Connecting perspectives: from bytes and molecules to organisms and populations
"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".
Jordi Camí, General Director of the PRBB.
The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.
With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.
Hospital del Mar Medical Research Institute (IMIM)
Cancer
The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research
Epidemiology and Public Health
The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.
Biomedical Informatics
This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB).
Neuroscience
The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.
Inflammatory and Cardiovascular Disorders
This programme expands our knowledge of pathophysiological, inflammatory and genetic mechanisms of cardiovascular, respiratory and bone disorders, as well as other acute and chronic disorders, their diagnosis and treatment. The multidisciplinary team addresses basic biomedical scientific questions arising from clinical cases. This approach should lead to translational research that can be applied to medical care.
Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)
Cellular and Molecular Biology
The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.
Molecular Medicine
This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.
Evolutionary Biology and Complex Systems
The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.
Biomedical Informatics
The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.
Genetics and Neuroscience
The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.
Systems Bioengineering
The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.
Transversal Program
Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.
Centre for Genomic Regulation (CRG)
Bioinformatics and Genomics
Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).
Cell and Developmental Biology
The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.
Gene Regulation, Stem Cells and Cancer
The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.
Systems Biology
The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice.
The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.
Barcelona Institute for Global Health (ISGlobal, Mar Campus)
Climate and Health
Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.
Air pollution and urban environment
The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.
Non-communicable diseases and the environment
The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.
Childhood and Environment
This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.
Radiation
The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.
Other
ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.
Institute of Evolutionary Biology (IBE: CSIC-UPF)
Animal Biodiversity and Evolution
The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.
Comparative and Computational Genomics
This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.
Functional Genomics and Evolution
The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.
Population genetics
Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.
Complex Systems
This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.
European Molecular Biology Laboratory (EMBL)
Tissue biology and disease modelling
The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”
Institute of Applied Radiopharmacy of Barcelona (IRAB)
Research and Innovation
The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.
Animal research with the international accreditation from the AAALAC.
The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.
Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.
- Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
- The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
- The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).
For more information on the animal facility and animal experimentation visit:
Animal experimentation courses
The PRBB and Charles River Campus
Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:
- Euthanasia (Function b)
- Performing procedures (Function c)
- Designing projects and procedures (mice and fish/amphibians) (Function d)
The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.
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Shared facilities for high-impact research
"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."
Jordi Camí, General Director of the PRBB
The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.
The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection
Contact: Montserrat Torà
→ marbiobanc@imim.es
The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.
Contact: Julia Ponomarenko
→ biocore@crg.eu
The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.
Contact: Ivo Gut
→ projectmanager@cnag.crg.eu
This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.
Contact: Blanca Espinet
→ bespinet@parcdesalutmar.cat
This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.
Contact: Òscar Fornas
→ oscar.fornas@upf.edu
Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit
The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.
Contact: Dirección de secretaría
→ ceea@prbb.org
Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.
Contact: Dirección de secretaría
→ ceic-imas@imim.es
The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.
Contact: Secretaría
→ cbs@prbb.org
This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.
Contact: Carlo Carolis
→ bmspt@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit
BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.
Contact: Jordi Alonso
→ bibliopro@imim.es
The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.
Contact: Arcadi Navarro
→ helpdesk@ega-archive.org
This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.
Contact: Jochen Hecht
→ ngs@crg.eu
The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.
Contact: Montserrat Torà
→ margenomics@imim.es
The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.
Contact: Ferran Casals
→ genomica@upf.edu
The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.
Contact: Laura Batlle Morera
→ laura.batlle@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0
This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.
Contact: Ana Aldea
→ aaldea@imim.es
This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.
Contact: Jim Swoger
→ mif@embl.es
Web:
https://www.embl.es/services/mesoscopic-imaging-facility
The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.
Contact: Timo Zimmermann
→ timo.zimmermann@crg.es
Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit
Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)
Contact: David Andreu
→ david.andreu@upf.edu
This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.
Contact: Eduard Sabido Aguade
→ eduard.sabido@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit
Functional connectivity alterations associated with literacy difficulties in early readers.
Mateu-Estivill R, Forné S, López-Sala A, Falcón C, Caldú X, Sopena JM, Sans A, Adan A, Grau S, Bargalló N, Serra-Grabulosa JM
Brain Imaging Behav. 2020 Oct 13;
The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing.
Zubovic L, Piazza S, Tebaldi T, Cozzuto L, Palazzo G, Sidarovich V, De Sanctis V, Bertorelli R, Lammens T, Hofmans M, De Moerloose B, Ponomarenko J, Pigazzi M, Masetti R, Mecucci C, Basso G, Macchi P
J Hematol Oncol. 2020 Oct 12;13(1):135
Impact Microindentation in Men with Impaired Fasting Glucose and Type 2 Diabetes.
Holloway-Kew KL, Betson A, Rufus-Membere PG, Gaston J, Diez-Perez A, Kotowicz MA, Pasco JA
Bone. 2020 Oct 10;:115685
External validation of putative biomarkers in eutopic endometrium of women with endometriosis using NanoString technology.
Vallvé-Juanico J, López-Gil C, Ponomarenko J, Melnychuk T, Castellví J, Ballesteros A, Colás E, Gil-Moreno A, Santamaria Costa X
J Assist Reprod Genet. 2020 Oct 9;
Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling.
Hong SY, Sun B, Straub D, Blaakmeer A, Mineri L, Koch J, Brinch-Pedersen H, Holme IB, Burow M, Lyngs Jørgensen HJ, Albà MM, Wenkel S
Proc Natl Acad Sci U S A. 2020 Oct 8;
http://www.ncbi.nlm.nih.gov/en...
Impact of non-formulary drugs on pharmacological prescription in hospitalised patients.
Barceló-Vidal J, Fernández-Sala X, Grau S, Salas E, Duran-Jordan X, Riu M, Ferrández O
Eur J Hosp Pharm. 2020 Oct 8;
The development of chronic diuretic resistance can be predicted during a heart-failure hospitalization. Results from the REDIHF registry.
Blázquez-Bermejo Z, Farré N, Llagostera M, Caravaca Perez P, Morán-Fernández L, Fort A, De-Juan J, Ruiz S, Delgado JF
PLoS One. 2020;15(10):e0240098
http://www.ncbi.nlm.nih.gov/en...
Systematics, biogeography and evolution of the Saharo-Arabian naked-toed geckos genus Tropiocolotes.
Machado L, Salvi D, James Harris D, Brito JC, Crochet PA, Geniez P, Ahmadzadeh F, Carranza S
Mol Phylogenet Evol. 2020 Oct 5;:106969
Prevalence of basal ganglia and carotid artery calcifications in patients with permanent hypoparathyroidism after total thyroidectomy.
Lorente-Poch L, Rifà-Terricabras S, Sancho JJ, Torselli-Valladares D, González-Ortiz S, Sitges-Serra A
Endocr Connect. 2020 Oct;9(10):955-962
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids.
Arnoriaga-Rodríguez M, Mayneris-Perxachs J, Burokas A, Contreras-Rodríguez O, Blasco G, Coll C, Biarnés C, Miranda-Olivos R, Latorre J, Moreno-Navarrete JM, Castells-Nobau A, Sabater M, Palomo-Buitrago ME, Puig J, Pedraza S, Gich J, Pérez-Brocal V, Ricart W, Moya A, Fernández-Real X, Ramió-Torrentà L, Pamplona R, Sol J, Jové M, Portero-Otin M, Maldonado R, Fernández-Real JM
Cell Metab. 2020 Oct 6;32(4):548-560.e7
Dietary Quality Changes According to the Preceding Maximum Weight: A Longitudinal Analysis in the PREDIMED-Plus Randomized Trial.
Bouzas C, Bibiloni MDM, Garcia S, Mateos D, Martínez-González MÁ, Salas-Salvadó J, Corella D, Schröder H, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Bueno-Cavanillas A, Micó-Pérez RM, Pintó X, Delgado-Rodríguez M, Ortíz-Ramos M, Altés-Boronat A, Luca BL, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Bernabé-Casanova A, Martin-Padillo M, Garcia-Rios A, Castro-Barquero S, Fernández-García JC, Santos-Lozano JM, Fernandez-Lazaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari FJ, Canudas S, Goday A, Tur JA
Nutrients. 2020 Oct 2;12(10)
Differences in breast cancer risk after benign breast disease by type of screening diagnosis.
Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, Alcantara R, Sanchez M, Quintana MJ, Del Riego J, Ferrer J, Peñalva L, Bargalló X, Prieto M, Sala M, Castells X
Breast. 2020 Sep 20;
Tumor Cell Attack by Crotalicidin (Ctn) and Its Fragment Ctn[15-34]: Insights into Their Dual Membranolytic and Intracellular Targeting Mechanism.
Pérez-Peinado C, Valle J, Freire JM, Andreu D
ACS Chem Biol. 2020 Oct 6;
Nonlinear interaction between APOE Epsilon-4 allele load and age in the hippocampal surface of cognitively intact individuals.
Martí-Juan G, Sanroma-Guell G, Cacciaglia R, Falcon C, Operto G, Molinuevo JL, González Ballester MÁ, Gispert JD, Piella G, Alzheimer's Disease Neuroimaging Initiative., ALFA Study.
Hum Brain Mapp. 2020 Oct 5;
http://www.ncbi.nlm.nih.gov/en...
Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19).
Mancebo G, Solé-Sedeño JM, Membrive I, Taus A, Castells M, Serrano L, Carreras R, Miralpeix E
Int J Gynecol Cancer. 2020 Oct 5;
Additional Metabolic Effects of Bariatric Surgery in Patients with a Poor Mid-Term Weight Loss Response: A 5-Year Follow-Up Study.
Benaiges D, Bisbe M, Pedro-Botet J, de Vargas-Machuca A, Ramon JM, Pera M, Villatoro M, Fontané L, Julià H, Climent E, Castañer O, Flores-Le Roux JA, Goday A
J Clin Med. 2020 Oct 1;9(10)
MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma.
Pattanayak B, Garrido-Cano I, Adam-Artigues A, Tormo E, Pineda B, Cabello P, Alonso E, Bermejo B, Hernando C, Martínez MT, Rovira A, Albanell J, Rojo F, Burgués O, Cejalvo JM, Lluch A, Eroles P
Front Oncol. 2020;10:1661
http://www.ncbi.nlm.nih.gov/en...
To What Extent Do Fluorophores Bias the Biological Activity of Peptides? A Practical Approach Using Membrane-Active Peptides as Models.
Cavaco M, Pérez-Peinado C, Valle J, Silva RDM, Correia JDG, Andreu D, Castanho MARB, Neves V
Front Bioeng Biotechnol. 2020;8:552035
http://www.ncbi.nlm.nih.gov/en...
Liquid biopsy in oncology: A consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology.
Álvarez-Alegret R, Rojo Todo F, Garrido P, Bellosillo B, Rodríguez-Lescure Á, Rodríguez-Peralto JL, Vera R, de Álava E, García-Campelo R, Remon J
Rev Esp Patol. 2020 Oct - Dec;53(4):234-245
Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2-alfa.
Picón-Pagès P, Gutiérrez DA, Barranco-Almohalla A, Crepin G, Tajes M, Ill-Raga G, Guix FX, Menéndez S, Arumí-Uría M, Vicente R, Álvarez AR, Muñoz FJ
Oxid Med Cell Longev. 2020;2020:2739459
http://www.ncbi.nlm.nih.gov/en...
Genome-wide postnatal changes in immunity following fetal inflammatory response.
Costa D, Bonet N, Solé A, González de Aledo-Castillo JM, Sabidó E, Casals F, Rovira C, Nadal A, Luis Marin J, Cobo T, Castelo R
FEBS J. 2020 Oct 2;
Correction to: Sickness absence trajectories following labour market participation patterns: a cohort study in Catalonia (Spain), 2012-2014.
Hernando-Rodriguez JC, Serra L, Benavides FG, Ubalde-Lopez M
BMC Public Health. 2020 Oct 1;20(1):1493
http://www.ncbi.nlm.nih.gov/en...
Biophysical ambiguities prevent accurate genetic prediction.
Li X, Lehner B
Nat Commun. 2020 Oct 1;11(1):4923
http://www.ncbi.nlm.nih.gov/en...
