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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.


Hospital del Mar Medical Research Institute (IMIM)

Cancer

The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 

Neuroscience

The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Medicine and Life Sciences at Pompeu Fabra University (MELIS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry.

Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.

Radiation

The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.

Other

ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.


Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:

⟶ recercaambanimals.prbb.org

⟶ estabulari-prbb@prbb.org

⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news


Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza
marbiobanc@imim.es

Web:
https://marbiobanc.imim.es

The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko
biocore@crg.eu

Web:
https://biocore.crg.eu

The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut
projectmanager@cnag.crg.eu

Web:
https://www.cnag.crg.eu

This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet
bespinet@parcdesalutmar.cat

Web:
https://www.imim.es/sct/citogen_tica

This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas
oscar.fornas@upf.edu

Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit

The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.

Contact: Dirección de secretaría
ceea@prbb.org

Web:
https://www.prbb.org/ciencia.php#Animalario

This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis
bmspt@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit

Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop
CEIC-PSMAR@imim.es

Web:
https://www.imim.es/comitesetics/ceic/es_index.html

The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría
cbs@prbb.org

Web:
https://www.prbb.org (Acceso: Portal PRBB)

BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso
bibliopro@imim.es

Web:
https://www.bibliopro.org

The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro
helpdesk@ega-archive.org

Web:
https://ega-archive.org

This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht
ngs@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/genomics-unit

The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà
margenomics@imim.es

Web:
https://margenomics.imim.es

The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals
genomica@upf.edu

Web:
https://www.upf.edu/web/sct-genomics/home

The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera
laura.batlle@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0

This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea
aaldea@imim.es

Web:
https://www.imim.es/ofertadeserveis/assajos_clinics

This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger
mif@embl.es

Web:
https://www.embl.es/services/mesoscopic-imaging-facility

The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi
nadia.halidi@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit

Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu
david.andreu@upf.edu

Web:
https://www.upf.edu/web/sct-peptide-synthesis

This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade
eduard.sabido@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit


Scientific publications
(keywords, journal, author,...)

Four layer multi-omics reveals molecular responses to aneuploidy in Leishmania.

Cuypers B, Meysman P, Erb I, Bittremieux W, Valkenborg D, Baggerman G, Mertens I, Sundar S, Khanal B, Notredame C, Dujardin JC, Domagalska MA, Laukens K

PLoS Pathog. 2022 Sep 23;18(9):e1010848

http://www.ncbi.nlm.nih.gov/en...

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans, and paths forward.

Cavalier H, Trasande L, Porta M

Int J Cancer. 2022 Sep 22;

http://www.ncbi.nlm.nih.gov/en...

Correction: Maternal occupational exposure to chemicals and child cognitive function.

Ish J, Symanski E, Gimeno Ruiz de Porras D, Casas M, Delclos GL, Guxens M, Ibarluzea JM, Iñiguez C, Lertxundi A, Rebagliato M, Swartz MD, Whitworth KW

Pediatr Res. 2022 Sep 22;

http://www.ncbi.nlm.nih.gov/en...

Highly significant improvement of protein sequence alignments with AlphaFold2.

Baltzis A, Mansouri L, Jin S, Langer BE, Erb I, Notredame C

Bioinformatics. 2022 Sep 21;

http://www.ncbi.nlm.nih.gov/en...

Signaling oscillations: Molecular mechanisms and functional roles.

Casani-Galdon P, Garcia-Ojalvo J

Curr Opin Cell Biol. 2022 Sep 18;78:102130

http://www.ncbi.nlm.nih.gov/en...

Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study.

Gutiérrez-González E, Fernández-Navarro P, Pastor-Barriuso R, García-Pérez J, Castaño-Vinyals G, Martín-Sánchez V, Amiano P, Gómez-Acebo I, Guevara M, Fernández-Tardón G, Salcedo-Bellido I, Moreno V, Pinto-Carbó M, Alguacil J, Marcos-Gragera R, Gómez-Gómez JH, Gómez-Ariza JL, García-Barrera T, Varea-Jiménez E, Núñez O, Espinosa A, Molina de la Torre AJ, Aizpurua-Atxega A, Alonso-Molero J, Ederra-Sanz M, Belmonte T, Aragonés N, Kogevinas M, Pollán M, Pérez-Gómez B

Environ Int. 2022 Sep 14;169:107525

http://www.ncbi.nlm.nih.gov/en...

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis.

Morel S, Hostettler IC, Spinner GR, Bourcier R, Pera J, Meling TR, Alg VS, Houlden H, Bakker MK, Van't Hof F, Rinkel GJE, Foroud T, Lai D, Moomaw CJ, Worrall BB, Caroff J, Constant-Dits-Beaufils P, Karakachoff M, Rimbert A, Rouchaud A, Gaal-Paavola EI, Kaukovalta H, Kivisaari R, Laakso A, Jahromi BR, Tulamo R, Friedrich CM, Dauvillier J, Hirsch S, Isidor N, Kulcsàr Z, Lövblad KO, Martin O, Machi P, Mendes Pereira V, Rüfenacht D, Schaller K, Schilling S, Slowik A, Jaaskelainen JE, von Und Zu Fraunberg M, Jiménez-Conde J, Cuadrado-Godia E, Soriano-Tárraga C, Millwood IY, Walters RG, The neurIST Project, The Ican Study Group, Genetics And Observational Subarachnoid Haemorrhage Gosh Study Investigators, International Stroke Genetics Consortium Isgc, Kim H, Redon R, Ko NU, Rouleau GA, Lindgren A, Niemelä M, Desal H, Woo D, Broderick JP, Werring DJ, Ruigrok YM, Bijlenga P

J Pers Med. 2022 Aug 30;12(9)

http://www.ncbi.nlm.nih.gov/en...

Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties.

Carrera-Aubesart A, Defaus S, Pérez-Peinado C, Sandín D, Torrent M, Jiménez MÁ, Andreu D

Biomedicines. 2022 Aug 29;10(9)

http://www.ncbi.nlm.nih.gov/en...

The associations between traumatic experiences and subsequent onset of a substance use disorder: Findings from the World Health Organization World Mental Health surveys.

Degenhardt L, Bharat C, Glantz MD, Bromet EJ, Alonso J, Bruffaerts R, Bunting B, de Girolamo G, de Jonge P, Florescu S, Gureje O, Haro JM, Harris MG, Hinkov H, Karam EG, Karam G, Kovess-Masfety V, Lee S, Makanjuola V, Medina-Mora ME, Navarro-Mateu F, Piazza M, Posada-Villa J, Scott KM, Stein DJ, Tachimori H, Tintle N, Torres Y, Viana MC, Kessler RC, WHO World Mental Health Survey collaborators.

Drug Alcohol Depend. 2022 Jul 16;:109574

http://www.ncbi.nlm.nih.gov/en...

Morbid liver manifestations are intrinsically bound to metabolic syndrome and nutrient intake based on a machine-learning cluster analysis.

