Connecting perspectives: from bytes and molecules to organisms and populations
"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".
Jordi Camí, General Director of the PRBB.
The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.
With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.
Hospital del Mar Medical Research Institute (IMIM)
Cancer
The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research
Epidemiology and Public Health
The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.
Biomedical Informatics
This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB).
Neuroscience
The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.
Translational Clinical Research
The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.
Department of Medicine and Life Sciences at Pompeu Fabra University (MELIS-UPF)
Cellular and Molecular Biology
The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.
Molecular Medicine
This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.
Evolutionary Biology and Complex Systems
The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.
Biomedical Informatics
The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.
Genetics and Neuroscience
The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.
Systems Bioengineering
The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.
Transversal Program
Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.
Centre for Genomic Regulation (CRG)
Bioinformatics and Genomics
Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).
Cell and Developmental Biology
The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.
Gene Regulation, Stem Cells and Cancer
The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.
Systems Biology
The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.
Medical Genomics
Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry.
Barcelona Institute for Global Health (ISGlobal, Mar Campus)
Climate and Health
Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.
Air pollution and urban environment
The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.
Non-communicable diseases and the environment
The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.
Childhood and Environment
This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.
Radiation
The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.
Other
ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.
Institute of Evolutionary Biology (IBE: CSIC-UPF)
Animal Biodiversity and Evolution
The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.
Comparative and Computational Genomics
This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.
Functional Genomics and Evolution
The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.
Population genetics
Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.
Complex Systems
This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.
European Molecular Biology Laboratory (EMBL)
Tissue biology and disease modelling
The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”
Institute of Applied Radiopharmacy of Barcelona (IRAB)
Research and Innovation
The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.
Animal research with the international accreditation from the AAALAC.
The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.
Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.
- Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
- The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
- The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).
For more information on the animal facility and animal experimentation visit:
Animal experimentation courses
The PRBB and Charles River Campus
Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:
- Euthanasia (Function b)
- Performing procedures (Function c)
- Designing projects and procedures (mice and fish/amphibians) (Function d)
The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.
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Shared facilities for high-impact research
"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."
Jordi Camí, General Director of the PRBB
The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.
The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection
Contact: Núria Somoza
→ marbiobanc@imim.es
The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.
Contact: Julia Ponomarenko
→ biocore@crg.eu
The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.
Contact: Ivo Gut
→ projectmanager@cnag.crg.eu
This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.
Contact: Blanca Espinet
→ bespinet@parcdesalutmar.cat
The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals. The CEEA-PRBB has been authorized by the Catalan government to carry out the tasks as a competent body (OH) defined in Royal Decree 53/2013 which is framed in Directive 2010/63/EU adopted by the European Parliament.
Contact: Dirección de secretaría
→ ceea@prbb.org
This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.
Contact: Òscar Fornas
→ oscar.fornas@upf.edu
Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit
The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.
Contact: Secretaría
→ cbs@prbb.org
Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.
Contact: Cristina Llop
→ CEIC-PSMAR@imim.es
This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.
Contact: Carlo Carolis
→ bmspt@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit
BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.
Contact: Jordi Alonso
→ bibliopro@imim.es
The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.
Contact: Arcadi Navarro
→ helpdesk@ega-archive.org
This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.
Contact: Jochen Hecht
→ ngs@crg.eu
The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.
Contact: Montserrat Torà
→ margenomics@imim.es
The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.
Contact: Ferran Casals
→ genomica@upf.edu
The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.
Contact: Laura Batlle Morera
→ laura.batlle@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0
This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.
Contact: Ana Aldea
→ aaldea@imim.es
This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.
Contact: Jim Swoger
→ mif@embl.es
Web:
https://www.embl.es/services/mesoscopic-imaging-facility
The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.
Contact: Nadia Halidi
→ nadia.halidi@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit
Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)
Contact: David Andreu
→ david.andreu@upf.edu
This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.
Contact: Eduard Sabido Aguade
→ eduard.sabido@crg.eu
Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit
Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction.
Duran-Castells C, Llano A, Kawana-Tachikawa A, Prats A, Martinez-Zalacain I, Kobayashi-Ishihara M, Oriol-Tordera B, Peña R, Gálvez C, Silva-Arrieta S, Clotet B, Riveira-Muñoz E, Ballana E, Prado JG, Martinez-Picado J, Sanchez J, Mothe B, Hartigan-O'Connor D, Wyss-Coray T, Meyerhans A, Gisslén M, Price RW, Soriano-Mas C, Muñoz-Moreno JA, Brander C, Ruiz-Riol M
J Virol. 2023 Jan 31;:e0165522
Prevalence of atherogenic dyslipidemia, related factors and level of lipid control in the general population of Galicia. GALIPEMIAS study.
Názara C, Argüeso RM, Pedro-Botet J, Pintó X, Millán J, Pena Seijo M, Fernández PA, Eugenia Ameneiros M, Del Alamo A, Rodríguez A, Díaz-Peromingo JA, Vázquez Freire MR, Muñiz J, Pérez-Castro TR, Díaz-Díaz JL, Pose Reino A
Clin Investig Arterioscler. 2023 Jan 28;
Metabolomics in COPD.
Gea J, Enríquez-Rodríguez CJ, Pascual-Guardia S
Arch Bronconeumol. 2023 Jan 18;
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit.
Johnson SC, Suárez-Calvet M, Suridjan I, Minguillón C, Gispert JD, Jonaitis E, Michna A, Carboni M, Bittner T, Rabe C, Kollmorgen G, Zetterberg H, Blennow K
Alzheimers Res Ther. 2023 Jan 28;15(1):25
http://www.ncbi.nlm.nih.gov/en...
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03.
