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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.

Hospital del Mar Medical Research Institute (IMIM)


The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 


The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Medicine and Life Sciences at Pompeu Fabra University (MELIS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry.

Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.


The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.


ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.

Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:



⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news

Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza


The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko


The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut


This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet


The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals. The CEEA-PRBB has been authorized by the Catalan government to carry out the tasks as a competent body (OH) defined in Royal Decree 53/2013 which is framed in Directive 2010/63/EU adopted by the European Parliament.

Contact: Dirección de secretaría

Web: (Acceso: Portal PRBB)

This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas


The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría

Web: (Acceso: Portal PRBB)

Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop


This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis


BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso


The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro


This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht


The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà


The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals


The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera


This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea


This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger


The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi


Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu


This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade


Scientific publications
(keywords, journal, author,...)

EUROVISCO Good Practice Recommendations for a First Viscosupplementation in Patients with Knee Osteoarthritis.

Conrozier T, Diraçoglù D, Monfort J, Chevalier X, Bard H, Baron D, Jerosch J, Migliore A, Richette P, Henrotin Y

Cartilage. 2022 Nov 28;:19476035221138958

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.

Fernandez-Jimenez N, Fore R, Cilleros-Portet A, ... , Vrijheid M, Marsit CJ, Karagas MR, Räikkönen K, Bouchard L, Heude B, Santa-Marina L, Bustamante M, Hivert MF, Bilbao JR

Commun Biol. 2022 Nov 30;5(1):1313

Determinants of mortality in cancer patients with unscheduled admission to the Intensive Care Unit: A prospective multicenter study.

Cantón-Bulnes ML, Jiménez-Sánchez M, Alcántara-Carmona S, Gimeno-Costa R, Berezo-García JÁ, Beato C, Álvarez-Lerma F, Mojal S, Olaechea P, Gordo-Vidal F, Garnacho-Montero J

Med Intensiva (Engl Ed). 2022 Dec;46(12):669-679

The genomic analysis of current-day North African populations reveals the existence of trans-Saharan migrations with different origins and dates.

Lucas-Sánchez M, Fadhlaoui-Zid K, Comas D

Hum Genet. 2022 Nov 28;

The European baseline series and recommended additions: 2023.

Wilkinson SM, Gonçalo M, Aerts O, Badulici S, Dickel H, Gallo R, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Hervella M, Isaksson M, Johansen JD, Mahler V, Niklasson B, Pigatto P, Ponyai G, Rustemeyer T, Schuttelaar MLA, Spiewak R, Stingeni L, Thyssen JP, Uter W

Contact Dermatitis. 2022 Nov 28;

Living-donor kidney transplant: guidelines with updated evidence.

Frutos MÁ, Crespo M, de la Oliva Valentín M, Hernández D, de Sequera P, Domínguez-Gil B, Pascual J

Nefrologia (Engl Ed). 2022 Nov 25;

Ligelizumab improves angioedema, disease severity and quality-of-life in patients with chronic spontaneous urticaria.

Metz M, Bernstein JA, Giménez-Arnau AM, Hide M, Maurer M, Sitz K, Soong W, Sussman G, Hua E, Barve A, Barbier N, Balp MM, Severin T

World Allergy Organ J. 2022 Nov;15(11):100716

3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.

Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J

Nat Aging. 2022 Sep;2:851-866

Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke.

Bretzner M, Bonkhoff AK, Schirmer MD, Hong S, Dalca A, Donahue K, Giese AK, Etherton MR, Rist PM, Nardin M, Regenhardt RW, Leclerc X, Lopes R, Gautherot M, Wang C, Benavente OR, Cole JW, Donatti A, Griessenauer C, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McArdle PF, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, et al

Neurology. 2022 Nov 28;

The relevance of rich club regions for functional outcome post-stroke is enhanced in women.

Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Ropele S, Rosand J, Roquer J, ... , MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium

Hum Brain Mapp. 2022 Nov 28;

GENCODE: reference annotation for the human and mouse genomes in 2023.

Frankish A, Carbonell-Sala S, Diekhans M, Jungreis I, Loveland JE, Mudge JM, Sisu C, Wright JC, Arnan C, Barnes I, Banerjee A, Bennett R, Berry A, Bignell A, Boix C, Calvet F, Cerdán-Vélez D, Cunningham F, Davidson C, Donaldson S, Dursun C, Fatima R, Giorgetti S, Giron CG, Gonzalez JM, Hardy M, Harrison PW, Hourlier T, Hollis Z, Hunt T, James B, Jiang Y, Johnson R, Kay M, Lagarde J, ... , Guigo R, Hubbard TJP, Kellis M, Kundaje A, Paten B, Tress ML, Flicek P

Nucleic Acids Res. 2022 Nov 24;

Scaling up complexity in synthetic developmental biology.

Martínez-Ara G, Stapornwongkul KS, Ebisuya M

Science. 2022 Nov 25;378(6622):864-868


Carrión JA, Graupera I, Vergara M, Morillas RM, Pericàs JM, Poca M, Amador A, Fernandez R, Monllor T, Muñoz L, Bartres MC, Genescà J, Ginés P, Forns X

Gastroenterol Hepatol. 2022 Nov 23;

Correction: Impulsivity is longitudinally associated with healthy and unhealthy dietary patterns in individuals with overweight or obesity and metabolic syndrome within the framework of the PREDIMED-Plus trial.

Gómez-Martínez C, Babio N, Júlvez J, Nishi SK, Fernández-Aranda F, Martínez-González MÁ, Cuenca-Royo A, Fernández R, Jiménez-Murcia S, de la Torre R, Pintó X, Bloemendaal M, Fitó M, Corella D, Arias A, Salas-Salvadó J

Int J Behav Nutr Phys Act. 2022 Nov 23;19(1):140

Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome.

Castro-Barquero S, Casas R, Rimm EB, Tresserra-Rimbau A, Romaguera D, Martínez JA, Salas-Salvadó J, Martínez-González MA, Vidal J, Ruiz-Canela M, Konieczna J, Sacanella E, García-Gavilán JF, Fitó M, García-Arellano A, Estruch R

Mol Nutr Food Res. 2022 Nov 23;:e2200264

Usefulness of Inhaled Sedation in Patients With Severe ARDS Due to COVID-19.

Gómez Duque M, Medina R, Enciso C, Beltran E, Hernandez K, Franco DM, Masclans JR

Respir Care. 2022 Nov 22;

Recommendations for the diagnosis and treatment of hypoglycaemia after bariatric surgery.

Vilarrasa N, Bretón I, Ballesteros-Pomar M, Lecube A, Goday A, Pellitero S, Sánchez R, Zugasti A, Ciudin A, de Hollanda A, Rubio MA, GOSEEN (Grupo de Obesidad de la Sociedad Española de Endocrinología y Nutrición)

Endocrinol Diabetes Nutr (Engl Ed). 2022 Nov 21;

Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11.

Zadra I, Jimenez-Delgado S, Anglada-Girotto M, Segura-Morales C, Compton ZJ, Janke C, Serrano L, Ruprecht V, Vernos I

Nat Commun. 2022 Nov 21;13(1):7147

Exposure to natural environments during pregnancy and birth outcomes in 11 european birth cohorts.

Torres Toda M, Avraam D, James Cadman T, Fossati S, de Castro M, Dedele A, Donovan G, Elhakeem A, Estarlich M, Fernandes A, Gonçalves R, Grazuleviciene R, Harris JR, Harskamp-van Ginkel MW, Heude B, Ibarluzea J, Iñiguez C, Wv Jaddoe V, Lawlor D, Lertxundi A, Lepeule J, McEachan R, Moirano G, Lt Nader J, Nybo Andersen AM, Pedersen M, Pizzi C, Roumeliotaki T, Santos S, Sunyer J, Yang T, Vafeiadi M, Gm Vrijkotte T, Nieuwenhuijsen M, Vrijheid M, Foraster M, Dadvand P

Environ Int. 2022 Nov 19;170:107648

TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages.

Espinosa-Medina I, Feliciano D, Belmonte-Mateos C, Linda Miyares R, Garcia-Marques J, Foster B, Lindo S, Pujades C, Koyama M, Lee T

Neuron. 2022 Nov 18;

Contact Urticaria Syndrome: a Comprehensive Review.

Giménez-Arnau AM, Pesqué D, Maibach HI

Curr Dermatol Rep. 2022 Nov 18;:1-8

Periodic spatial patterning with a single morphogen.

Wang S, Garcia-Ojalvo J, Elowitz MB

Cell Syst. 2022 Nov 18;

Musculoskeletal Ultrasound Shows Muscle Mass Changes during Post-Acute Care Hospitalization in Older Men: A Prospective Cohort Study.

Meza-Valderrama D, Marco E, Muñoz-Redondo E, Morgado-Pérez A, Sánchez MT, Curbelo Peña Y, De Jaime E, Canchucaja L, Meza Concepción F, Perkisas S, Sánchez-Rodríguez D

Int J Environ Res Public Health. 2022 Nov 17;19(22)

Meat Intake, Cooking Methods, Doneness Preferences and Risk of Gastric Adenocarcinoma in the MCC-Spain Study.

Boldo E, Fernández de Larrea N, Pollán M, Martín V, Obón-Santacana M, Guevara M, Castaño-Vinyals G, Canga JM, Pérez-Gómez B, Gómez-Acebo I, Fernández-Tardón G, Vanaclocha-Espi M, Olmedo-Requena R, Alguacil J, Chirlaque MD, Kogevinas M, Aragonés N, Castelló A, MCC-Spain Researchers

Nutrients. 2022 Nov 16;14(22)

Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders.

Wedemeyer H, Di Marco V, Garcia-Retortillo M, Teti E, Fraser C, Morano Amado LE, Rodriguez-Tajes S, Acosta-López S, O'Loan J, Milella M, Buti M, Guerra-Veloz MF, Ramji A, Fenech M, Martins A, Borgia SM, Vanstraelen K, Mertens M, Hernández C, Ntalla I, Ramroth H, Milligan S

Viruses. 2022 Nov 11;14(11)

Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study.