Micó V, San-Cristobal R, Martín R, Martínez-González MÁ, Salas-Salvadó J, Corella D, Fitó M, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Martín Sánchez V, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, García-Arellano A, Pertusa-Martinez S, Chaplin A, Garcia-Rios A, Muñoz Bravo C, Schröder H, Babio N, Sorli JV, Gonzalez JI, Martinez-Urbistondo D, Toledo E, Bullón V, Ruiz-Canela M, Portillo MP, Macías-González M, Perez-Diaz-Del-Campo N, García-Gavilán J, Daimiel L, Martínez JA

Front Endocrinol (Lausanne). 2022;13:936956

http://www.ncbi.nlm.nih.gov/en...

Prenatal exposure to mixtures of phthalates and phenols and body mass index and blood pressure in Spanish preadolescents.

Güil-Oumrait N, Cano-Sancho G, Montazeri P, Stratakis N, Warembourg C, Lopez-Espinosa MJ, Vioque J, Santa-Marina L, Jimeno-Romero A, Ventura R, Monfort N, Vrijheid M, Casas M

Environ Int. 2022 Sep 15;169:107527

http://www.ncbi.nlm.nih.gov/en...

One-year longitudinal association between changes in dietary choline or betaine intake association with cardiometabolic variables in the PREDIMED-Plus trial.

Díez-Ricote L, San-Cristobal R, Concejo MJ, Martínez-González MÁ, Corella D, Salas-Salvadó J, Goday A, ..., Malcampo M, ..., Gasulla G, Micó V, Salaverria-Lete I, Ochandorena EG, Babio N, Herraiz X, Ordovás JM, Daimiel L

Am J Clin Nutr. 2022 Sep 16;

http://www.ncbi.nlm.nih.gov/en...

Ambient air pollution and risk of incident dementia in older men living in a region with relatively low concentrations of pollutants: The health in Men study.

Trevenen ML, Heyworth J, Almeida OP, Yeap BB, Hankey GJ, Golledge J, Etherton-Beer C, Robinson S, Nieuwenhuijsen MJ, Flicker L

Environ Res. 2022 Sep 15;:114349

http://www.ncbi.nlm.nih.gov/en...

Sentinel Lymph Node Biopsy in Prostate Cancer Patients: Results From an Injection Technique Targeting the Index Lesion in the Prostate Gland.

Fumadó L, Abascal JM, Mestre-Fusco A, Vidal-Sicart S, Aguilar G, Juanpere N, Cecchini L

Front Med (Lausanne). 2022;9:931867

http://www.ncbi.nlm.nih.gov/en...

Disruption of cellular immune response among male rotating night shift workers in Spain- The HORMONIT study.

Harding BN, Aguilar R, Espinosa A, Castaño-Vinyals G, Papantoniou K, Navarrete JM, Such Faro P, Torrejón A, Dobaño C, Moncunill G, Kogevinas M

Front Immunol. 2022;13:776917

http://www.ncbi.nlm.nih.gov/en...

The climate crisis. What about the public health?

Antó JM

Gac Sanit. 2022 Sep 12;37:102248

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Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review.

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Expert Rev Anti Infect Ther. 2022 Sep 12;:1-10

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Exposure to secondhand aerosol from electronic cigarettes at homes: A real-life study in four European countries.

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Sci Total Environ. 2022 Sep 10;:158668

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RNA. 2022 Sep 14;

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First description of the t(3;17)(q27;q21)/IGF2BP2::LSM12 translocation in marginal zone lymphoma.

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Blood Adv. 2022 Sep 12;

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Cancer Cell. 2022 Sep 12;40(9):917-919

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Dev Cell. 2022 Sep 12;57(17):2140-2150.e5

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Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism.

Martínez-Torres S, Bergadà-Martínez A, Ortega JE, Galera-López L, Hervera A, de Los Reyes-Ramírez L, Ortega-Álvaro A, Remmers F, Muñoz-Moreno E, Soria G, Del Río JA, Lutz B, Ruíz-Ortega JÁ, Meana JJ, Maldonado R, Ozaita A

Neuropsychopharmacology. 2022 Sep 10;

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Predictors and changes of physical activity in idiopathic pulmonary fibrosis.

Badenes-Bonet D, Rodó-Pin A, Castillo-Villegas D, Vicens-Zygmunt V, Bermudo G, Hernández-González F, Portillo K, Martínez-Llorens J, Chalela R, Caguana O, Sellarés J, Molina-Molina M, Duran X, Gea J, Rodríguez-Chiaradia DA, Balcells E

BMC Pulm Med. 2022 Sep 9;22(1):340

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Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors.

Rivas EI, Linares J, Zwick M, Gómez-Llonin A, Guiu M, Labernadie A, Badia-Ramentol J, Lladó A, Bardia L, Pérez-Núñez I, Martínez-Ciarpaglini C, Tarazona N, Sallent-Aragay A, Garrido M, Celià-Terrassa T, Burgués O, Gomis RR, Albanell J, Calon A

Nat Commun. 2022 Sep 9;13(1):5310

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Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants.

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Genet Med. 2022 Sep 9;

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Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria.

Maurer M, Berger W, Giménez-Arnau A, Hayama K, Jain V, Reich A, Haemmerle S, Lheritier K, Walsh P, Xia S, Storim J

J Allergy Clin Immunol. 2022 Sep 9;

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The Immunobiogram, a novel in vitro diagnostic test to measure the pharmacodynamic response to immunosuppressive therapy in kidney transplant patients.

Pascual J, Jiménez C, Krajewska M, Seron D, Kotton CN, Portolés J, Witzke O, Sorensen SS, Andrés A, Crespo M, Paz-Artal E, Díez T, Ortega A, Portero I

Transpl Immunol. 2022 Sep 9;:101711

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Liquid biopsy detects early molecular response and predicts benefit to first-line chemotherapy plus cetuximab in metastatic colorectal cancer: PLATFORM-B study.

Vidal J, Fernández-Rodríguez MC, Casadevall D, Garcia-Alfonso P, Páez D, Guix M, Alonso V, Cano MT, Santos C, Durán G, Élez E, Manzano JL, Garcia-Carbonero R, Ferreiro-Monteagudo R, Losa F, Pineda E, Sastre J, Rivera F, Bellosillo B, Tabernero J, Aranda E, Salazar R, Montagut C

Clin Cancer Res. 2022 Sep 8;

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Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes.

Jiménez-Vacas JM, Montero-Hidalgo AJ, Gómez-Gómez E, Sáez-Martínez P, Fuentes-Fayos AC, Closa A, González-Serrano T, Martínez-López A, Sánchez-Sánchez R, López-Casas PP, Sarmento-Cabral A, Olmos D, Eyras E, Castaño JP, Gahete MD, Luque RM

Transl Res. 2022 Sep 8;

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Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824).

Maya-Enero S, Fàbregas-Mitjans M, Llufriu-Marquès RM, Candel-Pau J, Garcia-Garcia J, López-Vílchez MÁ

Eur J Pediatr. 2022 Sep 8;

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Mini pulse corticosteroid therapy with oral dexamethasone for moderate to severe alopecia areata: a multicentric study.