Garcia-Donas J, Hurtado A, Garrigos L, Santaballa A, Redondo A, Vidal L, Lainez N, Guerra E, Rodriguez V, Cueva J, Bover I, Palacio I, Rubio MJ, Prieto M, Lopez-Guerrero JA, Rodriguez-Moreno JF, Garcia-Casado Z, Garcia-Martinez E, Taus A, de Castro IP, Navarro P, Grande E, Spanish Group for Research in Orphan, Infrequent Tumors (GETHI)
Clin Transl Oncol. 2023 Jan 28;
Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men.
Zamora A, Ramos R, Comas-Cufi M, García-Gil M, Martí-Lluch R, Plana N, Alves-Cabratosa L, Ponjoan A, Rodríguez-Borjabad C, Ibarretxe D, Roman-Degano I, Marrugat J, Elosua R, Martín-Urda A, Masana L
Sci Rep. 2023 Jan 27;13(1):1492
http://www.ncbi.nlm.nih.gov/en...
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation.
Fuertes G, Del Valle-Pérez B, Pastor J, Andrades E, Peña R, García de Herreros A, Duñach M
EMBO Rep. 2023 Jan 27;:e54895
Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis.
Toll A, Blanco-Hinojo L, Berge D, Martín-Subero M, Casanovas F, El-Abidi K, Perez-Solà V, Mané A
Eur Neuropsychopharmacol. 2023 Jan 27;69:47-55
Multi-omics data integration methods and their applications in psychiatric disorders.
Sathyanarayanan A, Mueller TT, Ali Moni M, Schueler K, Baune BT, Lio P, Mehta D, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network, Baune BT, Dierssen M, Ebert B, Fabbri C, Fusar-Poli P, Gennarelli M, Harmer C, Howes OD, Janzing JGE, Lio P, Maron E, Mehta D, Minelli A, Nonell L, Pisanu C, Potier MC, Rybakowski F, Serretti A, Sqassina A, Stacey D, van Westrhenen R, Xicota L
Eur Neuropsychopharmacol. 2023 Jan 25;69:26-46
The impact of climate change on health needs structured evidence assessment and an evidence to action framework to make decisions: A proposal to adopt the GRADE approach.
Neumann I, Antó JM, Bousquet J, Schünemann HJ
J Clin Epidemiol. 2023 Jan 24;
Gut-associated lymphoid tissue attrition associates with response to anti-?4?7 therapy in ulcerative colitis.
Canales-Herrerias P, Uzzan M, Seki A, Czepielewski RS, Verstockt B, Livanos A, Raso F, Dunn A, Dai D, Wang A, Al-Taie Z, Martin J, Ko HM, Tokuyama M, Tankelevich M, Meringer H, Cossarini F, Jha D, Krek A, Paulsen JD, Nakadar MZ, Wong J, Erlich EC, Onufer EJ, Helmink BA, Sharma K, Rosenstein A, Chung G, Dawson T, Juarez J, Yajnik V, Cerutti A, Faith J, Suarez-Farinas M, Argmann C, Petralia F, Randolph GJ, Polydorides AD, Reboldi A, Colombel JF, Mehandru S
bioRxiv. 2023 Jan 20;
http://www.ncbi.nlm.nih.gov/en...
Defective engram allocation contributes to impaired fear memory performance in Down syndrome.
Fernández-Blanco Á, Zamora-Moratalla A, Sabariego-Navarro M, Dierssen M
bioRxiv. 2023 Jan 11;
http://www.ncbi.nlm.nih.gov/en...
Modelling of daily radiofrequency electromagnetic field dose for a prospective adolescent cohort.
Eeftens M, Shen C, Sönksen J, Schmutz C, van Wel L, Liorni I, Vermeulen R, Cardis E, Wiart J, Toledano M, Röösli M
Environ Int. 2023 Jan 5;172:107737
The "Bayés Spirit" as a guide for new generations: How to combine one's personal life and friendships with science and profession.
Martínez-Sellés M, Elosua R, Baranchuk A
J Electrocardiol. 2023 Jan 4;78:17-20
Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration.
Buxeda A, Llinàs-Mallol L, Gimeno J, Redondo-Pachón D, Arias-Cabrales C, Burballa C, Puche A, López-Botet M, Yélamos J, Vilches C, Naesens M, Pérez-Sáez MJ, Pascual J, Crespo M
Am J Transplant. 2023 Jan 3;
Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air(®) approach.
Bousquet J, Anto JM, Sousa-Pinto B, Czarlewski W, Bedbrook A, Haahtela T, Klimek L, Pfaar O, Kuna P, Kupczyk M, Regateiro FS, Samolinski B, Valiulis A, Yorgancioglu A, Arnavielhe S, Basagaña X, Bergmann KC, Bosnic-Anticevich S, Brussino L, Canonica GW, Cardona V, Cecchi L, Chaves-Loureiro C, Costa E, Cruz AA, Gemicioglu B, Fokkens WJ, Ivancevich JC, Kraxner H, Kvedariene V, Larenas-Linnemann DE, Laune D, Louis R, Makris M, Maurer M, Melén E, Micheli Y, Morais-Almeida M, Mullol J, Niedoszytko M, Okamoto Y, Papadopoulos NG, Patella V, Pham-Thi N, Rouadi PW, Sastre J, Scichilone N, Sheikh A, Sofiev M, Taborda-Barata L, Toppila-Salmi S, Tsiligianni I, Valovirta E, Ventura MT, Vieira RJ, Zidarn M, Amaral R, Ansotegui IJ, Bédard A, Benveniste S, Bewick M, Bindslev-Jensen C, Blain H, Bonini M, Bourret R, Braido F, Carreiro-Martins P, Charpin D, Cherrez-Ojeda I, Chivato T, Chu DK, Cingi C, Del Giacco S, de Blay F, Devillier P, De Vries G, Doulaptsi M, Doyen V, Dray G, Fontaine JF, Gomez RM, Hagemann J, Heffler E, Hofmann M, Jassem E, Jutel M, Keil T, Kritikos V, Kull I, Kulus M, Lourenço O, Mathieu-Dupas E, Menditto E, Mösges R, Murray R, Nadif R, Neffen H, Nicola S, O'Hehir R, Olze H, Palamarchuk Y, Pépin JL, Pétré B, Picard R, Pitsios C, Puggioni F, Quirce S, Raciborski F, Reitsma S, Roche N, Rodriguez-Gonzalez M, Romantowski J, Sá-Sousa A, Serpa FS, Savouré M, Shamji MH, Sova M, Sperl A, Stellato C, Todo-Bom A, Tomazic PV, Vandenplas O, Van Eerd M, Vasankari T, Viart F, Waserman S, Fonseca JA, Zuberbier T
Clin Transl Allergy. 2023 Jan;13(1):e12215
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Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies.