Gutiérrez-Bedmar M, Gil F, Olmedo P, Ruiz-Canela M, Martínez-González MÁ, Salas-Salvadó J, Babio N, Fitó M, Del Val García JL, Corella D, Sorlí JV, Ros E, Fiol M, Estruch R, Santos-Lozano JM, Arós F, Serra-Majem L, Pintó X, Gómez-Gracia E, Muñoz-Bravo C

J Clin Med. 2022 Nov 10;11(22)

Current situation of shared decision making in osteoporosis: A comprehensive literature review of patient decision aids and decision drivers.

Nogués X, Carbonell MC, Canals L, Lizán L, Palacios S

Health Sci Rep. 2022 Nov;5(6):e849

Real-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities.

Sousa-Pinto B, Anto A, Berger M, ... , Antó JM, Zuberbier T, Fonseca JA, Bousquet J

Clin Transl Allergy. 2022 Nov;12(11):e12208

Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app.

Bousquet J, Sousa-Pinto B, Anto JM, et al

Pulmonology. 2022 Nov 22;

Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.

Coombes BJ, Millischer V, Batzler A, Larrabee B, Hou L, Papiol S, Heilbronner U, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, et al

Complex Psychiatry. 2021 Dec;7(3-4):80-89

Sensitization to isothiazolinones in the spanish contact dermatitis registry (reidac): 2019-2021 epidemiological situation.

Hernández Fernández CP, Borrego L, García PM, Giménez Arnau AM, Sánchez Pérez J, Silvestre Salvador JF, González Pérez R, Sanz Sánchez T, Sánchez Gilo A, Melé Ninot G, Zaragoza Ninet V, Miquel Miquel FJ, Carrascosa Carrillo JM, Córdoba Guijarro S, Gatica Ortega ME, Ruiz González I, Serra Baldrich E, Tous Romero F, Rodríguez Serna M, Pastor Nieto MA, Pérez Feal P, Garcés MH, de Vega Martínez M, García Doval I

Contact Dermatitis. 2022 Nov 20;

ASO Author Reflections: Superior Mesenteric Artery Dissection for Minimally Invasive Pancreaticoduodenectomy: A Technique That All Surgeons Should be Familiar With.

Ielpo B, Anselmo A, Masuda Y, Xuan MYH, Burdio F, De Blasi V, Sanchez-Velazquez P, Giuliani A, Azagra JS, Viola GM, Podda M, Pellino G, Rosso E

Ann Surg Oncol. 2022 Nov 19;

Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.

Torralba J, de la Arada I, Partida-Hanon A, Rujas E, Arribas M, Insausti S, Valotteau C, Valle J, Andreu D, Caaveiro JMM, Jiménez MA, Apellániz B, Redondo-Morata L, Nieva JL

Commun Biol. 2022 Nov 18;5(1):1265

Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development.

Bigas A, Galán Palma L, Kartha GM, Giorgetti A

Stem Cells Transl Med. 2022 Nov 18;11(11):1123-1134

Drug-induced ultraviolet B photosensitivity due to hydroxychloroquine: the unexpected side effect.

Pesqué D, Pérez-Manich J, García-Díez I, Segura S, Ferran M, Gonzàlez-Farré M, Pujol RM, Giménez-Arnau AM

Contact Dermatitis. 2022 Nov 18;

Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature.

Grau S, Miró JM, Olalla J, Alcalá JC, Castro A, Rubio-Rodríguez D, Rubio-Terrés C

Expert Rev Anti Infect Ther. 2022 Nov 18;

Parallel evolution of amphioxus and vertebrate small-scale gene duplications.

Brasó-Vives M, Marlétaz F, Echchiki A, Mantica F, Acemel RD, Gómez-Skarmeta JL, Hartasánchez DA, Le Targa L, Pontarotti P, Tena JJ, Maeso I, Escriva H, Irimia M, Robinson-Rechavi M

Genome Biol. 2022 Nov 18;23(1):243

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation.

Seuma M, Lehner B, Bolognesi B

Nat Commun. 2022 Nov 18;13(1):7084

Changes in Population Health-Related Behaviors During a COVID-19 Surge: A Natural Experiment.

Delgado-Ortiz L, Carsin AE, Merino J, Cobo I, Koch S, Goldberg X, Chevance G, Bosch de Basea M, Castaño-Vinyals G, Espinosa A, Carreras A, Cortes Martínez B, Straif K, de Cid R, Kogevinas M, Garcia-Aymerich J

Ann Behav Med. 2022 Nov 17;

SEGCOND predicts putative transcriptional condensate-associated genomic regions by integrating multi-omics data.

Klonizakis A, Nikolaou C, Graf T

Bioinformatics. 2022 Nov 17;

Treatment of hypertriglyceridaemia with icosapent ethyl in patients with high/very high cardiovascular risk. Consensus document of the Sociedad Española de Cardiología [Spanish Society of Cardiology] and the Sociedad Española de Diabetes [Spanish Diabetes Society].

Pedro-Botet J, Barrios V, Sánchez-Margalet V, Tamargo J, Arrieta F, Gámez JM, Gimeno-Orna JA, Escobar C, Gómez-Doblas JJ, Pérez A, Working Groups of Cardiovascular Pharmacotherapy of the Sociedad Española de Cardiología and Cardiovascular Disease of the Sociedad Española de Diabetes.

Endocrinol Diabetes Nutr (Engl Ed). 2022 Nov 16;

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington's disease.

Galyan SM, Ewald CY, Jalencas X, Masrani S, Meral S, Mestres J

Sci Rep. 2022 Nov 16;12(1):19642

Safety and tolerability of a 90-minute rapid infusion of Sandoz biosimilar rituximab in B-cell lymphoproliferative disorders in a real-world setting.

Muntañola A, Arguiñano-Pérez JM, Dávila J, González de Villambrosia S, Carpio C, Jiménez-Ubieto A, Salar A, GELTAMO (Grupo español de linfomas y trasplante de médula ósea).

Clin Transl Sci. 2022 Nov 16;

DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium.

Rijlaarsdam J, Cosin-Tomas M, Schellhas L, Abrishamcar S, Malmberg A, Neumann A, Felix JF, Sunyer J, Gutzkow KB, Grazuleviciene R, Wright J, Kampouri M, Zar HJ, Stein DJ, Heinonen K, Räikkönen K, Lahti J, Hüls A, Caramaschi D, Alemany S, Cecil CAM

Mol Psychiatry. 2022 Nov 16;

A cultural evolutionary theory that explains both gradual and punctuated change.

Vidiella B, Carrignon S, Bentley RA, O'Brien MJ, Valverde S

J R Soc Interface. 2022 Nov;19(196):20220570

Validation of the Spanish Activity Questionnaire in COPD (SAQ-COPD) in Patients with Chronic Obstructive Pulmonary Disease.

Soler-Cataluña JJ, Puente Maestu L, Román Rodríguez M, Esteban C, Gea J, Bernabeu Mora R, Pleguezuelos Cobo E, Ancochea J, García-Río F

Int J Chron Obstruct Pulmon Dis. 2022;17:2835-2846

IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis.

Neuman H, Arrouasse J, Kedmi M, Cerutti A, Magri G, Mehr R

Front Immunol. 2022;13:822834

Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study.

Domínguez-López I, Arancibia-Riveros C, Tresserra-Rimbau A, Castro-Barquero S, Casas R, Vázquez-Ruiz Z, Ros E, Fitó M, Estruch R, López-Sabater MC, Lamuela-Raventós RM

Front Nutr. 2022;9:991277

Responding to the need of postgraduate education for Planetary Health: Development of an online Master's Degree.

O'Callaghan-Gordo C, Moreno A, Bosque-Prous M, Castro-Sanchez E, Dadvand P, Guzmán CAF, García-Juanatey A, Gascon M, Grau O, Jordana J, Lowe R, March H, Medina FX, Mélon L, Navas G, Núñez Casal A, Ruiz-Mallén I, Sánchez-Valdivia N, Tonne C, Triguero-Mas M, Zografos C, Antó JM

Front Public Health. 2022;10:969065

Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis.

Riera J, Barbeta E, Tormos A, Mellado-Artigas R, ... , Marin J, Añón JM, Sipmann FS, Muñiz G, Castellanos-Ortega Á, Adell-Serrano B, Catalán M, de la Gándara AM, Ricart P, Carbajales C, Rodríguez A, Díaz E, de la Torre MC, Gallego E, Cantón-Bulnes L, Carbonell N, González J, de Gonzalo-Calvo D, Barbé F, Torres A, CiberesUCICOVID Consortium.

Eur Respir J. 2022 Nov 17;

Cutaneous Lymphangitis Carcinomatosa: Dermoscopic and Reflectance Confocal Microscopy Features.

Lopez-Trujillo E, Olmos-Alpiste F, Pujol RM, Segura S

Indian J Dermatol. 2022 May-Jun;67(3):316

Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer.

Palafox M, Monserrat L, Bellet M, Villacampa G, Gonzalez-Perez A, Oliveira M, Brasó-Maristany F, Ibrahimi N, Kannan S, Mina L, Herrera-Abreu MT, Òdena A, Sánchez-Guixé M, Capelán M, Azaro A, Bruna A, Rodríguez O, Guzmán M, Grueso J, Viaplana C, Hernández J, Su F, Lin K, Clarke RB, Caldas C, Arribas J, Michiels S, García-Sanz A, Turner NC, Prat A, Nuciforo P, Dienstmann R, Verma CS, Lopez-Bigas N, Scaltriti M, Arnedos M, Saura C, Serra V

Nat Commun. 2022 Nov 14;13(1):6928

A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase.

Marquina M, Lambea E, Carmona M, Sánchez-Marinas M, López-Aviles S, Ayte J, Hidalgo E, Aligue R

Sci Rep. 2022 Nov 14;12(1):19501

Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia.

