jones M, White MP, Elliott LR, Weinstein N, Grellier J, Economou T, Bratman GN, Cleary A, Gascon M, Korpela KM, Nieuwenhuijsen M, O'Connor A, Ojala A, van den Bosch M, Fleming LE
Sci Rep. 2020 Nov 6;10(1):19408
Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition.
Battistelli C, Garbo S, Riccioni V, Montaldo C, Santangelo L, Vandelli A, Strippoli R, Tartaglia GG, Tripodi M, Cicchini C
Cancer Res. 2020 Nov 6;
Defining pathways to healthy sustainable urban development.
Tonne C, Adair L, Adlakha D, Anguelovski I, Belesova K, Berger M, Brelsford C, Dadvand P, Dimitrova A, Giles-Corti B, Heinz A, Mehran N, Nieuwenhuijsen M, Pelletier F, Ranzani O, Rodenstein M, Rybski D, Samavati S, Satterthwaite D, Schöndorf J, Schreckenberg D, Stollmann J, Taubenböck H, Tiwari G, van Wee B, Adli M
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Profile of exposures and lung function in adults with asthma: an exposome approach in the EGEA study.
Guillien A, Lepeule J, Seyve E, Le Moual N, Pin I, Degano B, Garcia-Aymerich J, Pépin JL, Pison C, Dumas O, Varraso R, Siroux V
Environ Res. 2020 Nov 5;:110422
The CHEK2 Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor.
Brandão A, Paulo P, Maia S, Pinheiro M, Peixoto A, Cardoso M, Silva MP, Santos C, Eeles RA, Kote-Jarai Z, Muir K, Ukgpcs Collaborators, Schleutker J, Wang Y, Pashayan N, Batra J, Apcb BioResource, Grönberg H, Neal DE, Nordestgaard BG, Tangen CM, Southey MC, Wolk A, Albanes D, Haiman CA, Travis RC, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Vega A, The Impact Study Steering Committee And Collaborators, Kogevinas M, Wiklund F, Penney KL, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, Ruyck K, Razack A, Newcomb LF, Canary Pass Investigators, Lessel D, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Roobol MJ, The Profile Study Steering Committee, The Practical Consortium, Teixeira MR
Cancers (Basel). 2020 Nov 4;12(11)
Dyslipidemias and stroke prevention: recommendations of the Study Group of Cerebrovascular Diseases of the Spanish Society of Neurology.
Palacio-Portilla EJ, Roquer J, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo MM, Fuentes B, García-Pastor A, Gomis M, Gómez-Choco M, López-Cancio E, Martínez-Sánchez P, Morales A, Rodríguez-Yáñez M, Segura T, Serena J, Vivancos-Mora J, de Leciñana MA, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología.
Neurologia. 2020 Nov 4;
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Quality of colonoscopy is associated with adenoma detection and post-colonoscopy colorectal cancer prevention in Lynch syndrome.
Sánchez A, Roos VH, Navarro M, Pineda M, Caballol B, Moreno L, Carballal S, Rodríguez-Alonso L, Ramon Y Cajal T, Llort G, Piñol V, Fernandez AL, Salces I, Picó MD, Rivas L, Bujanda L, Garzon M, Pizarro A, Martinez de Castro E, López-Arias MJ, Poves C, Garau C, Rodriguez-Alcalde D, Herraiz M, Alvarez-Urrutia C, Dacal A, Carrillo-Palau M, Cid L, Ponce M, Barreiro-Alonso E, Saperas E, Aguirre E, Romero C, Bastiaansen B, Gonzalez-Acosta M, Morales-Romero B, Ocaña T, Rivero-Sánchez L, Jung G, Bessa X, Cubiella J, Jover R, Rodríguez-Moranta F, Balmaña J, Brunet J, Castells A, Dekker E, Capella G, Serra-Burriel M, Moreira L, Pellise M, Balaguer F
Clin Gastroenterol Hepatol. 2020 Nov 3;
The Helsinki Declaration 2020: Europe that protects.
