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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.


Hospital del Mar Medical Research Institute (IMIM)

Cancer

The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 

Neuroscience

The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry. 


Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.

Radiation

The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.

Other

ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.


Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:

⟶ recercaambanimals.prbb.org

⟶ estabulari-prbb@prbb.org

⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news


Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza
marbiobanc@imim.es

Web:
https://marbiobanc.imim.es

The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko
biocore@crg.eu

Web:
https://biocore.crg.eu

The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut
projectmanager@cnag.crg.eu

Web:
https://www.cnag.crg.eu

This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet
bespinet@parcdesalutmar.cat

Web:
https://www.imim.es/sct/citogen_tica

This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas
oscar.fornas@upf.edu

Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit

The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.

Contact: Dirección de secretaría
ceea@prbb.org

Web:
https://www.prbb.org/ciencia.php#Animalario

This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis
bmspt@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit

Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop
CEIC-PSMAR@imim.es

Web:
https://www.imim.es/comitesetics/ceic/es_index.html

The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría
cbs@prbb.org

Web:
https://www.prbb.org (Acceso: Portal PRBB)

BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso
bibliopro@imim.es

Web:
https://www.bibliopro.org

The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro
helpdesk@ega-archive.org

Web:
https://ega-archive.org

This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht
ngs@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/genomics-unit

The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà
margenomics@imim.es

Web:
https://margenomics.imim.es

The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals
genomica@upf.edu

Web:
https://www.upf.edu/web/sct-genomics/home

The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera
laura.batlle@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0

This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea
aaldea@imim.es

Web:
https://www.imim.es/ofertadeserveis/assajos_clinics

This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger
mif@embl.es

Web:
https://www.embl.es/services/mesoscopic-imaging-facility

The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi
nadia.halidi@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit

Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu
david.andreu@upf.edu

Web:
https://www.upf.edu/web/sct-peptide-synthesis

This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade
eduard.sabido@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit


Scientific publications
(keywords, journal, author,...)

A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells.

Martin L, Vicario C, Castells-García Á, Lakadamyali M, Neguembor MV, Cosma MP

STAR Protoc. 2021 Dec 17;2(4):100865

http://www.ncbi.nlm.nih.gov/en...

Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice.

Cabana-Domínguez J, Martín-García E, Gallego-Roman A, Maldonado R, Fernàndez-Castillo N, Cormand B

Transl Psychiatry. 2021 Oct 11;11(1):521

http://www.ncbi.nlm.nih.gov/en...

Routine provision of feedback from patient-reported outcome measurements to healthcare providers and patients in clinical practice.

Gibbons C, Porter I, Gonçalves-Bradley DC, Stoilov S, Ricci-Cabello I, Tsangaris E, Gangannagaripalli J, Davey A, Gibbons EJ, Kotzeva A, Evans J, van der Wees PJ, Kontopantelis E, Greenhalgh J, Bower P, Alonso J, Valderas JM

Cochrane Database Syst Rev. 2021 Oct 12;10:CD011589

http://www.ncbi.nlm.nih.gov/en...

Cross-Sectional Associations Between HDL Structure or Function, Cell Membrane Fatty Acid Composition, and Inflammation in Elderly Adults.

Muralidharan J, Papandreou C, Soria-Florido MT, Sala-Vila A, Blanchart G, Estruch R, Martínez-González MA, Corella D, Ros E, Ruiz-Canela M, Fito M, Salas-Salvadó J, Bulló M

J Nutr. 2021 Oct 12;

http://www.ncbi.nlm.nih.gov/en...

Correction: Characterization of Anorexia Nervosa on Social Media: Textual, Visual, Relational, Behavioral, and Demographical Analysis.

Ramírez-Cifuentes D, Freire A, Baeza-Yates R, Sanz Lamora N, Álvarez A, González-Rodríguez A, Lozano Rochel M, Llobet Vives R, Velazquez DA, Gonfaus JM, Gonzàlez J

J Med Internet Res. 2021 Oct 12;23(10):e33447

http://www.ncbi.nlm.nih.gov/en...

Tapentadol effects on brain response to pain in sensitized patients with knee osteoarthritis.

Pujol J, Martínez-Vilavella G, Doreste A, Blanco-Hinojo L, Ojeda F, Llorente-Onaindia J, Polino L, Deus J, Monfort J

Rheumatology (Oxford). 2021 Oct 12;

http://www.ncbi.nlm.nih.gov/en...

Societal and equity challenges for Brain Health Services. A user manual for Brain Health Services-part 6 of 6.

Milne R, Altomare D, Ribaldi F, Molinuevo JL, Frisoni GB, Brayne C, European Task Force for Brain Health Services.

Alzheimers Res Ther. 2021 Oct 11;13(1):173

http://www.ncbi.nlm.nih.gov/en...

Dementia risk communication. A user manual for Brain Health Services-part 3 of 6.

Visser LNC, Minguillon C, Sánchez-Benavides G, Abramowicz M, Altomare D, Fauria K, Frisoni GB, Georges J, Ribaldi F, Scheltens P, van der Schaar J, Zwan M, van der Flier WM, Molinuevo JL

Alzheimers Res Ther. 2021 Oct 11;13(1):170

http://www.ncbi.nlm.nih.gov/en...

Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services-part 1 of 6.

Altomare D, Molinuevo JL, Ritchie C, Ribaldi F, Carrera E, Dubois B, Jessen F, McWhirter L, Scheltens P, van der Flier WM, Vellas B, Démonet JF, Frisoni GB, European Task Force for Brain Health Services.

Alzheimers Res Ther. 2021 Oct 11;13(1):168

http://www.ncbi.nlm.nih.gov/en...

Protocols for cognitive enhancement. A user manual for Brain Health Services-part 5 of 6.

Brioschi Guevara A, Bieler M, Altomare D, Berthier M, Csajka C, Dautricourt S, Démonet JF, Dodich A, Frisoni GB, Miniussi C, Molinuevo JL, Ribaldi F, Scheltens P, Chételat G

Alzheimers Res Ther. 2021 Oct 11;13(1):172

http://www.ncbi.nlm.nih.gov/en...

Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.

Ranson JM, Rittman T, Hayat S, Brayne C, Jessen F, Blennow K, van Duijn C, Barkhof F, Tang E, Mummery CJ, Stephan BCM, Altomare D, Frisoni GB, Ribaldi F, Molinuevo JL, Scheltens P, Llewellyn DJ, European Task Force for Brain Health Services.

Alzheimers Res Ther. 2021 Oct 11;13(1):169

http://www.ncbi.nlm.nih.gov/en...

The genetic impact of an Ebola outbreak on a wild gorilla population.

Fontsere C, Frandsen P, Hernandez-Rodriguez J, Niemann J, Scharff-Olsen CH, Vallet D, Le Gouar P, Ménard N, Navarro A, Siegismund HR, Hvilsom C, Gilbert MTP, Kuhlwilm M, Hughes D, Marques-Bonet T

BMC Genomics. 2021 Oct 11;22(1):735

http://www.ncbi.nlm.nih.gov/en...

Transanal Total Mesorectal Excision Versus Anterior Total Mesorectal Excision For Rectal Cancer: A Propensity-Score Matched, Population-Based Study In Catalonia, Spain.

Manchon-Walsh P, de Lacy FB, Pera M, Espin-Basany E, Targarona EM, Biondo S, Aliste L, Pallarès N, Tebé C, Pata F, Lacy AM, Guarga A, Borràs JM

Dis Colon Rectum. 2021 Oct 11;

http://www.ncbi.nlm.nih.gov/en...

Revised International Prognostic Index and genetic alterations are associated with early failure to R-CHOP in patients with diffuse large B-cell lymphoma.

Dlouhy I, Karube K, Enjuanes A, Salaverria I, Nadeu F, Ramis-Zaldivar JE, Valero JG, Rivas-Delgado A, Magnano L, Martin-García D, Pérez-Galán P, Clot G, Rovira J, Jares P, Balagué O, Giné E, Mozas P, Briones J, Sancho JM, Salar A, Mercadal S, Alcoceba M, Valera A, Campo E, López-Guillermo A

Br J Haematol. 2021 Oct 10;

http://www.ncbi.nlm.nih.gov/en...

The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment.

Callegaro G, Kunnen SJ, Trairatphisan P, Grosdidier S, Niemeijer M, den Hollander W, Guney E, Piñero Gonzalez J, Furlong L, Webster YW, Saez-Rodriguez J, Sutherland JJ, Mollon J, Stevens JL, van de Water B

Arch Toxicol. 2021 Oct 9;

http://www.ncbi.nlm.nih.gov/en...

A Large Multicenter Prospective Study of Community-Onset Healthcare Associated Bacteremic Urinary Tract Infections in the Era of Multidrug Resistance: Even Worse than Hospital Acquired Infections?

Gómez-Zorrilla S, Becerra-Aparicio F, López Montesinos I, Ruiz de Gopegui E, Grau I, Pintado V, Padilla B, Benito N, Boix-Palop L, Fariñas MC, Peñaranda M, Gamallo MR, Martinez JA, Morte-Romea E, Del Pozo JL, Durán-Jordá X, Díaz-Regañón J, López-Mendoza D, Cantón R, Oliver A, Ruiz-Garbajosa P, Horcajada JP, REIPI/GEIRAS-GEMARA SEIMC ITUBRAS-2 Group.

Infect Dis Ther. 2021 Oct 9;

http://www.ncbi.nlm.nih.gov/en...

Molecular characterization of triple negative breast cancer formaldehyde-fixed paraffin-embedded samples by data-independent acquisition proteomics.

García-Adrián S, Trilla-Fuertes L, Gámez-Pozo A, Chiva C, López-Vacas R, López-Camacho E, Zapater-Moros A, Lumbreras-Herrera MI, Hardisson D, Yébenes L, Zamora P, Sabidó E, Vara JÁF, Espinosa E

Proteomics. 2021 Oct 8;:e2100110

http://www.ncbi.nlm.nih.gov/en...

Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work - the HORMONIT study.

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The effect of short term exposure to outdoor air pollution on fertility.

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Lancet Planet Health. 2021 Oct;5(10):e718-e730

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Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo.

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Mol Syst Biol. 2021 Oct;17(10):e10145

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WHO Air Quality Guidelines 2021-Aiming for Healthier Air for all: A Joint Statement by Medical, Public Health, Scientific Societies and Patient Representative Organisations.

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Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice.

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Sci Transl Med. 2021 Sep 29;13(613):eabe7104

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Conserved ancestral tropical niche but different continental histories explain the latitudinal diversity gradient in brush-footed butterflies.