Pascual-Guardia S, Amati F, Marin-Corral J, Aliberti S, Gea J, Soni NJ, Rodriguez A, Sibila O, Sanz F, Sotgiu G, Marcos PJ, Uranga A, Milenkovic B, Meyer CN, Kolditz M, Anzueto AR, Restrepo MI, GLIMP investigators.

Arch Bronconeumol. 2022 Sep 22;

Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation.

Serra-Camprubí Q, Verdaguer H, Oliveros W, Lupión-Garcia N, Llop-Guevara A, Molina C, Vila-Casadesús M, Turpin A, Neuzillet C, Frigola J, Querol J, Yáñez-Bartolomé M, Castet F, Fabregat-Franco C, Escudero-Iriarte C, Escorihuela M, Arenas EJ, Bernado-Morales C, Haro N, Giles FJ, Pozo OJ, Miquel JM, Nuciforo PG, Vivancos A, Melé M, Serra V, Arribas J, Tabernero J, Peiró S, Macarulla T, Tian TV

Clin Cancer Res. 2022 Nov 14;

Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis: A Nation-Wide cohort study.

Ródenas-Quiñonero I, Chen-Liang T, Martín-Santos T, Salar A, Fernández-González M, Celades C, Navarro JT, Martínez-Garcia AB, Andreu R, Balaguer A, Martin García-Sancho A, Baile M, López-Jiménez J, Marquet-Palomanes J, Teruel AI, Terol MJ, Benet C, Frutos L, Navarro JL, Uña J, Suarez M, Cortes M, Contreras J, Ruiz C, Tamayo P, Mucientes J, Sopena-Novales P, Reguilón-Gallego L, Sánchez-Blanco JJ, Pérez-Ceballos E, Jerez A, Ortuño FJ

Cancer Med. 2022 Nov 13;

Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays.

Ashton NJ, Puig-Pijoan A, Milà-Alomà M, Fernández-Lebrero A, García-Escobar G, González-Ortiz F, Kac PR, Brum WS, Benedet AL, Lantero-Rodriguez J, Day TA, Vanbrabant J, Stoops E, Vanmechelen E, Triana-Baltzer G, Moughadam S, Kolb H, Ortiz-Romero P, Karikari TK, Minguillon C, Hernández Sánchez JJ, Navalpotro-Gómez I, Grau-Rivera O, María Manero R, Puente-Periz V, de la Torre R, Roquer J, Dage JL, Zetterberg H, Blennow K, Suárez-Calvet M

Alzheimers Dement. 2022 Nov 12;

Minimally invasive pancreatic anastomosis after pancreaticoduodenectomy: multi-institutional step by step video description of the technique.

Ielpo B, Anselmo A, Koh Y, Burdio F, De Blasi V, Sanchez-Velazquez P, Azagra JS, Huscher C, Giuliani A, Pellino G, Rosso E

Updates Surg. 2022 Nov 12;

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.

Boix O, Martinez M, Vidal S, Giménez-Alejandre M, Palenzuela L, Lorenzo-Sanz L, Quevedo L, Moscoso O, Ruiz-Orera J, Ximénez-Embún P, Ciriaco N, Nuciforo P, Stephan-Otto Attolini C, Albà MM, Muñoz J, Tian TV, Varela I, Vivancos A, Ramón Y Cajal S, Muñoz P, Rivas C, Abad M

Nat Commun. 2022 Nov 11;13(1):6840

Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients.

Pujol J, Blanco-Hinojo L, Doreste A, Ojeda F, Martínez-Vilavella G, Pérez-Sola V, Deus J, Monfort J

Arthritis Res Ther. 2022 Nov 11;24(1):252

The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study.

Erber AC, Wagner A, Karachaliou M, Jeleff M, Kalafatis P, Kogevinas M, Peplonska B, Santonja I, Schernhammer E, Stockinger H, Straif K, Wiedermann U, Waldhör T, Papantoniou K

J Biol Rhythms. 2022 Nov 11;:7487304221132355

Mediterranean Diet, Energy Restriction, Physical Activity and Atherogenicity of Very-Low Density Lipoproteins: Findings from Two Randomized Controlled Trials.

Pérez-Vega KA, Castañer O, Sanllorente A, Lassale C, Ros E, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez ÁM, Serra-Majem L, Razquin C, Fiol M, Lapetra J, Gómez-Gracia E, Tinahones FJ, Hernáez Á, Fitó M

Mol Nutr Food Res. 2022 Nov 10;:e2200338

The long-term risk of endoleak-related-complications may be falsely elevated according to a competing risk analysis.

Clara A, Romero-Montaña L, Mellado M, Casajuana E, Elosua R, Subirana I

Eur J Vasc Endovasc Surg. 2022 Nov 8;

Population Genetics of the European Roma-A Review.

Ena GF, Aizpurua-Iraola J, Font-Porterias N, Calafell F, Comas D

Genes (Basel). 2022 Nov 8;13(11)

Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort.

Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C

Environ Pollut. 2022 Nov 7;316(Pt 2):120571

Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats.

Ramos-Romero S, Ponomarenko J, Amézqueta S, Hereu M, Miralles-Pérez B, Romeu M, Méndez L, Medina I, Torres JL

Nutrients. 2022 Nov 3;14(21)

Role of SALL4 in HER2+ Breast Cancer Progression: Regulating PI3K/AKT Pathway.

Pattanayak B, Lameirinhas A, Torres-Ruiz S, Burgués O, Rovira A, Martínez MT, Tapia M, Zazo S, Albanell J, Rojo F, Bermejo B, Eroles P

Int J Mol Sci. 2022 Oct 31;23(21)

Editorial overview: Understanding the biology of cancer genomes in the context of DNA, RNA, histone marks, and 3D chromatin organization.

Di Croce L, Skok J

Curr Opin Genet Dev. 2022 Oct 26;77:102001

Effectiveness and Cost-Effectiveness of Case Management in Advanced Heart Failure Patients Attended in Primary Care: A Systematic Review and Meta-Analysis.

Checa C, Canelo-Aybar C, Suclupe S, Ginesta-López D, Berenguera A, Castells X, Brotons C, Posso M

Int J Environ Res Public Health. 2022 Oct 24;19(21)

Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa: In Vivo and In Vitro Evidence.

Lopez-Montesinos I, Montero MM, Domene-Ochoa S, López-Causapé C, Echeverria D, Sorlí L, Campillo N, Luque S, Padilla E, Prim N, Grau S, Oliver A, Horcajada JP

Antibiotics (Basel). 2022 Oct 22;11(11)

Comparative Analysis of Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum B-Lactamase-Producing Klebsiella pneumoniae.

Sendra E, López Montesinos I, Rodriguez-Alarcón A, Du J, Siverio-Parés A, Arenas-Miras M, Cañas-Ruano E, Prim N, Durán-Jordà X, Blasco-Hernando F, García-Alzorriz E, Cots F, Ferrández O, Gómez-Zorrilla S

Antibiotics (Basel). 2022 Oct 29;11(11)

Moderate sedation with dexmedetomidine-remifentanil is safer than deep sedation with propofol-remifentanil for endobronchial ultrasound while providing comparable quality: A randomized double-blind trial.

Bermejo S, Covas B, Silva-Costa-Gomes T, Sánchez-Font A, Curull V, Pérez-Ramos À, Mases A, Gallart L

Expert Rev Respir Med. 2022 Nov 9;

Patient-centered care in Coronary Heart Disease: what do you want to measure? A systematic review of reviews on patient-reported outcome measures.

Pardo Y, Garin O, Oriol C, Zamora V, Ribera A, Ferrer M

Qual Life Res. 2022 Nov 9;

MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.

Laguillo-Diego A, Kiewisz R, Martí-Gómez C, Baum D, Müller-Reichert T, Vernos I

Mol Biol Cell. 2022 Nov 9;:mbcE22080306T

Comparison of two radiofrequency-based hemostatic devices: saline-linked bipolar vs. cooled-electrode monopolar.

Moll X, Fondevila D, García-Arnas F, Burdio F, Trujillo M, Irastorza RM, Berjano E, Andaluz A

Int J Hyperthermia. 2022;39(1):1397-1407

Mental health inequalities in times of crisis: evolution between 2005 and 2021 among the Spanish salaried population.

Esteve-Matalí L, Llorens-Serrano C, Alonso J, Vilagut G, Moncada S, Navarro-Giné A

J Epidemiol Community Health. 2022 Nov 7;

Endocrine resistance and breast cancer plasticity are controlled by CoREST.

Garcia-Martinez L, Adams AM, Chan HL, Nakata Y, Weich N, Stransky S, Zhang Z, Alshalalfa M, Sarria L, Mahal BA, Kesmodel SB, Celià-Terrassa T, Liu Z, Minucci S, Bilbao D, Sidoli S, Verdun RE, Morey L

Nat Struct Mol Biol. 2022 Nov 7;

Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study.

Rodríguez-Fernández B, Vilor-Tejedor N, Arenaza-Urquijo EM, Sánchez-Benavides G, Suárez-Calvet M, Operto G, Minguillón C, Fauria K, Kollmorgen G, Suridjan I, de Moura MC, Piñeyro D, Esteller M, Blennow K, Zetterberg H, De Vivo I, Molinuevo JL, Navarro A, Gispert JD, Sala-Vila A, Crous-Bou M, ALFA study.

Alzheimers Res Ther. 2022 Nov 7;14(1):167


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Curr Biol. 2022 Nov 7;32(21):R1214-R1215

Migratory behavior is positively associated with genetic diversity in butterflies.

García-Berro A, Talla V, Vila R, Kar Wai H, Shipilina D, Chan KG, Pierce NE, Backström N, Talavera G

Mol Ecol. 2022 Nov 6;

Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults.

Blackman J, Stankeviciute L, Arenaza-Urquijo EM, Suárez-Calvet M, Sánchez-Benavides G, Vilor-Tejedor N, Iranzo A, Molinuevo JL, Gispert JD, Coulthard E, Grau-Rivera O, European Prevention of Alzheimer’s Disease (EPAD) Consortium.

Brain Commun. 2022;4(6):fcac257

High incidence of PTSD diagnosis and trauma-related symptoms in a trauma exposed bipolar I and II sample.