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ERJ Open Research receives its first impact factor and plans for the next step.
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Epidermotropic B-Cell Lymphoma: A Case of Secondary Cutaneous Splenic Marginal Zone B-Cell Lymphoma With Autoinvolutive and Recurrent Cutaneous Lesions.
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Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.
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Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms.
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Impact of the "Zero Resistance" program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study.
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Mood disorders in higher education in Flanders during the 2(nd) and 3(rd) COVID-19 wave: Prevalence and help-seeking: Findings from the Flemish College Surveys (FLeCS).
Bootsma E, Jansen L, Kiekens G, Voorpoels W, Mortier P, Proost S, Vande Poel I, Jacobs K, Demyttenaere K, Alonso J, Kessler RC, Cuijpers P, Auerbach RP, Bruffaerts R
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A Genome-Wide Functional Screen Identifies Enhancer and Protective Genes for Amyloid Beta-Peptide Toxicity.
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Clinical Guideline on Perioperative Management of Patients with Advanced Chronic Liver Disease.
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Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.
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Sex Differences in the Association between Risk of Anterior Cruciate Ligament Rupture and COL5A1 Polymorphisms in Elite Footballers.
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Evaluation of the host immune response assay SeptiCyte RAPID for potential triage of COVID-19 patients.
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Parallel duplication and loss of aquaporin-coding genes during the 'out of the sea' transition as potential key drivers of animal terrestrialization.
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Trends in the Prevalence of Methylchloroisothiazolinone/Methylisothiazolinone Contact Allergy in North America and Europe.
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Women in Spanish institutional medicine leadership: The glass ceiling remains seemingly invulnerable.
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Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress.
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A Bioengineered Model for Studying Vascular-Pericyte Interactions of the Placenta.
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The relationship between air pollution and multimorbidity: Can two birds be killed with the same stone?
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Correction: Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.
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Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline.
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Exposure to outdoor residential noise during pregnancy, embryonic size, fetal growth, and birth outcomes.
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Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.
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Perturbed fatty-acid metabolism is linked to localized chromatin hyperacetylation, increased stress-response gene expression and resistance to oxidative stress.
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Pharmacokinetics/pharmacodynamics and therapeutic drug monitoring of ceftazidime/avibactam administered by continuous infusion in patients with MDR Gram-negative bacterial infections.
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Sociodemographic characteristics, functional status, and health resource use of older patients treated in Spanish emergency departments: a description of the EDEN cohort.
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Personal strategies to mitigate the effects of air pollution exposure during sport and exercise: a narrative review and position statement by the Canadian Academy of Sport and Exercise Medicine and the Canadian Society for Exercise Physiology.
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RBD-Based ELISA and Luminex Predict Anti-SARS-CoV-2 Surrogate-Neutralizing Activity in Two Longitudinal Cohorts of German and Spanish Health Care Workers.
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NiftyPAD - Novel Python Package for Quantitative Analysis of Dynamic PET Data.
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Performance analysis of a STEMI network: prognostic impact of the type of first medical contact facility.
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Severe perioperative anaphylaxis: Incidence in a tertiary hospital in Spain over a 20-year period. A historical cohort study.
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Global assessment of chemical quality of drinking water: The case of trihalomethanes.
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The right to the unhealthy deprived city: An exploration into the impacts of state-led redevelopment projects on the determinants of mental health.
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Development and evaluation of a risk algorithm predicting alcohol dependence after early onset of regular alcohol use.
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Addiction. 2023 Jan 7;
Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.
Jobin ML, De Smedt-Peyrusse V, Ducrocq F, Baccouch R, Oummadi A, Pedersen MH, Medel-Lacruz B, Angelo MF, Villette S, Van Delft P, Fouillen L, Mongrand S, Selent J, Tolentino-Cortez T, Barreda-Gómez G, Grégoire S, Masson E, Durroux T, Javitch JA, Guixà-González R, Alves ID, Trifilieff P
Mol Psychiatry. 2023 Jan 6;
Antimicrobial stewardship in hospitals: Expert recommendation guidance document for activities in specific populations, syndromes and other aspects (PROA-2) from SEIMC, SEFH, SEMPSPGS, SEMICYUC and SEIP.
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Potential of desorption electrospray ionization and paper spray ionization with high-resolution mass spectrometry for the screening of sports doping agents in urine.
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Anal Methods. 2023 Jan 5;
Carbon dioxide (CO(2)) emissions and adherence to Mediterranean diet in an adult population: the Mediterranean diet index as a pollution level index.