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Rev Esp Quimioter. 2021 Sep;34 Suppl 1:35-37

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Comparison of Different Methods for Defining Hyperprogressive Disease in NSCLC.

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JTO Clin Res Rep. 2021 Jan;2(1):100115

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Functional Characterization of the Cell Division Gene Cluster of the Wall-less Bacterium Mycoplasma genitalium.

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Life Sci Alliance. 2021 Dec;4(12)

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The human sperm basal body is a complex centrosome important for embryo pre-implantation development.

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A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function: a substudy of the PREDIMED-Plus randomized controlled trial.

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Biomedicines. 2021 Sep 21;9(9)

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Beneficial Effects of Resveratrol in Mouse Gastrocnemius: A Hint to Muscle Phenotype and Proteolysis.

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Iron Replacement and Redox Balance in Non-Anemic and Mildly Anemic Iron Deficiency COPD Patients: Insights from a Clinical Trial.

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J Clin Med. 2021 Sep 7;10(18)

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Intracellular Life Cycle Kinetics of SARS-CoV-2 Predicted Using Mathematical Modelling.

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Liquid Biopsy from research to clinical practice: focus on Non-Small Cell Lung Cancer.

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Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome.

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Uniparental markers and their role in the future of Molecular Anthropology.

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J Anthropol Sci. 2021 Sep 26;99

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TV medical dramas: health sciences students' viewing habits and potential for teaching issues related to bioethics and professionalism.

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BMC Med Educ. 2021 Sep 26;21(1):509

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Peritoneal dialysis in heart failure: focus on kidney and ventricular dysfunction.

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Enhancing the Sensitivity of Memory Tests: Reference Data for the Free and Cued Selective Reminding Test and the Logical Memory Task from Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels.

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Opioid use and misuse in Europe: COVID-19 new challenges?

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Clin Transl Allergy. 2021 Aug;11(7):e12062

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Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke.

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Evaluation of routine CT scans in the follow-up of diffuse large B-cell lymphomas.

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Examining the cooperativity mode of antibody and CD8+ T cell immune responses for vaccinology.

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Trends Immunol. 2021 Oct;42(10):852-855

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Computational methods for RNA modification detection from nanopore direct RNA sequencing data.

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RNA Biol. 2021 Sep 24;:1-10

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Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.

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Designing an app for home-based enriched Music-supported Therapy in the rehabilitation of patients with chronic stroke: a pilot feasibility study.

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Brain Inj. 2021 Sep 23;:1-13

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CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study.

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Author Correction: Engineering self-organized criticality in living cells.

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Determinants of brain swelling in pediatric and adult cerebral malaria.

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JCI Insight. 2021 Sep 22;6(18)

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Tracking progress on health and climate change in Europe.

Romanello M, van Daalen K, Anto JM, Dasandi N, Drummond P, Hamilton IG, Jankin S, Kendrovski V, Lowe R, Rocklöv J, Schmoll O, Semenza JC, Tonne C, Nilsson M

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Activation of EGFR signaling by Tc-Vein and Tc-Spitz regulates the metamorphic transition in the red flour beetle Tribolium castaneum.

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Sci Rep. 2021 Sep 22;11(1):18807

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Negative immune responses to two-dose mRNA COVID-19 vaccines in renal allograft recipients assessed with simple antibody and interferon gamma release assay cellular monitoring.

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Frontal fibrosing alopecia in men: a multicenter study of 39 patients.

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Leflunomide: A safe and effective alternative in systemic lupus erythematosus.

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DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium.

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Spanish normative studies (NEURONORMA-Plus project): norms for the Wisconsin Card Sorting Test, the Modified Taylor Complex Figure, and the Ruff-Light Trail Learning Test.

Pérez-Enríquez C, García-Escobar G, Florido-Santiago M, Piqué-Candini J, Arrondo-Elizarán C, Grau-Guinea L, Pereira-Cuitiño B, Manero RM, Puig-Pijoan A, Peña-Casanova J, Sánchez-Benavides G

Neurologia. 2021 Sep 20;

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Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study.

Rosato V, Gómez-Rubio P, Molina-Montes E, Márquez M, Löhr M, O'Rorke M, Michalski CW, Molero X, Farré A, Perea J, Kleeff J, Crnogorac-Jurcevic T, Greenhalf W, Ilzarbe L, Tardón A, Gress T, Barberá VM, Domínguez-Muñoz E, Muñoz-Bellvís L, Balsells J, Costello E, Iglesias M, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Ye W, Hidalgo M, Sharp L, Carrato A, Real FX, La Vecchia C, Malats N, PanGenEU Study Investigators.

Eur J Cancer Prev. 2021 Nov 1;30(6):423-430

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New-onset and exacerbations of psoriasis after mRNA COVID-19 vaccines: two sides of the same coin?

Pesqué D, Lopez-Trujillo E, Marcantonio O, Giménez-Arnau AM, Pujol RM

J Eur Acad Dermatol Venereol. 2021 Sep 21;

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Alternative splicing regulation of cell cycle genes by SPF45/SR140/CHERP complex controls cell proliferation.

Martin E, Vivori C, Rogalska M, Herrero J, Valcarcel J

RNA. 2021 Sep 20;

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Population screening for liver fibrosis: towards early diagnosis and intervention for chronic liver diseases.

Ginès P, Castera L, Lammert F, Graupera I, Serra-Burriel M, Allen AM, Wong VW, Hartmann P, Thiele M, Caballeria L, de Knegt RJ, Grgurevic I, Augustin S, Tsochatzis EA, Schattenberg JM, Guha IN, Martini A, Morillas RM, Garcia-Retortillo M, de Koning HJ, Fabrellas N, Pich J, Ma AT, Diaz MA, Roulot D, Newsome PN, Manns M, Kamath PS, Krag A, LiverScreen Consortium Investigators.

Hepatology. 2021 Sep 19;

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Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer.

Villanueva CM, Espinosa A, Gracia-Lavedan E, Vlaanderen J, Vermeulen R, Molina AJ, Amiano P, Gómez-Acebo I, Castaño-Vinyals G, Vineis P, Kogevinas M

Environ Int. 2021 Sep 17;157:106873

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Assessment of the Control of Allergic Rhinitis and Asthma Test (CARAT) using MASK-air.

Sousa-Pinto B, Sá-Sousa A, Amaral R, Czarlewski W, Bedbrook A, Anto JM, Bousquet J, Fonseca JA, MASK study group.

J Allergy Clin Immunol Pract. 2021 Sep 16;

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Associations between air pollution and biomarkers of Alzheimer's disease in cognitively unimpaired individuals.

Alemany S, Crous-Bou M, Vilor-Tejedor N, Milà-Alomà M, Suárez-Calvet M, Salvadó G, Cirach M, Arenaza-Urquijo EM, Sanchez-Benavides G, Grau-Rivera O, Minguillon C, Fauria K, Kollmorgen G, Domingo Gispert J, Gascón M, Nieuwenhuijsen M, Zetterberg H, Blennow K, Sunyer J, Luis Molinuevo J, ALFA study.

Environ Int. 2021 Sep 16;157:106864

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Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers.

Català-Castro F, Venturini V, Ortiz-Vásquez S, Ruprecht V, Krieg M

J Vis Exp. 2021 Aug 31;(174)

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Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor Fc-gamma-RIIIb.

Valle Del Barrio B, Maya-Enero S, Rodríguez-Sevilla JJ, Canals Surís C, Bosch Llobet A, López-Vílchez MÁ

Transfus Med Hemother. 2021 Aug;48(4):259-262

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The mRNA-1273 Vaccine Induces Cross-Variant Antibody Responses to SARS-CoV-2 With Distinct Profiles in Individuals With or Without Pre-Existing Immunity.

Tejedor Vaquero S, de Campos-Mata L, Ramada JM, Díaz P, Navarro-Barriuso J, Ribas-Llaurado C, Rodrigo Melero N, Carolis C, Cerutti A, Gimeno R, Magri G

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Salmonella enterica from a soldier from the 1652 siege of Barcelona (Spain) supports historical transatlantic epidemic contacts.

de-Dios T, Carrión P, Olalde I, Llovera Nadal L, Lizano E, Pàmies D, Marques-Bonet T, Balloux F, van Dorp L, Lalueza-Fox C

iScience. 2021 Sep 24;24(9):103021

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Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitisation.

Krantz C, Accordini S, Alving K, Corsico AG, Demoly P, Ferreira DS, Forsberg B, Garcia-Aymerich J, Gislason T, Heinrich J, Jõgi R, Johannessen A, Leynaert B, Marcon A, Martínez-Moratalla Rovira J, Nerpin E, Nowak D, Olin AC, Olivieri M, Pereira-Vega A, Raherison-Semjen C, Real FG, Sigsgaard T, Squillacioti G, Janson C, Malinovschi A, European Community Respiratory Health Survey III.

Clin Exp Allergy. 2021 Sep 18;

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The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Zuberbier T, Abdul Latiff AH, Abuzakouk M, Aquilina S, Asero R, Baker D, Ballmer-Weber B, Bangert C, Ben-Shoshan M, Bernstein JA, Bindslev-Jensen C, Brockow K, Brzoza Z, Chong-Neto HJ, Church MK, Criado PR, Danilycheva IV, Dressler C, Ensina LF, Fonacier L, Gaskins M, Gáspár K, Gelincik A, Giménez-Arnau A, Godse K, Gonçalo M, Grattan C, Grosber M, Hamelmann E, Hébert J, Hide M, Kaplan A, Kapp A, Kessel A, Kocatürk E, Kulthanan K, Larenas-Linnemann D, Lauerma A, Leslie T, Magerl M, Makris M, Meshkova RY, Metz M, Micallef D, Mortz CG, Nast A, Oude-Elberink H, Pawankar R, Pigatto P, Ratti Sisa H, Gutiérrez MIR, Saini SS, Schmid-Grendelmeier P, Sekerel BE, Siebenhaar F, Siiskonen H, Soria A, Staubach-Renz P, Stingeni L, Sussman G, Szegedi A, Thomsen SF, Vadasz Z, Vestergaard C, Wedi B, Zhao Z, Maurer M

Allergy. 2021 Sep 18;

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Are Cutibacterium acnes present at the end of primary shoulder prosthetic surgeries responsible for infection? Prospective study.

Torrens C, Bellosillo B, Gibert J, Alier A, Santana F, Prim N, Corvec S

Eur J Clin Microbiol Infect Dis. 2021 Sep 17;

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SPOP and CHD1 alterations in prostate cancer: Relationship with PTEN loss, tumor grade, perineural infiltration, and PSA recurrence.

Hernández-Llodrà S, Segalés L, Juanpere N, Marta Lorenzo T, Salido M, Nonell L, David López T, Rodríguez-Vida A, Bellmunt J, Fumadó L, Cecchini L, Lloreta-Trull J

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Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation.

Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, Baños MC, Hafner-Bratkovi? I, Oliva B, Pelegrín P

Sci Adv. 2021 Sep 17;7(38):eabf4468

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Yield of clinically reportable genetic variants in unselected cerebral palsy by whole genome sequencing.

van Eyk CL, Webber DL, Minoche AE, Pérez-Jurado LA, Corbett MA, Gardner AE, Berry JG, Harper K, MacLennan AH, Gecz J

NPJ Genom Med. 2021 Sep 16;6(1):74

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The use of secukinumab in an HIV-positive patient with axial spondyloarthritis: a case-based review.

Vílchez-Oya F, Orpinell Palacio L, Castillo Vilella M, González Mena A, Salman-Monte TC

Clin Rheumatol. 2021 Sep 16;

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Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila.

Ullastres A, Merenciano M, González J

Genome Biol. 2021 Sep 14;22(1):265

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Estudios normativos españoles (Proyecto NEURONORMA Plus): normas para las pruebas Delis Kaplan-Design Fluency Test (DK-DFT), Color Trails Tests (CTT) y DualTask (DT)

García-Escobar G, Pérez-Enríquez C, Arrondo-Elizarán C, Pereira-Cuitiño B, Grau-Guinea L, Florido-Santiago M, Piqué-Candini J, Manero RM, Puig-Pijoan A, Peña-Casanova J, Sánchez-Benavides G

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New urban models for more sustainable, liveable and healthier cities post covid19; reducing air pollution, noise and heat island effects and increasing green space and physical activity.

Nieuwenhuijsen MJ

Environ Int. 2021 Sep 6;:106850

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ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer.

Trincado JL, Reixachs-Solé M, Pérez-Granado J, Fugmann T, Sanz F, Yokota J, Eyras E

PLoS Comput Biol. 2021 Sep;17(9):e1009411

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Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome.

Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent J

Chem Sci. 2021 Aug 25;12(33):10990-11003

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Simple sugar intake and cancer incidence, cancer mortality and all-cause mortality: A cohort study from the PREDIMED trial.

Laguna JC, Alegret M, Cofán M, Sánchez-Tainta A, Díaz-López A, Martínez-González MA, Sorlí JV, Salas-Salvadó J, Fitó M, Alonso-Gómez ÁM, Serra-Majem L, Lapetra J, Fiol M, Gómez-Gracia E, Pintó X, Muñoz MA, Castañer O, Ramírez-Sabio JB, Portu JJ, Estruch R, Ros E

Clin Nutr. 2021 Aug 10;40(10):5269-5277

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The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients.

Torres A, Motos A, Riera J, Fernández-Barat L, Ceccato A, Pérez-Arnal R, García-Gasulla D, Peñuelas O, Lorente JA, Rodriguez A, de Gonzalo-Calvo D, Almansa R, Gabarrús A, Menéndez R, Bermejo-Martin JF, Ferrer R, Amaya Villar R, Añón JM, Barberà C, Barberán J, Blandino Ortiz A, Bustamante-Munguira E, Caballero J, Carbajales C, Carbonell N, Catalán-González M, Galbán C, Gumucio-Sanguino VD, de la Torre MDC, Díaz E, Estella Á, Gallego E, García Garmendia JL, Garnacho-Montero J, Gómez JM, Huerta A, Jorge García RN, Loza-Vázquez A, Marin-Corral J, Martínez de la Gándara A, Martínez Varela I, López Messa J, M Albaiceta G, Novo MA, Peñasco Y, Pozo-Laderas JC, Ricart P, Salvador-Adell I, Sánchez-Miralles A, Sancho Chinesta S, Socias L, Solé-Violan J, Suares Sipmann F, Tamayo Lomas L, Trenado J, Barbé F, CIBERESUCICOVID Project (COV20/00110, ISCIII).

Crit Care. 2021 Sep 13;25(1):331

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Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease.

El-Hussuna A, Karer MLM, Uldall Nielsen NN, Mujukian A, Fleshner PR, Iesalnieks I, Horesh N, Kopylov U, Jacoby H, Al-Qaisi HM, Colombo F, Sampietro GM, Marino MV, Ellebæk M, Steenholdt C, Sørensen N, Celentano V, Ladwa N, Warusavitarne J, Pellino G, Zeb A, Di Candido F, Hurtado-Pardo L, Frasson M, Kunovsky L, Yalcinkaya A, Tatar OC, Alonso S, Pera M, Granero AG, Rodríguez CA, Minaya A, Spinelli A, Qvist N

BJS Open. 2021 Sep 6;5(5)

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Usefulness of red cell distribution width to predict mortality in patients undergoing endovascular repair of abdominal aortic aneurysms.

Castellà A, Diaz-Duran C, Velescu A, Galarza A, Miralles M, Clará A

Int Angiol. 2021 Sep 13;

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The Built Environment and Health in Low- and Middle-Income Countries: a Review on Quantitative Health Impact Assessments.

Thondoo M, Goel R, Tatah L, Naraynen N, Woodcock J, Nieuwenhuijsen M

Curr Environ Health Rep. 2021 Sep 13;

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Assessment of aphasia: dialectical and cultural considerations in neurology.

Peña-Casanova J, Vinaixa L, Diéguez-Vide F, Gramunt-Fombuena N, Soler-Campillo A

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Bariatric surgery improves metabolic and nonalcoholic fatty liver disease markers in metabolically healthy patients with morbid obesity at 5 years.

Goday A, Julià H, de Vargas-Machuca A, Pedro-Botet J, Benavente S, Ramon JM, Pera M, Casajoana A, Villatoro M, Fontané L, Bisbe M, Climent E, Castañer O, Flores Le Roux JA, Benaiges D

Surg Obes Relat Dis. 2021 Aug 12;

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CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis.

Comabella M, Sastre-Garriga J, Borras E, Villar LM, Saiz A, Martínez-Yélamos S, García-Merino JA, Pinteac R, Fissolo N, Sánchez López AJ, Costa-Frossard L, Blanco Y, Llufriu S, Vidal-Jordana A, Sabidó E, Montalban X

Neurol Neuroimmunol Neuroinflamm. 2021 Nov;8(6)

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MOrgAna: accessible quantitative analysis of organoids with machine learning.

Gritti N, Lim JL, Anla? K, Pandya M, Aalderink G, Martínez-Ara G, Trivedi V

Development. 2021 Sep 15;148(18)

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HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders.

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Sci Rep. 2021 Sep 8;11(1):17823

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Author Correction: The utility of Next Generation Sequencing for molecular diagnostics in Rett syndrome.

Vidal S, Brandi N, Pacheco P, Gerotina E, Blasco L, Trotta JR, Derdak S, Del Mar O'Callaghan M, Garcia-Cazorla À, Pineda M, Armstrong J, Rett Working Group.

Sci Rep. 2021 Sep 7;11(1):18146

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Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts.

Papadopoulou E, Stratakis N, Basagaña X, Brantsæter AL, Casas M, Fossati S, Gražulevi?ien? R, Småstuen Haug L, Heude B, Maitre L, McEachan RRC, Robinson O, Roumeliotaki T, Sabidó E, Borràs E, Urquiza J, Vafeiadi M, Zhao Y, Slama R, Wright J, Conti DV, Vrijheid M, Chatzi L

Environ Int. 2021 Sep 6;157:106853

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Air Pollution, Residential Greenness and Metabolic Dysfunction during Early Pregnancy in the INfancia y Medio Ambiente (INMA) Cohort.

Rammah A, Whitworth KW, Amos CI, Estarlich M, Guxens M, Ibarluzea J, Iñiguez C, Subiza-Pérez M, Vrijheid M, Symanski E

Int J Environ Res Public Health. 2021 Sep 4;18(17)

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Mental Health Outcomes in Barcelona: The Interplay between Gentrification and Greenspace.

Zayas-Costa M, Cole HVS, Anguelovski I, Connolly JJT, Bartoll X, Triguero-Mas M

Int J Environ Res Public Health. 2021 Sep 3;18(17)

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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

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Nat Genet. 2021 Sep;53(9):1311-1321

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Falaguera MJ, Mestres J

Molecules. 2021 Aug 30;26(17)

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J Affect Disord. 2021 Aug 27;295:578-586

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SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naïve-like and memory B-cell responses.

de Campos-Mata L, Tejedor Vaquero S, Tachó-Piñot R, Piñero J, Grasset EK, Arrieta Aldea I, Rodrigo Melero N, Carolis C, Horcajada JP, Cerutti A, Villar-García J, Magri G

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Editorial: Drug Repurposing for COVID-19 Therapy.

Maldonado R, Drago F

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Widespread ribosome stalling in a genome-reduced bacterium and the need for translational quality control.

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Domínguez-Andrés J, Kuijpers Y, Bakker OB, Jaeger M, Xu CJ, Van der Meer JW, Jakobsson M, Bertranpetit J, Joosten LA, Li Y, Netea MG

Elife. 2021 Sep 7;10

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García-Eguren G, González-Ramírez M, Vizán P, Giró O, Vega-Beyhart A, Boswell L, Mora M, Halperin I, Carmona F, Gracia M, Casals G, Squarcia M, Enseñat J, Vidal O, Di Croce L, Hanzu FA

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Impact and Management of COVID-19 Among Healthcare Workers in Two Acute Care Hospitals and Two Associated Long-term Care Centres in Barcelona, Spain.

Montero-Moraga JM, Buron A, Sala M, Santia P, Lupia M, Beltrán A, Villar R, Horcajada JP, Castells X, Gil OD, León EP, Serra C

J Occup Environ Med. 2021 Sep 1;63(9):e586-e591

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Interplay Between Notch and YAP/TAZ Pathways in the Regulation of Cell Fate During Embryo Development.

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Long-Term Evolution of the Adaptive NKG2C+ NK Cell Response to Cytomegalovirus Infection in Kidney Transplantation: An Insight on the Diversity of Host-Pathogen Interaction.

Ataya M, Redondo-Pachón D, Llinàs-Mallol L, Yélamos J, Alari-Pahissa E, Pérez-Sáez MJ, Altadill M, Raïch-Regué D, Vilches C, Pascual J, Crespo M, López-Botet M

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Working life, health and well-being of parents: a joint effort to uncover hidden treasures in European birth cohorts.

Ubalde-Lopez M, Garani-Papadatos T, Scelo G, Casas M, Lissåker C, Peters S, Nohr EA, Albin M, Lucas R, Papantoniou K, Pola?ska K, Ramlau-Hansen CH, Šarac J, Selander J, Skröder H, Vasileiou E, Kogevinas M, Bültmann U, Mehlum IS, Maule M

Scand J Work Environ Health. 2021 Oct 1;47(7):550-560

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Ancient and modern genomes unravel the evolutionary history of the rhinoceros family.