Hogg B, Valiente-Gómez A, Redolar-Ripoll D, Gardoki-Souto I, Fontana-McNally M, Lupo W, Jiménez E, Madre M, Blanco-Presas L, Reinares M, Cortizo R, Massó-Rodriguez A, Castaño J, Argila I, Castro-Rodríguez JI, Comes M, Doñate M, Herrería E, Macias C, Mur E, Novo P, Rosa AR, Vieta E, Radua J, Padberg F, Pérez-Solà V, Moreno-Alcázar A, Amann BL

Front Psychiatry. 2022;13:931374

Superior Mesenteric Artery First Approach for Minimally Invasive Pancreaticoduodenectomy: A Step-By-Step Surgical Technique Video.

Ielpo B, Anselmo A, Masuda Y, Xuan MYH, Burdio F, De Blasi V, Sanchez-Velazquez P, Giuliani A, Azagra JS, Viola GM, Podda M, Pellino G, Rosso E

Ann Surg Oncol. 2022 Nov 5;

Radiofrequency-assisted transection of the pancreas versus stapler in distal pancreatectomy: study protocol for a multicentric randomised clinical trial (TRANSPAIRE).

Sánchez-Velázquez P, Pueyo-Périz E, Álamo JM, Suarez Artacho G, Gómez Bravo MÁ, Marcello M, Vicente E, Quijano Y, Ferri V, Caruso R, Dorcaratto D, Sabater L, González Chávez P, Noguera J, Navarro Gonzalo A, Bellido-Luque J, Téllez-Marques C, Ielpo B, Burdio F

BMJ Open. 2022 Nov 4;12(11):e062873

Founder lineages in the Iberian Roma mitogenomes recapitulate the Roma diaspora and show the effects of demographic bottlenecks.

Aizpurua-Iraola J, Giménez A, Carballo-Mesa A, Calafell F, Comas D

Sci Rep. 2022 Nov 4;12(1):18720

Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia patients enrolled in measurable residual disease-oriented trials.

González-Gil C, Morgades M, Lopes T, Fuster-Tormo F, García-Chica J, Zhao R, Montesinos P, Torrent A, Diaz-Beya M, Coll R, Hermosín L, Mercadal S, González-Campos J, Zamora L, Artola T, Vall-Llovera F, Tormo M, Gil-Cortés C, Barba P, Novo A, Ribera J, Bernal T, De Ugarriza PL, Queipo MP, Martínez-Sánchez P, Giménez A, González-Martínez T, Cladera A, Cervera J, Fernández-Martín R, Ardaiz MÁ, Vidal MJ, Baena Á, López-Bigas N, Bigas A, Maciejewski J, Orfao A, Ribera JM, Genescà E

Haematologica. 2022 Nov 3;

Benchmarking of robotic and laparoscopic spleen-preserving distal pancreatectomy by using two different methods.

van Ramshorst TME, Giani A, Mazzola M, Dokmak S, Ftériche FS, Esposito A, de Pastena M, Lof S, Edwin B, Sahakyan M, Boggi U, Kauffman EF, Fabre JM, Souche RF, Zerbi A, Butturini G, Molenaar Q, Al-Sarireh B, Marino MV, Keck T, White SA, Casadei R, Burdio F, Björnsson B, Soonawalla Z, Koerkamp BG, Fusai GK, Pessaux P, Jah A, Pietrabissa A, Hackert T, D'Hondt M, Pando E, Besselink MG, Ferrari G, Hilal MA, European Consortium on Minimally Invasive Pancreatic Surgery.

Br J Surg. 2022 Nov 2;

Extracellular fluid viscosity enhances cell migration and cancer dissemination.

Bera K, Kiepas A, Godet I, Li Y, Mehta P, Ifemembi B, Paul CD, Sen A, Serra SA, Stoletov K, Tao J, Shatkin G, Lee SJ, Zhang Y, Boen A, Mistriotis P, Gilkes DM, Lewis JD, Fan CM, Feinberg AP, Valverde MA, Sun SX, Konstantopoulos K

Nature. 2022 Nov 2;

Importance of immunometabolic markers for the classification of patients with major depressive disorder using machine learning.

Sánchez-Carro Y, de la Torre-Luque A, Leal-Leturia I, Salvat-Pujol N, Massaneda C, de Arriba-Arnau A, Urretavizcaya M, Pérez-Solà V, Toll A, Martínez-Ruiz A, Ferreirós-Martínez R, Pérez S, Sastre J, Álvarez P, Soria V, López-García P

Prog Neuropsychopharmacol Biol Psychiatry. 2022 Nov 1;121:110674

Increased mortality after kidney transplantation in mildly frail recipients.

Pérez-Sáez MJ, Arias-Cabrales CE, Redondo-Pachón D, Burballa C, Buxeda A, Bach A, Faura A, Junyent E, Marco E, Rodríguez-Mañas L, Crespo M, Pascual J, FRAIL-MAR Study Group .

Clin Kidney J. 2022 Nov;15(11):2089-2096

Symmetrical drug-related intertriginous and flexural exanthema-like rash related to severe acute respiratory syndrome coronavirus 2 infection.

Escolà H, March-Rodriguez A, Pujol RM

Indian J Dermatol Venereol Leprol. 2022 Oct 17;:1-3

Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children.

Suñol M, Alemany S, Bustamante M, Diez I, Contreras-Rodríguez O, Laudo B, Macià D, Martínez-Vilavella G, Martínez-Zalacaín I, Menchón JM, Pujol J, Sunyer J, Sepulcre J, Soriano-Mas C

Biol Psychiatry Glob Open Sci. 2022 Oct;2(4):411-420

Consistent trajectories of rhinitis control and treatment in 16,177?weeks: The MASK-air® longitudinal study.

Sousa-Pinto B, Schünemann HJ, Sá-Sousa A, Vieira RJ, Amaral R, Anto JM, et al

Allergy. 2022 Nov 3;

Phosphorylation of S6RP in peritubular capillaries of kidney grafts and circulating HLA donor-specific antibodies.

Raïch-Regué D, Gimeno J, Llinàs-Mallol L, Menéndez S, Benito D, Redondo D, Pérez-Sáez MJ, Riera M, Reed EF, Pascual J, Crespo M

Front Med (Lausanne). 2022;9:988080

Protocol to generate a patient derived xenograft model of acquired resistance to immunotherapy in humanized mice.

Martínez-Sabadell A, Ovejero Romero P, Arribas J, Arenas EJ

STAR Protoc. 2022 Dec 16;3(4):101712

Relationship of Circulating Vegetable Omega-3 to Prognosis in Patients With Heart Failure.

Lázaro I, Lupón J, Cediel G, Codina P, Fitó M, Domingo M, Santiago-Vacas E, Zamora E, Sala-Vila A, Bayés-Genís A

J Am Coll Cardiol. 2022 Nov 1;80(18):1751-1758

Spanish National Registry of Major Osteoporotic Fractures (REFRA) seen at Fracture Liaison Services (FLS): objectives and quality standards.

Montoya-Garcia MJ, Carbonell-Abella C, Cancio-Trujillo JM, Moro-Álvarez MJ, Mora-Fernández J, Izquierdo-Avino R, Nogues X, Mesa-Ramos M, San Segundo-Mozo RM, Calero-Muñoz E, Naves-Diaz M, Olmo-Montes FJ, Duaso E, GRUPO REFRA-FLS.

Arch Osteoporos. 2022 Nov 1;17(1):138

NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.

Pérez KT, Scrofani J, Vernos I

Biol Open. 2022 Oct 31;

Qualitative development of the PROMIS Profile v1.0-Familial Chylomicronemia Syndrome (FCS) 28.

Kaiser K, Fox RS, Perschon C, Vera-Llonch M, Alonso J, Cubells L, Cella D

Qual Life Res. 2022 Oct 31;

scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells.

Bianchi A, Scherer M, Zaurin R, Quililan K, Velten L, Beekman R

Genome Biol. 2022 Oct 28;23(1):229

Safety and efficacy of avelumab plus carboplatin in patients with metastatic castration-resistant prostate cancer in an open-label Phase Ib study.

Rodriguez-Vida A, Maroto P, Font A, Martin C, Mellado B, Corbera A, Orrillo M, Reig O, Querol R, Rios-Hoyo A, Cano L, Alonso J, Martinez G, Galtes S, Taus A, Martinez-Garcia M, Juanpere N, Juan O, Bellmunt J

Br J Cancer. 2022 Oct 26;

Mortality and incidence of cardiovascular events in patients treated with aspirin and statins at one year after myocardial injury in noncardiac surgery: a prospective observational study.

Beltrán de Heredia S, Mases A, Recasens L, Sabaté S, Núñez M, Bosch L, Roman L, Rueda M, Alonso E, Gallart L

Minerva Anestesiol. 2022 Oct 26;

Perioperative hyperoxia and myocardial injury after surgery (MINS): a randomized controlled trial.

Sadurni M, Castelltort L, Rivera P, Gallart L, Pascual M, Duran X, Grocott MP

Minerva Anestesiol. 2022 Oct 25;

Human genetics: A tale of two historical Jewish communities.

Lalueza-Fox C

Curr Biol. 2022 Oct 24;32(20):R1023-R1025

Residential Proximity to Urban Play Spaces and Childhood Overweight and Obesity in Barcelona, Spain: A Population-Based Longitudinal Study.

Sánchez-Valdivia N, Pérez-Del-Pulgar C, de Bont J, Anguelovski I, López-Gay A, Pistillo A, Triguero-Mas M, Duarte-Salles T

Int J Environ Res Public Health. 2022 Oct 21;19(20)

Follow-up care of 12 months of patients with bladder cancer in Spain: A multicenter prospective cohort study.

Bonfill X, Martinez-Zapata MJ, Barrionuevo-Rosas L, Vernooij RW, Sánchez MJ, Morales-Suárez-Varela M, De la Cruz J, Emparanza JI, Ferrer M, Pijoan JI, Palou J, Frances A, Madrid E, Coscia C, Zamora J, EMPARO-CU study group.