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Environ Health. 2023 Jan 5;22(1):1
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SPICE, A Dataset of Drug-like Molecules and Peptides for Training Machine Learning Potentials.
Eastman P, Behara PK, Dotson DL, Galvelis R, Herr JE, Horton JT, Mao Y, Chodera JD, Pritchard BP, Wang Y, De Fabritiis G, Markland TE
Sci Data. 2023 Jan 4;10(1):11
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Current advances in primate genomics: novel approaches for understanding evolution and disease.
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Nat Rev Genet. 2023 Jan 4;
Bacterial expression of a designed single-chain IL-10 prevents severe lung inflammation.
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Mol Syst Biol. 2023 Jan;19(1):e11037
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Retail Food Environment around Schools in Barcelona by Neighborhood Socioeconomic Status: Implications for Local Food Policy.
Londoño-Cañola C, Serral G, Díez J, Martínez-García A, Franco M, Artazcoz L, Ariza C
Int J Environ Res Public Health. 2022 Dec 30;20(1)
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Effect of Perioperative Blood Transfusions and Infectious Complications on Inflammatory Activation and Long-Term Survival Following Gastric Cancer Resection.
Puértolas N, Osorio J, Jericó C, Miranda C, Santamaría M, Artigau E, Galofré G, Garsot E, Luna A, Aldeano A, Olona C, Molinas J, Pulido L, Gimeno M, Pera M
Cancers (Basel). 2022 Dec 26;15(1)
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Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial.
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Int J Mol Sci. 2022 Dec 23;24(1)
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?-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.
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EMBO Mol Med. 2023 Jan 4;:e16554
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins.
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Nat Microbiol. 2023 Jan;8(1):77-90
Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene.
Ortega M, De Toma I, Fernández-Blanco Á, Calderón A, Barahona L, Trullàs R, Sabidó E, Dierssen M
Front Mol Neurosci. 2022;15:1015220
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Precision medicine implementation challenges for APOL1 testing in chronic kidney disease in admixed populations.
Giudicelli GC, De Souza CMB, Veronese FV, Pereira LV, Hünemeier T, Vianna FSL
Front Genet. 2022;13:1016341
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Dynamics of Humoral and Cellular Responses in Renal Transplant Recipients Receiving 3 Doses of SARS-CoV-2 mRNA Vaccine.
Arias-Cabrales C, Folgueiras M, Faura A, Eguia J, Padilla E, Hurtado S, Ribera L, Echeverria-Esnal D, Pérez-Sáez MJ, Redondo-Pachón D, Burballa C, Buxeda A, Llinàs-Mallol L, Cao H, Barbosa F, Rovira X, Cima F, Pascual J, Crespo M
Transplantation. 2023 Feb 1;107(2):457-465
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Health associations of liver enzymes and inflammatory scores with urinary citrus flavonoid metabolites.
Bullón-Vela V, Xu Y, Razquin C, Abete I, Zulet MA, Martínez-González MA, Buil-Corsiales P, Vitelli-Storelli F, Martín Sánchez V, Vazquez-Ruíz Z, Sayón-Orea C, Domínguez-Fernández M, Cid C, Estruch R, Lamuela-Raventós RM, Fitó M, Blanchart G, Babio N, Salas-Salvadó J, Tinahones FJ, Tur JA, Romaguera D, Konieczna J, Pintó X, Daimiel L, Rodriguez-Mateos A, Martínez JA
Food Funct. 2023 Jan 23;14(2):1011-1023
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The molecular evolution of spermatogenesis across mammals.
Murat F, Mbengue N, Winge SB, Trefzer T, Leushkin E, Sepp M, Cardoso-Moreira M, Schmidt J, Schneider C, Mößinger K, Brüning T, Lamanna F, Belles MR, Conrad C, Kondova I, Bontrop R, Behr R, Khaitovich P, Pääbo S, Marques-Bonet T, Grützner F, Almstrup K, Schierup MH, Kaessmann H
Nature. 2023 Jan;613(7943):308-316
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Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration.
Moiseeva V, Cisneros A, Sica V, Deryagin O, Lai Y, Jung S, Andrés E, An J, Segalés J, Ortet L, Lukesova V, Volpe G, Benguria A, Dopazo A, Aznar-Benitah S, Urano Y, Del Sol A, Esteban MA, Ohkawa Y, Serrano AL, Perdiguero E, Muñoz-Cánoves P
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Impact of Center-related Characteristics and Macroeconomic Factors on the Outcome of Adult Patients With Acute Lymphoblastic Leukemia Treated With Pediatric-inspired Protocols.
Barba P, Morgades M, Montesinos P, Gonzalez-Campos J, Torrent A, Gil C, Bernal T, Tormo M, Mercadal S, Novoa S, García-Cadenas I, de Llano MPQ, Cervera M, Coll R, Bermudez A, Amigo ML, Monsalvo S, Esteve J, Garcia-Boyero R, Novo A, Hernandez Rivas JM, Cladera A, Martinez-Sanchez P, Serrano J, Artola MT, Soria B, Abella E, Vall-Llovera F, Bergua J, Herrera P, Barrios D, Ribera JM
Hemasphere. 2023 Jan;7(1):e810
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Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis.
Mosquera-Orgueira A, Pérez-Encinas M, Hernández-Sánchez A, González-Martínez T, Arellano-Rodrigo E, Martínez-Elicegui J, Villaverde-Ramiro Á, Raya JM, Ayala R, Ferrer-Marín F, Fox ML, Velez P, Mora E, Xicoy B, Mata-Vázquez MI, García-Fortes M, Angona A, Cuevas B, Senín MA, Ramírez-Payer A, Ramírez MJ, Pérez-López R, González de Villambrosía S, Martínez-Valverde C, Gómez-Casares MT, García-Hernández C, Gasior M, Bellosillo B, Steegmann JL, Álvarez-Larrán A, Hernández-Rivas JM, Hernández-Boluda JC
Hemasphere. 2023 Jan;7(1):e818
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Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer's disease (ALFASleep project): protocol for an observational study.