Liu S, Westbury MV, Dussex N, Mitchell KJ, Sinding MS, Heintzman PD, Duchêne DA, Kapp JD, von Seth J, Heiniger H, Sánchez-Barreiro F, Margaryan A, André-Olsen R, De Cahsan B, Meng G, Yang C, Chen L, van der Valk T, Moodley Y, Rookmaaker K, Bruford MW, Ryder O, Steiner C, Bruins-van Sonsbeek LGR, Vartanyan S, Guo C, Cooper A, Kosintsev P, Kirillova I, Lister AM, Marques-Bonet T, Gopalakrishnan S, Dunn RR, Lorenzen ED, Shapiro B, Zhang G, Antoine PO, Dalén L, Gilbert MTP

Cell. 2021 Sep 16;184(19):4874-4885.e16

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Validation of 3D printing materials for high dose-rate brachytherapy using ionisation chamber and custom phantom.

Pera O, Membrive I, Lambisto D, Quera J, Fernandez-Velilla E, Foro P, Reig A, Rodríguez N, Sanz J, Algara V, Algara M

Phys Med Biol. 2021 Sep 14;66(18)

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CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration.

Sreenivasan K, Rodríguez-delaRosa A, Kim J, Mesquita D, Segalés J, Arco PG, Espejo I, Ianni A, Di Croce L, Relaix F, Redondo JM, Braun T, Serrano AL, Perdiguero E, Muñoz-Cánoves P

Stem Cell Reports. 2021 Sep 14;16(9):2089-2098

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Resting heart rate, cardiovascular events, and all-cause mortality: the REGICOR study.

Puig E, Clará A, Pérez S, Degano IR, Subirana I, García-García C, Martí R, Ramos R, Marrugat J, Elosua R

Eur J Prev Cardiol. 2021 Sep 3;

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Prediction of ventilator-associated pneumonia outcomes according to the early microbiological response: a retrospective observational study.

Ceccato A, Dominedò C, Ferrer M, Martin-Loeches I, Barbeta E, Gabarrús A, Cillóniz C, Ranzani OT, De Pascale G, Nogas S, Di Giannatale P, Antonelli M, Torres A

Eur Respir J. 2021 Sep 2;

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Differential contribution to gene expression prediction of histone modifications at enhancers or promoters.

González-Ramírez M, Ballaré C, Mugianesi F, Beringer M, Santanach A, Blanco E, Di Croce L

PLoS Comput Biol. 2021 Sep;17(9):e1009368

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Drosophila Evolution over Space and Time (DEST) - A New Population Genomics Resource.

Kapun M, Nunez JCB, Bogaerts-Márquez M, Murga-Moreno J, Paris M, Outten J, Coronado-Zamora M, Tern C, Rota-Stabelli O, García Guerreiro MP, Casillas S, Orengo DJ, Puerma E, Kankare M, Ometto L, Loeschcke V, Onder BS, Abbott JK, Schaeffer SW, Rajpurohit S, Behrman EL, Schou MF, Merritt TJS, Lazzaro BP, Glaser-Schmitt A, Argyridou E, Staubach F, Wang Y, Tauber E, Serga SV, Fabian DK, Dyer KA, Wheat CW, Parsch J, Grath S, Veselinovic MS, Stamenkovic-Radak M, Jelic M, Buendía-Ruíz AJ, Gómez-Julián MJ, Espinosa-Jimenez ML, Gallardo-Jiménez FD, Patenkovic A, Eric K, Tanaskovic M, Ullastres A, Guio L, Merenciano M, Guirao-Rico S, Horváth V, Obbard DJ, Pasyukova E, Alatortsev VE, Vieira CP, Vieira J, Torres JR, Kozeretska I, Maistrenko OM, Montchamp-Moreau C, Mukha DV, Machado HE, Lamb K, Paulo T, Yusuf L, Barbadilla A, Petrov D, Schmidt P, Gonzalez J, Flatt T, Bergland AO

Mol Biol Evol. 2021 Sep 1;

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The association between air pollutants and hippocampal volume from magnetic resonance imaging: A systematic review and meta-analysis.

Balboni E, Filippini T, Crous-Bou M, Guxens M, Erickson LD, Vinceti M

Environ Res. 2021 Sep 1;204(Pt A):111976

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Use of Linear Ion Traps in Data-Independent Acquisition Methods Benefits Low-Input Proteomics.

Borràs E, Pastor O, Sabidó E

Anal Chem. 2021 Aug 31;93(34):11649-11653

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Frailty and kidney transplant candidates.

Pérez-Sáez MJ, Gutiérrez-Dalmau Á, Moreso F, Rodríguez-Mañas L, Pascual J

Nefrologia. 2021 May-Jun;41(3):237-243

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Studying evolution of the primary body axis in vivo and in vitro.

Anlas K, Trivedi V

Elife. 2021 Aug 31;10

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Molecular and functional profiling identifies therapeutically targetable vulnerabilities in plasmablastic lymphoma.

Frontzek F, Staiger AM, Zapukhlyak M, Xu W, Bonzheim I, Borgmann V, Sander P, Baptista MJ, Heming JN, Berning P, Wullenkord R, Erdmann T, Lutz M, Veratti P, Ehrenfeld S, Wienand K, Horn H, Goodlad JR, Wilson MR, Anagnostopoulos I, Lamping M, Gonzalez-Barca E, Climent F, Salar A, Castellvi J, Abrisqueta P, Menarguez J, Aldamiz T, Richter J, Klapper W, Tzankov A, Dirnhofer S, Rosenwald A, Mate JL, Tapia G, Lenz P, Miething C, Hartmann W, Chapuy B, Fend F, Ott G, Navarro JT, Grau M, Lenz G

Nat Commun. 2021 Aug 31;12(1):5183

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A randomized phase II study comparing consolidation with a single dose of 90Y ibritumomab tiuxetan vs. maintenance with rituximab for two years in patients with newly diagnosed follicular lymphoma responding to R-CHOP. Long-term follow-up results.

López-Guillermo A, Canales MÁ, Dlouhy I, Mercadal S, Briones J, Martín García-Sancho A, Sancho JM, Moraleda JM, Terol MJ, Salar A, Palomera L, Gardella S, Jarque I, Ferrer S, Bargay J, López A, Panizo C, Muntañola A, Montalbán C, Conde E, Hernández MT, Soler A, García Marco JA, Deben G, Marín J, Tomás JF, PETHEMA/GELTAMO/GELCAB Spanish Intergroup.

Leuk Lymphoma. 2021 Aug 30;:1-8

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Insights into the mechanisms underlying aberrant SOX11 oncogene expression in mantle cell lymphoma.

Vilarrasa-Blasi R, Verdaguer-Dot N, Belver L, Soler-Vila P, Beekman R, Chapaprieta V, Kulis M, Queirós AC, Parra M, Calasanz MJ, Agirre X, Prosper F, Beà S, Colomer D, Marti-Renom MA, Ferrando A, Campo E, Martin-Subero JI

Leukemia. 2021 Aug 28;

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Automatic screening of self-evaluation apps for urticaria and angioedema shows a high unmet need.

Antó A, Maurer R, Gimenez-Arnau A, Cherrez-Ojeda I, Hawro T, Magerl M, Metz M, Weller K, Zuberbier T, Bousquet J, Maurer M

Allergy. 2021 Aug 26;

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SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports.

Martin-Cardona A, Lloreta Trull J, Albero-González R, Paraira Beser M, Andújar X, Ruiz-Ramirez P, Tur-Martínez J, Ferrer C, De Marcos Izquierdo JA, Pérez-Madrigal A, Goiburú González L, Espinós Perez J, Esteve M

BMC Gastroenterol. 2021 Aug 26;21(1):334

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HBM4EU combines and harmonises human biomonitoring data across the EU, building on existing capacity - The HBM4EU survey.

Gilles L, Govarts E, Rambaud L, Vogel N, Castaño A, Esteban López M, Rodriguez Martin L, Koppen G, Remy S, Vrijheid M, Montazeri P, Birks L, Sepai O, Stewart L, Fiddicke U, Loots I, Knudsen LE, Kolossa-Gehring M, Schoeters G

Int J Hyg Environ Health. 2021 Aug 26;237:113809

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Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study.

Ferrero-De-Loma-Osorio Á, Cózar R, García-Alberola A, Valles E, Barrera A, Toquero J, Ormaetxe JM, Sánchez JM, Ruiz-Granell R, Amador PB, Rubio JM, Martí-Amor J, Pascual P, Molina I, Martínez-Alday JD, RECABA Investigators.

Sci Rep. 2021 Aug 26;11(1):17268

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Objectively Measured Physical Activity in Patients with COPD: Recommendations from an International Task Force on Physical Activity.

Demeyer H, Mohan D, Burtin C, Vaes A, Heasley M, Bowler R, Casaburi R, Cooper CB, Corriol-Rohou S, Frei A, Hamilton A, Hopkinson NS, Karlsson N, Man WD, Moy ML, Pitta F, Polkey MI, Puhan M, Rennard SI, Rochester CL, Rossiter HB, Sciurba F, Singh S, Tal-Singer R, Vogiatzis I, Watz H, Lummel RV, Wyatt J, Merrill DD, Spruit MA, Garcia-Aymerich J, Troosters T, COPD Biomarker Qualification Consortium (CBQC) Task Force on Physical Activity.

Chronic Obstr Pulm Dis. 2021 Aug 25;

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Active use and perceptions of parks as urban assets for physical activity: A mixed-methods study.

Fontán-Vela M, Rivera-Navarro J, Gullón P, Díez J, Anguelovski I, Franco M

Health Place. 2021 Aug 25;71:102660

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Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU.

Estella Á, Vidal-Cortés P, Rodríguez A, Andaluz Ojeda D, Martín-Loeches I, Díaz E, Suberviola B, Gracia Arnillas MP, Catalán González M, Álvarez-Lerma F, Ramírez P, Nuvials X, Borges M, Zaragoza R

Med Intensiva (Engl Ed). 2021 Aug 24;

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Regulation of metamorphosis in neopteran insects is conserved in the paleopteran Cloeon dipterum (Ephemeroptera).

Kamsoi O, Ventos-Alfonso A, Casares F, Almudi I, Belles X

Proc Natl Acad Sci U S A. 2021 Aug 24;118(34)

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Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth.