Medicine (Baltimore). 2022 Oct 21;101(42):e31175

Antimicrobial Peptides Can Generate Tolerance by Lag and Interfere with Antimicrobial Therapy.

Sandín D, Valle J, Morata J, Andreu D, Torrent M

Pharmaceutics. 2022 Oct 11;14(10)

Genetics Abnormalities with Clinical Impact in Primary Cutaneous Lymphomas.

Gallardo F, Pujol RM

Cancers (Basel). 2022 Oct 11;14(20)

Heat stress and incidence of acute kidney injury among agricultural workers in Spain.

O'Callaghan-Gordo C, Arjona L, Brocal F, Caplin B, Espinosa A, García R, Martín-Bustamante M, Malpica-Lander C, Ramirez-Rubio O, Ronda E, Pearce N, Kogevinas M

Lancet Planet Health. 2022 Oct;6 Suppl 1:S16

Impact of Phenol-Enriched Olive Oils on Serum Metabonome and Its Relationship with Cardiometabolic Parameters: A Randomized, Double-Blind, Cross-Over, Controlled Trial.

Farràs M, Swann JR, Rowland I, Rubió L, Subirana I, Catalán Ú, Motilva MJ, Solà R, Covas MI, Blanco-Vaca F, Fitó M, Mayneris-Perxachs J

Antioxidants (Basel). 2022 Sep 30;11(10)

Peripheral Neutrophil-to-Lymphocyte Ratio in Bronchiectasis: A Marker of Disease Severity.

Martinez-García MÁ, Olveira C, Girón R, García-Clemente M, Máiz-Carro L, Sibila O, Golpe R, Méndez R, Rodríguez Hermosa JL, Barreiro E, Prados C, Rodríguez López J, de la Rosa D

Biomolecules. 2022 Sep 30;12(10)

Identification of Two Novel EPOR Gene Variants in Primary Familial Polycythemia: Case Report and Literature Review.

Lo Riso L, Vargas-Parra G, Navarro G, Arenillas L, Fernández-Ibarrondo L, Robredo B, Ballester C, López B, Perez-Montaña A, Sampol A, Florensa L, Besses C, Duran MA, Bellosillo B

Genes (Basel). 2022 Sep 20;13(10)

The 2022 Europe report of the Lancet Countdown on health and climate change: towards a climate resilient future.

van Daalen KR, Romanello M, Rocklöv J, Semenza JC, Tonne C, Markandya A, Dasandi N, Jankin S, Achebak H, Ballester J, ... , Lloyd SJ, Lotto Batista M, Martinez-Urtaza J, Milà C, Minx JC, Nieuwenhuijsen M, Palamarchuk J, Quijal-Zamorano M, ... , Anto JM, Nilsson M, Lowe R

Lancet Public Health. 2022 Oct 25;

Editorial: Inner ear biology: Development, physiopathology, repair and recovery.

Alsina B, Heller S, Varela-Nieto I

Front Cell Dev Biol. 2022;10:1049463

Editorial: Disruptive technologies for the study of host-pathogen interactions.

Quintana JF, Harding C, Huet D, Sateriale A, Bernabeu M

Front Cell Infect Microbiol. 2022;12:1048342

Association between ultra-processed food consumption and gut microbiota in senior subjects with overweight/obesity and metabolic syndrome.

Atzeni A, Martínez MÁ, Babio N, Konstanti P, Tinahones FJ, Vioque J, Corella D, Fitó M, Vidal J, Moreno-Indias I, Pertusa-Martinez S, Álvarez-Sala A, Castañer O, Goday A, Damas-Fuentes M, Belzer C, Martínez-Gonzalez MÁ, Hu FB, Salas-Salvadó J

Front Nutr. 2022;9:976547

Total IgE levels are linked to the course of chronic spontaneous urticaria during pregnancy.

Kocatürk E, Thomsen SF, Al-Ahmad M, Gimenez Arnau AM, Conlon N, Savk E, Criado RFJ, Danilycheva I, Fomina D, Khoshkhui M, Gelincik A, Yüksel EN, Ertan S, Ensina LF, Kasperska-Zajac A, Rudenko M, Bauer A, Medina IV, Maurer M

J Allergy Clin Immunol Pract. 2022 Oct 26;

INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing.

Ivancic D, Mir-Pedrol J, Jaraba-Wallace J, Rafel N, Sanchez-Mejias A, Güell M

Genome Biol. 2022 Oct 25;23(1):227

Big dynorphin is a neuroprotector scaffold against amyloid Beta-peptide aggregation and cell toxicity.

Gallego-Villarejo L, Wallin C, Król S, Enrich-Bengoa J, Suades A, Aguilella-Arzo M, Gomara MJ, Haro I, Wärmlander S, Muñoz FJ, Gräslund A, Perálvarez-Marín A

Comput Struct Biotechnol J. 2022;20:5672-5679

Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice.

Escudero-Lara A, Cabañero D, Maldonado R

Front Behav Neurosci. 2022;16:946975

Prediction of Adverse Drug Reaction Linked to Protein Targets Using Network-Based Information and Machine Learning.

Galletti C, Aguirre-Plans J, Oliva B, Fernandez-Fuentes N

Front Bioinform. 2022;2:906644

Phylotranscriptomics interrogation uncovers a complex evolutionary history for the planarian genus Dugesia (Platyhelminthes, Tricladida) in the Western Mediterranean.

Benítez-Álvarez L, Leria L, Fernández R, Mateos E, El Ouanighi Y, Bennas N, El Alami M, Yacoubi-Khebiza M, Ayt Ougougdal H, Riutort M

Mol Phylogenet Evol. 2022 Oct 21;:107649

Susceptible windows of exposure to fine particulate matter and fetal growth trajectories in the Spanish INMA (INfancia y Medio Ambiente) birth cohort.

Chen WJ, Rector AM, Guxens M, Iniguez C, Swartz MD, Symanski E, Ibarluzea J, Ambros A, Estarlich M, Lertxundi A, Riano-Galán I, Sunyer J, Fernandez-Somoano A, Chauhan SP, Ish J, Whitworth KW

Environ Res. 2022 Oct 21;:114628

Burden and satisfaction experienced in relatives and patients during home hospitalisation in psychiatry.

León-Caballero J, Sabaté A, Roldan M, González-Fresnedo AM, Samos P, Jerónimo MA, Martín LM, Perez V, Pacchiarotti I, Córcoles D

Actas Esp Psiquiatr. 2022 Sep;50(5):226-232

Benchmarking post-GWAS analysis tools in major depression: Challenges and implications.

Pérez-Granado J, Piñero J, Furlong LI

Front Genet. 2022;13:1006903

The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures.

Bouzón-Arnáiz I, Avalos-Padilla Y, Biosca A, Caño-Prades O, Román-Álamo L, Valle J, Andreu D, Moita D, Prudêncio M, Arce EM, Muñoz-Torrero D, Fernàndez-Busquets X

BMC Biol. 2022 Oct 22;20(1):197

Multi-hit TET2 mutations as a differential molecular signature of oligomonocytic and overt chronic myelomonocytic leukemia.

Garcia-Gisbert N, Arenillas L, Roman-Bravo D, Rodriguez-Sevilla JJ, Fernández-Rodríguez C, Garcia-Avila S, Velez P, Gibert J, Fernández-Ibarrondo L, Salar A, Florensa L, Bellosillo B, Ferrer A, Calvo X

Leukemia. 2022 Oct 22;

Early-life and health behaviour influences on lung function in early-adulthood.

Mahmoud O, Granell R, Peralta GP, Garcia-Aymerich J, Jarvis D, Henderson J, Sterne J

Eur Respir J. 2022 Oct 20;

Evaluation of four prognostic indices in follicular lymphoma treated in first line with immunochemotherapy.

Rodríguez-Sevilla JJ, Fernández-Rodríguez C, Bento L, Diez-Feijóo R, Pinzon SF, Gibert J, Fernández-Ibarrondo L, Lafuente M, Ferrer A, Sanchez-Gonzalez B, Gimeno E, Sainz J, Ramos-Asensio R, Garcia JF, Colomo L, Bellosillo B, Gutierrez A, Salar-Silvestre A

Blood Adv. 2022 Oct 19;

Occupational heat exposure and prostate cancer risk: A pooled analysis of case-control studies.

Hinchliffe A, Alguacil J, Bijoux W, Kogevinas M, Menegaux F, Parent ME, Gomez BP, Uuksulainen S, Turner MC

Environ Res. 2022 Oct 19;:114592

Early progression in follicular lymphoma in the absence of histological transformation or high-risk Follicular Lymphoma International Prognostic Index still has a favourable outcome.

Muntañola A, Mozas P, Mercadal S, Huguet M, Bobillo S, Bastos-Oreiro M, Jiménez-Ubieto A, Rovira J, Rivero A, Tolosa C, Luizaga L, de Villambrosia SG, Novelli S, Caballero D, Salar A, Alonso-Álvarez S, Magnano L, Gutiérrez NC, Sancho JM, López-Guillermo A, GELTAMO group (Grupo Español de Linfomas y Trasplante de Médula Ósea).

Br J Haematol. 2022 Oct 19;

The target antigen determines the mechanism of acquired resistance to T cell-based therapies.

Martínez-Sabadell A, Morancho B, Rius Ruiz I, Román Alonso M, Ovejero Romero P, Escorihuela M, Chicote I, Palmer HG, Nonell L, Alemany-Chavarria M, Klein C, Bacac M, Arribas J, Arenas EJ

Cell Rep. 2022 Oct 18;41(3):111430

Precisiones sobre la metodología de RECALCAR. Respuesta.

Marrugat J, Subsirana I, Dégano IR

Rev Esp Cardiol (Engl Ed). 2022 Oct 18;

Deciphering the roadmap of in vivo reprogramming toward pluripotency.

Chondronasiou D, Martínez de Villarreal J, Melendez E, Lynch CJ, Pozo ND, Kovatcheva M, Aguilera M, Prats N, Real FX, Serrano M

Stem Cell Reports. 2022 Oct 7;

Ten simple rules for a successful international consortium in big data omics.