Fauria K, Minguillon C, Knezevic I, Tort-Colet N, Stankeviciute L, Hernández L, R?doi A, Deulofeu C, Fuentes-Julián S, Turull I, Fusté D, Sánchez-Benavides G, Arenaza-Urquijo EM, Suárez-Calvet M, Holst SC, Garcés P, Mueggler T, Zetterberg H, Blennow K, Arqueros A, Iranzo Á, Domingo Gispert J, Molinuevo JL, Grau-Rivera O
BMJ Open. 2022 Dec 30;12(12):e067159
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Psychosocial factors partially explain gender differences in health-related quality of life in heart failure patients.
Tapia J, Basalo M, Enjuanes C, Calero E, José N, Ruíz M, Calvo E, Garcimartín P, Moliner P, Hidalgo E, Yun S, Garay A, Jiménez-Marrero S, Pons A, Corbella X, Colet JC
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Unveiling chronic spontaneous urticaria pathophysiology through systems biology.
Segú-Vergés C, Gómez J, Terradas P, Artigas L, Smeets S, Ferrer M, Savic S
J Allergy Clin Immunol. 2022 Dec 29;
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A computational pipeline to learn gene expression predictive models from epigenetic information at enhancers or promoters.
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STAR Protoc. 2022 Dec 29;4(1):101948
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NOTCH1 mutation in chronic lymphocytic leukaemia is associated with an enhanced cell cycle G1/S transition and specific cyclin overexpression: Preclinical ground for targeted inhibition.
Carrillo-Tornel S, Chen-Liang TH, Zurdo M, Puiggros A, Gómez-Llonín A, García-Malo MD, Cuenca-Zamora EJ, Ortuño FJ, López AMH, Espinet B, Jerez A
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Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.
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Leukemia. 2022 Dec 24;
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The effectiveness of a "EspaiJove.net"- a school-based intervention programme in increasing mental health knowledge, help seeking and reducing stigma attitudes in the adolescent population: a cluster randomised controlled trial.
Casañas R, Castellvi P, Gil JJ, Torres-Torres M, Barón J, Teixidó M, Sampietro HM, Díez M, Fernández R, Sorli R, Siñol P, Jurado F, Carreras-Salvador R, Vazquez D, Gonzalez S, Martín MIF, Raya-Tena A, Alvarez R, Amado-Rodriguez I, López LMM, Alonso J, Lalucat-Jo L
BMC Public Health. 2022 Dec 24;22(1):2425
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ASO Visual Abstract: Superior Mesenteric Artery-First Approach for Minimally-Invasive Pancreaticoduodenectomy: A Step-by-Step Surgical Technique Video.
Ielpo B, Anselmo A, Masuda Y, Xuan MYH, Burdio F, De Blasi V, Sanchez-Velazquez P, Giuliani A, Azagra JS, Viola GM, Podda M, Pellino G, Rosso E
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IELSG40/CLEO phase II trial of clarithromycin and lenalidomide in relapsed/refractory extranodal marginal zone lymphoma.
Pirosa MC, Sassone M, Kiesewetter B, Guillermo AL, Devizzi L, Domènech ED, Tucci A, Mannina D, Merli M, Salar A, Visco C, Esposito F, Bonomini L, Zucca E, Ferreri AJM, Raderer M
Haematologica. 2022 Dec 22;
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Cut-off values of MASK-air® Patient-Reported Outcome Measures (PROMs).
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J Allergy Clin Immunol Pract. 2022 Dec 22;
Hypertensive mediated organ damage evolution in resistant hypertension patients after adding spironolactone.
Galceran I, Vázquez S, Crespo M, Pascual J, Oliveras A
Nefrologia (Engl Ed). 2022 Dec 21;
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Incidence rate and distinctive characteristics of first episode psychosis during the COVID-19 pandemic: a multicenter observational study.
Casanovas F, Trabsa A, Bergé D, Sánchez-Gistau V, Moreno I, Sanchez J, Montalvo I, Tost M, Labad J, Pérez-Solà V, Mané A
Sci Rep. 2022 Dec 21;12(1):22036
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A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management.
Bradbury M, Borràs E, Vilar M, Castellví J, Sánchez-Iglesias JL, Pérez-Benavente A, Gil-Moreno A, Santamaria A, Sabidó E
J Transl Med. 2022 Dec 21;20(1):611
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The ADP-ribose hydrolase NUDT5 is important for DNA repair.
Qi H, Grace Wright RH, Beato M, Price BD
Cell Rep. 2022 Dec 20;41(12):111866
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Alloimmune risk assessment for antibody-mediated rejection in kidney transplantation: A practical proposal.
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Transplant Rev (Orlando). 2022 Dec 20;37(1):100745
Risk Factors for COVID-19 in Inflammatory Bowel Disease: A National, ENEIDA-Based Case-Control Study (COVID-19-EII).
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J Clin Med. 2022 Dec 19;11(24)
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Adaptive NK cell response to human cytomegalovirus: Facts and open issues.
López-Botet M, De Maria A, Muntasell A, Della Chiesa M, Vilches C
Semin Immunol. 2022 Dec 19;65:101706
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Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet.