Halonen JI, Erhola M, Furman E, Haahtela T, Jousilahti P, Barouki R, Bergman Å, Billo NE, Fuller R, Haines A, Kogevinas M, Kolossa-Gehring M, Krauze K, Lanki T, Vicente JL, Messerli P, Nieuwenhuijsen M, Paloniemi R, Peters A, Posch KH, Timonen P, Vermeulen R, Virtanen SM, Bousquet J, Antó JM
Lancet Planet Health. 2020 Nov;4(11):e503-e505
Guidelines for Modeling and Reporting Health Effects of Climate Change Mitigation Actions.
Hess JJ, Ranadive N, Boyer C, Aleksandrowicz L, Anenberg SC, Aunan K, Belesova K, Bell ML, Bickersteth S, Bowen K, Burden M, Campbell-Lendrum D, Carlton E, Cissé G, Cohen F, Dai H, Dangour AD, Dasgupta P, Frumkin H, Gong P, Gould RJ, Haines A, Hales S, Hamilton I, Hasegawa T, Hashizume M, Honda Y, Horton DE, Karambelas A, Kim H, Kim SE, Kinney PL, Kone I, Knowlton K, Lelieveld J, Limaye VS, Liu Q, Madaniyazi L, Martinez ME, Mauzerall DL, Milner J, Neville T, Nieuwenhuijsen M, Pachauri S, Perera F, Pineo H, Remais JV, Saari RK, Sampedro J, Scheelbeek P, Schwartz J, Shindell D, Shyamsundar P, Taylor TJ, Tonne C, Van Vuuren D, Wang C, Watts N, West JJ, Wilkinson P, Wood SA, Woodcock J, Woodward A, Xie Y, Zhang Y, Ebi KL
Environ Health Perspect. 2020 Nov;128(11):115001
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Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in A-Beta pathology are detected.
Suárez-Calvet M, Karikari TK, Ashton NJ, Lantero Rodríguez J, Milà-Alomà M, Gispert JD, Salvadó G, Minguillon C, Fauria K, Shekari M, Grau-Rivera O, Arenaza-Urquijo EM, Sala-Vila A, Sánchez-Benavides G, González-de-Echávarri JM, Kollmorgen G, Stoops E, Vanmechelen E, Zetterberg H, Blennow K, Molinuevo JL, ALFA Study.
EMBO Mol Med. 2020 Nov 10;:e12921
Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk.
Sánchez-Quesada C, Toledo E, González-Mata G, Ramos-Ballesta MI, Peis JI, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, Cano-Ibáñez N, Matía-Martín P, Daimiel L, Sánchez-Rodríguez R, Vidal J, Vázquez C, Ros E, Hernández-Alonso P, Barragan R, Muñoz-Martínez J, López M, González-Palacios S, Vaquero-Luna J, Crespo-Oliva E, Zulet MA, Díaz-González V, Casas R, Fernandez-Garcia JC, Santos-Lozano JM, Galera A, Ripoll-Vera T, Buil-Cosiales P, Canudas S, Martinez-Lacruz R, Pérez-Vega KA, Rios Á, Lloret-Macián R, Moreno-Rodriguez A, Ruiz-Canela M, Babio N, Zomeño Fajardo MD, Gaforio JJ
Atherosclerosis. 2020 Oct 10;314:48-57
Markers of myocardial injury in the prediction of short-term COVID-19 prognosis.
Calvo-Fernández A, Izquierdo A, Subirana I, Farré N, Vila J, Durán X, García-Guimaraes M, Valdivielso S, Cabero P, Soler C, García-Ribas C, Rodríguez C, Llagostera M, Mojón D, Vicente M, Solé-González E, Sánchez-Carpintero A, Tevar C, Marrugat J, Vaquerizo B
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The endocannabinoid system in modulating fear, anxiety, and stress?.
Maldonado R, Cabañero D, Martín-García E
Dialogues Clin Neurosci. 2020 Sep;22(3):229-239
Novel Protein Biomarkers of Monoamine Metabolism Defects Correlate with Disease Severity.