Stobbe MD, Gonzalez-Perez A, Lopez-Bigas N, Gut IG

PLoS Comput Biol. 2022 Oct;18(10):e1010546

Correction to: Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera.

Triguero A, Pedraza A, Perez-Encinas M, Mata-Vazquez MI, Vélez P, Fox L, Gomez-Calafat M, Garcia-Delgado R, Gasior M, Ferrer-Marin F, Garcia-Gutierrez V, Angona A, Gomez-Casares MT, Cuevas B, Martínez C, Pérez R, Raya JM, Guerrero L, Murillo I, Bellosillo B, Hernandez-Boluda JC, Sanz C, Alvarez-Larran A, On behalf of the MPN Spanish Group (GEMFIN).

Ann Hematol. 2022 Oct 20;

Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide.

Molina-Fernández R, Picón-Pagès P, Barranco-Almohalla A, Crepin G, Herrera-Fernández V, García-Elías A, Fanlo-Ucar H, Fernàndez-Busquets X, García-Ojalvo J, Oliva B, Muñoz FJ

Brain Commun. 2022;4(5):fcac243

Real-world effectiveness and persistence of reference etanercept versus biosimilar etanercept GP2015 among rheumatoid arthritis patients: A cohort study.

Carballo N, Pérez García C, Grau S, Monfort J, Durán-Jordà X, Echeverría-Esnal D, Ferrández O

Front Pharmacol. 2022;13:980832

Proposal for a summary index of the non-pharmacological preventive measures adopted against SARS-CoV-2 in companies, the case of Parc de Salut Mar (Barcelona).

Utzet Sadurni M, Serra C, Ramada JM, Villar R, De Travesedo C, Del Prado J, G Benavides F

Arch Prev Riesgos Labor. 2022 Jul 15;25(3):300-309

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis.

Zhang Y, Li Y, Thompson KN, Stoletov K, Yuan Q, Bera K, Lee SJ, Zhao R, Kiepas A, Wang Y, Mistriotis P, Serra SA, Lewis JD, Valverde MA, Martin SS, Sun SX, Konstantopoulos K

Nat Commun. 2022 Oct 17;13(1):6128

Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation.

Cutler KJ, Stringer C, Lo TW, Rappez L, Stroustrup N, Brook Peterson S, Wiggins PA, Mougous JD

Nat Methods. 2022 Oct 17;

Cholesterol and Hypertension Treatment Improve Coronary Risk Prediction but Not Time-Dependent Covariates or Competing Risks.

Subirana I, Camps-Vilaró A, Elosua R, Marrugat J, Tizón-Marcos H, Palomo I, Dégano IR

Clin Epidemiol. 2022;14:1145-1154

Air pollution exposure during pregnancy and childhood, APOE E-4 status and alzheimer polygenic risk score, and brain structural morphology in preadolescents.

Essers E, Binter AC, Neumann A, White T, Alemany S, Guxens M

Environ Res. 2022 Oct 15;:114595

The ulcerative colitis-associated gene FUT8 regulates the quantity and quality of secreted mucins.

Cantero-Recasens G, Burballa C, Ohkawa Y, Fukuda T, Harada Y, IBD Character Consortium., Curwin AJ, Brouwers N, Thun GA, Gu J, Gut I, Taniguchi N, Malhotra V

Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2205277119

Lifetime spirometry patterns of obstruction and restriction, and their risk factors and outcomes: a prospective cohort study.

Dharmage SC, Bui DS, Walters EH, Lowe AJ, Thompson B, Bowatte G, Thomas P, Garcia-Aymerich J, Jarvis D, Hamilton GS, Johns DP, Frith P, Senaratna CV, Idrose NS, Wood-Baker RR, Hopper J, Gurrin L, Erbas B, Washko GR, Faner R, Agusti A, Abramson MJ, Lodge CJ, Perret JL

Lancet Respir Med. 2022 Oct 13;

Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome.

Valle-Hita C, Becerra-Tomás N, Díaz-López A, Vázquez-Ruiz Z, Megías I, Corella D, Goday A, ... , Fitó M, ... , Castañer O, Garcia-Rios A, Gisbert-Sellés C, Sayón-Orea C, Schröder H, Salas-Salvadó J, Babio N

Front Nutr. 2022;9:986190

Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk.

Marhuenda-Muñoz M, Domínguez-López I, Langohr K, Tresserra-Rimbau A, Martínez González MÁ, Salas-Salvadó J, Corella D, Zomeño MD, ... , Fitó M, ... , Gili-Riu MM, Bullon V, Moreno-Rodriguez A, Lecea O, Babio N, Peñas Lopez F, Gómez Melis G, Lamuela-Raventós RM

Front Nutr. 2022;9:967967

Palbociclib with Fulvestrant or Letrozole in Endocrine-Sensitive Patients with HR-Positive/HER2-Negative Advanced Breast Cancer: A Detailed Safety Analysis of the Randomized PARSIFAL Trial.

Di Cosimo S, Pérez-García JM, Bellet M, Dalenc F, Gil Gil MJ, Ruiz Borrego M, Gavilá J, Sampayo-Cordero M, Aguirre E, Schmid P, Marmé F, Gligorov J, Schneeweiss A, Albanell J, Zamora P, Wheatley D, Martínez-De Dueñas E, Carañana V, Amillano K, Mina L, Malfettone A, Cortés J, Llombart-Cussac A

Oncologist. 2022 Oct 14;

Influence of COPD systemic environment on the myogenic function of muscle precursor cells in vitro.

Casadevall C, Sancho-Muñoz A, Vicente I, Pascual-Guardia S, Admetlló M, Gea J

Respir Res. 2022 Oct 14;23(1):282

Sustained seropositivity up to 20.5 months after COVID-19.

Dobaño C, Ramírez-Morros A, Alonso S, Rubio R, Ruiz-Olalla G, Vidal-Alaball J, Macià D, Catalina QM, Vidal M, Casanovas AF, Prados de la Torre E, Barrios D, Jiménez A, Zanoncello J, Melero NR, Carolis C, Izquierdo L, Aguilar R, Moncunill G, Ruiz-Comellas A

BMC Med. 2022 Oct 13;20(1):379

Addictive and other mental disorders: a call for a standardized definition of dual disorders.

Szerman N, Torrens M, Maldonado R, Balhara YPS, Salom C, Maremmani I, Sher L, Didia-Attas J, Chen J, Baler R, World Association on Dual Disorders (WADD).

Transl Psychiatry. 2022 Oct 13;12(1):446

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature.

Servello FA, Fernandes R, Eder M, Harris N, Martin OMF, Oswal N, Lindberg A, Derosiers N, Sengupta P, Stroustrup N, Apfeld J

Elife. 2022 Oct 13;11

Therapy-induced senescence enhances the efficacy of HER2-targeted antibody-drug conjugates in breast cancer.

Duro-Sánchez S, Nadal-Serrano M, Lalinde-Gutiérrez M, Arenas EJ, Bernadó Morales CB, Morancho B, Escorihuela M, Pérez-Ramos S, Escrivá-de-Romaní S, Gandullo-Sánchez L, Pandiella A, Esteve-Codina A, Rodilla V, Dijcks FA, Dokter WHA, Cortés J, Saura C, Arribas J

Cancer Res. 2022 Oct 12;

Omalizumab-associated steatohepatitis.

Barbosa J, Coelho M, Brasileiro A, Giménez-Arnau A

Actas Dermosifiliogr. 2022 Oct 12;

Reply to "A rare case of adrenergic urticaria in a child" by Schnebert et al.

Pesqué D, Pujol RM, Giménez-Arnau AM

J Eur Acad Dermatol Venereol. 2022 Oct 12;

Clinical trial to determine whether the timing of tranexamic acid administration influences perioperative bleeding in total knee arthroplasty.

Luis C, Pardo A, Moreno CE, Teixell C, Santiveri X, Bisbe E

Rev Esp Anestesiol Reanim (Engl Ed). 2022 Oct 11;

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome.

Navarro-Romero A, Galera-López L, Ortiz-Romero P, Llorente-Ovejero A, de Los Reyes-Ramírez L, Bengoetxea de Tena I, Garcia-Elias A, Mas-Stachurska A, Reixachs-Solé M, Pastor A, de la Torre R, Maldonado R, Benito B, Eyras E, Rodríguez-Puertas R, Campuzano V, Ozaita A

Elife. 2022 Oct 11;11

Green Tea Catechins Modulate Skeletal Development with Effects Dependent on Dose, Time, and Structure in a down Syndrome Mouse Model.

Llambrich S, González-Colom R, Wouters J, Roldán J, Salassa S, Wouters K, Van Bulck V, Sharpe J, Callaerts-Vegh Z, Vande Velde G, Martínez-Abadías N

Nutrients. 2022 Oct 7;14(19)

Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome.

Konieczna J, Fiol M, Colom A, Martínez-González MÁ, Salas-Salvadó J, Corella D, Soria-Florido MT, ... , Goday A, et al

Nutrients. 2022 Oct 5;14(19)

MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution.

Neguembor MV, Arcon JP, Buitrago D, Lema R, Walther J, Garate X, Martin L, Romero P, AlHaj Abed J, Gut M, Blanc J, Lakadamyali M, Wu CT, Brun Heath I, Orozco M, Dans PD, Cosma MP

Nat Struct Mol Biol. 2022 Oct;29(10):1011-1023

Sequence diversity of the uniparentally transmitted portions of the genome in the resident population of Catalonia.

Font-Porterias N, García-Fernández C, Aizpurua-Iraola J, Comas D, Torrents D, de Cid R, Calafell F

Forensic Sci Int Genet. 2022 Sep 28;61:102783

Association between the Use of Folic Acid Supplements during Pregnancy and Children's Cognitive Function at 7-9 Years of Age in the INMA Cohort Study.