Miralles-Pérez B, Nogués MR, Sánchez-Martos V, Fortuño-Mar À, Ramos-Romero S, Torres JL, Ponomarenko J, Amézqueta S, Zhang X, Romeu M
Foods. 2022 Dec 16;11(24)
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Prospective Association between Adherence to the Mediterranean Diet and Health-Related Quality of Life in Spanish Children.
Juton C, Berruezo P, Rajmil L, Lerin C, Fíto M, Homs C, Según G, Gómez SF, Schröder H
Nutrients. 2022 Dec 14;14(24)
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Anti-TNF vs tocilizumab in refractory uveitic cystoid macular edema due to Behcet's disease. Multicenter study of 49 patients.
Barroso-García N, Atienza-Mateo B, Ferraz-Amaro I, Prieto-Peña D, Beltrán E, Adán A, Hernández-Garfella M, Martínez-Costa L, Cordero-Coma M, Díaz-Llopis M, Herreras JM, Maíz-Alonso O, Torre-Salaberri I, De Vicente-Delmás A, Díaz-Valle D, Atanes-Sandoval A, Francisco F, Insua S, Sánchez J, Almodóvar-González R, Jiménez-Sosa A, Ruiz-Moreno O, Gandía-Martínez M, Nolla JM, Calvo-Río V, Castañeda S, González-Gay MA, Blanco R
Semin Arthritis Rheum. 2022 Dec 14;58:152153
Sialyltransferase Inhibitor Ac(5)3F(ax)Neu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice.
Miró L, López J, Guerrero PE, Martínez-Bosch N, Manero-Rupérez N, Moreno M, Ortiz MR, Llop E, Navarro P, Peracaula R
Cancers (Basel). 2022 Dec 12;14(24)
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Mid-childhood fat mass and airflow limitation at 15?years: The mediating role of insulin resistance and C-reactive protein.
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Pediatr Allergy Immunol. 2022 Dec;33(12):e13894
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Study of Excipients in Delayed Skin Reactions to mRNA Vaccines: Positive Delayed Intradermal Reactions to Polyethylene Glycol Provide New Insights for COVID-19 Arm.
Pesqué D, Pujol RM, Marcantonio O, Vidal-Navarro A, Ramada JM, Arderiu-Formentí A, Albalat-Torres A, Serra C, Giménez-Arnau AM
Vaccines (Basel). 2022 Nov 30;10(12)
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Editorial: Neurodevelopmental, neuropsychiatric and psychosocial correlates of joint hypermobility and related disorders.
Guinchat V, Baeza-Velasco C, Bulbena A, Castori M
Front Psychiatry. 2022;13:1109515
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Editorial: Stromal and immune microenvironment in breast cancer metastasis.
Lu X, Liu X, Celià-Terrassa T, Ren G
Front Immunol. 2022;13:1104362
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Prevalence of clozapine-induced sialorrhea and its effect on quality of life.
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Psychopharmacology (Berl). 2023 Jan;240(1):203-211
Long-term outcomes of extended DAPT in a real-life cohort of consecutive STEMI patients.
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Nano3P-seq: transcriptome-wide analysis of gene expression and tail dynamics using end-capture nanopore cDNA sequencing.
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Nat Methods. 2023 Jan;20(1):75-85
Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation.
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Isolated Patchy Heterochromia With Pili Annulati Features on Light and Electron Microscopy.
Lobato-Berezo A, Pesqué D, Pujol RM
Dermatol Pract Concept. 2022 Nov;12(4):e2022204
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome.
Soldevila-Domenech N, Pastor A, Sala-Vila A, Lázaro I, Boronat A, Muñoz D, Castañer O, Fagundo B, Corella D, Fernández-Aranda F, Martínez-González MÁ, Salas-Salvadó J, Fitó M, de la Torre R
Front Nutr. 2022;9:1076677
Obesity and related comorbidities in a large population-based cohort of subjects with type 1 diabetes in Catalonia.
Genua I, Franch-Nadal J, Navas E, Mata-Cases M, Giménez-Pérez G, Vlacho B, Mauricio D, Goday A
Front Endocrinol (Lausanne). 2022;13:1015614
Editorial: Unconventional protein secretion: From basic mechanisms to dysregulation in disease.
Chiritoiu-Butnaru M, Stewart SE, Zhang M, Malhotra V, Villeneuve J
Front Cell Dev Biol. 2022;10:1088002
Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data.
de Villarreal JM, Kalisz M, Piedrafita G, Graña-Castro O, Chondronasiou D, Serrano M, Real FX
Bioinformatics. 2023 Jan 1;39(1)
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Protective ileostomy creation after anterior resection of the rectum: shared decision-making or still subjective?
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Design and validation of a multi-task, multi-context protocol for real-world gait simulation.
Scott K, Bonci T, Salis F, Alcock L, Buckley E, Gazit E, Hansen C, Schwickert L, Aminian K, Bertuletti S, Caruso M, Chiari L, Sharrack B, Maetzler W, Becker C, Hausdorff JM, Vogiatzis I, Brown P, Del Din S, Eskofier B, Paraschiv-Ionescu A, Keogh A, Kirk C, Kluge F, Micó-Amigo EM, Mueller A, Neatrour I, Niessen M, Palmerini L, Sillen H, Singleton D, Ullrich M, Vereijken B, Froehlich M, Brittain G, Caulfield B, Koch S, Carsin AE, Garcia-Aymerich J, Kuederle A, Yarnall A, Rochester L, Cereatti A, Mazzà C, Mobilise-D consortium
J Neuroeng Rehabil. 2022 Dec 16;19(1):141
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Sleep and breast and prostate cancer risk in the MCC-Spain study.