Lobato-Berezo A, March-Rodríguez A, Grimalt R, Rodríguez-Lomba E, Setó-Torrent N, Pujol RM, Ruiz-Villaverde R

Dermatol Ther. 2022 Sep 7;:e15806

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Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse.

Berthoux C, Hamieh AM, Rogliardo A, Doucet EL, Coudert C, Ango F, Grychowska K, Chaumont-Dubel S, Zajdel P, Maldonado R, Bockaert J, Marin P, Bécamel C

EMBO Mol Med. 2022 Sep 7;14(9):e16481

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Corrigendum: Patch Testing with Propolis of Different Geographical Origins in a Baseline Series.

Nyman GSA, Giménez-Arnau AM, Grigaitiene J, Malinauskiene L, Paulsen E, Hagvall L

Acta Derm Venereol. 2022 Sep 6;102:adv00775

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Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and Beta-amyloid?

Akinci M, Sánchez-Benavides G, Brugulat-Serrat A, Peña-Gómez C, Palpatzis E, Shekari M, Deulofeu C, Fuentes-Julian S, Salvadó G, González-de-Echávarri JM, Suárez-Calvet M, Minguillón C, Fauria K, Molinuevo JL, Gispert JD, Grau-Rivera O, Arenaza-Urquijo EM, ALFA Study

Alzheimers Res Ther. 2022 Sep 6;14(1):126

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BlaDimiR: A Urine-based miRNA Score for Accurate Bladder Cancer Diagnosis and Follow-up.

Suarez-Cabrera C, Estudillo L, Ramón-Gil E, Martínez-Fernández M, Peral J, Rubio C, Lodewijk I, Martín de Bernardo Á, García-Escudero R, Villacampa F, Duarte J, de la Rosa F, Castellano D, Guerrero-Ramos F, Real FX, Malats N, Paramio JM, Dueñas M

Eur Urol. 2022 Sep 6;

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Treatment patterns and outcomes in patients with chronic urticaria during pregnancy: Results of PREG-CU, a UCARE Study.

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J Eur Acad Dermatol Venereol. 2022 Sep 6;

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First-time fathers show longitudinal gray matter cortical volume reductions: evidence from two international samples.

Martínez-García M, Paternina-Die M, Cardenas SI, Vilarroya O, Desco M, Carmona S, Saxbe DE

Cereb Cortex. 2022 Sep 4;

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Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals.

Matera C, Calvé P, Casadó-Anguera V, Sortino R, Gomila AMJ, Moreno E, Gener T, Delgado-Sallent C, Nebot P, Costazza D, Conde-Berriozabal S, Masana M, Hernando J, Casadó V, Puig MV, Gorostiza P

Int J Mol Sci. 2022 Sep 4;23(17)

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Prenatal and child vitamin D levels and allergy and asthma in childhood.

Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, Garcia-Aymerich J, Guxens M, Irizar A, Júlvez J, Luque-García L, Rodríguez-Dehli AC, Tardón A, Torrent M, Vioque J, Vrijheid M, Casas M

Pediatr Res. 2022 Sep 3;

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Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program.

Jiménez C, Antonelli R, Nadal-Ribelles M, Devis-Jauregui L, Latorre P, Solé C, Masanas M, Molero-Valenzuela A, Soriano A, Sánchez de Toledo J, Llobet-Navas D, Roma J, Posas F, de Nadal E, Gallego S, Moreno L, Segura MF

Mol Cancer. 2022 Sep 3;21(1):175

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Med Clin (Engl Ed). 2022 Sep 2;

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The 3D-Evo Space: Evolution of Gene Expression and Alternative Splicing Regulation.

Mantica F, Irimia M

Annu Rev Genet. 2022 Sep 2;

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Dis Colon Rectum. 2022 Sep 2;

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Clinical insight in first-episode psychosis: Clinical, neurocognitive and metacognitive predictors.

Pousa E, Brébion G, López-Carrilero R, Ruiz AI, Grasa E, Barajas A, Peláez T, Alfonso-Gutiérrrez-Zotes, Lorente E, Barrigón ML, Ruiz-Delgado I, González-Higueras F, Cid J, Pérez-Solà V, Spanish Metacognition Study Group., Insight Barcelona Work Group., Ochoa S

Schizophr Res. 2022 Sep 2;248:158-167

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Mental health symptoms 1 year after the COVID-19 outbreak in Spain: The role of pre-existing mental disorders and their type.

Monistrol-Mula A, Felez-Nobrega M, Moneta MV, Condominas E, Vilagut G, Martin-Iñigo L, Domènech-Abella J, Sánchez-Niubó A, Mortier P, Cristóbal-Narváez P, Olaya B, Alonso J, Haro JM

J Affect Disord. 2022 Sep 1;318:22-28

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Impact of the mucosal milieu on antibody responses to allergens.

Cerutti A, Filipska M, Fa XM, Tachó-Piñot R

J Allergy Clin Immunol. 2022 Sep;150(3):503-512

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Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: A 2-year diagnostic accuracy study of participants from a randomized controlled trial.

Kurnikowski A, Nordheim E, Schwaiger E, Krenn S, Harreiter J, Kautzky-Willer A, Leutner M, Werzowa J, Tura A, Budde K, Eller K, Pascual J, Krebs M, Jenssen TG, Hecking M

Am J Transplant. 2022 Sep 1;

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Endurance Time During Constant Work Rate Cycle Ergometry in COPD: Development of an Integrated Database From Interventional Studies.

Casaburi R, Merrill D, Dolmage T, Garcia-Aymerich J, Fageras M, Goldstein R, Harding G, Kline Leidy N, Maltais F, O'Donnell D, Porszasz J, Puente-Maestu L, Rennard S, Sciurba F, Spruit MA, Tal-Singer R, Tetzlaff K, Van't Hul A, Yu R, Hamilton A

Chronic Obstr Pulm Dis. 2022 Aug 31;

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Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators.

Zamanillo-Campos R, Chaplin A, Romaguera D, Abete I, Salas-Salvadó J, Martín V, Estruch R, Vidal J, Ruiz-Canela M, Babio N, Fiol F, de Paz JA, Casas R, Olbeyra R, Martínez-González MA, García-Gavilán JF, Goday A, Fernandez-Lazaro CI, Martínez JA, Hu FB, Konieczna J

Clin Nutr. 2022 Aug 20;41(10):2264-2274

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The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study.

Puig-Vallverdú J, Romaguera D, Fernández-Barrés S, Gignac F, Ibarluzea J, Santa-Maria L, Llop S, Gonzalez S, Vioque J, Riaño-Galán I, Fernández-Tardón G, Pinar A, Turner MC, Arija V, Salas-Savadó J, Vrijheid M, Julvez J

Clin Nutr. 2022 Aug 19;41(10):2275-2283

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Eleven-month longitudinal study of antibodies in SARS-CoV-2 exposed and naïve primary health care workers upon COVID-19 vaccination.