Glioblastoma TCGA mesenchymal and IGS 23 tumors are identifiable by immunohistochemistry and have an immune-phenotype indicating potential benefit from immunotherapy.
Carrato C, Alameda F, Esteve-Codina A, Pineda E, Arpí O, Martinez Garcia M, Mallo M, Gut M, Lopez-Martos R, Del Barco S, Ribalta T, Capellades J, Puig J, Gallego O, Mesia C, Muñoz-Mármol AM, Archilla I, Arumí M, Blanc JM, Bellosillo B, Menéndez S, Esteve A, Bague S, Hernandez A, Craven-Bartle J, Fuentes R, Vidal N, Aldecoa I, de la Iglesia N, Balana C
Clin Cancer Res. 2020 Sep 30;
The shaping of immunological responses through natural selection after the Roma Diaspora.
Dobon B, Ter Horst R, Laayouni H, Mondal M, Bianco E, Comas D, Ioana M, Bosch E, Bertranpetit J, Netea MG
Sci Rep. 2020 Sep 30;10(1):16134
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Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development.
Brena D, Bertran J, Porta-de-la-Riva M, Guillén Y, Cornes E, Kukhtar D, Campos-Vicens L, Fernández L, Pecharroman I, García-López A, Islam ABMMK, Marruecos L, Bigas A, Cerón J, Espinosa L
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Development of Helicobacter pylori Whole-Proteome Arrays and Identification of Serologic Biomarkers for Noncardia Gastric Cancer in the MCC-Spain Study.
Jeske R, Reininger D, Turgu B, Brauer A, Harmel C, Fernández de Larrea-Baz N, Martín V, Moreno V, Kogevinas M, Pollán M, Hoheisel JD, Waterboer T, Butt J, Aragonés N, Hufnagel K
Cancer Epidemiol Biomarkers Prev. 2020 Sep 30;
Protein Kinase C-Gamma Knockout Mice Show Impaired Hippocampal Short-Term Memory While Preserved Long-Term Memory.
Gomis-González M, Galera-López L, Ten-Blanco M, Busquets-Garcia A, Cox T, Maldonado R, Ozaita A
Mol Neurobiol. 2020 Sep 30;
Topologically selective islet vulnerability and self-sustained downregulation of markers for beta-cell maturity in streptozotocin-induced diabetes.
Hahn M, van Krieken PP, Nord C, Alanentalo T, Morini F, Xiong Y, Eriksson M, Mayer J, Kostromina E, Ruas JL, Sharpe J, Pereira T, Berggren PO, Ilegems E, Ahlgren U
Commun Biol. 2020 Sep 30;3(1):541
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Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment.
De Toma I, Ortega M, Catuara-Solarz S, Sierra C, Sabidó E, Dierssen M
Sci Rep. 2020 Sep 29;10(1):16023
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Neuroinflammatory and behavioral susceptibility profile of mice exposed to social stress towards cocaine effects.
Ballestín R, Alegre-Zurano L, Ferrer-Pérez C, Cantacorps L, Miñarro J, Valverde O, Rodríguez-Arias M
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Sep 28;105:110123
Normative Data for Impact Microindentation for Australian Men: Cross-Sectional Data From the Geelong Osteoporosis Study.
Rufus-Membere P, Holloway-Kew KL, Kotowicz MA, Diez-Perez A, Pasco JA
JBMR Plus. 2020 Sep;4(9):e10384
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Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T, Hoekzema K, Vecchio D, Wu H, Sulovari A, Coe BP, Gillentine MA, Wilfert AB, Perez-Jurado LA, Kvarnung M, Sleyp Y, Earl RK, Rosenfeld JA, Geisheker MR, Han L, Du B, Barnett C, Thompson E, Shaw M, Carroll R, Friend K, Catford R, Palmer EE, Zou X, Ou J, Li H, Guo H, Gerdts J, Avola E, Calabrese G, Elia M, Greco D, Lindstrand A, Nordgren A, Anderlid BM, Vandeweyer G, Van Dijck A, Van der Aa N, McKenna B, Hancarova M, Bendova S, Havlovicova M, Malerba G, Bernardina BD, Muglia P, van Haeringen A, Hoffer MJV, Franke B, Cappuccio G, Delatycki M, Lockhart PJ, Manning MA, Liu P, Scheffer IE, Brunetti-Pierri N, Rommelse N, Amaral DG, Santen GWE, Trabetti E, Sedlácek Z, Michaelson JJ, Pierce K, Courchesne E, Kooy RF, SPARK Consortium., Nordenskjöld M, Romano C, Peeters H, Bernier RA, Gecz J, Xia K, Eichler EE
Nat Commun. 2020 Oct 1;11(1):4932
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How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.
Trujillo M, Prakash P, Faridi P, Radosevic A, Curto S, Burdio F, Berjano E
Int J Hyperthermia. 2020;37(1):1131-1138
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In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm.
Artigas L, Coma M, Matos-Filipe P, Aguirre-Plans J, Farrés J, Valls R, Fernandez-Fuentes N, de la Haba-Rodriguez J, Olvera A, Barbera J, Morales R, Oliva B, Mas JM
PLoS One. 2020;15(10):e0240149
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The cost-effectiveness of isavuconazole compared to voriconazole, the standard of care in the treatment of patients with invasive mould diseases, prior to differential pathogen diagnosis in Spain.
Azanza JR, Grau S, Vázquez L, Rebollo P, Peral C, López-Ibáñez de Aldecoa A, López-Gómez V
Mycoses. 2020 Sep 29;
Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL.
Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, Davis ZA, Yan XJ, Jeromin S, Schneider C, Pedersen LB, Tschumper R, Sutton LA, Baliakas P, Scarfò L, van Gastel EJ, Armand M, Tausch E, Biderman B, Baer C, Bagnara D, Navarro A, de Septenville A, Guido V, Mitterbauer-Hohendanner G, Dimovski A, Brieghel C, Lawless S, Meggendorfer M, Stranska K, Ritgen M, Facco M, Tresoldi C, Visentin A, Patriarca A, Catherwood M, Bonello L, Sudarikov A, Vanura K, Roumelioti M, Skuhrova Francova H, Moysiadis T, Veronese SM, Giannopoulos K, Mansouri L, Karan-Djurasevic T, Sandaltzopoulos R, Bödör C, Fais F, Kater AP, Panovska-Stavridis I, Rossi D, Alshemmari S, Panagiotidis P, Costeas PA, Espinet B, Antic D, Foroni L, Montillo M, Trentin L, Stavroyianni N, Gaidano G, Francia di Celle P, Niemann CU, Campo E, Anagnostopoulos A, Pott C, Fischer K, Hallek M, Oscier DG, Stilgenbauer S, Haferlach C, Jelinek DF, Chiorazzi N, Pospisilova S, Lefranc MP, Kossida S, Langerak AW, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K
Blood. 2020 Sep 29;
Author Correction: Characterization of partially ordered states in the intrinsically disordered N-terminal domain of p53 using millisecond molecular dynamics simulations.
Herrera-Nieto P, Pérez A, De Fabritiis G
Sci Rep. 2020 Sep 29;10(1):16374
Deficient muscle regeneration potential in sarcopenic COPD patients: Role of satellite cells.
Sancho-Muñoz A, Guitart M, Rodríguez DA, Gea J, Martínez-Llorens J, Barreiro E
J Cell Physiol. 2020 Sep 28;
Evaluation of Specific Absorption Rate in the Far-Field, Near-to-Far Field and Near-Field Regions for Integrative Radiofrequency Exposure Assessment.
Liorni I, Capstick M, van Wel L, Wiart J, Joseph W, Cardis E, Guxens M, Vermeulen R, Thielens A
Radiat Prot Dosimetry. 2020 Sep 28;
Stroke prevention in patients with type 2 diabetes or prediabetes. Recommendations from the Cerebrovascular Diseases Study Group, Spanish Society of Neurology.
Fuentes B, Amaro S, Alonso de Leciñana M, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo M, García-Pastor A, Gomis M, Gómez Choco M, López-Cancio E, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Rodríguez-Yáñez M, Roquer J, Segura T, Serena J, Vivancos-Mora J, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología.
Neurologia. 2020 Sep 24;
Experts Document About an Adequate Utilization of SYSADOAs in Controversial Clinical Situations.
Monfort J, Carné X, Abarca B, Giménez S, Romera M, Möller I, Bibas M, Vitaloni M, Batlle A, Vergés J
Reumatol Clin. 2020 Sep 24;
Recognition of air pollution as a risk factor for stroke in clinical practice guidelines: a literature review.
Avellaneda-Gómez C, Roquer J, Vivanco-Hidalgo R
Neurologia. 2020 Sep 23;
Chronic urticaria treatment patterns and changes in quality of life: AWARE study 2-year results.
Maurer M, Giménez-Arnau A, Ensina LF, Chu CY, Jaumont X, Tassinari P
World Allergy Organ J. 2020 Sep;13(9):100460
Phenotypic Variability in a Coinfection With Three Independent Candida parapsilosis Lineages.
Gómez-Molero E, Willis JR, Dudakova A, Carreté L, Weig M, Groß U, Gácser A, Gabaldón T, Bader O
Front Microbiol. 2020;11:1994
Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data.
Nicoara-Farcau O, Han G, Rudler M, Angrisani D, Monescillo A, Torres F, Casanovas G, Bosch J, Lv Y, Thabut D, Fan D, Hernández-Gea V, García-Pagán JC, pre-emptive TIPS individual data metanalysis, International Variceal Bleeding Study and Baveno Cooperation Study groups., Bureau C, Abraldes JG, Nevens F, Caca K, Laleman W, Appenrodt B, Luca A, Vinel JP, Mössner J, Di Pascoli M, Zipprich A, Sauerbruch T, Martinez-Lagares F, Ruiz-Del-Arbol L, Sierra A, Guevara C, Jimenez E, Marrero JM, Buceta E, Sanchez J, Castellot A, Penate M, Cruz A, Pena E, Procopet B, Giráldez Á, Amitrano L, Villanueva C, Ibañez-Samaniego L, Silva-Junior G, Martinez J, Genescà J, Trebicka J, Llop E, Palazon JM, Castellote J, Rodrigues S, Gluud LL, Ferreira CN, Barcelo R, Cañete N, Rodríguez M, Ferlitsch A, Mundi JL, Gronbaek H, Hernández-Guerra M, Sassatelli R, Dell'Era A, Senzolo M, Romero-Gómez M, Casas M, Masnou H, Primignani M, Krag A, Calleja JL, Jansen C, Robic MA, Conejo I, Catalina MV, Albillos A, Alvarado E, Guardascione MA, Tantau M, Zuo L, Zhu X, Zhao J, Xue H, Jiang Z, Zhuge Y, Zhang C, Sun J, Ding P, Ren W, Li Y, Zhang K, Zhang W, He C, Zhong J, Peng Q, Ma F, Luo J, Zhang M, Wang G, Sun M, Dong J, Bai W, Guo W, Wang Q, Yuan X, Wang Z, Yu T, Luo B, Li X, Yuan J, Han N, Zhu Y, Niu J, Li K, Yin Z, Nie Y, Fischer P, Stefanescu H, Pop A, Laursen SB, Turon F, Baiges A, Ferrusquía-Acosta J, Magaz M, Cerda E, Tellez L, Allegretti G, Macedo G, Haldrup D, Santos P, Moura M, Reis D, Meireles L, Sousa P, Alexandrino P, Navascues C, Augustin S, La Mura V, Bañares R, Diaz R, Gómez ML, Ripoll C
Gastroenterology. 2020 Sep 24;
General Analyses of Gene Expression Dependencies on Genetic Burden.
González-Colell M, Macía J
Front Bioeng Biotechnol. 2020;8:1017
Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells.
Benfield AH, Defaus S, Lawrence N, Chaousis S, Condon N, Cheneval O, Huang YH, Chan LY, Andreu D, Craik DJ, Henriques ST
Biochim Biophys Acta Biomembr. 2020 Sep 24;1863(1):183480
Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain Study).