Turner MC, Gracia-Lavedan E, Papantoniou K, Aragonés N, Castaño-Vinyals G, Dierssen-Sotos T, Amiano P, Ardanaz E, Marcos-Delgado A, Molina-Barceló A, Alguacil J, Benavente Y, Belmonte T, Jiménez-Moleón JJ, Marcos-Gragera R, Pérez B, Gómez-Acebo I, Pollán M, Kogevinas M
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Corrigendum to "Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up": [Annals of Oncology 31 (2020) 17-29].
Zucca E, Arcaini L, Buske C, Johnson PW, Ponzoni M, Raderer M, Ricardi U, Salar A, Stamatopoulos K, Thieblemont C, Wotherspoon A, Ladetto M, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
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Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects.
Rogalska ME, Vivori C, Valcárcel J
Nat Rev Genet. 2022 Dec 16;
Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
Falkenhain-López D, Muniesa C, Estrach MT, Morillo-Andújar M, Peñate Y, Acebo E, Pujol RM, García-Muret MP, Machan S, Medina S, Botella-Estrada R, Fernández de Misa R, Blanes M, Flórez A, Pérez-Paredes G, Izu R, Yanguas I, Silva-Díaz E, Pérez-Ferriols A, Prieto-Torres L, Zayas A, Parera-Amer ME, Pérez A, Aspe L, Román C, Sánchez-Caminero MP, Bassas-Vila J, Domínguez-Auñón JD, Calzado L, Navedo M, Ortiz-Prieto A, Servitje O, Polo-Rodríguez I, Torres I, Hernández-Hernández MN, Mitxelena-Eceiza J, García-Vázquez A, García-Doval I, Ortiz-Romero PL
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When and how did the first blood cells evolve?
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Blood. 2022 Dec 15;140(24):2531-2532
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Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes.
Michel-Todó L, Bancells C, Casas-Vila N, Rovira-Graells N, Hernández-Ferrer C, González JR, Cortés A
Microbiol Spectr. 2022 Dec 14;:e0304922
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Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.
Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L
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A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1.
Closa A, Reixachs-Solé M, Fuentes-Fayos AC, Hayer KE, Melero JL, Adriaanse FRS, Bos RS, Torres-Diz M, Hunger SP, Roberts KG, Mullighan CG, Stam RW, Thomas-Tikhonenko A, Castaño JP, Luque RM, Eyras E
NAR Cancer. 2022 Dec;4(4):zcac041
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Studying the Immunomodulatory Functions of PARP1 and PARP2 in Mouse Models of Cancer.
Lutfi N, Martínez C, Yélamos J
Methods Mol Biol. 2023;2609:195-212
Antimicrobial resistance in Gram-negative bacilli in Spain: an experts' view.
Retamar-Gentil P, Cantón R, Abril López de Medrano V, Barberán J, Canut Blasco A, Dueñas Gutiérrez C, García-Vidal C, Larrosa Escartín N, Lora-Tamayo J, Martínez Marcos FJ, Martín Ruíz C, Pasquau Liaño J, Rascado P, Sanz Peláez O, Yagüe Girao G, Horcajada JP
Rev Esp Quimioter. 2023 Feb;36(1):65-81
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PFAS levels and exposure determinants in sensitive population groups.
Fábelová L, Beneito A, Casas M, Colles A, Dalsager L, Den Hond E, Dereumeaux C, Ferguson K, Gilles L, Govarts E, Irizar A, Lopez Espinosa MJ, Montazeri P, Morrens B, Patayová H, Rausová K, Richterová D, Rodriguez Martin L, Santa-Marina L, Schettgen T, Schoeters G, Haug LS, Uhl M, Villanger GD, Vrijheid M, Zaros C, Palkovi?ová Murínová ?
Chemosphere. 2023 Feb;313:137530
Advancing the treatment of long-lasting borderline personality disorder: a feasibility and acceptability study of an expanded DBT-based skills intervention.
Soler J, Casellas-Pujol E, Pascual JC, Schmidt C, Domínguez-Clavé E, Cebolla A, Alvear D, Muro A, Elices M
Borderline Personal Disord Emot Dysregul. 2022 Dec 12;9(1):34
Recommendations for living donor kidney transplantation.
Frutos MÁ, Crespo M, Valentín MO, Alonso-Melgar Á, Alonso J, Fernández C, García-Erauzkin G, González E, González-Rinne AM, Guirado L, Gutiérrez-Dalmau A, Huguet J, Moral JLLD, Musquera M, Paredes D, Redondo D, Revuelta I, Hofstadt CJV, Alcaraz A, Alonso-Hernández Á, Alonso M, Bernabeu P, Bernal G, Breda A, Cabello M, Caro-Oleas JL, Cid J, Diekmann F, Espinosa L, Facundo C, García M, Gil-Vernet S, Lozano M, Mahillo B, Martínez MJ, Miranda B, Oppenheimer F, Palou E, Pérez-Saez MJ, Peri L, Rodríguez O, Santiago C, Tabernero G, Hernández D, Domínguez-Gil B, Pascual J
Nefrologia (Engl Ed). 2022 Dec;42 Suppl 2:5-132
Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study.
Gardoki-Souto I, Redolar-Ripoll D, Fontana M, Hogg B, Castro MJ, Blanch JM, Ojeda F, Solanes A, Radua J, Valiente-Gómez A, Cirici R, Pérez V, Amann BL, Moreno-Alcázar A
Pain Res Manag. 2022;2022:2114451
Drug-related problems in patients admitted for SARS-CoV-2 infection during the COVID-19 pandemic.
Barceló-Vidal J, Echeverría-Esnal D, Carballo N, De Antonio-Cuscó M, Fernández-Sala X, Navarrete-Rouco ME, Colominas-González E, Luque S, Fuster-Esteva M, Domingo L, Sala M, Duran X, Grau S, Ferrández O
Front Pharmacol. 2022;13:993158
Brain cancer after radiation exposure from CT examinations of children and young adults: results from the EPI-CT cohort study.