Dobaño C, Ramírez-Morros A, Alonso S, Ruiz-Olalla G, Rubio R, Vidal M, Prados de la Torre E, Jairoce C, Mitchell RA, Barrios D, Jiménez A, Rodrigo Melero N, Carolis C, Izquierdo L, Zanoncello J, Aguilar R, Vidal-Alaball J, Moncunill G, Ruiz-Comellas A

Immunology. 2022 Jul 31;

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High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer.

Palafox M, Monserrat L, Bellet M, Villacampa G, Gonzalez-Perez A, Oliveira M, Brasó-Maristany F, Ibrahimi N, Kannan S, Mina L, Herrera-Abreu MT, Òdena A, Sánchez-Guixé M, Capelán M, Azaro A, Bruna A, Rodríguez O, Guzmán M, Grueso J, Viaplana C, Hernández J, Su F, Lin K, Clarke RB, Caldas C, Arribas J,..., Lopez-Bigas N, et al

Nat Commun. 2022 Sep 7;13(1):5258

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Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules.

Cavaco M, Frutos S, Oliete P, Valle J, Andreu D, Castanho MARB, Vila-Perelló M, Neves V

ACS Med Chem Lett. 2021 Nov 11;12(11):1663-1668

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State-of-the-art methods for exposure-health studies: Results from the exposome data challenge event.

Maitre L, Guimbaud JB, Warembourg C, Güil-Oumrait N, Petrone PM, Chadeau-Hyam M, Vrijheid M, Basagaña X, Gonzalez JR, Exposome Data Challenge Participant Consortium

Environ Int. 2022 Aug 27;168:107422

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Anti-SARS-COV-2 specific immunity in HIV immunological non-responders after mRNA-based COVID-19 vaccination.

Sisteré-Oró M, Andrade N, Wortmann DDJ, Du J, Garcia-Giralt N, González-Cao M, Güerri-Fernández R, Meyerhans A

Front Immunol. 2022;13:994173

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Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics.

Bonkhoff AK, Ullberg T, Bretzner M, Hong S, Schirmer MD, Regenhardt RW, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Ropele S, Rosand J, Roquer J, et al

Front Neurosci. 2022;16:994458

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Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders.

Sadeghi I, Gispert JD, Palumbo E, Muñoz-Aguirre M, Wucher V, D'Argenio V, Santpere G, Navarro A, Guigo R, Vilor-Tejedor N

Comput Struct Biotechnol J. 2022;20:4549-4561

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Genetically predicted telomere length and its relationship with neurodegenerative diseases and life expectancy.

Rodríguez-Fernández B, Gispert JD, Guigo R, Navarro A, Vilor-Tejedor N, Crous-Bou M

Comput Struct Biotechnol J. 2022;20:4251-4256

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The genome sequence of the European peacock butterfly, Aglais io (Linnaeus, 1758).

Lohse K, Mackintosh A, Vila R, Darwin Tree of Life Barcoding collective., Wellcome Sanger Institute Tree of Life programme., Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective., Tree of Life Core Informatics collective., Darwin Tree of Life Consortium

Wellcome Open Res. 2021;6:258

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Lymph Node Ratio Nomogram-Based Prognostic Model for Resected Distal Cholangiocarcinoma.

Perez M, Hansen CP, Burdio F, Pellino G, Podda M, Salvia R, Cacciaguerra AB, Abu Hilal M, Aldrighetti L, Ielpo B, and the Cholangiocarcinoma Multicenter Study Coauthor Group

J Am Coll Surg. 2022 Jun 17;

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Publisher Correction: Plasma p-tau231 and p-tau217 as state markers of amyloid-Beta pathology in preclinical Alzheimer's disease.

Milà-Alomà M, Ashton NJ, Shekari M, Salvadó G, Ortiz-Romero P, Montoliu-Gaya L, Benedet AL, Karikari TK, Lantero-Rodriguez J, Vanmechelen E, Day TA, González-Escalante A, Sánchez-Benavides G, Minguillon C, Fauria K, Molinuevo JL, Dage JL, Zetterberg H, Gispert JD, Suárez-Calvet M, Blennow K

Nat Med. 2022 Sep 13;

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Differential expression of miR-1249-3p and miR-34b-5p between vulnerable and resilient phenotypes of cocaine addiction.

Domingo-Rodriguez L, Cabana-Domínguez J, Fernàndez-Castillo N, Cormand B, Martín-García E, Maldonado R

Addict Biol. 2022 Sep;27(5):e13201

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Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy.

Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollán A, González-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cánoves P

Cell Stem Cell. 2022 Sep 1;29(9):1298-1314.e10

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Flight or protection: the genes Ultrabithorax and apterous in the determination of membranous and sclerotized wings in insects.

Elias-Neto M, Alvarez N, Ventos-Alfonso A, Belles X

Proc Biol Sci. 2022 Aug 31;289(1981):20220967

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Individualizing the treatment of patients with heart failure with reduced ejection fraction: a journey from hospitalization to long-term outpatient care.

Escobar C, Luis-Bonilla J, Crespo-Leiro MG, Esteban-Fernández A, Farré N, Garcia A, Nuñez J

Expert Opin Pharmacother. 2022 Aug 31;:1-11

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Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera.

Triguero A, Pedraza A, Pérez-Encinas M, Mata-Vázquez MI, Vélez P, Fox L, Gómez-Calafat M, García-Delgado R, Gasior M, Ferrer-Marín F, García-Gutiérrez V, Angona A, Gómez-Casares MT, Cuevas B, Martínez C, Pérez R, Raya JM, Guerrero L, Murillo I, Bellosillo B, Hernández-Boluda JC, Sanz C, Álvarez-Larrán A, On behalf of the MPN Spanish Group (GEMFIN).

Ann Hematol. 2022 Aug 30;

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Does HER2 status influence in the benefit of ramucirumab and paclitaxel as second line treatment of advanced gastro-esophageal adenocarcinoma? Data from the AGAMENON-SEOM registry.

Valcarcel S, Gallego J, Jimenez-Fonseca P, Diez M, de Castro EM, Hernandez R, Arrazubi V, Custodio A, Cano JM, Montes AF, Macias I, Visa L, Calvo A, Tocino RV, Lago NM, Limón ML, Granja M, Gil M, Pimentel P, Macia-Rivas L, Pérez CH, Mangas M, Carnicero AM, Cerdà P, Gonzalez LG, Navalon FG, Rambla MDM, Richard MM, Carmona-Bayonas A

J Cancer Res Clin Oncol. 2022 Aug 30;

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Hair cortisol as a biomarker of chronic stress in preadolescents: influence of school context and bullying.

Babarro I, Ibarluzea J, Theodorsson E, Fano E, Lebeña A, Guxens M, Sunyer J, Andiarena A

Child Neuropsychol. 2022 Aug 28;:1-18

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Causality in transcription and genome folding: Insights from X inactivation.

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The CORCOBIA study: Cut-off points of Alzheimer's disease CSF biomarkers in a clinical cohort.