Compañ-Gabucio LM, Torres-Collado L, Garcia-de la Hera M, Fernández-Somoano A, Tardón A, Julvez J, Sunyer J, Rebagliato M, Murcia M, Ibarluzea J, Santa-Marina L, Vioque J

Int J Environ Res Public Health. 2022 Sep 25;19(19)

Iron Depletion in Systemic and Muscle Compartments Defines a Specific Phenotype of Severe COPD in Female and Male Patients: Implications in Exercise Tolerance.

Pérez-Peiró M, Alvarado M, Martín-Ontiyuelo C, Duran X, Rodríguez-Chiaradía DA, Barreiro E

Nutrients. 2022 Sep 22;14(19)

Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile.

Rubio R, Aguilar R, Bustamante M, Muñoz E, Vázquez-Santiago M, Santano R, Vidal M, Melero NR, Parras D, Serra P, Santamaria P, Carolis C, Izquierdo L, Gómez-Roig MD, Dobaño C, Moncunill G, Mazarico E

Front Immunol. 2022;13:999136

Cost-Effectiveness of Robotic vs. Laparoscopic Surgery for Different Surgical Procedures: Protocol for a Prospective, Multicentric Study (ROBOCOSTES).

Ielpo B, Podda M, Burdio F, Sanchez-Velazquez P, Guerrero MA, Nuñez J, Toledano M, Morales-Conde S, Mayol J, Lopez-Cano M, Espín-Basany E, Pellino G, ROBOCOSTES Study Collaborators.

Front Surg. 2022;9:866041

Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke.

Jaworek T, Xu H, Gaynor BJ, Cole JW, ... , INVENT Consortium., Irvin MR, Jackson RD, Jacob MA, Janssen RR, Jimenez-Conde J, et al, Early Onset Stroke Genetics Consortium of the International Stroke Genetics Consortium (ISGC).

Neurology. 2022 Aug 31;

Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease.

Khera AV, Wang M, Chaffin M, Emdin CA, Samani NJ, Schunkert H, Watkins H, McPherson R, Elosua R, Boerwinkle E, Ardissino D, Butterworth AS, Di Angelantonio E, Naheed A, Danesh J, Chowdhury R, Krumholz HM, Sheu WH, Rich SS, Rotter JI, Chen YI, Gabriel S, Lander ES, Saleheen D, Kathiresan S

Circ Genom Precis Med. 2022 Oct 10;:101161CIRCGEN121003598

Plasma Metabolite Profiles Associated With the Amount and Source of Meat and Fish Consumption and the Risk of Type 2 Diabetes.

García-Gavilán J, Nishi S, Paz-Graniel I, Guasch-Ferré M, Razquin C, Clish CB, Toledo E, Ruiz-Canela M, Corella D, Deik A, Drouin-Chartier JP, Wittenbecher C, Babio N, Estruch R, Ros E, Fitó M, Arós F, Fiol M, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J

Mol Nutr Food Res. 2022 Oct 10;:e2200145

Diversification linked to larval host plant in the butterfly Eumedonia eumedon.

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SURE editing: combining oligo-recombineering and programmable insertion/deletion of selection markers to efficiently edit the Mycoplasma pneumoniae genome.

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Metabolic profiling of night shift work - The HORMONIT study.

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Chronobiol Int. 2022 Oct 9;:1-9

Proteomic signatures of synergistic interactions in antimicrobials.

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OPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized clinical trial.

Algara M, Rodríguez E, Martínez-Arcelus FJ, Salinas J, Sanz X, Beato I, Manso A, Soler A, Rodríguez JR, Frías A, Calín A, Juan G, Meireles P, Flaquer A, OPTIMAL investigators.

Radiother Oncol. 2022 Sep 19;176:76-82

Fluorescent transgenic mouse models for whole-brain imaging in health and disease.

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Front Mol Neurosci. 2022;15:958222

Editorial: Models to study malaria parasite-host interactions and pathogenesis.

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Front Cell Infect Microbiol. 2022;12:1039887

On the use of wearable sensors as mobility biomarkers in the marketing authorization of new drugs: A regulatory perspective.

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Front Med (Lausanne). 2022;9:996903

Electrochemical potential enables dormant spores to integrate environmental signals.

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Science. 2022 Oct 7;378(6615):43-49

Dystrophic xanthomization secondary to lichen planus pigmentosus associated with frontal fibrosing alopecia.

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J Cosmet Dermatol. 2022 Oct 7;

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy.

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LP07 and LLC pre-clinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting.

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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A.

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UEG and EAES rapid guideline: Update systematic review, network meta-analysis, CINeMA and GRADE assessment, and evidence-informed European recommendations on surgical management of GERD.

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FOSL2 truncating variants in the last exon cause a neurodevelopmental disorder with scalp and enamel defects.

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Genet Med. 2022 Oct 4;

A longitudinal and multidesign epidemiological study to analyze the effect of the volcanic eruption of Tajogaite volcano. The ASHES study protocol.

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Certification program of Addiction Centres for hepatitis C virus elimination in Spain. HepCelentes Project.

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Adicciones. 2022 Oct 1;0(0):1743

The association of age with depression, anxiety, and posttraumatic stress symptoms during the COVID-19 pandemic in Spain: the role of loneliness and pre-pandemic mental disorder.

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Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement-the Mobilise-D study protocol.

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PLoS One. 2022;17(10):e0269615

Machine learning-based automated planning for hippocampal avoidance prophylactic cranial irradiation.

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Assessing the digenic model in rare disorders using population sequencing data.

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Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine.

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Environ Res. 2022 Oct 1;:114443

Health impact assessments of shipping and port-sourced air pollution on a global scale: A scoping literature review.

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Environ Res. 2022 Sep 30;:114460

Psychiatric and Psychosocial Characteristics of a Cohort of Spanish Individuals Attending Genetic Counseling Due to Risk for Genetically Conditioned Dementia.

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J Alzheimers Dis Rep. 2022;6(1):461-478

IBCL-123 inMIND: A Phase 3 Study of Tafasitamab Plus Lenalidomide and Rituximab Versus Placebo Plus Lenalidomide and Rituximab for Relapsed/Refractory (R/R) Follicular Lymphoma (FL) or Marginal Zone Lymphoma (MZL).

Sehn LH, Hubel K, Luminari S, Salar A, Wahlin BE, Gopal AK, Bonnet C, Paneesha S, Trneny M, Mashegu H, Lihou CF, Cheng L, Scholz CW

Clin Lymphoma Myeloma Leuk. 2022 Oct;22 Suppl 2:S385-S386

ABCL-320 Initial Safety Run-In Results of the Phase 3 LOTIS-5 Trial: Novel Combination of Loncastuximab Tesirine With Rituximab (Lonca-R) Versus Immunochemotherapy in Patients With R/R DLBCL.

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Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth.

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Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.

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Clin Epigenetics. 2022 Sep 30;14(1):124

A dynamic and expandable Digital 3D-Atlas MAKER for monitoring the temporal changes in tissue growth during hindbrain morphogenesis.

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Elife. 2022 Sep 28;11

Associations of residential greenspace exposure and fetal growth across four areas in Spain.

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Palbociclib Rechallenge for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-Negative Advanced Breast Cancer: Findings from the Phase II BioPER Trial.

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Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation.

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Allergic contact dermatitis to alkyl glucosides: epidemiological situation in Spain.

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The evaluation of the 3-30-300 green space rule and mental health.

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Jericó C, Puértolas N, Osorio J, Miranda C, Santamaría M, Artigau E, Galofré G, Garsot E, Luna A, Aldeano A, Olona C, Pulido L, Pera M, Spanish EURECCA Esophagogastric Cancer Group.

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Nat Commun. 2022 Sep 14;13(1):5400

A hierarchical process model links behavioral aging and lifespan in C. elegans.

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PLoS Comput Biol. 2022 Sep;18(9):e1010415

Live donor kidney transplantation. Situation analysis and roadmap.

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Nefrologia (Engl Ed). 2022 Jan-Feb;42(1):85-93

The population genomic legacy of the second plague pandemic.

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Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Delta-ppr10 cells with defective mitochondrial protein synthesis.

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Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania.

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Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans, and paths forward.

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Correction: Maternal occupational exposure to chemicals and child cognitive function.

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Recommendations from the International Consensus Conference on Anemia Management in Surgical Patients (ICCAMS).

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Highly significant improvement of protein sequence alignments with AlphaFold2.

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Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage.

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Signaling oscillations: Molecular mechanisms and functional roles.

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SARS-CoV-2 Seroprevalence Study in Pediatric Patients and Health Care Workers Using Multiplex Antibody Immunoassays.

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Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study.

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Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.

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J Pers Med. 2022 Aug 30;12(9)

Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties.

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Biomedicines. 2022 Aug 29;10(9)

The associations between traumatic experiences and subsequent onset of a substance use disorder: Findings from the World Health Organization World Mental Health surveys.

Degenhardt L, Bharat C, Glantz MD, Bromet EJ, Alonso J, Bruffaerts R, Bunting B, de Girolamo G, de Jonge P, Florescu S, Gureje O, Haro JM, Harris MG, Hinkov H, Karam EG, Karam G, Kovess-Masfety V, Lee S, Makanjuola V, Medina-Mora ME, Navarro-Mateu F, Piazza M, Posada-Villa J, Scott KM, Stein DJ, Tachimori H, Tintle N, Torres Y, Viana MC, Kessler RC, WHO World Mental Health Survey collaborators.

Drug Alcohol Depend. 2022 Jul 16;:109574

Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis.

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One-year longitudinal association between changes in dietary choline or betaine intake association with cardiometabolic variables in the PREDIMED-Plus trial.

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Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents.

Güil-Oumrait N, Cano-Sancho G, Montazeri P, Stratakis N, Warembourg C, Lopez-Espinosa MJ, Vioque J, Santa-Marina L, Jimeno-Romero A, Ventura R, Monfort N, Vrijheid M, Casas M

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Ambient air pollution and risk of incident dementia in older men living in a region with relatively low concentrations of pollutants: The health in Men study.