Weitzer J, Castaño-Vinyals G, Aragonés N, Gómez-Acebo I, Guevara M, Amiano P, Martín V, Molina-Barceló A, Alguacil J, Moreno V, Suarez-Calleja C, Jiménez-Moleón JJ, Marcos-Gragera R, Papantoniou K, Pérez-Gómez B, Llorca J, Ascunce N, Gil L, Gracia-Lavedan E, Casabonne D, Lope V, Pollán M, Kogevinas M
Int J Cancer. 2020 Sep 25;
The evolutionary history of Neanderthal and Denisovan Y chromosomes.
Petr M, Hajdinjak M, Fu Q, Essel E, Rougier H, Crevecoeur I, Semal P, Golovanova LV, Doronichev VB, Lalueza-Fox C, de la Rasilla M, Rosas A, Shunkov MV, Kozlikin MB, Derevianko AP, Vernot B, Meyer M, Kelso J
Science. 2020 Sep 25;369(6511):1653-1656
Beyond clinical outcomes: the social and healthcare system implications of hepatitis C treatment.
Torrens M, Soyemi T, Bowman D, Schatz E
BMC Infect Dis. 2020 Sep 24;20(1):702
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Mendelian randomization analysis of n-6 polyunsaturated fatty acid levels and pancreatic cancer risk.
Ghoneim DH, Zhu J, Zheng W, Long J, Murff HJ, Ye F, Setiawan VW, Wilkens LR, Khankari NK, Haycock P, Antwi SO, Yang Y, Arslan AA, Beane Freeman LE, Bracci PM, Canzian F, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Le Marchand L, Neale RE, Scelo G, Visvanathan K, White E, Albanes D, Amiano P, Andreotti G, Babic A, Bamlet WR, Berndt SI, Brais LK, Brennan P, Bueno-de-Mesquita B, Buring JE, Campbell PT, Rabe KG, Chanock SJ, Duggal P, Fuchs CS, Gaziano JM, Goggins MG, Hackert T, Hassan MM, Helzlsouer KJ, Holly EA, Hoover RN, Katzke V, Kurtz RC, Lee IM, Malats N, Milne RL, Murphy N, Oberg AL, Porta M, Rothman N, Sesso HD, Silverman DT, Thompson IM, Wactawski-Wende J, Wang X, Wentzensen N, Yu H, Zeleniuch-Jacqotte A, Yu K, Wolpin BM, Jacobs EJ, Duell EJ, Risch HA, Petersen GM, Amundadottir LT, Kraft P, Klein AP, Stolzenberg-Solomon RZ, Shu XO, Wu L
Cancer Epidemiol Biomarkers Prev. 2020 Sep 23;
Cardboard floor: about the barriers for social progression and their impact on the representativeness of epidemiological studies.
Arias-de la Torre J, Valderas JM, Benavides FG, Alonso J
J Epidemiol Community Health. 2020 Sep 22;
Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome.
Bullón-Vela V, Abete I, Zulet MA, Xu Y, Martínez-González MA, Sayón-Orea C, Ruiz-Canela M, Toledo E, Sánchez VM, Estruch R, Lamuela-Raventós RM, Almanza-Aguilera E, Fitó M, Salas-Salvadó J, Díaz-López A, Tinahones FJ, Tur JA, Romaguera D, Konieczna J, Pintó X, Daimiel L, Rodriguez-Mateos A, Alfredo Martínez J
Molecules. 2020 Sep 22;25(18)
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Galaxy InteractoMIX: An Integrated Computational Platform for the Study of Protein-Protein Interaction Data.
Mirela-Bota P, Aguirre-Plans J, Meseguer A, Galletti C, Segura J, Planas-Iglesias J, Garcia-Garcia J, Guney E, Oliva B, Fernandez-Fuentes N
J Mol Biol. 2020 Sep 22;
Health policy strategies for Patient Blood Management implementation throughout the Spanish health systems.
Garcia-Casanovas A, Bisbe E, Colomina MJ, Arbona C, Varela J
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Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.
Pont L, Alechaga É, Terrero A, Monfort N, Ventura R
J Chromatogr A. 2020 Sep 17;1631:461548
Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis.
Cáceres A, González JR
Neurobiol Aging. 2020 Sep 2;96:104-108
Detection of postoperative plasma circulating tumour DNA and lack of CDX2 expression as markers of recurrence in patients with localised colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Huerta M, Roselló S, Zuniga S, Calon A, Carbonell-Asins JA, Fontana E, Martinez-Ciarpaglini C, Eason K, Rentero-Garrido P, Fleitas T, Papaccio F, Moro-Valdezate D, Nyamundanda G, Castillo J, Espí A, Sadanandam A, Roda D, Cervantes A
ESMO Open. 2020 Sep;5(5)
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Synthetic soil crusts against green-desert transitions: a spatial model.
Vidiella B, Sardanyés J, Solé RV
R Soc Open Sci. 2020 Aug;7(8):200161
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Mutations make gut antibodies promiscuous.
Grasset EK, Cerutti A
J Exp Med. 2020 Nov 2;217(11)
methylclock: a Bioconductor package to estimate DNA methylation age.
Pelegí-Sisó D, de Prado P, Ronkainen J, Bustamante M, González JR
Bioinformatics. 2020 Sep 22;
Fit-for-Discharge Criteria after Esophagectomy: An International Expert Delphi Consensus.
Müller PC, Kapp JR, Vetter D, Bonavina L, Brown W, Castro S, Cheong E, Darling GE, Egberts J, Ferri L, Gisbertz SS, Gockel I, Grimminger PP, Hofstetter WL, Hölscher AH, Low DE, Luyer M, Markar SR, Mönig SP, Moorthy K, Morse CR, Müller-Stich BP, Nafteux P, Nieponice A, Nieuwenhuijzen GAP, Nilsson M, Palanivelu C, Pattyn P, Pera M, Räsänen J, Ribeiro U, Rosman C, Schröder W, Sgromo B, van Berge Henegouwen MI, van Hillegersberg R, van Veer H, van Workum F, Watson DI, Wijnhoven BPL, Gutschow CA
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Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.
Doñate-Macian P, Duarte Y, Rubio-Moscardo F, Pérez-Vilaró G, Canan J, Díez J, González-Nilo F, Valverde MA
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Extensive germline genome engineering in pigs.
Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, Wu J, Xiong J, Goswami D, Yang M, Lamriben L, Xu M, Zhang Q, Luo Y, Guo J, Mao S, Jiao D, Nguyen TD, Li Z, Layer JV, Li M, Paragas V, Youd ME, Sun Z, Ding Y, Wang W, Dou H, Song L, Wang X, Le L, Fang X, George H, Anand R, Wang SY, Westlin WF, Güell M, Markmann J, Qin W, Gao Y, Wei HJ, Church GM, Yang L
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Analysis of hydroxylated phenylalkylamine stimulants in urine by GC-APPI-HRMS.
Bressan C, Ayala-Cabrera JF, Santos FJ, Cuadras S, Garrostas L, Monfort N, Alechaga É, Moyano E, Ventura R
Anal Bioanal Chem. 2020 Sep 21;
The global burden of chronic urticaria for the patient and society.
Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, Ben-Shoshan M, Bernstein JA, Ensina LF, Fomina D, Galvàn CA, Godse K, Grattan C, Hide M, Katelaris CH, Khoshkhui M, Kocatürk E, Kulthanan K, Medina I, Nasr I, Peter J, Staubach P, Wang L, Weller K, Maurer M
Br J Dermatol. 2020 Sep 21;
Rezafungin versus Caspofungin in a Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive Candidiasis- The STRIVE Trial.
Thompson GR, Soriano A, Skoutelis A, Vazquez JA, Honore PM, Horcajada JP, Spapen H, Bassetti M, Ostrosky-Zeichner L, Das AF, Viani RM, Sandison T, Pappas PG
Clin Infect Dis. 2020 Sep 21;
Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status.
Mayneris-Perxachs J, Arnoriaga-Rodríguez M, Luque-Córdoba D, Priego-Capote F, Pérez-Brocal V, Moya A, Burokas A, Maldonado R, Fernández-Real JM
Microbiome. 2020 Sep 20;8(1):136
Effects of high fat diet and maternal binge-like alcohol consumption and their influence on cocaine response in female mice offspring.
Duart-Castells L, Cantacorps L, López-Arnau R, Montagud-Romero S, Puster B, Mera P, Serra D, Camarasa J, Pubill D, Valverde O, Escubedo E
Int J Neuropsychopharmacol. 2020 Sep 19;
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Maturity Assessment model for Patient Blood Management to assist hospitals in improving patients' safety and outcomes. The MAPBM project.
Bisbe E, Garcia-Casanovas A, Illa C, Varela J, Basora M, Barquero M, Colomina MJ, González L, Hofmann A, MAPBM Working Group., Rodríguez LEF, Gosálbez AA, Fornet AP, Soler X, Planella T, Ricos P, Goterris R, Olmedilla L, Jericó C, Morales A, Gala JMG, Dueñas V, Fernández C, Tolos R, Villanueva MA, Cassinello C, Graciani IF, Aragon S, Subira M, Turcu V, Vilariño SAD, Zavala E, González LM, Moreno G, de Gracia SR, García A, Gallofre AP, Duque P, Sánchez LL, Vagace JM, Medina Á, Rodríguez MO, Faura A, Rosello L, Johansson E, Poch P, Santamaría MA, Rubio ML, Jara I, Carmona C, Lluch CR, Almirante M, López ÁF, Caldes M, Loureiro E, Quintana M, Azparren G, Puerta J, Romero EM, Rubio AA, Santaella J, Cerdan G, Arbones R, Palacios Á, Llamas P
Blood Transfus. 2020 Sep 18;
Mechanisms of cell specification and differentiation in vertebrate cranial sensory systems.
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Curr Opin Cell Biol. 2020 Sep 17;67:79-85
Brain Functional Connectivity Correlates of Subclinical Obsessive-Compulsive Symptoms in Healthy Children.
Suñol M, Saiz-Masvidal C, Contreras-Rodríguez O, Macià D, Martínez-Vilavella G, Martínez-Zalacaín I, Menchón JM, Pujol J, Sunyer J, Soriano-Mas C
J Am Acad Child Adolesc Psychiatry. 2020 Sep 17;
Respiratory muscle senescence in ageing and chronic lung diseases.
Gea J, Ausín P, Martínez-Llorens JM, Barreiro E
Eur Respir Rev. 2020 Sep 30;29(157)
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Circulating cell-free DNA improves the molecular characterisation of Ph-negative myeloproliferative neoplasms.
Garcia-Gisbert N, Fernández-Ibarrondo L, Fernández-Rodríguez C, Gibert J, Andrade-Campos M, Arenillas L, Camacho L, Angona A, Longarón R, Salar A, Calvo X, Besses C, Bellosillo B
Br J Haematol. 2020 Sep 18;
Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Matsuda M, Hayashi H, Garcia-Ojalvo J, Yoshioka-Kobayashi K, Kageyama R, Yamanaka Y, Ikeya M, Toguchida J, Alev C, Ebisuya M
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The Chronic Urticaria Registry (CURE):Rationale, Methods, and Initial Implementation.
Weller K, Giménez-Arnau A, Grattan C, Asero R, Mathelier-Fusade P, Bizjak M, Hanna M, Maurer M, Cure Investigators.
J Eur Acad Dermatol Venereol. 2020 Sep 18;
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Elimination profiles of betamethasone after different administration routes: evaluation of the reporting level and washout periods to ensure safe therapeutic administrations.
Coll S, Monfort N, Alechaga É, Matabosch X, Pérez-Mañá C, Ventura R
Drug Test Anal. 2020 Sep 18;
Feasibility, tolerability, and effects of exercise-based prehabilitation after neoadjuvant therapy in esophagogastric cancer patients undergoing surgery: an interventional pilot study.
Argudo N, Rodó-Pin A, Martínez-Llorens J, Marco E, Visa L, Messaggi-Sartor M, Balañá-Corberó A, Ramón JM, Rodríguez-Chiaradía DA, Grande L, Pera M
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Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study.
Trinka E, Rocamora R, Chaves J, Moreira J, Ikedo F, Soares-da-Silva P, BIA-2093-311/EXT Investigators Study Group.
Epilepsia. 2020 Sep 17;
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B Cells and Tertiary Lymphoid Structures Influence Survival in Lung Cancer Patients with Resectable Tumors.