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Validation of a Parent-Reported Physical Activity Questionnaire by Accelerometry in European Children Aged from 6 to 12 Years Old.

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Social norms (not threat) mediate willingness to sacrifice in individuals fused with the nation: Insights from the COVID-19 pandemic.

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Brief Research Report: Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination.

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Best Treatment Option for Patients With Refractory Aggressive B-Cell Lymphoma in the CAR-T Cell Era: Real-World Evidence From GELTAMO/GETH Spanish Groups.

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An intensive, structured, mobile devices-based healthcare intervention to optimize the lipid-lowering therapy improves lipid control after an acute coronary syndrome.

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Characterization of the spectrum of trivalent VAV1-mutation-driven tumors using a gene-edited mouse model.

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Into the Dark: Exploring the Deep Ocean with Single-Virus Genomics.

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Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression.

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In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias.

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The Influence of Artificial Light at Night on Asthma and Allergy, Mental Health, and Cancer Outcomes: A Systematic Scoping Review Protocol.

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Antidepressant Drugs and COVID-19: A Review of Basic and Clinical Evidence.

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Optical Genome Mapping: A Promising New Tool to Assess Genomic Complexity in Chronic Lymphocytic Leukemia (CLL).

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Cell-Free DNA for Genomic Analysis in Primary Mediastinal Large B-Cell Lymphoma.

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Computational Analysis of Alternative Splicing Using VAST-TOOLS and the VastDB Framework.

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ATP Bioluminescence Assay To Evaluate Antibiotic Combinations against Extensively Drug-Resistant (XDR) Pseudomonas aeruginosa.

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Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.

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Integr Org Biol. 2022;4(1):obac018

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A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype.

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The Epigenetic Regulation in Plant Specialized Metabolism: DNA Methylation Limits Paclitaxel in vitro Biotechnological Production.

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In silico Identification of Immune Cell-Types and Pathways Involved in Chronic Spontaneous Urticaria.

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Machine Learning Risk Prediction Model of 90-day Mortality after Gastrectomy for Cancer.

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Supporting employees with mental illness and reducing mental illness-related stigma in the workplace: an expert survey.

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Cancer effects of low to moderate doses of ionising radiation in young people with cancer predisposing conditions: A systematic review.

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Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision.

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http://www.ncbi.nlm.nih.gov/en...

Gene expression profile of epithelial-mesenchymal transition in tumours of patients with nonsmall cell lung cancer: the influence of COPD.

Xia Y, Zha J, Curull V, Sánchez-Font A, Guitart M, Rodríguez-Fuster A, Aguiló R, Barreiro E

ERJ Open Res. 2022 Jul;8(3)

http://www.ncbi.nlm.nih.gov/en...

LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries.

Graupera I, Thiele M, Ma AT, Serra-Burriel M, Pich J, Fabrellas N, Caballeria L, de Knegt RJ, Grgurevic I, Reichert M, Roulot D, Schattenberg JM, Pericas JM, Angeli P, Tsochatzis EA, Guha IN, Garcia-Retortillo M, et al., LiverScreen Consortium investigators.

BMC Public Health. 2022 Jul 19;22(1):1385

http://www.ncbi.nlm.nih.gov/en...

Dietary diversity and Depression: Cross-sectional and longitudinal analyses in Spanish adult population with Metabolic Syndrome. Findings from PREDIMED-PLUS Trial.

Cano-Ibáñez N, Serra-Majem L, Martín-Peláez S, Martínez-González MÁ, Salas-Salvadó J, Corella D, Lassale C, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Gómez-Pérez AM, Lapetra J, Fernández-Aranda F, Bueno-Cavanillas A, Tur JA, Cubelos N, Pintó X, Gaforio JJ, Matía P, Vidal J, Calderón C, Daimiel L, Ros E, Gea A, Babio N, Gimenez-Alba IM, Zomeño-Fajardo MD, Abete I, Tojal Sierra L, Romero-Galisteo RP, García de la Hera M, Martín-Padillo M, García-Ríos A, Casas RM, Fernández-García JC, Santos-Lozano JM, Toledo E, Becerra-Tomas N, Sorli JV, Schröder H, Zulet MA, Sorto-Sánchez C, Diez-Espino J, Gómez-Martínez C, Fitó M, Sánchez-Villegas A

Public Health Nutr. 2022 Jul 19;:1-29

http://www.ncbi.nlm.nih.gov/en...

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum.

Salvadó G, Milà-Alomà M, Shekari M, Ashton NJ, Operto G, Falcon C, Cacciaglia R, Minguillon C, Fauria K, Niñerola-Baizán A, Perissinotti A, Benedet AL, Kollmorgen G, Suridjan I, Wild N, Molinuevo JL, Zetterberg H, Blennow K, Suárez-Calvet M, Gispert JD, ALFA Study.

Eur J Nucl Med Mol Imaging. 2022 Jul 18;

http://www.ncbi.nlm.nih.gov/en...

A fair day's wage for a fair day's work.

Guinart D, Pérez-Sola V, Amann BL

Lancet. 2022 Jul 16;400(10347):160

http://www.ncbi.nlm.nih.gov/en...

Common bile duct adenomas: A diagnostic and therapeutic challenge.

Ochoa Segarra F, Sánchez Velázquez P, Grande Posa L, Burdio F, Ielpo B

Cir Esp (Engl Ed). 2022 Jul 15;

http://www.ncbi.nlm.nih.gov/en...

Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis.

Mestre-Farràs N, Guerrero S, Bley N, Rivero E, Coll O, Borràs E, Sabidó E, Indacochea A, Casillas-Serra C, Järvelin AI, Oliva B, Castello A, Hüttelmaier S, Gebauer F

Nucleic Acids Res. 2022 Jul 15;

http://www.ncbi.nlm.nih.gov/en...

A rapid assessment of take-home naloxone provision during COVID-19 in Europe.

McDonald R, Eide D, Abel-Ollo K, Barnsdale L, Carter B, Clausen T, Day E, Fonseca F, Holmén E, Horsburgh K, Kelleher M, Kåberg M, Ladenhauf M, McAuley A, Metrebian N, Neale J, Parkin S, Ratcliffe K, Rintoul C, Smith J, Stifanoviciute V, Torrens M, Thiesen H, Strang J

Int J Drug Policy. 2022 Jul 1;107:103787

http://www.ncbi.nlm.nih.gov/en...

Liquid biopsy for disease monitoring after anti-CD19 chimeric antigen receptor T cell in diffuse large B-cell lymphoma.

Maluquer C, Bellosillo B, Mussetti A, Domingo-Domènech E, Parody R, Fernández-Ibarrondo L, Velasco R, Moreno-González G, Sanz G, Cortés M, Sureda A

EJHaem. 2021 Feb;2(1):109-111

http://www.ncbi.nlm.nih.gov/en...

Detailed stratified GWAS analysis for severe COVID-19 in four European populations.