Everson TM, Vives-Usano M, Seyve E, Cardenas A, Lacasaña M, Craig JM, Lesseur C, Baker ER, Fernandez-Jimenez N, Heude B, Perron P, Gónzalez-Alzaga B, Halliday J, Deyssenroth MA, Karagas MR, Íñiguez C, Bouchard L, Carmona-Sáez P, Loke YJ, Hao K, Belmonte T, Charles MA, Martorell-Marugán J, Muggli E, Chen J, Fernández MF, Tost J, Gómez-Martín A, London SJ, Sunyer J, Marsit CJ, Lepeule J, Hivert MF, Bustamante M

Nat Commun. 2021 Aug 24;12(1):5095

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Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome.

Real de Asua D, Mayer MA, Ortega MDC, Borrel JM, Bermejo TJ, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M

J Clin Med. 2021 Aug 23;10(16)

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Childhood adversities and suicidal thoughts and behaviors among first-year college students: results from the WMH-ICS initiative.

Mortier P, Alonso J, Auerbach RP, Bantjes J, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Green JG, Hasking P, Karyotaki E, Kiekens G, Mak A, Nock MK, O'Neill S, Pinder-Amaker S, Sampson NA, Stein DJ, Vilagut G, Wilks C, Zaslavsky AM, Mair P, Kessler RC, WHO WMH-ICS Collaborators.

Soc Psychiatry Psychiatr Epidemiol. 2021 Aug 23;

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Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology.

Dávila-Bouziguet E, Casòliba-Melich A, Targa-Fabra G, Galera-López L, Ozaita A, Maldonado R, Ávila J, Delgado-García JM, Gruart A, Soriano E, Pascual M

Brain. 2021 Aug 23;

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Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults.

Arnau-Barrés I, Pascual-Dapena A, López-Montesinos I, Gómez-Zorrilla S, Sorlí L, Herrero M, Nogués X, Montero M, Vázquez O, García-Giralt N, Miralles R, Güerri-Fernández R

J Clin Med. 2021 Aug 23;10(16)

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Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation.

Arenas MC, Castro-Zavala A, Martín-Sánchez A, Blanco-Gandía MC, Miñarro J, Valverde O, Manzanedo C

Behav Brain Res. 2021 Aug 23;416:113545

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Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.

Ruiz de Garibay G, Fernandez-Garcia I, Mazoyer S, Leme de Calais F, Ameri P, Vijayakumar S, Martinez-Ruiz H, Damiola F, Barjhoux L, Thomassen M, Andersen LVB, Herranz C, Mateo F, Palomero L, Espín R, Gómez A, García N, Jimenez D, Bonifaci N, Extremera AI, Castaño J, Raya A, Eyras E, Puente XS, Brunet J, Lázaro C, GEMO., CIMBA., Radice P, Barnes DR, Antoniou AC, Spurdle AB, de la Hoya M, Baralle D, Barcellos-Hoff MH, Pujana MA

Hum Mutat. 2021 Aug 22;

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Health-related quality of life with palbociclib plus endocrine therapy versus capecitabine in postmenopausal patients with hormone receptor-positive metastatic breast cancer: Patient-reported outcomes in the PEARL study.

Kahan Z, Gil-Gil M, Ruiz-Borrego M, Carrasco E, Ciruelos E, Muñoz M, Bermejo B, Margeli M, Antón A, Casas M, Csöszi T, Murillo L, Morales S, Calvo L, Lang I, Alba E, de la Haba-Rodriguez J, Ramos M, López IÁ, Gal-Yam E, Garcia-Palomo A, Alvarez E, González-Santiago S, Rodríguez CA, Servitja S, Corsaro M, Rodrigálvarez G, Zielinski C, Martín M

Eur J Cancer. 2021 Aug 20;156:70-82

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ExOrthist: a tool to infer exon orthologies at any evolutionary distance.

Márquez Y, Mantica F, Cozzuto L, Burguera D, Hermoso-Pulido A, Ponomarenko J, Roy SW, Irimia M

Genome Biol. 2021 Aug 20;22(1):239

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Large Between-Patient Variability in eGFR Decline Before Clinical Trial Enrollment and Impact on Atrasentan's Efficacy - A Post-Hoc Analysis From the SONAR Trial.

Waijer S, de Vries S, Busch R, Xie D, Gansevoort R, Hou FF, Gorriz J, Laverman G, De Nicola L, Pascual J, Provenzano M, Pergola P, Tang S, Wanner C, Zaoui P, Parving HH, de Zeeuw D, Heerspink H

J Am Soc Nephrol. 2021 Aug 20;

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Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial.

Ehrmann S, Li J, Ibarra-Estrada M, Perez Y, Pavlov I, McNicholas B, Roca O, Mirza S, Vines D, Garcia-Salcido R, Aguirre-Avalos G, Trump MW, Nay MA, Dellamonica J, Nseir S, Mogri I, Cosgrave D, Jayaraman D, Masclans JR, Laffey JG, Tavernier E, Awake Prone Positioning Meta-Trial Group.

Lancet Respir Med. 2021 Aug 20;

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The role of social support, detachment, and depressive and anxiety symptoms in suicidal thoughts and behaviours during the Covid-19 lockdown: Potential pathways.

Gabarrell-Pascuet A, Félez-Nóbrega M, Cristóbal-Narváez P, Mortier P, Vilagut G, Olaya B, Alonso J, Haro JM, Domènech-Abella J

Curr Psychol. 2021 Aug 19;:1-12

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Balanced and unbalanced translocations in a multicentric series of 2843 patients with chronic lymphocytic leukemia.

Costa D, Granada I, Espinet B, Collado R, Ruiz-Xivillé N, Puiggros A, Uribe M, Arias A, Gómez C, Delgado J, Pereira A, Magnano L, Colomer D, López C, Beà S

Genes Chromosomes Cancer. 2021 Aug 19;

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Associations between pre- and postnatal exposure to air pollution and lung health in children and assessment of CC16 as a potential mediator.

Stapleton A, Casas M, García J, García R, Sunyer J, Guerra S, Abellan A, Lavi I, Dobaño C, Vidal M, Gascon M

Environ Res. 2021 Aug 19;204(Pt A):111900

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Translational control by DHX36 binding to 5'UTR G-quadruplex is essential for muscle stem-cell regenerative functions.

Chen X, Yuan J, Xue G, Campanario S, Wang D, Wang W, Mou X, Liew SW, Umar MI, Isern J, Zhao Y, He L, Li Y, Mann CJ, Yu X, Wang L, Perdiguero E, Chen W, Xue Y, Nagamine Y, Kwok CK, Sun H, Muñoz-Cánoves P, Wang H

Nat Commun. 2021 Aug 19;12(1):5043

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Association between occupational exposure to irritant agents and a distinct asthma endotype in adults.

Andrianjafimasy MV, Febrissy M, Zerimech F, Dananché B, Kromhout H, Matran R, Nadif M, Oberson-Geneste D, Quinot C, Schlünssen V, Siroux V, Zock JP, Le Moual N, Nadif R, Dumas O

Occup Environ Med. 2021 Aug 19;

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A Comparison of Acute Pharmacological Effects of Methylone and MDMA Administration in Humans and Oral Fluid Concentrations as Biomarkers of Exposure.

Poyatos L, Papaseit E, Olesti E, Pérez-Mañá C, Ventura M, Carbón X, Grifell M, Fonseca F, Torrens M, de la Torre R, Farré M

Biology (Basel). 2021 Aug 17;10(8)

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Predictors of return to work after autologous stem cell transplantation in patients with multiple myeloma.

Granell M, Senín A, Barata A, Cibeira MT, Gironella M, López-Pardo J, Motlló C, Garcia-Guiñón A, Ben-Azaiz R, Abella E, Soler A, Canet M, Martí JM, Martino R, Sierra J, de Larrea CF, Oriol A, Rosiñol L, Group for the Study of Myeloma and Amyloidosis of Catalonia (GEMMAC).

Bone Marrow Transplant. 2021 Aug 17;

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Estimating personal solar ultraviolet radiation exposure through time spent outdoors, ambient levels and modelling approaches.

Soueid L, Triguero-Mas M, Dalmau A, Barrera-Gómez J, Alonso L, Basagaña X, Thieden E, Wulf HC, Diffey B, Young AR, Nieuwenhuijsen M, Dadvand P

Br J Dermatol. 2021 Aug 17;

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Publisher Correction: Assessment of the gene mosaicism burden in blood and its implications for immune disorders.

Solís-Moruno M, Mensa-Vilaró A, Batlle-Masó L, Lobón I, Bonet N, Marquès-Bonet T, Aróstegui JI, Casals F

Sci Rep. 2021 Aug 17;11(1):17030

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Tracing the evolutionary history of Ca2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP3 receptor ortholog.

Rosa N, Shabardina V, Ivanova H, Sebé-Pedrós A, Yule DI, Bultynck G

Biochim Biophys Acta Mol Cell Res. 2021 Aug 14;1868(12):119121

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Curcumin and Resveratrol Improve Muscle Function and Structure through Attenuation of Proteolytic Markers in Experimental Cancer-Induced Cachexia.

Penedo-Vázquez A, Duran X, Mateu J, López-Postigo A, Barreiro E

Molecules. 2021 Aug 13;26(16)

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Metabolic, Affective and Neurocognitive Characterization of Metabolic Syndrome Patients with and without Food Addiction. Implications for Weight Progression.

Camacho-Barcia L, Munguía L, Lucas I, de la Torre R, Salas-Salvadó J, Pintó X, Corella D, Granero R, Jiménez-Murcia S, González-Monje I, Esteve-Luque V, Cuenca-Royo A, Gómez-Martínez C, Paz-Graniel I, Forcano L, Fernández-Aranda F

Nutrients. 2021 Aug 13;13(8)

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Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles.

Henao Arias DC, Toro LJ, Téllez Ramirez GA, Osorio-Méndez JF, Rodríguez-Carlos A, Valle J, Marín-Luevano SP, Rivas-Santiago B, Andreu D, Castaño Osorio JC

Peptides. 2021 Aug 12;145:170626

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Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID).

Blanco-Fernández G, Fondevila-Campo C, Sanjuanbenito A, Fabregat-Prous J, Secanella-Medayo L, Rotellar-Sastre F, Pardo-Sánchez F, Prieto-Calvo M, Marín-Ortega H, Sánchez-Cabús S, Diez-Valladares L, Alonso-Casado Ó, González-Serrano C, Rodríguez-Sanjuan JC, García-Plaza G, Jaén-Torrejimeno I, Suárez-Muñoz MÁ, Becerra-Massare A, Rio PS, Pando E, López-Andújar R, Muñoz-Forner E, Rodriguez-López M, Pereira F, Serrablo-Requejo A, Turrión VS, Garrido MJ, Burdío F, Martín-Pérez E, Estevan-Estevan R, López-Guerra D, Castell-Gómez J, Salinas-Gómez J, López-Baena JÁ, López-Ben S, Solar-García L, Pérez-Alonso AJ, Martínez-Insfran LA, Blas JL, Cornejo M, Gutierrez-Calvo A, Pozo CD, Ochando-Cerdan F, Muñoz-Bellvís L, Rebollar-Saenz J, Sánchez B, Jover JM, Gómez-Bravo MÁ, Ramia JM, Rojas-Holguín A

Eur J Surg Oncol. 2021 Aug 11;

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Phenotypic Clustering in Non-Cystic Fibrosis Bronchiectasis Patients: The Role of Eosinophils in Disease Severity.