Tang J, Ramis-Cabrer D, Curull V, Wang X, Mateu-Jiménez M, Pijuan L, Duran X, Qin L, Rodríguez-Fuster A, Aguiló R, Barreiro E
Cancers (Basel). 2020 Sep 16;12(9)
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High Plasma Glutamate and a Low Glutamine-to-Glutamate Ratio Are Associated with Increased Risk of Heart Failure but Not Atrial Fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study.
Papandreou C, Hernández-Alonso P, Bulló M, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Cofán M, Fitó M, Razquin C, Arós F, Fiol M, Santos-Lozano JM, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J
J Nutr. 2020 Sep 16;
Relation of Interatrial Block to Cognitive Impairment in Patients ? 70 Years of Age (From the CAMBIAD Case-Control Study).
Herrera C, Bruña V, Abizanda P, Díez-Villanueva P, Formiga F, Torres R, Carreras J, Ayala R, Martin-Sánchez FJ, Bayés-Genis A, Elosua R, Bayés-de-Luna A, Martínez-Sellés M, CAMBIAD investigators (Appendix).
Am J Cardiol. 2020 Sep 16;
Drug repositioning and repurposing for Alzheimer disease.
Ballard C, Aarsland D, Cummings J, O'Brien J, Mills R, Molinuevo JL, Fladby T, Williams G, Doherty P, Corbett A, Sultana J
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Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015-2018.
Uter W, Bauer A, Belloni Fortina A, Bircher AJ, Brans R, Buhl T, Cooper SM, Czarnecka-Operacz M, Dickel H, Dugonik A, Geier J, Giménez-Arnau AM, Gonçalo M, Johansen JD, Johnston GA, Mahler V, Rustemeyer T, Sanchez-Perez J, Schuttelaar MLA, Simon D, Spiewak R, Valiukevicien S, Weisshaar E, White IR, Wilkinson M, ESSCA working group.
Contact Dermatitis. 2020 Sep 18;
Managing dual disorders: a statement by the Informal Scientific Network, UN Commission on Narcotic Drugs.
Volkow ND, Torrens M, Poznyak V, Sáenz E, Busse A, Kashino W, Krupchanka D, Kestel D, Campello G, Gerra G
World Psychiatry. 2020 Oct;19(3):396-397
MassIVE.quant: a community resource of quantitative mass spectrometry-based proteomics datasets.
Choi M, Carver J, Chiva C, Tzouros M, Huang T, Tsai TH, Pullman B, Bernhardt OM, Hüttenhain R, Teo GC, Perez-Riverol Y, Muntel J, Müller M, Goetze S, Pavlou M, Verschueren E, Wollscheid B, Nesvizhskii AI, Reiter L, Dunkley T, Sabidó E, Bandeira N, Vitek O
Nat Methods. 2020 Oct;17(10):981-984
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.
Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A
Cell. 2020 Oct 1;183(1):94-109.e23
Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A.
Lai CQ, Parnell LD, Smith CE, Guo T, Sayols-Baixeras S, Aslibekyan S, Tiwari HK, Irvin MR, Bender C, Fei D, Hidalgo B, Hopkins PN, Absher DM, Province MA, Elosua R, Arnett DK, Ordovas JM
Am J Clin Nutr. 2020 Sep 15;
OVOL1/2: Drivers of Epithelial Differentiation in Development, Disease, and Reprogramming.
Saxena K, Srikrishnan S, Celia-Terrassa T, Jolly MK
Cells Tissues Organs. 2020 Sep 15;:1-10
Primary resistance to integrase strand transfer inhibitors in Spain using ultrasensitive HIV-1 genotyping.
Casadellà M, Santos JR, Noguera-Julian M, Micán-Rivera R, Domingo P, Antela A, Portilla J, Sanz J, Montero-Alonso M, Navarro J, Masiá M, Valcarce-Pardeiro N, Ocampo A, Pérez-Martínez L, Pasquau J, Vivancos MJ, Imaz A, Carmona-Oyaga P, Muñoz-Medina L, Villar-García J, Barrufet P, Paredes R, Santos JR, Bravo I, Chamorro A, Miranda C, Micán R, González J, Antela A, Diez M, Portilla I, Carreres M, Giner L, Boix V, Reus S, Merino E, Torrús D, Portilla J, Sanz J, Liarte ÁG, Berrocal AG, Domingo P, Del M, Gutiérrez M, Mateo MG, Rodríguez JM, Montero-Alonso M, Curran A, Torrella A, Planas B, Navarro J, Masiá M, Padilla S, Robledano C, Adsuar A, Montolio F, Gutiérrez F, Pardeiro NV, Álvarez H, Mariño A, Ocampo A, Rodríguez A, Miralles C, Pérez-Martínez L, Blanco JR, Vallecillos CG, Pasquau J, Pérez-Elías MJ, Dronda F, Vivancos MJ, Moreno S, Imaz A, Podzamczer D, Ibarguren M, Kortajarena X, Carmona MP, Iribarren JA, Moreno LM, Quero JH, Villar-García J, Knobel H, Barrufet P, Force L, Casadellà M, Paredes R, Noguera-Julian M
J Antimicrob Chemother. 2020 Sep 15;
Impact of response to treatment in health-related quality of life patient-reported outcomes in elderly patients with relapsed multiple myeloma.
Oriol A, Ibarra G, Abella E, Motlló C, Cibeira MT, Garcia A, Escoda L, Granell M, Ben-Azaiz R, Cervera M, Cabezudo E, Fernandez C, Rosiñol L
Leuk Lymphoma. 2020 Sep 15;:1-11
The SEEN comprehensive clinical survey of adult obesity: Executive summary.
Ballesteros Pomar MD, Vilarrasa García N, Rubio Herrera MÁ, Barahona MJ, Bueno M, Caixàs A, Calañas Continente A, Ciudin A, Cordido F, de Hollanda A, Diaz MJ, Flores L, García Luna PP, García Pérez-Sevillano F, Goday A, Lecube A, López Gómez JJ, Miñambres I, Morales Gorria MJ, Morinigo R, Nicolau J, Pellitero S, Salvador J, Valdés S, Bretón Lesmes I
Endocrinol Diabetes Nutr. 2020 Sep 12;
Gastrointestinal involvement attenuates COVID-19 severity and mortality.
Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, Parigi TL, Ramos I, Dunleavy K, Lee B, Dixon R, Chen ST, Martinez-Delgado G, Nagula S, Ko HM, Reidy J, Naymagon S, Grinspan A, Ahmad J, Tankelevich M, Gordon R, Sharma K, Britton GJ, Chen-Liaw A, Spindler MP, Plitt T, Wang P, Cerutti A, Faith JJ, Colombel JF, Kenigsberg E, Argmann C, Merad M, Gnjatic S, Harpaz N, Danese S, Rahman A, Kumta NA, Aghemo A, Petralia F, van Bakel H, Garcia-Sastre A, Mehandru S
medRxiv. 2020 Sep 9;
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Incidence and Grading of Complications after Gastrectomy for Cancer Using the GASTRODATA Registry: A European Retrospective Observational Study.
Baiocchi GL, Giacopuzzi S, Reim D, Piessen G, Costa PMD, Reynolds JV, Meyer HJ, Morgagni P, Gockel I, Santos LL, Jensen LS, Murphy T, D'Ugo D, Rosati R, Fumagalli Romario U, Degiuli M, Kielan W, Mönig S, Kolodziejczyk P, Polkowski W, Pera M, Schneider PM, Wijnhoven B, de Steur WO, Gisbertz SS, Hartgrink H, van Sandick JW, Botticini M, Hölscher AH, Allum W, De Manzoni G
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Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children.
Aguilar-Lacasaña S, Vilor-Tejedor N, Jansen PR, López-Vicente M, Bustamante M, Burgaleta M, Sunyer J, Alemany S
Psychol Med. 2020 Sep 14;:1-9
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Asthma exacerbations, air pollution, and allergens.
Sunyer J, Antó JM
Lancet. 2020 Sep 12;396(10253):753
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Air pollution and IgE sensitization in four European birth cohorts - the MeDALL project.
Melén E, Standl M, Gehring U, Altug H, Antó JM, Berdel D, Bergström A, Bousquet J, Heinrich J, Koppelman GH, Kull I, Lupinek C, Markevych I, Schikowski T, Thiering E, Valenta R, van Hage M, von Berg A, Vonk JM, Wickman M, Wijga A, Gruzieva O
J Allergy Clin Immunol. 2020 Sep 11;
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Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial.
Hernáez Á, Castañer O, Tresserra-Rimbau A, Pintó X, Fitó M, Casas R, Martínez-González MÁ, Corella D, Salas-Salvadó J, Lapetra J, Gómez-Gracia E, Arós F, Fiol M, Serra-Majem L, Ros E, Estruch R
Mol Nutr Food Res. 2020 Sep 12;:e2000350
Correction to: The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest.
Rispe C, Legeai F, Nabity PD, Fernández R, Arora AK, Baa-Puyoulet P, Banfill CR, Bao L, Barberà M, Bouallègue M, Bretaudeau A, Brisson JA, Calevro F, Capy P, Catrice O, Chertemps T, Couture C, Delière L, Douglas AE, Dufault-Thompson K, Escuer P, Feng H, Forneck A, Gabaldón T, Guigó R, Hilliou F, Hinojosa-Alvarez S, Hsiao YM, Hudaverdian S, Jacquin-Joly E, James EB, Johnston S, Joubard B, Le Goff G, Le Trionnaire G, Librado P, Liu S, Lombaert E, Lu HL, Maïbèche M, Makni M, Marcet-Houben M, Martínez-Torres D, Meslin C, Montagné N, Moran NA, Papura D, Parisot N, Rahbé Y, Lopes MR, Ripoll-Cladellas A, Robin S, Roques C, Roux P, Rozas J, Sánchez-Gracia A, Sánchez-Herrero JF, Santesmasses D, Scatoni I, Serre RF, Tang M, Tian W, Umina PA, van Munster M, Vincent-Monégat C, Wemmer J, Wilson ACC, Zhang Y, Zhao C, Zhao J, Zhao S, Zhou X, Delmotte F, Tagu D
BMC Biol. 2020 Sep 11;18(1):123
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Cell type-specific genetic regulation of gene expression across human tissues.
Kim-Hellmuth S, Aguet F, Oliva M, Muñoz-Aguirre M, Kasela S, Wucher V, Castel SE, Hamel AR, Viñuela A, Roberts AL, Mangul S, Wen X, Wang G, Barbeira AN, Garrido-Martín D, Nadel BB, Zou Y, Bonazzola R, Quan J, Brown A, Martinez-Perez A, Soria JM, GTEx Consortium., Getz G, Dermitzakis ET, Small KS, Stephens M, Xi HS, Im HK, Guigó R, Segrè AV, Stranger BE, Ardlie KG, Lappalainen T
Science. 2020 Sep 11;369(6509)
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The impact of sex on gene expression across human tissues.
Oliva M, Muñoz-Aguirre M, Kim-Hellmuth S, Wucher V, Gewirtz ADH, Cotter DJ, Parsana P, Kasela S, Balliu B, Viñuela A, Castel SE, Mohammadi P, Aguet F, Zou Y, Khramtsova EA, Skol AD, Garrido-Martín D, Reverter F, Brown A, Evans P, Gamazon ER, Payne A, Bonazzola R, Barbeira AN, Hamel AR, Martinez-Perez A, Soria JM, GTEx Consortium., Pierce BL, Stephens M, Eskin E, Dermitzakis ET, Segrè AV, Im HK, Engelhardt BE, Ardlie KG, Montgomery SB, Battle AJ, Lappalainen T, Guigó R, Stranger BE
Science. 2020 Sep 11;369(6509)
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Bariatric surgery and LDL cholesterol (BASALTO) trial study protocol: randomised controlled study evaluating the effect of gastric bypass versus sleeve gastrectomy on high LDL cholesterol.
Benaiges D, Goday A, Flores-Le Roux JA, Fitó M, Pozo O, Rodríguez-Morató J, Serra C, Pera M, Llauradó G, Climent E, Castañer O, Ramon JM, Pedro-Botet J
BMJ Open. 2020 Sep 10;10(9):e037712
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High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation.