Degenhardt F, Ellinghaus D, Juzenas S, ... , Kogevinas M, et al

Hum Mol Genet. 2022 Jul 15;

http://www.ncbi.nlm.nih.gov/en...

Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort.

Martínez-Urbistondo D, San Cristóbal R, Villares P, Martínez-González MÁ, Babio N, Corella D, Del Val JL, Ordovás JM, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Marcos A, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Ros E, Bullón Vela MV, Palau A, Masagué M, Abete I, Moreno-Rodríguez A, Candela-García I, Konieczna J, García-Ríos A, Juárez OL, Martín P, Goday A, Zulet MÁ, Vaquero-Luna J, Orea MDCS, Megías I, Baltasar E, Martínez JA, Daimiel L

Front Endocrinol (Lausanne). 2022;13:868795

http://www.ncbi.nlm.nih.gov/en...

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter Beta-TrCP delivers anti-inflammatory responses in mouse liver.

Fernández-Ginés R, Encinar JA, Hayes JD, Oliva B, Rodríguez-Franco MI, Rojo AI, Cuadrado A

Redox Biol. 2022 Jul 11;55:102396

http://www.ncbi.nlm.nih.gov/en...

Accounting for diet and age.

Tonnelé H, Baud A

Elife. 2022 Jul 15;11

http://www.ncbi.nlm.nih.gov/en...

Transcriptome innovations in primates revealed by single-molecule long-read sequencing.

Ferrandez-Peral L, Zhan X, Alvarez-Estape M, Chiva C, Esteller-Cucala P, Garcia-Perez R, Julia E, Lizano E, Fornas O, Sabido E, Li Q, Marques-Bonet T, Juan D, Zhang G

Genome Res. 2022 Jul 15;

http://www.ncbi.nlm.nih.gov/en...

A profile of delafloxacin in the treatment of adults with community-acquired bacterial pneumonia.

Gómez-Zorrilla S, Sendra E, Horcajada JP

Expert Rev Clin Pharmacol. 2022 Jul 15;

http://www.ncbi.nlm.nih.gov/en...

Ecological firewalls for synthetic biology.

Vidiella B, Solé R

iScience. 2022 Jul 15;25(7):104658

http://www.ncbi.nlm.nih.gov/en...

Air pollution exposure during pregnancy and childhood, cognitive function, and emotional and behavioral problems in adolescents.

Kusters MSW, Essers E, Muetzel R, Ambrós A, Tiemeier H, Guxens M

Environ Res. 2022 Jul 12;:113891

http://www.ncbi.nlm.nih.gov/en...

The Open-Access European Prevention of Alzheimer's Dementia (EPAD) MRI dataset and processing workflow.

Lorenzini L, Ingala S, Wink AM, Kuijer JPA, Wottschel V, Dijsselhof M, Sudre CH, Haller S, Molinuevo JL, Gispert JD, Cash DM, Thomas DL, Vos SB, Prados F, Petr J, Wolz R, Palombit A, Schwarz AJ, Chételat G, Payoux P, Di Perri C, Wardlaw JM, Frisoni GB, Foley C, Fox NC, Ritchie C, Pernet C, Waldman A, Barkhof F, Mutsaerts HJMM, EPAD consortium.

Neuroimage Clin. 2022 Jul 7;35:103106

http://www.ncbi.nlm.nih.gov/en...

Standardized annotation of translated open reading frames.

Mudge JM, Ruiz-Orera J, Prensner JR, Brunet MA, Calvet F, Jungreis I, Gonzalez JM, Magrane M, Martinez TF, Schulz JF, Yang YT, Albà MM, Aspden JL, Baranov PV, Bazzini AA, Bruford E, Martin MJ, Calviello L, Carvunis AR, Chen J, Couso JP, Deutsch EW, Flicek P, Frankish A, Gerstein M, Hubner N, Ingolia NT, Kellis M, Menschaert G, Moritz RL, Ohler U, Roucou X, Saghatelian A, Weissman JS, van Heesch S

Nat Biotechnol. 2022 Jul;40(7):994-999

http://www.ncbi.nlm.nih.gov/en...

Benchmarking of minimally invasive distal pancreatectomy with splenectomy: European multicentre study.

Giani A, van Ramshorst T, Mazzola M, ... , Burdio F, Keck T, Hackert T, Groot Koerkamp B, d'Hondt M, Coratti A, Pessaux P, Pietrabissa A, Al-Sarireh B, Marino MV, Molenaar Q, Yip V, Besselink M, Ferrari G, Hilal MA, European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS).

Br J Surg. 2022 Jul 14;

http://www.ncbi.nlm.nih.gov/en...

Subclinical Left Ventricular Dysfunction Detected by Speckle-Tracking Echocardiography in Breast Cancer Patients Treated With Radiation Therapy: A Six-Month Follow-Up Analysis (MEDIRAD EARLY-HEART study).

Locquet M, Spoor D, Crijns A, van der Harst P, Eraso A, Guedea F, Fiuza M, Santos SCR, Combs S, Borm K, Mousseaux E, Gencer U, Frija G, Cardis E, Langendijk H, Jacob S

Front Oncol. 2022;12:883679

http://www.ncbi.nlm.nih.gov/en...

Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes.

Lobon I, Solís-Moruno M, Juan D, Muhaisen A, Abascal F, Esteller-Cucala P, García-Pérez R, Martí MJ, Tolosa E, Ávila J, Rahbari R, Marques-Bonet T, Casals F, Soriano E

Front Aging. 2022;3:851039

http://www.ncbi.nlm.nih.gov/en...

Transient drop in the neutrophil count during COVID-19 regardless of clozapine treatment in patients with mental illness.

Vallecillo G, Marti-Bonany J, Robles MJ, Fortuny JR, Lana F, Pérez V

Rev Psiquiatr Salud Ment (Engl Ed). 2022 Apr-Jun;15(2):134-137

http://www.ncbi.nlm.nih.gov/en...

Linking large-scale genetic structure of three Argynnini butterfly species to geography and environment.

Polic D, Yildirim Y, Lee KM, Franzén M, Mutanen M, Vila R, Forsman A

Mol Ecol. 2022 Jul 15;

http://www.ncbi.nlm.nih.gov/en...

Exploring the Association of Cancer and Depression in Electronic Health Records: Combining Encoded Diagnosis and Mining Free-Text Clinical Notes.

Leis A, Casadevall D, Albanell J, Posso M, Macià F, Castells X, Ramírez-Anguita JM, Martínez Roldán J, Furlong LI, Sanz F, Ronzano F, Mayer MA

JMIR Cancer. 2022 Jul 11;8(3):e39003

http://www.ncbi.nlm.nih.gov/en...

Context-dependent roles of cellular senescence in normal, aged, and disease states.

Moiseeva V, Cisneros A, Calls Cobos A, Beà Tarrega A, Santos Oñate C, Perdiguero E, Serrano AL, Muñoz-Cánoves P

FEBS J. 2022 Jul 11;

http://www.ncbi.nlm.nih.gov/en...