Wang X, Villa C, Dobarganes Y, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, Golpe R, Menéndez R, Rodríguez-López J, Prados C, Martinez-García MA, Rodriguez JL, de la Rosa D, Duran X, Garcia-Ojalvo J, Barreiro E

Int J Environ Res Public Health. 2021 Aug 10;18(16)

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Left Atrium Assessment by Speckle Tracking Echocardiography in Cryptogenic Stroke: Seeking Silent Atrial Fibrillation.

Ble M, Benito B, Cuadrado-Godia E, Pérez-Fernández S, Gómez M, Mas-Stachurska A, Tizón-Marcos H, Molina L, Martí-Almor J, Cladellas M

J Clin Med. 2021 Aug 9;10(16)

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Cataract Surgery in Elderly Subjects with Heterozygous Familial Hypercholesterolemia in Prolonged Treatment with Statins.

Marco-Benedí V, Laclaustra M, Sánchez-Hernández RM, Ortega-Martínez de Victoria E, Pedro-Botet J, Puzo J, Civeira F

J Clin Med. 2021 Aug 8;10(16)

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Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses.

Cañas-Arranz R, de León P, Defaus S, Torres E, Forner M, Bustos MJ, Andreu D, Blanco E, Sobrino F

Molecules. 2021 Aug 4;26(16)

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Antimicrobial Consumption among 66 Acute Care Hospitals in Catalonia: Impact of the COVID-19 Pandemic.

Grau S, Hernández S, Echeverría-Esnal D, Almendral A, Ferrer R, Limón E, Horcajada JP, Catalan Infection Control and Antimicrobial Stewardship Program (VINCat-PROA).

Antibiotics (Basel). 2021 Aug 4;10(8)

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Corrigendum to: Gene Similarity Networks Unveil a Potential Novel Unicellular Group Closely Related to Animals from the Tara Oceans Expedition.

Arroyo AS, Iannes R, Bapteste E, Ruiz-Trillo I

Genome Biol Evol. 2021 Aug 3;13(8)

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CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals.

Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuévo JL, Engelborghs S, Freund-Levi Y, Froelich L, Bertram L, Lovestone S, Streffer J, Vos S, Adni, Blennow K, Scheltens P, Zetterberg H, Visser PJ

Proteomes. 2021 Aug 2;9(3)

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NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake.

Alari-Pahissa E, Ataya M, Moraitis I, Campos-Ruiz M, Altadill M, Muntasell A, Moles A, López-Botet M

PLoS Pathog. 2021 Aug;17(8):e1009868

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Data set from large-scale citizen science provides high-resolution nitrogen dioxide values for enhancing community knowledge and collective action to related health issues.

Perelló J, Cigarini A, Vicens J, Bonhoure I, Rojas-Rueda D, Nieuwenhuijsen MJ, Cirach M, Daher C, Targa J, Ripoll A

Data Brief. 2021 Aug;37:107269

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The Association of Nighttime Fasting Duration and Prostate Cancer Risk: Results from the Multicase-Control (MCC) Study in Spain.

Palomar-Cros A, Espinosa A, Straif K, Pérez-Gómez B, Papantoniou K, Gómez-Acebo I, Molina-Barceló A, Olmedo-Requena R, Alguacil J, Fernández-Tardón G, Casabonne D, Aragonés N, Castaño-Vinyals G, Pollán M, Romaguera D, Kogevinas M

Nutrients. 2021 Jul 30;13(8)

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Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study.

Wang X, Villa C, Dobarganes Y, Olveira C, Girón R, García-Clemente M, Maíz L, Sibila O, Golpe R, Menéndez R, Rodríguez-López J, Prados C, Martinez-García MA, Rodriguez JL, de la Rosa D, Duran X, Barreiro E

Biomedicines. 2021 Jul 28;9(8)

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Association of Kidney Disease, Potassium, and Cardiovascular Risk Factor Prevalence with Coronary Arteriosclerotic Burden, by Sex.

Lizama PM, Ríos DL, Cachinero IS, Lopez-Egea AT, Camps A, Belzares O, Pacheco C, Cerro C, Wehinger S, Fuentes E, Marrugat J, Palomo I

J Pers Med. 2021 Jul 27;11(8)

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Modelling the Human Placental Interface In Vitro-A Review.

Cherubini M, Erickson S, Haase K

Micromachines (Basel). 2021 Jul 27;12(8)

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Mortality in Hemodialysis Patients with COVID-19, the Effect of Paricalcitol or Calcimimetics.

Arenas Jimenez MD, González-Parra E, Riera M, Rincón Bello A, López-Herradón A, Cao H, Hurtado S, Collado S, Ribera L, Barbosa F, Dapena F, Torregrosa V, Broseta JJ, Soto Montañez C, Navarro-González JF, Ramos R, Bover J, Nogués-Solan X, Crespo M, Dusso AS, Pascual J

Nutrients. 2021 Jul 26;13(8)

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The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease.

Urpi-Sarda M, Casas R, Sacanella E, Corella D, Andrés-Lacueva C, Llorach R, Garrabou G, Cardellach F, Sala-Vila A, Ros E, Ruiz-Canela M, Fitó M, Salas-Salvadó J, Estruch R

Biomedicines. 2021 Jul 22;9(8)

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Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.

Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A

Mol Syndromol. 2021 Jul;12(4):202-218

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The discovery, distribution, and diversity of DNA viruses associated with Drosophila melanogaster in Europe.

Wallace MA, Coffman KA, Gilbert C, Ravindran S, Albery GF, Abbott J, Argyridou E, Bellosta P, Betancourt AJ, Colinet H, Eric K, Glaser-Schmitt A, Grath S, Jelic M, Kankare M, Kozeretska I, Loeschcke V, Montchamp-Moreau C, Ometto L, Onder BS, Orengo DJ, Parsch J, Pascual M, Patenkovic A, Puerma E, Ritchie MG, Rota-Stabelli O, Schou MF, Serga SV, Stamenkovic-Radak M, Tanaskovic M, Veselinovic MS, Vieira J, Vieira CP, Kapun M, Flatt T, González J, Staubach F, Obbard DJ

Virus Evol. 2021 Jan;7(1):veab031

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Editorial: Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!

Dierssen M, Barone E

Front Neurosci. 2021;15:730378

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Awareness of Cognitive Decline in Patients With Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Cacciamani F, Houot M, Gagliardi G, Dubois B, Sikkes S, Sánchez-Benavides G, Denicolò E, Molinuevo JL, Vannini P, Epelbaum S

Front Aging Neurosci. 2021;13:697234

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Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression.

Ortiz-Romero P, González-Simón A, Egea G, Pérez-Jurado LA, Campuzano V

Front Pharmacol. 2021;12:670785

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Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study.

Rodríguez de Dios N, Couñago F, Murcia-Mejía M, Rico-Oses M, Calvo-Crespo P, Samper P, Vallejo C, Luna J, Trueba I, Sotoca A, Cigarral C, Farré N, Manero RM, Durán X, Gispert JD, Sánchez-Benavides G, Rognoni T, Torrente M, Capellades J, Jiménez M, Cabada T, Blanco M, Alonso A, Martínez-San Millán J, Escribano J, González B, López-Guerra JL

J Clin Oncol. 2021 Oct 1;39(28):3118-3127

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SUDEP-3: probable improvement in risk stratification for sudden death in epilepsy.

Barguilla A, Panadés-de Oliveira L, Principe A, Rocamora R

Epilepsia. 2021 Oct;62(10):2568

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Physical activity and metabolic syndrome severity among older adults at cardiovascular risk: 1-Year trends.

Gallardo-Alfaro L, Bibiloni MDM, Bouzas C, Mascaró CM, Martínez-González MÁ, Salas-Salvadó J, Corella D, Schröder H, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, Lopez-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Bueno-Cavanillas A, Micó RM, Pintó X, Gaforio JJ, Ortíz-Ramos M, Altés-Boronat A, Luca BL, Daimiel L, Ros E, Sayon-Orea C, Becerra-Tomás N, Gimenez-Alba IM, Castañer O, Abete I, Tojal-Sierra L, Pérez-López J, Torres-Collado L, Colom A, Garcia-Rios A, Castro-Barquero S, Bernal R, Santos-Lozano JM, Fernandez-Lazaro CI, Hernández-Alonso P, Saiz C, Zomeño MD, Zulet MA, Belló-Mora MC, Basterra-Gortari FJ, Canudas S, Goday A, Tur JA, PREDIMED-Plus investigators.

Nutr Metab Cardiovasc Dis. 2021 Sep 22;31(10):2870-2886

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Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer.

Guardia C, Bianchini G, Arpí-LLucià O, Menendez S, Casadevall D, Galbardi B, Dugo M, Servitja S, Montero JC, Soria-Jiménez L, Sabbaghi M, Peña R, Madoz-Gúrpide J, Lloveras B, Lluch A, Eroles P, Arribas J, Pandiella A, Gianni L, Rojo F, Rovira A, Albanell J

Clin Cancer Res. 2021 Sep 15;27(18):5096-5108

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Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis.

Herranz C, Mateo F, Baiges A, Ruiz de Garibay G, Junza A, Johnson SR, Miller S, García N, Capellades J, Gómez A, Vidal A, Palomero L, Espín R, Extremera AI, Blommaert E, Revilla-López E, Saez B, Gómez-Ollés S, Ancochea J, Valenzuela C, Alonso T, Ussetti P, Laporta R, Xaubet A, Rodríguez-Portal JA, Montes-Worboys A, Machahua C, Bordas J, Menendez JA, Cruzado JM, Guiteras R, Bontoux C, La Motta C, Noguera-Castells A, Mancino M, Lastra E, Rigo-Bonnin R, Perales JC, Viñals F, Lahiguera A, Zhang X, Cuadras D, van Moorsel CHM, van der Vis JJ, Quanjel MJR, Filippakis H, Hakem R, Gorrini C, Ferrer M, Ugun-Klusek A, Billett E, Radzikowska E, Casanova Á, Molina-Molina M, Roman A, Yanes O, Pujana MA

EMBO Mol Med. 2021 Sep 7;13(9):e13929

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Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates.