Hernández Martínez G, Rodriguez ML, Vaquero MC, Ortiz R, Masclans JR, Roca O, Colinas L, de Pablo R, Espinosa MD, Garcia-de-Acilu M, Climent C, Cuena-Boy R
N Engl J Med. 2020 Sep 10;383(11):1009-1017
Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population-based cohort study.
Jansana A, Del Cura I, Prados-Torres A, Sanz Cuesta T, Poblador-Plou B, Gimeno Miguel A, Lanzuela M, Ibañez B, Tamayo I, Moreno-Iribas C, Padilla-Ruiz M, Redondo M, Comas M, Domingo L, Díaz-Holgado A, Salamanca FJ, Castells X, Sala M, SURBCAN group.
BMJ Open. 2020 Sep 9;10(9):e040253
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Maternal mild thyroid dysfunction and offspring cognitive and motor development from infancy to childhood: the Rhea mother-child cohort study in Crete, Greece.
Kampouri M, Margetaki K, Koutra K, Kyriklaki A, Karakosta P, Anousaki D, Chalkiadaki G, Vafeiadi M, Kogevinas M, Chatzi L
J Epidemiol Community Health. 2020 Sep 9;
Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides.
de León P, Cañas-Arranz R, Saez Y, Forner M, Defaus S, Cuadra D, Bustos MJ, Torres E, Andreu D, Blanco E, Sobrino F, Hammer SE
Vaccines (Basel). 2020 Sep 8;8(3)
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Parestomal hernia repair. Prospective observational study based on the Spanish Registry of Incisional Hernia (EVEREG).
López-Cano M, Pereira JA, Rodrigues-Gonçalves V, Verdaguer-Tremolosa M, Hernández-Granados P, Bravo-Salvá A, miembros del registro EVEREG., Miembros del grupo EVEREG.
Cir Esp. 2020 Sep 8;
Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution.
García Pastor A, López-Cancio Martínez E, Rodríguez-Yáñez M, Alonso de Leciñana M, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Fuentes B, Freijo MM, Gomis M, Gómez Choco M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Segura T, Serena J, Vivancos-Mora J, Roquer J, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología.
Neurologia. 2020 Sep 8;
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Medicolegal Aspects of Teledermatology.
Arimany-Manso J, Pujol RM, García-Patos V, Saigí U, Martin-Fumadó C
Actas Dermosifiliogr. 2020 Sep 7;
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Molecular barcoding of native RNAs using nanopore sequencing and deep learning.
Smith MA, Ersavas T, Ferguson JM, Liu H, Lucas MC, Begik O, Bojarski L, Barton K, Novoa EM
Genome Res. 2020 Sep;30(9):1345-1353
Distinct phosphorylation sites in a prototypical GPCR differently orchestrate beta-arrestin interaction, trafficking, and signaling.
Dwivedi-Agnihotri H, Chaturvedi M, Baidya M, Stepniewski TM, Pandey S, Maharana J, Srivastava A, Caengprasath N, Hanyaloglu AC, Selent J, Shukla AK
Sci Adv. 2020 Sep;6(37)
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Psychiatric hospitalization at home unit in Spain: clinical and functional outcomes after three years of experience.
León-Caballero J, Córcoles D, Alba-Pale L, Sabaté-Gomez A, Pérez E, Monteagudo E, Miguel Martin L, Pérez V, Pacchiarotti I
Actas Esp Psiquiatr. 2020 May;48(3):138-44
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Professional perception of clozapine use in patients with dual psychosis.
Grau-López L, Szerman N, Torrens M, Basurte I, Vega P, Martínez-Raga J, Casas M, Roncero C
Actas Esp Psiquiatr. 2020 May;48(3):99-105
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On the cognitive bases of illusionism.
Camí J, Gomez-Marin A, Martínez LM
PeerJ. 2020;8:e9712
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COVID-19 in Grade 4-5 Chronic Kidney Disease Patients.
Collado S, Arenas MD, Barbosa F, Cao H, Montero MM, Villar-García J, Barrios C, Rodríguez E, Sans L, Sierra A, Pérez-Sáez MJ, Redondo-Pachón D, Coca A, Maiques JM, Güerri-Fernández R, Horcajada JP, Crespo M, Pascual J
Kidney Blood Press Res. 2020 Sep 8;:1-7
Cutaneous Lymphomas - Part I: Mycosis Fungoides, Sézary Syndrome, and CD30+ Cutaneous Lymphoproliferative Disorders.
Pujol RM, Gallardo F
Actas Dermosifiliogr. 2020 Sep 4;
Long non-coding RNA-polycomb intimate rendezvous.
Cerase A, Tartaglia GG
Open Biol. 2020 Sep;10(9):200126
The fingerprint of the summer 2018 drought in Europe on ground-based atmospheric CO2 measurements.
Ramonet M, Ciais P, Apadula F, Bartyzel J, Bastos A, Bergamaschi P, Blanc PE, Brunner D, Caracciolo di Torchiarolo L, Calzolari F, Chen H, Chmura L, Colomb A, Conil S, Cristofanelli P, Cuevas E, Curcoll R, Delmotte M, di Sarra A, Emmenegger L, Forster G, Frumau A, Gerbig C, Gheusi F, Hammer S, Haszpra L, Hatakka J, Hazan L, Heliasz M, Henne S, Hensen A, Hermansen O, Keronen P, Kivi R, Komínková K, Kubistin D, Laurent O, Laurila T, Lavric JV, Lehner I, Lehtinen KEJ, Leskinen A, Leuenberger M, Levin I, Lindauer M, Lopez M, Myhre CL, Mammarella I, Manca G, Manning A, Marek MV, Marklund P, Martin D, Meinhardt F, Mihalopoulos N, Mölder M, Morgui JA, Necki J, O'Doherty S, O'Dowd C, Ottosson M, Philippon C, Piacentino S, Pichon JM, Plass-Duelmer C, Resovsky A, Rivier L, Rodó X, Sha MK, Scheeren HA, Sferlazzo D, Spain TG, Stanley KM, Steinbacher M, Trisolino P, Vermeulen A, Vítková G, Weyrauch D, Xueref-Remy I, Yala K, Yver Kwok C
Philos Trans R Soc Lond B Biol Sci. 2020 Oct 26;375(1810):20190513
Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.
Argente J, Flores R, Gutiérrez-Arumí A, Verma B, Martos-Moreno GÁ, Cuscó I, Oghabian A, Chowen JA, Frilander MJ, Pérez-Jurado LA
EMBO Mol Med. 2020 Sep 7;12(9):e13133
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Response to growth hormone in patients with RNPC3 mutations.
Martos-Moreno GÁ, Travieso-Suárez L, Pozo-Román J, Muñoz-Calvo MT, Chowen JA, Frilander MJ, Pérez-Jurado LA, Hawkins FG, Argente J
EMBO Mol Med. 2020 Sep 7;12(9):e13132
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High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study.
Prats-Uribe A, Sayols-Baixeras S, Fernández-Sanlés A, Subirana I, Carreras-Torres R, Vilahur G, Civeira F, Marrugat J, Fitó M, Hernáez Á, Elosua R
Metabolism. 2020 Sep 4;112:154351
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Stroke prevention in patients with arterial hypertension: Recommendations of the Spanish Society of Neurology's Stroke Study Group.
Rodríguez-Yañez M, Gómez-Choco M, López-Cancio E, Amaro S, Alonso de Leciñana M, Arenillas JF, Ayo-Martín O, Castellanos M, Freijo MM, García-Pastor A, Gomis M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Roquer J, Segura T, Serena J, Vivancos-Mora J, Fuentes B, Comité ad hoc del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología.
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Marrugat J
Curr Probl Cardiol. 2020 Oct;45(10):100657
Real-world effectiveness of dual HER2 blockade with pertuzumab and trastuzumab for neoadjuvant treatment of HER2-positive early breast cancer (The NEOPETRA Study).
González-Santiago S, Saura C, Ciruelos E, Alonso JL, de la Morena P, Santisteban Eslava M, Gallegos Sancho MI, de Luna A, Dalmau E, Servitja S, Ruiz Borrego M, Chacón JI
Breast Cancer Res Treat. 2020 Sep 2;
A freeze-all strategy does not increase live birth rates in women of advanced reproductive age.
Lattes K, López S, Checa MA, Brassesco M, García D, Vassena R
J Assist Reprod Genet. 2020 Sep 2;
Importance of structure-based studies for the design of a novel HIV-1 inhibitor peptide.
Gomara MJ, Perez Y, Gomez-Gutierrez P, Herrera C, Ziprin P, Martinez JP, Meyerhans A, Perez JJ, Haro I
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Mocavini I, Di Croce L
Nat Genet. 2020 Sep;52(9):866-867
PREOPERATIVE BODY WEIGHT AND ALBUMIN PREDICT SURVIVAL IN PATIENTS WITH RESECTABLE LUNG NEOPLASMS: ROLE OF COPD.
Tang J, Curull V, Ramis-Cabrer D, Duran X, Rodríguez-Fuster A, Espases RA, Barreiro E
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Knockdown of alfa-2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion.
Guerrero PE, Miró L, Wong BS, Massaguer A, Martínez-Bosch N, Llorens R, Navarro P, Konstantopoulos K, Llop E, Peracaula R
Int J Mol Sci. 2020 Aug 28;21(17)
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Behavioural and molecular effects of cannabidiolic acid in mice.
Alegre-Zurano L, Martín-Sánchez A, Valverde O
Life Sci. 2020 Aug 13;259:118271
Guest editorial: The SHAMISEN project - Applicability or lessons learnt and recommendations for disaster situations.
Schneider T, Oughton D, Cardis E
Environ Int. 2020 Aug 7;144:106000
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Common errors in inhalation therapy: Impact and solutions.
Rodriguez-Garcia C, Barreiro E, Muñoz-Gall X, Bustamante-Madariaga V, de-Granda-Orive I, Gonzalez-Barcala FJ
Clin Respir J. 2020 Jul 24;
Expanded encyclopaedias of DNA elements in the human and mouse genomes.
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Defining Benchmark Outcomes for Pancreatoduodenectomy With Portomesenteric Venous Resection.
Raptis DA, Sánchez-Velázquez P, Machairas N, Sauvanet A, Rueda de Leon A, Oba A, Groot Koerkamp B, Lovasik B, Chan C, Yeo CJ, Bassi C, Ferrone CR, Kooby D, Moskal D, Tamburrino D, Yoon DS, Barroso E, de Santibañes E, Kauffmann EF, Vigia E, Robin F, Casciani F, Burdío F, Belfiori G, Malleo G, Lavu H, Hartog H, Hwang HK, Han HS, Poves I, Rosado ID, Park JS, Lillemoe KD, Roberts KJ, Sulpice L, Besselink MG, Abuawwad M, Del Chiaro M, de Santibañes M, Falconi M, D'Silva M, Silva M, Abu Hilal M, Qadan M, Sell NM, Beghdadi N, Napoli N, Busch ORC, Mazza O, Muiesan P, Müller PC, Ravikumar R, Schulick R, Powell-Brett S, Abbas SH, Mackay TM, Stoop TF, Gallagher TK, Boggi U, van Eijck C, Clavien PA, Conlon KCP, Fusai GK
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Sex-biased patterns shaped the genetic history of Roma.
García-Fernández C, Font-Porterias N, Kucinskas V, Sukarova-Stefanovska E, Pamjav H, Makukh H, Dobon B, Bertranpetit J, Netea MG, Calafell F, Comas D
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Formaldehyde 2% is not a useful means of detecting allergy to formaldehyde releasers- results of the ESSCA network, 2015 - 2018.
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Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry.