Tristán-Noguero A, Borràs E, Molero-Luis M, Wassenberg T, Peters T, Verbeek MM, Willemsen M, Opladen T, Jeltsch K, Pons R, Thony B, Horvath G, Yapici Z, Friedman J, Hyland K, Agosta GE, López-Laso E, Artuch R, Sabidó E, García-Cazorla À
Mov Disord. 2020 Nov 5;
Rethinking embryology in vitro: A synergy between engineering, data science and theory.
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Dev Biol. 2020 Nov 2;
Recognizing obesity as a disease: A true challenge.
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Expanding the Geographic Characterisation of Epstein-Barr Virus Variation through Gene-Based Approaches.
Telford M, Hughes DA, Juan D, Stoneking M, Navarro A, Santpere G
Microorganisms. 2020 Oct 29;8(11)
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Soluble suppression of tumorigenicity-2 predicts pneumonia in patients with inhalation injury: Results of a pilot study.
Ruiz-Castilla M, Dos Santos B, Vizcaíno C, Baena J, Guilabert P, Marin-Corral J, Masclans JR, Roca O, Barret JP
Burns. 2020 Oct 21;
Children's visual impairment and visual care related to socioeconomic status in Catalonia (Spain).
Vila-Vidal N, Guisasola L, Rius A, Alonso J, Tresserras R
Child Care Health Dev. 2020 Nov 5;
Chemotherapy or Allogeneic Transplantation in High-Risk Philadelphia Chromosome-Negative Adult Lymphoblastic Leukemia.
Ribera JM, Morgades M, Ciudad J, Montesinos P, Esteve J, Genesca E, Barba P, Ribera J, García Cadenas I, Moreno MJ, Martínez-Carballeira D, Torrent A, Martínez-Sánchez P, Monsalvo S, Gil C, Tormo M, Artola MT, Cervera M, González-Campos J, Rodríguez-Medina C, Bermúdez A, Novo A, Soria B, Coll R, Amigo ML, López A, Fernández Martín R, Serrano J, Mercadal S, Cladera A, Giménez-Conca AD, Peñarrubia MJ, Abella E, Vall-Llovera F, Hernández-Rivas JM, Garcia A, Bergua Burgues JM, de Rueda B, Sánchez-Sánchez MJ, Serrano A, Calbacho M, Alonso Vence N, Méndez-Sánchez JÁ, García-Boyero R, Olivares M, Barrena S, Zamora L, Granada I, Lhermitte L, Feliu E, Orfao A
Blood. 2020 Nov 4;
The impact of the COVID-19 pandemic on harm reduction services in Spain.
Picchio CA, Valencia J, Doran J, Swan T, Pastor M, Martró E, Colom J, Lazarus JV
Harm Reduct J. 2020 Nov 4;17(1):87
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José Luis Gómez-Skarmeta (1966-2020).
Bogdanovic O, Irimia M
Nat Genet. 2020 Nov 4;
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Prolonged Immobilization Exacerbates the Loss of Muscle Mass and Function Induced by Cancer-Associated Cachexia through Enhanced Proteolysis in Mice.
Mañas-García L, Penedo-Vázquez A, López-Postigo A, Deschrevel J, Durán X, Barreiro E
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Association between ankle-brachial index and cognitive function in participants in the PREDIMED-Plus study: cross-sectional assessment.
López M, Ríos A, Romaguera D, Martínez-González MÁ, Fernández-Aranda F, Salas-Salvadó J, Corella D, Fitó M, Vioque J, Alonso-Gómez ÁM, Crespo-Oliva E, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, García-Ríos A, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Sánchez-Rodríguez R, Vidal J, Sanz-Martínez E, Ros E, Toledo E, Barrubés L, Barragán R, de la Torre R, Fiol M, González-Palacios S, Sorto-Sánchez C, Martín-Ruiz MV, Zulet MÁ, Díaz-Collado F, Casas R, Fernández-García JC, Santos-Lozano JM, Mallorqui-Bagué N, Argelich E, Lecea Ó, Paz-Graniel I, Sorlí JV, Cuenca A, Munuera S, Hernándis-Marsán MV, Vaquero-Luna J, Ruiz-Canela M, Camacho-Barcia L, Jiménez-Murcia S, Castañer O, Yáñez AM
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Accuracy of Self-Reported Items for the Screening of Depression in the General Population.