Montero MM, Domene Ochoa S, López-Causapé C, Luque S, Sorlí L, Campillo N, López Montesinos I, Padilla E, Prim N, Angulo-Brunet A, Grau S, Oliver A, Horcajada JP

Microbiol Spectr. 2021 Sep 3;9(1):e0058521

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REST is a major negative regulator of endocrine differentiation during pancreas organogenesis.

Rovira M, Atla G, Maestro MA, Grau V, García-Hurtado J, Maqueda M, Mosquera JL, Yamada Y, Kerr-Conte J, Pattou F, Ferrer J

Genes Dev. 2021 Sep 1;35(17-18):1229-1242

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SpikChIP: a novel computational methodology to compare multiple ChIP-seq using spike-in chromatin.

Blanco E, Di Croce L, Aranda S

NAR Genom Bioinform. 2021 Sep;3(3):lqab064

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Classifying and communicating risks in prediabetes according to fasting glucose and/or glycated hemoglobin: PREDAPS cohort study.

Regidor E, Cea-Soriano L, Ruiz A, Goday A, Carabantes D, Díez-Espino J, Artola S, Franch-Nadal J, PREDAPS Study Group.

Scand J Prim Health Care. 2021 Sep;39(3):355-363

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Pharmacological management of antifungal agents in pulmonary aspergillosis: an updated review.

Echeverria-Esnal D, Martín-Ontiyuelo C, Navarrete-Rouco ME, Barcelo-Vidal J, Conde-Estévez D, Carballo N, De-Antonio Cuscó M, Ferrández O, Horcajada JP, Grau S

Expert Rev Anti Infect Ther. 2021 Aug 18;:1-19

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Contribution of Biotransformations Carried Out by the Microbiota, Drug-Metabolizing Enzymes, and Transport Proteins to the Biological Activities of Phytochemicals Found in the Diet.

Boronat A, Rodriguez-Morató J, Serreli G, Fitó M, Tyndale RF, Deiana M, de la Torre R

Adv Nutr. 2021 Aug 13;

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Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability.

Sandín D, Valle J, Chaves-Arquero B, Prats-Ejarque G, Larrosa MN, González-López JJ, Jiménez MÁ, Boix E, Andreu D, Torrent M

J Med Chem. 2021 Aug 12;64(15):11472-11482

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Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study.

García-Escobar E, Valdés S, Soriguer F, Vendrell J, Urrutia-Etxebarria IM, Maldonado-Araque C, Ortega E, Ocón P, Montanya E, Menéndez E, Lago-Sampedro A, González-Frutos T, Gomis R, Goday A, García-Serrano S, Galán-García JL, Castell C, Bordiú E, Badía R, Aguilera-Venegas G, Girbés J, Gaztambide S, Delgado E, Chaves FJ, Castaño L, Calle-Pascual A, Rojo-Martínez G, Franch-Nadal J

Sci Rep. 2021 Aug 12;11(1):16453

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The inhibition of enkephalin catabolism by dual enkephalinase inhibitor: a novel possible therapeutic approach for opioid use disorders.

Alvarez-Perez B, Poras H, Maldonado R

Br J Pharmacol. 2021 Aug 11;

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The evolution of hematopoietic cells under cancer therapy.

Pich O, Cortes-Bullich A, Muiños F, Pratcorona M, Gonzalez-Perez A, Lopez-Bigas N

Nat Commun. 2021 Aug 10;12(1):4803

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Perceived helpfulness of treatment for generalized anxiety disorder: a World Mental Health Surveys report.

Stein DJ, Kazdin AE, Ruscio AM, Chiu WT, Sampson NA, Ziobrowski HN, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Altwaijri Y, Bruffaerts R, Bunting B, de Girolamo G, de Jonge P, Degenhardt L, Gureje O, Haro JM, Harris MG, Karam A, Karam EG, Kovess-Masfety V, Lee S, Medina-Mora ME, Moskalewicz J, Navarro-Mateu F, Nishi D, Posada-Villa J, Scott KM, Viana MC, Vigo DV, Xavier M, Zarkov Z, Kessler RC, WHO World Mental Health Survey collaborators.

BMC Psychiatry. 2021 Aug 9;21(1):392

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Acute sarcopenia changes following hospitalization: influence of pre-admission care dependency level.

De Spiegeleer A, Kahya H, Sanchez-Rodriguez D, Piotrowicz K, Surquin M, Marco E, Detremerie C, Hussein D, Hope S, Dallmeier D, Decker G, Hrnciarikova D, Czesak J, Toscano-Rico M, Meza-Valderrama D, Bahat G, Descamps A, Wynendaele E, Elewaut D, Vankova H, Landi F, Benoit F, Gasowski J, Van Den Noortgate N

Age Ageing. 2021 Aug 9;

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Prenatal and infant antibiotic exposure and childhood growth, obesity and cardiovascular risk factors: The Rhea mother-child cohort study, Crete, Greece.

Margetaki K, Stratakis N, Roumeliotaki T, Karachaliou M, Alexaki M, Kogevinas M, Chatzi L, Vafeiadi M

Pediatr Obes. 2021 Aug 9;:e12843

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Roles of the physical environment in health-related quality of life in patients with chronic obstructive pulmonary disease.

Moitra S, Foraster M, Arbillaga-Etxarri A, Marín A, Barberan-Garcia A, Rodríguez-Chiaradia DA, Balcells E, Koreny M, Torán-Monserrat P, Vall-Casas P, Rodríguez-Roisin R, Garcia-Aymerich J

Environ Res. 2021 Aug 8;203:111828

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Exposure to metals and metalloids among pregnant women from Spain: Levels and associated factors.

Lozano M, Murcia M, Soler-Blasco R, Casas M, Zubero B, Riutort-Mayol G, Gil F, Olmedo P, Grimalt JO, Amorós R, Lertxundi A, Vrijheid M, Ballester F, Llop S

Chemosphere. 2021 Aug 6;286(Pt 2):131809

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Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.

Galindo-Campos MA, Lutfi N, Bonnin S, Martínez C, Velasco-Hernandez T, García-Hernández V, Martin-Caballero J, Ampurdanés C, Gimeno R, Colomo L, Roue G, Guilbaud G, Dantzer F, Navarro P, Murga M, Fernandez-Capetillo O, Bigas A, Menendez P, Sale J, Yélamos J

Blood. 2021 Aug 6;

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A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival.

Lara-Chica M, Correa-Sáez A, Jiménez-Izquierdo R, Garrido-Rodríguez M, Ponce FJ, Moreno R, Morrison K, Di Vona C, Arató K, Jiménez-Jiménez C, Morrugares R, Schmitz ML, de la Luna S, de la Vega L, Calzado MA

Cell Death Differ. 2021 Aug 6;

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Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses.

Ortega N, Ribes M, Vidal M, Rubio R, Aguilar R, Williams S, Barrios D, Alonso S, Hernández-Luis P, Mitchell RA, Jairoce C, Cruz A, Jimenez A, Santano R, Méndez S, Lamoglia M, Rosell N, Llupià A, Puyol L, Chi J, Melero NR, Parras D, Serra P, Pradenas E, Trinité B, Blanco J, Mayor A, Barroso S, Varela P, Vilella A, Trilla A, Santamaria P, Carolis C, Tortajada M, Izquierdo L, Angulo A, Engel P, García-Basteiro AL, Moncunill G, Dobaño C

Nat Commun. 2021 Aug 6;12(1):4740

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Orthology clusters from gene trees with Possvm.

Grau-Bové X, Sebé-Pedrós A

Mol Biol Evol. 2021 Aug 5;

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Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum.

Vilor-Tejedor N, Ciampa I, Operto G, Falcón C, Suárez-Calvet M, Crous-Bou M, Shekari M, Arenaza-Urquijo EM, Milà-Alomà M, Grau-Rivera O, Minguillon C, Kollmorgen G, Zetterberg H, Blennow K, Guigo R, Molinuevo JL, Gispert JD, ALFA study.

Alzheimers Res Ther. 2021 Aug 5;13(1):135

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The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy with Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis.

Machairas N, Raptis DA, Velázquez PS, Sauvanet A, de Leon AR, Oba A, Koerkamp BG, Lovasik B, Chan C, Yeo C, Bassi C, Ferrone CR, Kooby D, Moskal D, Tamburrino D, Yoon DS, Barroso E, de Santibañes E, Kauffmann EF, Vigia E, Robin F, Casciani F, Burdío F, Belfiori G, Malleo G, Lavu H, Hartog H, Hwang HK, Han HS, Marques HP, Poves I, Rosado ID, Park JS, Lillemoe KD, Roberts K, Sulpice L, Besselink MG, Abuawwad M, Del Chiaro M, de Santibañes M, Falconi M, D'Silva M, Silva M, Hilal MA, Qadan M, Sell NM, Beghdadi N, Napoli N, Busch OR, Mazza O, Muiesan P, Müller PC, Ravikumar R, Schulick R, Powell-Brett S, Abbas SH, Mackay TM, Stoop TF, Gallagher TK, Boggi U, van Eijck C, Clavien PA, Conlon KCP, Fusai GK

Ann Surg. 2021 Aug 4;

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Associations of exposure to cadmium, antimony, lead and their mixture with gestational thyroid homeostasis.

Margetaki K, Vafeiadi M, Kampouri M, Roumeliotaki T, Karakosta P, Daraki V, Kogevinas M, Hu H, Kippler M, Chatzi L

Environ Pollut. 2021 Aug 4;289:117905

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Identifying Factors Influencing Attention in Adolescents with a Co-Created Questionnaire: A Citizen Science Approach with Secondary Students in Barcelona, Spain.

Gignac F, Solé C, Barrera-Gómez J, Persavento C, Tena È, López-Vicente M, Júlvez J, Sunyer J, Couso D, Basagaña X

Int J Environ Res Public Health. 2021 Aug 3;18(15)

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Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA

Nat Commun. 2021 Aug 3;12(1):4688

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Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice.

Alegre-Zurano L, López-Arnau R, Luján MÁ, Camarasa J, Valverde O

Int J Mol Sci. 2021 Aug 2;22(15)

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Association between informal employment and mortality rate by welfare regime in Latin America and the Caribbean: an ecological study.

Silva-Peñaherrera M, López-Ruiz M, Merino-Salazar P, Gomez Garcia AR, Benavides FG

BMJ Open. 2021 Aug 2;11(8):e044920

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Effects Of Mixing Energy Drinks With Alcohol On Driving-Related Skills.