Ntaios G, Michel P, Georgiopoulos G, Guo Y, Li W, Xiong J, Calleja P, Ostos F, González-Ortega G, Fuentes B, Alonso de Leciñana M, Díez-Tejedor E, García-Madrona S, Masjuan J, DeFelipe A, Turc G, Gonçalves B, Domigo V, Dan GA, Vezeteu R, Christensen H, Christensen LM, Meden P, Hajdarevic L, Rodriguez-Lopez A, Díaz-Otero F, García-Pastor A, Gil-Nuñez A, Maslias E, Strambo D, Werring DJ, Chandratheva A, Benjamin L, Simister R, Perry R, Beyrouti R, Jabbour P, Sweid A, Tjoumakaris S, Cuadrado-Godia E, Campello AR, Roquer J, Moreira T, Mazya MV, Bandini F, Matz K, Iversen HK, González-Duarte A, Tiu C, Ferrari J, Vosko MR, Salzer HJF, Lamprecht B, Dünser MW, Cereda CW, Quintero ÁBC, Korompoki E, Soriano-Navarro E, Soto-Ramírez LE, Castañeda-Méndez PF, Bay-Sansores D, Arauz A, Cano-Nigenda V, Kristoffersen ES, Tiainen M, Strbian D, Putaala J, Lip GYH
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Publisher Correction: The tuatara genome reveals ancient features of amniote evolution.
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Synthesis, Structure, and Activity of the Antifungal Plant Defensin PvD1.
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Targeted Therapy for Chronic Spontaneous Urticaria: Rationale and Recent Progress.
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Zooming in on protein-RNA interactions: a multi-level workflow to identify interaction partners.
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Azithromycin in the treatment of COVID-19: a review.
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Sickness absence trajectories following labour market participation patterns: a cohort study in Catalonia (Spain), 2012-2014.
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Developing a cosmetic series - results from the ESSCA network, 2009-2018.
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Safe and successful treatment of refractory polyarteritis nodosa with tocilizumab in a patient with past hepatitis B virus infection: a case-based review.
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The road ahead in genetics and genomics.
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Curr Biol. 2020 Aug 22;
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Infected Hepatic Echinococcosis. Clinical, Therapeutic, and Prognostic Aspects. A Systematic Review.
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Antibiotic consumption trends among acute care hospitals in Catalonia (2008-2016): Impact of different adjustments on the results.
Fondevilla E, Grau S, Echeverría-Esnal D, Gudiol F on behalf of the VINCat Program Group
Expert Rev Anti Infect Ther. 2020 Aug 21;
Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis.
Farré N, Mojón D, Llagostera M, Belarte-Tornero LC, Calvo-Fernández A, Vallés E, Negrete A, García-Guimaraes M, Bartolomé Y, Fernández C, García-Duran AB, Marrugat J, Vaquerizo B
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Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017.
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Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies.
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Alzheimers Dement. 2020 Aug 20;
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology.
Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, Cuadrado A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Ten Kate M, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Rasmussen KL, Nordestgaard BG, Frikke-Schmidt R, Nielsen SF, Soininen H, Vellas B, Kloszewska I, Mecocci P, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Bertram L, Nevado-Holgado AJ, Lovestone S
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Domestic exposure to irritant cleaning agents and asthma in women.
Lemire P, Dumas O, Chanoine S, Temam S, Severi G, Boutron-Ruault MC, Zock JP, Siroux V, Varraso R, Le Moual N
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Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma.
Ordoñez R, Kulis M, Russiñol N, Chapaprieta V, Carrasco-Leon A, García-Torre B, Charalampopoulou S, Clot G, Beekman R, Meydan C, Duran-Ferrer M, Verdaguer-Dot N, Vilarrasa-Blasi R, Soler-Vila P, Garate L, Miranda E, José-Enériz ES, Rodriguez-Madoz JR, Ezponda T, Martínez-Turrilas R, Vilas-Zornoza A, Lara-Astiaso D, Dupéré-Richer D, Martens JHA, El-Omri H, Taha RY, Calasanz MJ, Paiva B, Miguel JS, Flicek P, Gut I, Melnick A, Mitsiades CS, Licht JD, Campo E, Stunnenberg HG, Agirre X, Prosper F, Martin-Subero JI
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In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children.
Vives-Usano M, Hernandez-Ferrer C, Maitre L, Ruiz-Arenas C, Andrusaityte S, Borràs E, Carracedo Á, Casas M, Chatzi L, Coen M, Estivill X, González JR, Grazuleviciene R, Gutzkow KB, Keun HC, Lau CE, Cadiou S, Lepeule J, Mason D, Quintela I, Robinson O, Sabidó E, Santorelli G, Schwarze PE, Siskos AP, Slama R, Vafeiadi M, Martí E, Vrijheid M, Bustamante M
BMC Med. 2020 Aug 19;18(1):243
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Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain).
García-Pérez J, Fernández de Larrea-Baz N, Lope V, Molina AJ, O'Callaghan-Gordo C, Alonso MH, Rodríguez-Suárez MM, Mirón-Pozo B, Alguacil J, Gómez-Acebo I, Ascunce N, Vanaclocha-Espi M, Amiano P, Chirlaque MD, Simó V, Jiménez-Moleón JJ, Tardón A, Moreno V, Castaño-Vinyals G, Martín V, Aragonés N, Pérez-Gómez B, Kogevinas M, Pollán M
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Participatory quantitative health impact assessment of urban transport planning: A case study from Eastern Africa.
Thondoo M, Mueller N, Rojas-Rueda D, de Vries D, Gupta J, Nieuwenhuijsen MJ
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FASTQINS and ANUBIS: two bioinformatic tools to explore facts and artifacts in transposon sequencing and essentiality studies.
Miravet-Verde S, Burgos R, Delgado J, Lluch-Senar M, Serrano L
Nucleic Acids Res. 2020 Aug 19;
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Largest-scale dissociation of brain activity at propofol-induced loss of consciousness.
Pujol J, Blanco-Hinojo L, Gallart L, Moltó L, Martínez-Vilavella G, Vilà E, Pacreu S, Adalid I, Deus J, Pérez-Sola V, Fernández-Candil J
Sleep. 2020 Aug 19;
Polymorphic and multimetameric herpes zoster.
Lobato-Berezo A, Olmos-Alpiste F, Pujol RM
Med Clin (Barc). 2020 Aug 18;
How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs.
Torrens-Fontanals M, Stepniewski TM, Aranda-García D, Morales-Pastor A, Medel-Lacruz B, Selent J
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Alcohol Induced Depression: Clinical, Biological and Genetic Features.
Farré A, Tirado J, Spataro N, Alías-Ferri M, Torrens M, Fonseca F
J Clin Med. 2020 Aug 18;9(8)
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Clinical Profiles in Renal Patients with COVID-19.
Arenas MD, Crespo M, Pérez-Sáez MJ, Collado S, Redondo-Pachón D, Llinàs-Mallol L, Montero MM, Villar-García J, Arias-Cabrales C, Barbosa F, Buxeda A, Burballa C, Sans L, Vázquez S, Oliveras A, Mir M, Outón S, Galcerán I, Solá E, Sierra A, Barrios C, Rodríguez E, Cao H, Güerri-Fernández R, Horcajada JP, Pascual J
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Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-Epsilon4 in middle-age cognitively unimpaired individuals from the ALFA study.
Vilor-Tejedor N, Operto G, Evans TE, Falcon C, Crous-Bou M, Minguillón C, Cacciaglia R, Milà-Alomà M, Grau-Rivera O, Suárez-Calvet M, Garrido-Martín D, Morán S, Esteller M, Adams HH, Molinuevo JL, Guigó R, Gispert JD, ALFA Study.
Brain Struct Funct. 2020 Aug 17;
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DiMSum: an error model and pipeline for analyzing deep mutational scanning data and diagnosing common experimental pathologies.
Faure AJ, Schmiedel JM, Baeza-Centurion P, Lehner B
Genome Biol. 2020 Aug 17;21(1):207
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Residential urban greenspace and hypertension: A comparative study in two European cities.
Bauwelinck M, Zijlema WL, Bartoll X, Vandenheede H, Cirach M, Lefebvre W, Vanpoucke C, Basagaña X, Nieuwenhuijsen MJ, Borrell C, Deboosere P, Dadvand P
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Impact of road traffic noise on obesity measures: Observational study of three European cohorts.
Cai Y, Zijlema WL, Sørgjerd EP, Doiron D, de Hoogh K, Hodgson S, Wolffenbuttel B, Gulliver J, Hansell AL, Nieuwenhuijsen M, Rahimi K, Kvaløy K
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Prevalence of neonatal ankyloglossia in a tertiary care hospital in Spain: a transversal cross-sectional study.
Maya-Enero S, Pérez-Pérez M, Ruiz-Guzmán L, Duran-Jordà X, López-Vílchez MÁ
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Interatrial block and cognitive impairment in the BAYES prospective registry.
Martínez-Sellés M, Martínez-Larrú ME, Ibarrola M, Santos A, Díez-Villanueva P, Bayés-Genis A, Baranchuk A, Bayés-de-Luna A, Elosua R
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Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations.
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The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis.
Jiménez J, Queralt E, Posas F, de Nadal E
Cell Cycle. 2020 Aug 14;:1-14
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Prenatal exposure to organophosphate pesticides and brain morphology and white matter microstructure in preadolescents.
van den Dries MA, Lamballais S, El Marroun H, Pronk A, Spaan S, Ferguson KK, Longnecker MP, Tiemeier H, Guxens M
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Using collections of structural models to predict changes of binding affinity caused by mutations in protein-protein interactions.
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Belimumab, a useful alternative therapy in systemic lupus erythematosus serositis.
Salman-Monte TC, Carrión-Barberà I, Rodríguez García E
Med Clin (Barc). 2020 Aug 14;
Respiratory and Gastrointestinal COVID-19 Phenotypes in Kidney Transplant Recipients.
Crespo M, Mazuecos A, Rodrigo E, Gavela E, Villanego F, Sánchez-Alvarez E, González-Monte E, Jiménez-Martín C, Melilli E, Diekman F, Zárraga S, Hernández D, Pascual J, Spanish Society of Nephrology COVID-19 Group.
Transplantation. 2020 Aug 13;
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Short and long-term outcome of aneurysmal subarachnoid hemorrhage patients.
Roquer J, Cuadrado-Godia E, Guimaraens L, Conesa G, Rodríguez-Campello A, Capellades J, García-Arnillas MP, Fernández-Candil JL, Avellaneda-Gómez C, Giralt-Steinhauer E, Jiménez-Conde J, Soriano-Tárraga C, Villalba-Martínez G, Vivanco-Hidalgo RM, Vivas E, Ois A
Neurology. 2020 Aug 13;
Sex differences between women and men with COPD: A new analysis of the 3CIA study.
Perez TA, Castillo EG, Ancochea J, Pastor Sanz MT, Almagro P, Martínez-Camblor P, Miravitlles M, Rodríguez-Carballeira M, Navarro A, Lamprecht B, Ramírez-García Luna AS, Kaiser B, Alfageme I, Casanova C, Esteban C, Soler-Cataluña JJ, De-Torres JP, Celli BR, Marin JM, Lopez-Campos JL, Riet GT, Sobradillo P, Lange P, Garcia-Aymerich J, Anto JM, Turner AM, Han MK, Langhammer A, Sternberg A, Leivseth L, Bakke P, Johannessen A, Oga T, Cosío B, Echazarreta A, Roche N, Burgel PR, Sin DD, Puhan MA, Soriano JB
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Correlation of RECIST, Computed Tomography Morphological Response, and Pathological Regression in Hepatic Metastasis Secondary to Colorectal Cancer: The AVAMET Study.
Vera R, Gómez ML, Ayuso JR, Figueras J, García-Alfonso P, Martínez V, Lacasta A, Ruiz-Casado A, Safont MJ, Aparicio J, Campos JM, Cámara JC, Martín-Richard M, Montagut C, Pericay C, Vieitez JM, Falcó E, Jorge M, Marín M, Salgado M, Viúdez A
Cancers (Basel). 2020 Aug 12;12(8)
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Biological age is a novel biomarker to predict stroke recurrence.
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Correction to: Features of intracranial hemorrhage in cerebral venous thrombosis.
Afifi K, Bellanger G, Buyck PJ, Zuurbier SM, Garcia-Esperon C, Barboza MA, Costa P, Escudero I, Renard D, Lemmens R, Hinteregger N, Fazekas F, Jimenez-Conde J, Giralt-Steinhauer E, Hiltunen S, Arauz A, Pezzini A, Montaner J, Putaala J, Weimar C, Schlamann M, Gattringer T, Tatlisumak T, Coutinho JM, Demaerel P, Thijs V
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Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries.