Trevenen ML, Heyworth J, Almeida OP, Yeap BB, Hankey GJ, Golledge J, Etherton-Beer C, Robinson S, Nieuwenhuijsen MJ, Flicker L

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Sentinel Lymph Node Biopsy in Prostate Cancer Patients: Results From an Injection Technique Targeting the Index Lesion in the Prostate Gland.

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Disruption of cellular immune response among male rotating night shift workers in Spain- The HORMONIT study.

Harding BN, Aguilar R, Espinosa A, Castaño-Vinyals G, Papantoniou K, Navarrete JM, Such Faro P, Torrejón A, Dobaño C, Moncunill G, Kogevinas M

Front Immunol. 2022;13:776917

Ataxin-2, Twenty-four, and Dicer-2 are components of a noncanonical cytoplasmic polyadenylation complex.

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Life Sci Alliance. 2022 Dec;5(12)

Genetic regulation of RNA splicing in human pancreatic islets.

Atla G, Bonàs-Guarch S, Cuenca-Ardura M, Beucher A, Crouch DJM, Garcia-Hurtado J, Moran I, T2DSystems Consortium., Irimia M, Prasad RB, Gloyn AL, Marselli L, Suleiman M, Berney T, de Koning EJP, Kerr-Conte J, Pattou F, Todd JA, Piemonti L, Ferrer J

Genome Biol. 2022 Sep 15;23(1):196

Genetic and phenotypic characterization of HIV-associated aggressive B-cell non-Hodgkin lymphomas, that do not occur specifically in this population: diagnostic and prognostic implications.

Baptista MJ, Tapia G, Muñoz-Marmol AM, Muncunill J, Garcia O, Montoto S, Gribben JG, Calaminici M, Martinez A, Veloza L, Martínez-Trillos A, Aldamiz T, Menarguez J, Terol MJ, Ferrandez A, Alcoceba M, Briones J, González-Barca E, Climent F, Muntañola A, Moraleda JM, Provencio M, Abrisqueta P, Abella E, Colomo L, García-Ballesteros C, Garcia-Caro M, Sancho JM, Ribera JM, Mate JL, Navarro JT

Histopathology. 2022 Sep 15;

Familial component of early-onset colorectal cancer: opportunity for prevention.

Daca-Alvarez M, Martí M, Spinelli A, de Miranda NFFC, Palles C, Vivas A, Lachtford A, Monahan K, Szczepkowski M, Tarnowski W, Makkai-Popa ST, Vidal R, López I, Hurtado E, Jiménez F, Jiménez-Toscano M, Álvaro E, Sanz G, Ballestero A, Melone S, Brandáriz L, Prieto I, García-Olmo D, Ocaña T, Moreira R, Moreno L, Carballal S, Moreira L, Pellisé M, González-Sarmiento R, Holowatyj AN, Perea J, Balaguer F, GEOCODE and SECOC consortia .

Br J Surg. 2022 Sep 15;

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma.

de Andrés MP, Jackson RJ, Felipe I, Zagorac S, Pilarsky C, Schlitter AM, Martinez de Villareal J, Jang GH, Costello E, Gallinger S, Ghaneh P, Greenhalf W, Knösel T, Palmer DH, Ruemmele P, Weichert W, Buechler M, Hackert T, Neoptolemos JP, Notta F, Malats N, Martinelli P, Real FX

Gut. 2022 Sep 15;


Kolkhir P, Giménez-Arnau AM, Kulthanan K, Peter J, Metz M, Maurer M

Nat Rev Dis Primers. 2022 Sep 15;8(1):61

Linkage mapping and genome annotation give novel insights into gene family expansions and regional recombination rate variation in the painted lady (Vanessa cardui) buttery.

Shipilina D, Näsvall K, Höök L, Vila R, Talavera G, Backström N

Genomics. 2022 Sep 14;114(6):110481

The climate crisis. What about the public health?

Antó JM

Gac Sanit. 2022 Sep 12;37:102248

Functional cure of a chronic virus infection by shifting the virus - host equilibrium state.

Bocharov G, Grebennikov D, Cebollada Rica P, Domenjo-Vila E, Casella V, Meyerhans A

Front Immunol. 2022;13:904342

Mental health symptoms 1 year after the COVID-19 outbreak in Spain: The role of pre-existing mental disorders and their type.

Monistrol-Mula A, Felez-Nobrega M, Moneta MV, Condominas E, Vilagut G, Martin-Iñigo L, Domènech-Abella J, Sánchez-Niubó A, Mortier P, Cristóbal-Narváez P, Olaya B, Alonso J, Haro JM

J Affect Disord. 2022 Dec 1;318:22-28

Exploring the epitranscriptome by native RNA sequencing.

Begik O, Mattick JS, Novoa EM

RNA. 2022 Sep 14;

First description of the t(3;17)(q27;q21)/IGF2BP2::LSM12 translocation in marginal zone lymphoma.

Diez-Feijóo R, Fernández-Rodríguez C, Lafuente M, Garcia-Gisbert N, Ferrer A, Colomo L, Salido M, Salar A

Blood Adv. 2022 Sep 12;

Cellular hierarchies predict drug response in acute myeloid leukemia.

Raffel S, Velten L, Haas S

Cancer Cell. 2022 Sep 12;40(9):917-919

4D reconstruction of murine developmental trajectories using spherical harmonics.

Dalmasso G, Musy M, Niksic M, Robert-Moreno A, Badía-Careaga C, Sanz-Ezquerro JJ, Sharpe J

Dev Cell. 2022 Sep 12;57(17):2140-2150.e5

Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review.

Rodríguez-Alarcón A, Barceló-Vidal J, Echeverría-Esnal D, Sorli L, Güerri-Fernández R, Ramis Fernández SM, Benitez-Cano A, Sendra E, López Montesinos I, Membrilla-Fernández E, Ferrández O, Adalia R, Horcajada JP, Escolano F, Gómez-Zorrilla S, Grau S, , on behalf of PROA-PSMAR group.

Expert Rev Anti Infect Ther. 2022 Sep 12;:1-10

Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism.

Martínez-Torres S, Bergadà-Martínez A, Ortega JE, Galera-López L, Hervera A, de Los Reyes-Ramírez L, Ortega-Álvaro A, Remmers F, Muñoz-Moreno E, Soria G, Del Río JA, Lutz B, Ruíz-Ortega JÁ, Meana JJ, Maldonado R, Ozaita A

Neuropsychopharmacology. 2022 Sep 10;

Exposure to secondhand aerosol from electronic cigarettes at homes: A real-life study in four European countries.

Amalia B, Fu M, Tigova O, Ballbè M, Paniello B, Castellano Y, Vyzikidou VK, O'Donnell R, Dobson R, Lugo A, Veronese C, Pérez-Ortuño R, Pascual JA, Cortés N, Gil F, Olmedo P, Soriano JB, Boffi R, Ruprecht A, Ancochea J, López MJ, Gallus S, Vardavas C, Semple S, Fernández E, TackSHS Project Investigators.

Sci Total Environ. 2022 Sep 10;:158668

Predictors and changes of physical activity in idiopathic pulmonary fibrosis.

Badenes-Bonet D, Rodó-Pin A, Castillo-Villegas D, Vicens-Zygmunt V, Bermudo G, Hernández-González F, Portillo K, Martínez-Llorens J, Chalela R, Caguana O, Sellarés J, Molina-Molina M, Duran X, Gea J, Rodríguez-Chiaradia DA, Balcells E

BMC Pulm Med. 2022 Sep 9;22(1):340

Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors.

Rivas EI, Linares J, Zwick M, Gómez-Llonin A, Guiu M, Labernadie A, Badia-Ramentol J, Lladó A, Bardia L, Pérez-Núñez I, Martínez-Ciarpaglini C, Tarazona N, Sallent-Aragay A, Garrido M, Celià-Terrassa T, Burgués O, Gomis RR, Albanell J, Calon A

Nat Commun. 2022 Sep 9;13(1):5310

Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes.

Jiménez-Vacas JM, Montero-Hidalgo AJ, Gómez-Gómez E, Sáez-Martínez P, Fuentes-Fayos AC, Closa A, González-Serrano T, Martínez-López A, Sánchez-Sánchez R, López-Casas PP, Sarmento-Cabral A, Olmos D, Eyras E, Castaño JP, Gahete MD, Luque RM

Transl Res. 2022 Sep 9;

Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants.

Kayumi S, Pérez-Jurado LA, Palomares M, Rangu S, Sheppard SE, Chung WK, Kruer MC, Kharbanda M, Amor DJ, McGillivray G, Cohen JS, García-Miñaúr S, van Eyk CL, Harper K, Jolly LA, Webber DL, Barnett CP, Santos-Simarro F, Pacio-Míguez M, Pozo AD, Bakhtiari S, Deardorff M, Dubbs HA, Izumi K, Grand K, Gray C, Mark PR, Bhoj EJ, Li D, Ortiz-Gonzalez XR, Keena B, Zackai EH, Goldberg EM, Perez de Nanclares G, Pereda A, Llano-Rivas I, Arroyo I, Fernández-Cuesta MÁ, Thauvin-Robinet C, Faivre L, Garde A, Mazel B, Bruel AL, Tress ML, Brilstra E, Fine AS, Crompton KE, Stegmann APA, Sinnema M, Stevens SCJ, Nicolai J, Lesca G, Lion-François L, Haye D, Chatron N, Piton A, Nizon M, Cogne B, Srivastava S, Bassetti J, Muss C, Gripp KW, Procopio RA, Millan F, Morrow MM, Assaf M, Moreno-De-Luca A, Joss S, Hamilton MJ, Bertoli M, Foulds N, McKee S, MacLennan AH, Gecz J, Corbett MA

Genet Med. 2022 Sep 9;

Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:

Latest news


Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar


UPF Business Shuttle and Innovation Unit


Technology and Business Development Office at the CRG


Analysis and Global Development at ISGlobal


EMBLEM Technology Transfer


  • The following start-ups have been created within the PRBB environment:


Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.



Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.



qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.



ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.



Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.



World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.


Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.


MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.



A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.


Integra Therapeutics

Integra Therapeutics, a spin-off company from MELIS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.


Latest news