Preventing organ damage in systemic lupus erythematosus: the impact of early biological treatment.

Rúa-Figueroa Fernández de Larrinoa Í, Lozano MJC, Fernández-Cid CM, Ibáñez TC, Salman Monte TC, Freire González M, Hidalgo Bermejo FJ, Román Gutiérrez CS, Cortés-Hernández J

Expert Opin Biol Ther. 2022 Jul 11;

http://www.ncbi.nlm.nih.gov/en...

Air pollution and green spaces in relation to breast cancer risk among pre and postmenopausal women: A mega cohort from Catalonia.

Terre-Torras I, Recalde M, Díaz Y, de Bont J, Bennett M, Aragón M, Cirach M, O'Callaghan-Gordo C, Nieuwenhuijsen MJ, Duarte-Salles T

Environ Res. 2022 Jul 7;:113838

http://www.ncbi.nlm.nih.gov/en...

Effects of malnutrition on mortality in oldest-old inpatients with COVID-19 in the GERIA-COVID cohort: Additional findings from the AgeBru cohort.

De Meester D, Marco E, Claessens M, Gautier J, Annweiler C, Lieten S, Benoit F, Surquin M, Sanchez-Rodriguez D

Maturitas. 2022 Jul 2;164:67-68

http://www.ncbi.nlm.nih.gov/en...

Analysis of Exposure and Respiratory Health Effects of Volcanic Eruption in the Canary Islands (ASHES). A SEPAR Study.

Ruano-Ravina A, Acosta O, Pérez DD, Casanova C, Velasco V, Llanos AB, Peces-Barba G, Barreiro E, Cañas A, Castaño A, Carmona MJC, Diego C, Garcia-Aymerich J, Martínez C, Molina-Molina M, Muñoz X, Sánchez-Íñigo FJ, Candal-Pedreira C

Arch Bronconeumol. 2022 May 21;

http://www.ncbi.nlm.nih.gov/en...

Association of Stroke Lesion Pattern and White Matter Hyperintensity Burden With Stroke Severity and Outcome.

Bonkhoff AK, Hong S, Bretzner M, Schirmer MD, Regenhardt RW, Arsava EM, Donahue K, Nardin M, Dalca A, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh E, Attia J, Benavente O, Cole JW, Donatti A, Griessenauer C, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner S, Lemmens R, Levi C, McDonough CW, Meschia J, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, et al

Neurology. 2022 Jul 8;

http://www.ncbi.nlm.nih.gov/en...

Real world study of children and young adults with myeloproliferative neoplasms identifying risks and unmet needs.

Sobas M, Kiladjian JJ, Beauverd Y, Curto-Garcia N, Sadjadian P, Shih LY, Devos T, Krochmalczyk D, Galli S, Bieniaszewska M, Seferynska I, McMullin MFF, Armatys A, Spalek A, Waclaw J, Zdrenghea M, Legros L, Girodon F, Lewandowski K, Angona Figueras A, ... , Besses C, Skoda RC, Giraudier S, Griesshammer M, Harrison CN, Ianotto JC

Blood Adv. 2022 Jul 8;

http://www.ncbi.nlm.nih.gov/en...

RATTLE: reference-free reconstruction and quantification of transcriptomes from Nanopore sequencing.

de la Rubia I, Srivastava A, Xue W, Indi JA, Carbonell-Sala S, Lagarde J, Albà MM, Eyras E

Genome Biol. 2022 Jul 8;23(1):153

http://www.ncbi.nlm.nih.gov/en...

Health Inequalities by Sexual Orientation: Results from the 2016-2017 Barcelona Health Survey.

Marti-Pastor M, German D, Perez G, Bartoll X, Diez E, Pont A, Garín O, Alonso J, Hernandez G, Mayoral K, Zamora V, Vilagut G, Ferrer M

LGBT Health. 2022 Jul 8;

http://www.ncbi.nlm.nih.gov/en...

Diversity of NKG2C genotypes in a European population - Conserved and recombinant haplotypes in the coding, promoter and 3'-untranslated regions.

Asenjo J, Moraru M, Al-Akioui-Sanz K, Altadill M, Muntasell A, López-Botet M, Vilches C

HLA. 2022 Jul 8;

http://www.ncbi.nlm.nih.gov/en...

Correction to: Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome.

Reula AJTI, Cochino AV, Martins AL, Angosto-Bazarra D, de Landazuri IO, Mensa-Vilaro A, Cabral M, Baroja-Mazo A, Baños MC, Lobato-Salinas Z, Fabregat V, Plaza S, Yagüe J, Casals F, Oliva B, Figueiredo AE, Pelegrín P, Aróstegui JI

J Clin Immunol. 2022 Jul 8;

http://www.ncbi.nlm.nih.gov/en...

Genome-wide transcriptomic changes reveal the genetic pathways involved in insect migration.

Doyle T, Jimenez-Guri E, Hawkes WLS, Massy R, Mantica F, Permanyer J, Cozzuto L, Hermoso Pulido T, Baril T, Hayward A, Irimia M, Chapman JW, Bass C, Wotton KR

Mol Ecol. 2022 Jul 8;

http://www.ncbi.nlm.nih.gov/en...

Unravelling oocyte ultrastructure.

Böke E

Nat Rev Mol Cell Biol. 2022 Jul 7;

http://www.ncbi.nlm.nih.gov/en...

I have an idea and need financing. How to prepare a competitive research project.

Grande L

Cir Esp (Engl Ed). 2022 Jul 2;

http://www.ncbi.nlm.nih.gov/en...

Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.

Midya V, Colicino E, Conti DV, Berhane K, Garcia E, Stratakis N, Andrusaityte S, Basagaña X, Casas M, Fossati S, Gražuleviciene R, Haug LS, Heude B, Maitre L, McEachan R, Papadopoulou E, Roumeliotaki T, Philippat C, Thomsen C, Urquiza J, Vafeiadi M, Varo N, Vos MB, Wright J, McConnell R, Vrijheid M, Chatzi L, Valvi D

JAMA Netw Open. 2022 Jul 1;5(7):e2220176

http://www.ncbi.nlm.nih.gov/en...

Lifetime Dual Disorder Screening and Treatment Retention: A Pilot Cohort Study.

Puértolas-Gracia B, Barbaglia MG, Gotsens M, Parés-Badell O, Brugal MT, Torrens M, Treviño L, Rodríguez-Díaz C, Vázquez-Vázquez JM, Pascual A, Coromina-Gimferrer M, Jiménez-Dueñas M, Oliva I, González E, Mestre N, Bartroli M

J Clin Med. 2022 Jun 28;11(13)

http://www.ncbi.nlm.nih.gov/en...

Informal Employment and Poor Mental Health in a Sample of 180,260 Workers from 13 Iberoamerican Countries.

Silva-Peñaherrera M, Santiá P, Benavides FG

Int J Environ Res Public Health. 2022 Jun 27;19(13)

http://www.ncbi.nlm.nih.gov/en...

ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group.