McGrath JJ, Lim CCW, Plana-Ripoll O, Holtz Y, Agerbo E, Momen NC, Mortensen PB, Pedersen CB, Abdulmalik J, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Bromet EJ, Bruffaerts R, Bunting B, de Almeida JMC, de Girolamo G, De Vries YA, Florescu S, Gureje O, Haro JM, Harris MG, Hu C, Karam EG, Kawakami N, Kiejna A, Kovess-Masfety V, Lee S, Mneimneh Z, Navarro-Mateu F, Orozco R, Posada-Villa J, Roest AM, Saha S, Scott KM, Stagnaro JC, Stein DJ, Torres Y, Viana MC, Ziv Y, Kessler RC, de Jonge P
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Discovery of EMRE in fungi resolves the true evolutionary history of the mitochondrial calcium uniporter.
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Nat Commun. 2020 Aug 12;11(1):4031
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Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy.
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J
Eur Urol. 2020 Aug 12;
Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis.
De Koninck M, Lapi E, Badía-Careaga C, Cossío I, Giménez-Llorente D, Rodríguez-Corsino M, Andrada E, Hidalgo A, Manzanares M, Real FX, Losada A
Cell Rep. 2020 Aug 11;32(6):108014
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Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project.
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Int J Hyg Environ Health. 2020 Aug 11;230:113597
Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.
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Influence of Operative Time in the Results of Infrainguinal Bypass for Chronic Limb Threatening Ischemia.
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World J Surg. 2020 Aug 11;
Irreversible habitat specialization does not constrain diversification in hypersaline water beetles.
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A compendium of mutational cancer driver genes.
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The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.
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Hum Genet. 2020 Aug 9;
Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via Beta-Catenin/TCF/LEF Functions.
Aulicino F, Pedone E, Sottile F, Lluis F, Marucci L, Cosma MP
Stem Cell Reports. 2020 Aug 9;
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PATTERNS OF INCIDENTAL PERINEURAL INVASION AND PROGNOSIS IN CUTANEOUS SQUAMOUS CELL CARCINOMA: A MULTICENTER, RETROSPECTIVE COHORT STUDY.
Conde-Ferreirós A, Corchete LA, Jaka A, Santos-Briz Á, Fuente MJ, Posada R, Pons L, Podlipnik S, Pujol RM, Román-Curto C, Toll A, Cañueto J
J Am Acad Dermatol. 2020 Aug 8;
Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria - a systematic review for the EAACI Biologicals Guidelines.
Agache I, Rocha C, Pereira A, Song Y, Alonso-Coello P, Solà I, Beltran J, Posso M, Akdis C, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong P, O'Mahony L, Schwarze J, Werfel T, Canelo-Aybar C, Palomares O, Jutel M
Allergy. 2020 Aug 7;
http://www.ncbi.nlm.nih.gov/en...
Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19.
Bousquet J, Anto JM, Czarlewski W, Haahtela T, Fonseca SC, Iaccarino G, Blain H, Vidal A, Sheikh A, Akdis CA, Zuberbier T, ARIA group.
Allergy. 2020 Aug 6;
http://www.ncbi.nlm.nih.gov/en...
Computed tomography of the head and the risk of brain tumours during childhood and adolescence: results from a case-control study in Japan.
Kojimahara N, Yoshitake T, Ono K, Kai M, Bynes G, Schüz J, Cardis E, Kesminiene A
J Radiol Prot. 2020 Aug 6;
http://www.ncbi.nlm.nih.gov/en...
Traumatic Events in Dual Disorders: Prevalence and Clinical Characteristics.
Blanco L, Sió A, Hogg B, Esteve R, Radua J, Solanes A, Gardoki-Souto I, Sauras R, Farré A, Castillo C, Valiente-Gómez A, Pérez V, Torrens M, Amann BL, Moreno-Alcázar A
J Clin Med. 2020 Aug 6;9(8)
http://www.ncbi.nlm.nih.gov/en...
Impact of non-adherence to radiotherapy on 1-year survival in cancer patients in catalonia, spain.
Borras JM, Font R, Solà J, Macia M, Tuset V, Arenas M, Eraso A, Verges R, Farré N, Pedro A, Mollà M, Algara M, Solé JM, Mira M, Espinàs JA
Radiother Oncol. 2020 Aug 6;
http://www.ncbi.nlm.nih.gov/en...
Residential Surrounding Greenspace and Mental Health in Three Spanish Areas.
Torres Toda M, Anabitarte Riol A, Cirach M, Estarlich M, Fernández-Somoano A, González-Safont L, Guxens M, Julvez J, Riaño-Galán I, Sunyer J, Dadvand P
Int J Environ Res Public Health. 2020 Aug 5;17(16)
http://www.ncbi.nlm.nih.gov/en...
Association of Lifestyle Factors and Neuropsychological Development of 4-Year-Old Children.
O'Connor G, Julvez J, Fernandez-Barrés S, Navarrete-Muñoz EM, Murcia M, Tardón A, Galán IR, Amiano P, Ibarluzea J, Garcia-Esteban R, Vrijheid M, Sunyer J, Romaguera D
Int J Environ Res Public Health. 2020 Aug 5;17(16)
http://www.ncbi.nlm.nih.gov/en...
Sex-specific Associations of Alcohol Withdrawal in Patients Admitted for the Treatment of Alcohol Use Disorder.
Sanvisens A, Zuluaga P, Short A, Rubio G, Gual A, Torrens M, Fuster D, Bolao F, Rodríguez de Fonseca F, Muga R, CohRTA study*.
J Addict Med. 2020 Aug 4;
Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo.
Cedó L, Fernández-Castillejo S, Rubió L, Metso J, Santos D, Muñoz-Aguayo D, Rivas-Urbina A, Tondo M, Méndez-Lara KA, Farràs M, Jauhiainen M, Motilva MJ, Fitó M, Blanco-Vaca F, Solà R, Escolà-Gil JC
Biomedicines. 2020 Aug 3;8(8)
http://www.ncbi.nlm.nih.gov/en...
Cytoreductive treatment in patients with CALR-mutated essential thrombocythaemia: a study comparing indications and efficacy among genotypes from the Spanish Registry of Essential Thrombocythaemia.
Alvarez-Larrán A, Angona A, Andrade-Campos M, Soledad Noya M, Teresa Gómez-Casares M, Cuevas B, Caballero G, García-Hernández C, García-Gutiérrez V, Palomino A, Ferrer-Marín F, Isabel Mata-Vázquez M, Moretó A, Magro E, Murillo I, Manuel Alonso-Domínguez J, María Guerra J, Guerrero L, María Raya J, Pérez-Encinas M, Carreño-Tarragona G, Fox L, Pastor-Galán I, Bellosillo B, Hernández-Boluda JC, MPN Spanish Group (GEMFIN).
Br J Haematol. 2020 Aug 3;
Ancient genomes in South Patagonia reveal population movements associated with technological shifts and geography.
Nakatsuka N, Luisi P, Motti JMB, Salemme M, Santiago F, D'Angelo Del Campo MD, Vecchi RJ, Espinosa-Parrilla Y, Prieto A, Adamski N, Lawson AM, Harper TK, Culleton BJ, Kennett DJ, Lalueza-Fox C, Mallick S, Rohland N, Guichón RA, Cabana GS, Nores R, Reich D
Nat Commun. 2020 Aug 3;11(1):3868
http://www.ncbi.nlm.nih.gov/en...
Axis Specification in Zebrafish Is Robust to Cell Mixing and Reveals a Regulation of Pattern Formation by Morphogenesis.
Fulton T, Trivedi V, Attardi A, Anlas K, Dingare C, Arias AM, Steventon B
Curr Biol. 2020 Aug 3;30(15):3063-3064
Role of cannabinoids in alcohol-induced neuroinflammation.
García-Baos A, Alegre-Zurano L, Cantacorps L, Martín-Sánchez A, Valverde O
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 3;104:110054
http://www.ncbi.nlm.nih.gov/en...
Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.
Chen TC, Tallo-Parra M, Cao QM, Kadener S, Böttcher R, Pérez-Vilaró G, Boonchuen P, Somboonwiwat K, Díez J, Sarnow P
PLoS Pathog. 2020 Aug;16(8):e1008346
http://www.ncbi.nlm.nih.gov/en...
Benefit of primary percutaneous coronary interventions in the elderly with ST segment elevation myocardial infarction.
Fernández-Bergés D, Degano IR, Gonzalez Fernandez R, Subirana I, Vila J, Jiménez-Navarro M, Perez-Fernandez S, Roqué M, Bayes-Genis A, Fernandez-Aviles F, Mayorga A, Bertomeu-Gonzalez V, Sanchis J, Rodríguez Esteban M, Sanchez-Hidalgo A, Sanchez-Insa E, Elorriaga A, Abu Assi E, Nuñez A, Garcia Ruiz JM, Morrondo Valdeolmillos P, Bosch-Portell D, Lekuona I, Carrillo-Lopez A, Zamora A, Vega-Hernandez B, Alameda Serrano J, Rubert C, Ruiz-Valdepeñas L, Quintas L, Rodríguez-Padial L, Vaquero J, Martinez Dolz L, Barrabes JA, Sanchez PL, Sionis A, Martí-Almor J, Elosua R, Lidon RM, Garcia-Dorado D, Marrugat J, ATHOS investigators.
Open Heart. 2020 Aug;7(2)
http://www.ncbi.nlm.nih.gov/en...
Did the COVID-19 pandemic silence the needs of people with epilepsy?
Granata T, Bisulli F, Arzimanoglou A, Rocamora R
Epileptic Disord. 2020 Aug 1;22(4):439-442
http://www.ncbi.nlm.nih.gov/en...
The tuatara genome reveals ancient features of amniote evolution.
Gemmell NJ, Rutherford K, Prost S, Tollis M, Winter D, Macey JR, Adelson DL, Suh A, Bertozzi T, Grau JH, Organ C, Gardner PP, Muffato M, Patricio M, Billis K, Martin FJ, Flicek P, Petersen B, Kang L, Michalak P, Buckley TR, Wilson M, Cheng Y, Miller H, Schott RK, Jordan MD, Newcomb RD, Arroyo JI, Valenzuela N, Hore TA, Renart J, Peona V, Peart CR, Warmuth VM, Zeng L, Kortschak RD, Raison JM, Zapata VV, Wu Z, Santesmasses D, Mariotti M, Guigó R, Rupp SM, Twort VG, Dussex N, Taylor H, Abe H, Bond DM, Paterson JM, Mulcahy DG, Gonzalez VL, Barbieri CG, DeMeo DP, Pabinger S, Van Stijn T, Clarke S, Ryder O, Edwards SV, Salzberg SL, Anderson L, Nelson N, Stone C, Ngatiwai Trust Board.
Nature. 2020 Aug;584(7821):403-409
http://www.ncbi.nlm.nih.gov/en...
Prevalence of gastroesophageal reflux disease: a population-based cross-sectional study in southern Chile.
Manterola C, Grande L, Bustos L, Otzen T
Gastroenterol Rep (Oxf). 2020 Aug;8(4):286-292
http://www.ncbi.nlm.nih.gov/en...
Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America: An individual participant data meta-analysis of 229,000 singleton births.
Philips EM, Santos S, Trasande L, Aurrekoetxea JJ, Barros H, von Berg A, Bergström A, Bird PK, Brescianini S, Ní Chaoimh C, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Costet N, Criswell R, Crozier S, Eggesbø M, Fantini MP, Farchi S, Forastiere F, van Gelder MMHJ, Georgiu V, Godfrey KM, Gori D, Hanke W, Heude B, Hryhorczuk D, Iñiguez C, Inskip H, Karvonen AM, Kenny LC, Kull I, Lawlor DA, Lehmann I, Magnus P, Manios Y, Melén E, Mommers M, Morgen CS, Moschonis G, Murray D, Nohr EA, Nybo Andersen AM, Oken E, Oostvogels AJJM, Papadopoulou E, Pekkanen J, Pizzi C, Polanska K, Porta D, Richiardi L, Rifas-Shiman SL, Roeleveld N, Rusconi F, Santos AC, Sørensen TIA, Standl M, Stoltenberg C, Sunyer J, Thiering E, Thijs C, Torrent M, Vrijkotte TGM, Wright J, Zvinchuk O, Gaillard R, Jaddoe VWV
PLoS Med. 2020 Aug;17(8):e1003182
http://www.ncbi.nlm.nih.gov/en...