Pérez-Mañá C, Mateus JA, Díaz-Pellicer P, Díaz-Baggerman A, Pérez M, Pujadas M, Fonseca F, Papaseit E, Pujol J, Langohr K, de la Torre R

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Plasmatic PCSK9 Levels Are Associated with Very Fast Progression of Asymptomatic Degenerative Aortic Stenosis.

Mateos N, Gómez M, Homar A, Garcia-Elias A, Yáñez L, Tajes M, Molina L, Ble M, Cladellas M, Roqueta C, Benito B

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Recurrence of IgA Nephropathy after Kidney Transplantation in Adults.

Uffing A, Pérez-Saéz MJ, Jouve T, Bugnazet M, Malvezzi P, Muhsin SA, Lafargue MC, Reindl-Schwaighofer R, Morlock A, Oberbauer R, Buxeda A, Burballa C, Pascual J, von Moos S, Seeger H, La Manna G, Comai G, Bini C, Russo LS, Farouk S, Nissaisorakarn P, Patel H, Agrawal N, Mastroianni-Kirsztajn G, Mansur J, Tedesco-Silva H, Ventura CG, Agena F, David-Neto E, Akalin E, Alani O, Mazzali M, Manfro RC, Bauer AC, Wang AX, Cheng XS, Schold JD, Berger SP, Cravedi P, Riella LV

Clin J Am Soc Nephrol. 2021 Aug;16(8):1247-1255

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Early Postoperative Basal Insulin Therapy versus Standard of Care for the Prevention of Diabetes Mellitus after Kidney Transplantation: A Multicenter Randomized Trial.

Schwaiger E, Krenn S, Kurnikowski A, Bergfeld L, Pérez-Sáez MJ, Frey A, Topitz D, Bergmann M, Hödlmoser S, Bachmann F, Halleck F, Kron S, Hafner-Giessauf H, Eller K, Rosenkranz AR, Crespo M, Faura A, Tura A, Song PXK, Port FK, Pascual J, Budde K, Ristl R, Werzowa J, Hecking M

J Am Soc Nephrol. 2021 Aug;32(8):2083-2098

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Exposure to green spaces and all-cause mortality: limitations in measurement and definitions of exposure - Authors' reply.

Rojas-Rueda D, Nieuwenhuijsen MJ, Gascon M, Perez-Leon D, Mudu P

Lancet Planet Health. 2021 Aug;5(8):e502

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CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells.

Soochit W, Sleutels F, Stik G, Bartkuhn M, Basu S, Hernandez SC, Merzouk S, Vidal E, Boers R, Boers J, van der Reijden M, Geverts B, van Cappellen WA, van den Hout M, Ozgur Z, van IJcken WFJ, Gribnau J, Renkawitz R, Graf T, Houtsmuller A, Grosveld F, Stadhouders R, Galjart N

Nat Cell Biol. 2021 Aug;23(8):881-893

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In silico saturation mutagenesis of cancer genes.

Muiños F, Martínez-Jiménez F, Pich O, Gonzalez-Perez A, Lopez-Bigas N

Nature. 2021 Aug;596(7872):428-432

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Coexpression of the discoidin domain receptor 1 gene with oligodendrocyte-related and schizophrenia risk genes in the developing and adult human brain.

Muntané G, Chillida M, Aranda S, Navarro A, Vilella E

Brain Behav. 2021 Aug;11(8):e2309

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Adaptation and psychometric validation of Diabetes Health Profile (DHP-18) in patients with type 2 diabetes in Quito, Ecuador: a cross-sectional study.

Benazizi I, Bernal-Soriano MC, Pardo Y, Ribera A, Peralta-Chiriboga A, Ferrer M, Alonso-Jaquete A, Alonso J, Lumbreras B, Parker LA

Health Qual Life Outcomes. 2021 Jul 31;19(1):189

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Perceptions from nurses, surgeons, and anesthetists about the use and benefits of the surgical checklist in a teaching hospital.

Domingo L, Sala M, Miret C, Montero-Moraga JM, Lasso de la Vega C, Comas M, Castells X

J Healthc Qual Res. 2021 Jul 31;

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Neuronal perception of the social environment generates an inherited memory that controls the development and generation time of C. elegans.

Perez MF, Shamalnasab M, Mata-Cabana A, Della Valle S, Olmedo M, Francesconi M, Lehner B

Curr Biol. 2021 Jul 31;

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Response to Letter to the Editor from Viola Viola: "Calcifediol treatment and COVID-19-related outcomes".

Nogues X, Quesada-Gómez JM, Garcia-Giralt N

J Clin Endocrinol Metab. 2021 Jul 31;

http://www.ncbi.nlm.nih.gov/en...

Genetic association study of childhood aggression across raters, instruments, and age.

Ip HF, van der Laan CM, Krapohl EML, Brikell I, Sánchez-Mora C, Nolte IM, St Pourcain B, Bolhuis K, Palviainen T, Zafarmand H, Colodro-Conde L, Gordon S, Zayats T, Aliev F, Jiang C, Wang CA, Saunders G, Karhunen V, Hammerschlag AR, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Seppälä I, Vilor-Tejedor N, Ahluwalia TS, Day FR, Hottenga JJ, Allegrini AG, Rimfeld K, Chen Q, Lu Y, Martin J, Soler Artigas M, Rovira P, Bosch R, Español G, Ramos Quiroga JA, Neumann A, Ensink J, Grasby K, Morosoli JJ, Tong X, Marrington S, Middeldorp C, Scott JG, Vinkhuyzen A, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ruth K, Tyrrell J, Davies GE, Ehli EA, Hagenbeek FA, De Zeeuw E, Van Beijsterveldt TCEM, Larsson H, Snieder H, Verhulst FC, Amin N, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Heath AC, Madden P, Haavik J, Harris JR, Helgeland Ø, Johansson S, Knudsen GPS, Njolstad PR, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds C, Smolen A, Stallings M, Wadsworth S, Wall TL, Silberg JL, Miller A, Keltikangas-Järvinen L, Hakulinen C, Pulkki-Råback L, Havdahl A, Magnus P, Raitakari OT, Perry JRB, Llop S, Lopez-Espinosa MJ, Bønnelykke K, Bisgaard H, Sunyer J, Lehtimäki T, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood LJ, Kennedy M, Poulton R, Eaves LJ, Maes HH, Hewitt J, Copeland WE, Costello EJ, Williams GM, Wray N, Järvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse A, Pennell CE, Klump KL, Burt SA, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribasés M, Lichtenstein P, Lundström S, Plomin R, Bartels M, Nivard MG, Boomsma DI

Transl Psychiatry. 2021 Jul 30;11(1):413

http://www.ncbi.nlm.nih.gov/en...

Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging.

Leduc-Gaudet JP, Hussain SNA, Barreiro E, Gouspillou G

Int J Mol Sci. 2021 Jul 30;22(15)

http://www.ncbi.nlm.nih.gov/en...

ADP-ribosyltransferases, an update on function and nomenclature.

Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Paw?owski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M

FEBS J. 2021 Jul 29;

http://www.ncbi.nlm.nih.gov/en...

¿La integración de la gestión de servicios sanitarios mejora la coordinación clínica? Experiencia en Cataluña.

Esteve-Matalí L, Vargas I, Cots F, Ramon I, Sánchez E, Escosa A, Vázquez ML

Gac Sanit. 2021 Jul 29;

http://www.ncbi.nlm.nih.gov/en...

EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old.

Agache I, Akdis C, Akdis M, Brockow K, Chivato T, Del Giacco S, Eiwegger T, Eyerich K, Giménez-Arnau A, Gutermuth J, Guttman-Yassky E, Maurer M, Ogg G, Ong PY, O'Mahony L, Schwarze J, Warner A, Werfel T, Palomares O, Jutel M

Allergy. 2021 Jul 29;

http://www.ncbi.nlm.nih.gov/en...

Interobserver and Intertest Agreement in Telemedicine Glaucoma Screening with Optic Disk Photos and Optical Coherence Tomography.

Anton A, Nolivos K, Pazos M, Fatti G, Herranz A, Ayala-Fuentes ME, Martínez-Prats E, Peral O, Vega-Lopez Z, Monleon-Getino A, Morilla-Grasa A, Comas M, Castells X

J Clin Med. 2021 Jul 28;10(15)

http://www.ncbi.nlm.nih.gov/en...

Clinical guide to perioperative management for videothoracoscopy lung resection (Section of Cardiac, Vascular and Thoracic Anesthesia, SEDAR; Spanish Society of Thoracic Surgery, SECT; Spanish Society of Physiotherapy).

Granell-Gil M, Murcia-Anaya M, Sevilla S, Martínez-Plumed R, Biosca-Pérez E, Cózar-Bernal F, Garutti I, Gallart L, Ubierna-Ferreras B, Sukia-Zilbeti I, Gálvez-Muñoz C, Delgado-Roel M, Mínguez L, Bermejo S, Valencia O, Real M, Unzueta C, Ferrando C, Sánchez F, González S, Ruiz-Villén C, Lluch A, Hernández A, Hernández-Beslmeisl J, Vives M, Vicente R

Rev Esp Anestesiol Reanim. 2021 Jul 27;

http://www.ncbi.nlm.nih.gov/en...

Diabetes mellitus and cardiovascular risk: an update of the recommendations of the Diabetes and Cardiovascular Disease Working Group of the Spanish Society of Diabetes (SED, 2021).

Arrieta F, Pedro-Botet J, Iglesias P, Obaya JC, Montanez L, Maldonado GF, Becerra A, Navarro J, Perez JC, Petrecca R, Pardo JL, Ribalta J, Sánchez V, Duran S, Tébar FJ, Aguilar M

Clin Investig Arterioscler. 2021 Jul 27;

http://www.ncbi.nlm.nih.gov/en...


Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:


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Innovation

Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar

→ https://www.imim.es/ofertas-empleo/

UPF Business Shuttle and Innovation Unit

→ www.upf.edu/web/innovacio

Technology and Business Development Office at the CRG

→ https://tbdo.crg.eu

Analysis and Global Development at ISGlobal

→ www.isglobal.org/es/policy-and-development

EMBLEM Technology Transfer

→ https://embl-em.de

  • The following start-ups have been created within the PRBB environment:

Acellera

Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.

→ https://www.acellera.com

Chemotargets

Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.

→ http://www.chemotargets.com/

qGenomics

qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.

→ https://qgenomics.com

ZeClinics

ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.

→ http://www.zeclinics.com

Microomics

Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.

→ http://www.microomics.eu

Flomics

World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.

→ http://www.flomics.com

Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.

→ http://biom.tech

MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.

→ http://www.disgenetplus.com/medbioinformatics/

Pulmobiotics

A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.

→ https://www.pulmobio.com/

Latest news