Pascual J, Attard G, Bidard FC, Curigliano G, De Mattos-Arruda L, Diehn M, Italiano A, Lindberg J, Merker JD, Montagut C, Normanno N, Pantel K, Pentheroudakis G, Popat S, Reis-Filho JS, Tie J, Seoane J, Tarazona N, Yoshino T, Turner NC

Ann Oncol. 2022 Jun 9;

http://www.ncbi.nlm.nih.gov/en...

The sex of scents.

Belles X

Nat Ecol Evol. 2022 Jul 4;

http://www.ncbi.nlm.nih.gov/en...

PCM1::JAK2 fusion associates with an atypical form of mycosis fungoides.

Rodriguez-Sevilla JJ, Salido M, Rodriguez-Rivera M, Sanchez-Gonzalez B, Gallardo F, Pujol RM, Colomo L

Virchows Arch. 2022 Jul 4;

http://www.ncbi.nlm.nih.gov/en...

Usage patterns of oral H1-antihistamines in 10 European countries: A study using MASK-air® and Google Trends real-world data.

Vieira RJ, Sousa-Pinto B, Anto JM, Sheikh A, Klimek L, Zuberbier T, Fonseca JA, Bousquet J

World Allergy Organ J. 2022 Jul;15(7):100660

http://www.ncbi.nlm.nih.gov/en...

¿Hasta qué nivel regional se puede analizar la calidad asistencial?

Marrugat J, Subirana I, Dégano IR

Rev Esp Cardiol (Engl Ed). 2022 Jul 1;

http://www.ncbi.nlm.nih.gov/en...

Regional associations of white matter hyperintensities and early cortical amyloid pathology.

Lorenzini L, Ansems LT, Lopes Alves I, Ingala S, Vállez García D, Tomassen J, Sudre C, Salvadó G, Shekari M, Operto G, Brugulat-Serrat A, Sánchez-Benavides G, Ten Kate M, Tijms B, Wink AM, Mutsaerts HJMM, den Braber A, Visser PJ, van Berckel BNM, Gispert JD, Barkhof F, Collij LE, EPAD consortium for the ALFA cohort .

Brain Commun. 2022;4(3):fcac150

http://www.ncbi.nlm.nih.gov/en...

Green gentrification in European and North American cities.

Anguelovski I, Connolly JJT, Cole H, Garcia-Lamarca M, Triguero-Mas M, Baró F, Martin N, Conesa D, Shokry G, Del Pulgar CP, Ramos LA, Matheney A, Gallez E, Oscilowicz E, Máñez JL, Sarzo B, Beltrán MA, Minaya JM

Nat Commun. 2022 Jul 2;13(1):3816

http://www.ncbi.nlm.nih.gov/en...

Bone loss induced by cancer treatments in breast and prostate cancer patients.

Castañeda S, Casas A, González-Del-Alba A, Martínez-Díaz-Guerra G, Nogués X, Ojeda Thies C, Torregrosa Suau Ó, Rodríguez-Lescure Á

Clin Transl Oncol. 2022 Jul 2;

http://www.ncbi.nlm.nih.gov/en...

Preventing Postendoscopic Mucosal Resection Bleeding of Large Nonpedunculated Colorectal Lesions.

Albéniz E, Montori S, Rodríguez de Santiago E, Lorenzo-Zúñiga V, Álvarez MA, Estremera-Arevalo F, Pohl H

Am J Gastroenterol. 2022 Jul 1;117(7):1080-1088

http://www.ncbi.nlm.nih.gov/en...

The central clock suffices to drive the majority of circulatory metabolic rhythms.

Petrus P, Smith JG, Koronowski KB, Chen S, Sato T, Greco CM, Mortimer T, Welz PS, Zinna VM, Shimaji K, Cervantes M, Punzo D, Baldi P, Muñoz-Cánoves P, Sassone-Corsi P, Aznar Benitah S

Sci Adv. 2022 Jul;8(26):eabo2896

http://www.ncbi.nlm.nih.gov/en...

SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis.

Sans-De San Nicolàs L, Figueras-Nart I, Bonfill-Ortí M, De Jesús-Gil C, García-Jiménez I, Guilabert A, Curto-Barredo L, Bertolín-Colilla M, Ferran M, Serra-Baldrich E, Zalewska-Janowska A, Wang YH, Howell MD, Pujol RM, Santamaria-Babí LF

Allergy. 2022 Jun 30;

http://www.ncbi.nlm.nih.gov/en...

Bmal1-knockout mice exhibit reduced cocaine-seeking behaviour and cognitive impairments.

Castro-Zavala A, Alegre-Zurano L, Cantacorps L, Gallego-Landin I, Welz PS, Benitah SA, Valverde O

Biomed Pharmacother. 2022 Jun 29;153:113333

http://www.ncbi.nlm.nih.gov/en...

Insights to estimate exposure to regulated and non-regulated disinfection by-products in drinking water.

Redondo-Hasselerharm PE, Cserbik D, Flores C, Farré MJ, Sanchís J, Alcolea JA, Planas C, Caixach J, Villanueva CM

J Expo Sci Environ Epidemiol. 2022 Jun 29;

http://www.ncbi.nlm.nih.gov/en...

Stress-induced cell depolarization through the MAP kinase-Cdc42 axis.

Salat-Canela C, Pérez P, Ayté J, Hidalgo E

Trends Cell Biol. 2022 Jun 28;

http://www.ncbi.nlm.nih.gov/en...

Activating cannabinoid receptor 2 preserves axonal health through GSK-3Beta/NRF2 axis in adrenoleukodystrophy.

Parameswaran J, Goicoechea L, Planas-Serra L, Pastor A, Ruiz M, Calingasan NY, Guilera C, Aso E, Boada J, Pamplona R, Portero-Otín M, de la Torre R, Ferrer I, Casasnovas C, Pujol A, Fourcade S

Acta Neuropathol. 2022 Jul 1;

http://www.ncbi.nlm.nih.gov/en...


Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:


Latest news


Innovation

Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar

→ https://www.imim.es/en_dareaestrategica.html

UPF Business Shuttle and Innovation Unit

→ www.upf.edu/web/innovacio

Technology and Business Development Office at the CRG

→ https://tbdo.crg.eu

Analysis and Global Development at ISGlobal

→ www.isglobal.org/es/policy-and-development

EMBLEM Technology Transfer

→ https://embl-em.de

  • The following start-ups have been created within the PRBB environment:

Acellera

Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.

→ https://www.acellera.com

Chemotargets

Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.

→ http://www.chemotargets.com/

qGenomics

qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.

→ https://qgenomics.com

ZeClinics

ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.

→ http://www.zeclinics.com

Microomics

Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.

→ http://www.microomics.eu

Flomics

World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.

→ http://www.flomics.com

Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.

→ https://www.bioinspiredmaterials.com/

MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.

→ https://www.medbioinformatics.com/

Pulmobiotics

A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.

→ https://www.pulmobio.com/

Integra Therapeutics

Integra Therapeutics, a spin-off company from MELIS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.

→ https://integra-tx.com/

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