The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation.
Vizán P, Gutiérrez A, Espejo I, García-Montolio M, Lange M, Carretero A, Lafzi A, de Andrés-Aguayo L, Blanco E, Thambyrajah R, Graf T, Heyn H, Bigas A, Di Croce L
Sci Adv. 2020 Aug;6(32):eabb2745
http://www.ncbi.nlm.nih.gov/en...
Environmental and nutritional impacts of dietary changes in Spain during the COVID-19 lockdown.
Batlle-Bayer L, Aldaco R, Bala A, Puig R, Laso J, Margallo M, Vázquez-Rowe I, Antó JM, Fullana-I-Palmer P
Sci Total Environ. 2020 Aug 1;748:141410
http://www.ncbi.nlm.nih.gov/en...
Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells.
Grasset EK, Chorny A, Casas-Recasens S, Gutzeit C, Bongers G, Thomsen I, Chen L, He Z, Matthews DB, Oropallo MA, Veeramreddy P, Uzzan M, Mortha A, Carrillo J, Reis BS, Ramanujam M, Sintes J, Magri G, Maglione PJ, Cunningham-Rundles C, Bram RJ, Faith J, Mehandru S, Pabst O, Cerutti A
Sci Immunol. 2020 Jul 31;5(49)
Antihistamine-resistant chronic spontaneous urticaria remains undertreated: 2-year data from the AWARE study.
Maurer M, Costa C, Gimenez Arnau A, Guillet G, Labrador-Horrillo M, Lapeere H, Meshkova R, Savic S, Chapman-Rothe N
Clin Exp Allergy. 2020 Jul 31;
Association of years to parent's sporadic onset and risk factors with neural integrity and Alzheimer's biomarkers.
Arenaza-Urquijo Em EM, Salvadó G, Operto G, Minguillón C, Sánchez-Benavides G, Crous-Bou M, Grau-Rivera O, Sala-Vila A, Falcón C, Suárez-Calvet M, Zetterberg H, Blennow K, Gispert JD, Molinuevo JL, ALFA study.
Neurology. 2020 Jul 31;
Clinical aspects of abdominal actinomycosis: a systematic review.
Manterola C, Grande L, Riffo-Campos ÁL, Salgado C, Otzen T
ANZ J Surg. 2020 Jul 30;
Omalizumab for the treatment of Chronic Inducible Urticaria in 80 patients.
Exposito-Serrano V, Curto-Barredo L, Aguilera Peiro P, Gómez Armayones S, Serra-Baldrich E, Spertino J, Bonfill Ortí M, Figueras Nart I, Melé-Ninot G, Baliu-Piqué C, Sala Cunill A, Labrador-Horrillo M, Guilabert Vidal A, Fernández Chico N, Giménez-Arnau AM
Br J Dermatol. 2020 Jul 30;
Multiple coronary aneurysms and acute myocardial infarction in a female patient with rhupus: case report and literature review.
Carrión-Barberà I, Zuccarino F, Escalante FA, Salman-Monte TC
Clin Rheumatol. 2020 Jul 30;
The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities.
Boni J, Rubio-Perez C, López-Bigas N, Fillat C, de la Luna S
Cancers (Basel). 2020 Jul 29;12(8)
http://www.ncbi.nlm.nih.gov/en...
Executive summary of the Consensus Document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and of the Spanish Association of Surgeons (AEC) in antibiotic prophylaxis in surgery.
Del Toro López MD, Arias Díaz J, Balibrea JM, Benito N, Canut Blasco A, Esteve E, Horcajada JP, Ruiz Mesa JD, Manuel Vázquez A, Muñoz Casares C, Del Pozo JL, Pujol M, Riera M, Jimeno J, Rubio Pérez I, Ruiz-Tovar Polo J, Serrablo A, Soriano A, Badia JM, Grupo de Estudio de PA de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) y Asociación Española de Cirujanos (AEC).
Cir Esp. 2020 Jul 28;
Early life exposure to air pollution, green spaces and built environment, and body mass index growth trajectories during the first 5 years of life: A large longitudinal study.
de Bont J, Hughes R, Tilling K, Díaz Y, de Castro M, Cirach M, Fossati S, Nieuwenhuijsen M, Duarte-Salles T, Vrijheid M
Environ Pollut. 2020 Jul 28;266(Pt 3):115266
Short- and Long-Term Mortality Trends in STEMI-Cardiogenic Shock over Three Decades (1989-2018): The Ruti-STEMI-Shock Registry.
García-García C, Oliveras T, El Ouaddi N, Rueda F, Serra J, Labata C, Ferrer M, Cediel G, Montero S, Martínez MJ, Resta H, de Diego O, Vila J, Dégano IR, Elosua R, Lupón J, Bayes-Genis A
J Clin Med. 2020 Jul 27;9(8)
http://www.ncbi.nlm.nih.gov/en...
Mediterranean Diet Effects on Type 2 Diabetes Prevention, Disease Progression, and Related Mechanisms. A Review.
Martín-Peláez S, Fito M, Castaner O
Nutrients. 2020 Jul 27;12(8)
http://www.ncbi.nlm.nih.gov/en...
Barriers and opportunities for the treatment of mild-to-moderate depression with a watchful waiting approach.
Iglesias-González M, Gil-Girbau M, Peñarrubia-María MT, Blanco-García E, Fernández-Vergel R, Serrano-Blanco A, Carbonell-Duacastella C, Alonso J, Rubio-Valera M
Patient Educ Couns. 2020 Jul 24;
Second Consensus on Treatment of Patients Recently Diagnosed With Mild Hypertension and Low Cardiovascular Risk.
Morales-Salinas A, Olsen MH, Kones R, Kario K, Wang J, Beilin L, Weber MA, Yano Y, Burrell L, Orias M, Cameroon DA, Lavie CC, Ventura H, Sundström J, de Simone G, Coca A, Rumana U, Marrugat J
Curr Probl Cardiol. 2020 Jul 22;:100653
Association of greenspace exposure with telomere length in preschool children.
Miri M, de Prado-Bert P, Alahabadi A, Najafi ML, Rad A, Moslem A, Aval HE, Ehrampoush MH, Bustamante M, Zare Sakhvidi MJ, Nawrot T, Sunyer J, Dadvand P
Environ Pollut. 2020 Jul 21;266(Pt 1):115228
Comorbidities and Mortality in Patients With COVID-19 Aged 60 Years and Older in a University Hospital in Spain.
Posso M, Comas M, Román M, Domingo L, Louro J, González C, Sala M, Anglès A, Cirera I, Cots F, Frías VM, Gea J, Güerri-Fernández R, Masclans JR, Noguès X, Vázquez O, Villar-García J, Horcajada JP, Pascual J, Castells X
Arch Bronconeumol. 2020 Jul 16;
http://www.ncbi.nlm.nih.gov/en...
Pulmonary Embolism in Patients With Covid-19 Pneumonia: The Utility of D-dimer.
Rodriguez-Sevilla J, Rodó-Pin A, Espallargas I, Villar-García J, Molina L, Pérez Terán P, Vázquez Sanchez A, Masclans JR, Jiménez C, Millan Segovia R, Zuccarino F, Salar A, Rodriguez-Chiaradía DA
Arch Bronconeumol. 2020 Jul 15;
http://www.ncbi.nlm.nih.gov/en...
The Forgotten Gastrointestinal Tract in COVID-19 Infection.
Pedro-Botet J, Climent E
Clin Transl Gastroenterol. 2020 Jul;11(7):e00216
http://www.ncbi.nlm.nih.gov/en...
A limited set of transcriptional programs define major cell types.
Breschi A, Muñoz-Aguirre M, Wucher V, Davis CA, Garrido-Martín D, Djebali S, Gillis J, Pervouchine DD, Vlasova A, Dobin A, Zaleski C, Drenkow J, Danyko C, Scavelli A, Reverter F, Snyder MP, Gingeras TR, Guigó R
Genome Res. 2020 Jul;30(7):1047-1059
http://www.ncbi.nlm.nih.gov/en...
The association between natural outdoor environments and common somatic symptoms.
Watson C, Nieuwenhuijsen MJ, Triguero-Mas M, Cirach M, Maas J, Gidlow C, Kruize H, Andrusaityte S, Grazuleviciene R, Zijlema WL
Health Place. 2020 Jul;64:102381
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1.
Simonet NG, Thackray JK, Vazquez BN, Ianni A, Espinosa-Alcantud M, Morales-Sanfrutos J, Hurtado-Bagès S, Sabidó E, Buschbeck M, Tischfield J, De La Torre C, Esteller M, Braun T, Olivella M, Serrano L, Vaquero A
Sci Adv. 2020 Jul;6(30):eaaz2590
http://www.ncbi.nlm.nih.gov/en...
Beta-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus.
Zhang M, Lai Y, Krupalnik V, Guo P, Guo X, Zhou J, Xu Y, Yu Z, Liu L, Jiang A, Li W, Abdul MM, Ma G, Li N, Fu X, Lv Y, Jiang M, Tariq M, Kanwal S, Liu H, Xu X, Zhang H, Huang Y, Wang L, Chen S, Babarinde IA, Luo Z, Wang D, Zhou T, Ward C, He M, Ibañez DP, Li Y, Zhou J, Yuan J, Feng Y, Arumugam K, Di Vicino U, Bao X, Wu G, Schambach A, Wang H, Sun H, Gao F, Qin B, Hutchins AP, Doble BW, Hartmann C, Cosma MP, Qin Y, Xu GL, Chen R, Volpe G, Chen L, Hanna JH, Esteban MA
Sci Adv. 2020 Jul;6(29):eaba1593
http://www.ncbi.nlm.nih.gov/en...
The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals.
Ingala S, Mazzai L, Sudre CH, Salvadó G, Brugulat-Serrat A, Wottschel V, Falcon C, Operto G, Tijms B, Gispert JD, Molinuevo JL, Barkhof F, ALFA Study.
Neurobiol Aging. 2020 Jun 29;95:104-114
http://www.ncbi.nlm.nih.gov/en...
Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.
Porta M, Pumarega J, Amaral AFS, Genkinger JM, Camargo J, Mucci L, Alguacil J, Gasull M, Zhang X, Morales E, Iglesias M, Ogino S, Engel LS, PANKRAS II Study Group.
Environ Res. 2020 Jun 11;190:109781
Prenatal Exposure to Perfluoroalkyl Substances Associated with Increased Susceptibility to Liver Injury in Children.
Stratakis N, Conti DV, Jin R, Margetaki K, Valvi D, Siskos AP, Maitre L, Garcia E, Varo N, Zhao Y, Roumeliotaki T, Vafeiadi M, Urquiza J, Fernández-Barrés S, Heude B, Basagana X, Casas M, Fossati S, Gražuleviciene R, Andrušaityte S, Uppal K, McEachan RR, Papadopoulou E, Robinson O, Haug LS, Wright J, Vos MB, Keun HC, Vrijheid M, Berhane KT, McConnell R, Chatzi L
Hepatology. 2020 Aug 1;
Top quality research with the utmost integrity
The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.
At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:
- The PRBB Code of Good Scientific Practices, approved by all the centres.
- An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
- Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.
To learn more about the code, the working group on good scientific practices and the various activities organised, visit:
More information
Contact
●Last news
Patents and companies
- The following links allow you to explore the technology on offer in the park’s centres:
Technology at the IMIM-Hospital del Mar
UPF Business Shuttle and Innovation Unit
Technology and Business Development Office at the CRG
Analysis and Global Development at ISGlobal
EMBLEM Technology Transfer
- The following start-ups have been created within the PRBB environment:
Acellera
Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.
→ https://www.acellera.comChemotargets
Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.
→ http://www.chemotargets.com/qGenomics
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qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.
→ https://qgenomics.comZeClinics
ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.
→ http://www.zeclinics.comMicroomics
Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.
→ http://www.microomics.euFlomics
World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.
→ http://www.flomics.comBioinspired Materials
This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.
→ http://biom.techMedBioinformatics Solutions
MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.
→ http://www.disgenet.orgPulmobiotics
A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.
→ https://www.pulmobio.com/●Last news
Microomics: next-generation sequencing to analyze the microbiome