Arias-de la Torre J, Vilagut G, Serrano-Blanco A, Martín V, Molina AJ, Valderas JM, Alonso J
Int J Environ Res Public Health. 2020 Oct 29;17(21)
Morphogenesis in robot swarms.
Slavkov I, Carrillo-Zapata D, Carranza N, Diego X, Jansson F, Kaandorp J, Hauert S, Sharpe J
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Are carcinogens direct mutagens?
Lopez-Bigas N, Gonzalez-Perez A
Nat Genet. 2020 Nov;52(11):1137-1138
Prenatal Exposure to Multiple Air Pollutants, Mediating Molecular Mechanisms, and Shifts in Birthweight.
Laine JE, Bodinier B, Robinson O, Plusquin M, Scalbert A, Keski-Rahkonen P, Robinot N, Vermeulen R, Pizzi C, Asta F, Nawrot T, Gulliver J, Chatzi L, Kogevinas M, Nieuwenhuijsen M, Sunyer J, Vrijheid M, Chadeau-Hyam M, Vineis P
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Chromatin-Bound Proteome Profiling by Genome Capture.
Aranda S, Borràs E, Sabidó E, Di Croce L
STAR Protoc. 2020 Jun 19;1(1):100014
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Effect of statin therapy on SARS-CoV-2 infection-related.
Masana L, Correig E, Rodríguez-Borjabad C, Anoro E, Arroyo JA, Jericó C, Pedragosa A, Miret M, Näf S, Pardo A, Perea V, Pérez-Bernalte R, Plana N, Ramírez-Montesinos R, Royuela M, Soler C, Urquizu-Padilla M, Zamora A, Pedro-Botet J, Group OBOTSR
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Highly sensitive and specific multiplex antibody assays to quantify immunoglobulins M, A and G against SARS-CoV-2 antigens.
Dobaño C, Vidal M, Santano R, Jiménez A, Chi J, Barrios D, Ruiz-Olalla G, Rodrigo Melero N, Carolis C, Parras D, Serra P, Martínez de Aguirre P, Carmona-Torre F, Reina G, Santamaria P, Mayor A, García-Basteiro A, Izquierdo L, Aguilar R, Moncunill G
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ViceCT and whiceCT for simultaneous high-resolution visualization of craniofacial, brain and ventricular anatomy from micro-computed tomography.
Llambrich S, Wouters J, Himmelreich U, Dierssen M, Sharpe J, Gsell W, Martínez-Abadías N, Vande Velde G
Sci Rep. 2020 Oct 30;10(1):18772
Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice.
Cáceres M, Quesada R, Iglesias M, Real FX, Villamonte M, de Villarreal JM, Pérez M, Andaluz A, Moll X, Berjano E, Dorcaratto D, Velazquez PS, Grande L, Burdío F
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Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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Top quality research with the utmost integrity
The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.
At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:
- The PRBB Code of Good Scientific Practices, approved by all the centres.
- An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
- Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.
To learn more about the code, the working group on good scientific practices and the various activities organised, visit:
More information
Contact
●Latest news
Patents and companies
- The following links allow you to explore the technology on offer in the park’s centres:
Technology at the IMIM-Hospital del Mar
UPF Business Shuttle and Innovation Unit
Technology and Business Development Office at the CRG
Analysis and Global Development at ISGlobal
EMBLEM Technology Transfer
- The following start-ups have been created within the PRBB environment:
Acellera
Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.
→ https://www.acellera.comChemotargets
Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.
→ http://www.chemotargets.com/qGenomics
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qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.
→ https://qgenomics.comZeClinics
ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.
→ http://www.zeclinics.comMicroomics
Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.
→ http://www.microomics.euFlomics
World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.
→ http://www.flomics.comBioinspired Materials
This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.
→ http://biom.techMedBioinformatics Solutions
MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.
→ http://www.disgenet.orgPulmobiotics
A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.
→ https://www.pulmobio.com/●Latest news
Public-private collaboration to develop a treatment for fragile X syndrome