Hauptmann M, Byrnes G, Cardis E, Bernier MO, Blettner M, Dabin J, Engels H, Istad TS, Johansen C, Kaijser M, Kjaerheim K, Journy N, Meulepas JM, Moissonnier M, Ronckers C, Thierry-Chef I, Le Cornet L, Jahnen A, Pokora R, Bosch de Basea M, Figuerola J, Maccia C, Nordenskjold A, Harbron RW, Lee C, Simon SL, Berrington de Gonzalez A, Schüz J, Kesminiene A
Lancet Oncol. 2023 Jan;24(1):45-53
Methodological challenges in the genomic analysis of an endangered mammal population with low genetic diversity.
Escoda L, Hawlitschek O, González-Esteban J, Castresana J
Sci Rep. 2022 Dec 10;12(1):21390
The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors.
Green L, Coronado-Zamora M, Radío S, Rech GE, Salces-Ortiz J, González J
BMC Biol. 2022 Dec 8;20(1):275
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Dysphagia in Hospitalized Patients: Prevalence, Related Factors and Impact on Aspiration Pneumonia and Mortality.
Bosch G, Comas M, Domingo L, Guillen-Sola A, Duarte E, Castells X, Sala M
Eur J Clin Invest. 2022 Dec 7;:e13930
Quantification of [(18) F]florbetaben amyloid-PET imaging in a mixed memory clinic population: The ABIDE project.
Collij LE, Salvadó G, de Wilde A, Altomare D, Shekari M, Gispert JD, Bullich S, Stephens A, Barkhof F, Scheltens P, Bouwman F, van der Flier WM
Alzheimers Dement. 2022 Dec 7;
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The benefit of complete response to treatment in patients with chronic spontaneous urticaria - CURE results.
Kolkhir P, Laires PA, Salameh P, Asero R, Bizjak M, Košnik M, Dissemond J, van Doorn M, Hawro T, Kasperska-Zajac A, Zajac M, Kocatürk E, Peter J, Parisi CAS, Ritchie CA, Kulthanan K, Tuchinda P, Fomina D, Kovalkova E, Khoshkhui M, Kouzegaran S, Papapostolou N, Du-Thanh A, Kamegashira A, Meshkova R, Vitchuk A, Bauer A, Grattan C, Staubach P, Bouillet L, Giménez-Arnau AM, Maurer M, Weller K
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Amyloid Beta-Peptide Causes the Permanent Activation of CaMKII-alfa through Its Oxidation.
Picón-Pagès P, Fanlo-Ucar H, Herrera-Fernández V, Ausellé-Bosch S, Galera-López L, Gutiérrez DA, Ozaita A, Álvarez AR, Oliva B, Muñoz FJ
Int J Mol Sci. 2022 Dec 2;23(23)
Current challenges in understanding the role of enhancers in disease.
Zaugg JB, Sahlén P, Andersson R, Alberich-Jorda M, de Laat W, Deplancke B, Ferrer J, Mandrup S, Natoli G, Plewczynski D, Rada-Iglesias A, Spicuglia S
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Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances.
Kaplan A, Lebwohl M, Giménez-Arnau AM, Hide M, Armstrong AW, Maurer M
Allergy. 2023 Feb;78(2):389-401
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Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids.
Barrera-Conde M, Veza-Estévez E, Gomis-Gonzalez M, Garcia-Quintana J, Trabsa A, Martínez-Sadurní L, Pujades M, Perez V, de la Torre R, Bergé D, Robledo P
Neurobiol Dis. 2023 Jan;176:105942
APC couples neuronal mRNAs to multiple kinesins, EB1, and shrinking microtubule ends for bidirectional mRNA motility.
Baumann SJ, Grawenhoff J, Rodrigues EC, Speroni S, Gili M, Komissarov A, Maurer SP
Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211536119
robustica: customizable robust independent component analysis.
Anglada-Girotto M, Miravet-Verde S, Serrano L, Head SA
BMC Bioinformatics. 2022 Dec 5;23(1):519
Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy.
Morales-Curiel LF, Gonzalez AC, Castro-Olvera G, Lin LL, El-Quessny M, Porta-de-la-Riva M, Severino J, Morera LB, Venturini V, Ruprecht V, Ramallo D, Loza-Alvarez P, Krieg M
Commun Biol. 2022 Dec 3;5(1):1330
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Chemoinformatics and artificial intelligence colloquium: progress and challenges in developing bioactive compounds.
Bajorath J, Chávez-Hernández AL, Duran-Frigola M, Fernández-de Gortari E, Gasteiger J, López-López E, Maggiora GM, Medina-Franco JL, Méndez-Lucio O, Mestres J, Miranda-Quintana RA, Oprea TI, Plisson F, Prieto-Martínez FD, Rodríguez-Pérez R, Rondón-Villarreal P, Saldívar-Gonzalez FI, Sánchez-Cruz N, Valli M
J Cheminform. 2022 Dec 2;14(1):82
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Y-chromosome target enrichment reveals rapid expansion of haplogroup R1b-DF27 in Iberia during the Bronze Age transition.
García-Fernández C, Lizano E, Telford M, Olalde Í, de Cid R, Larmuseau MHD, M de Pancorbo M, Calafell F
Sci Rep. 2022 Dec 1;12(1):20708
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Comparison between an exact and a heuristic neural mass model with second-order synapses.
Clusella P, Köksal-Ersöz E, Garcia-Ojalvo J, Ruffini G
Biol Cybern. 2022 Dec 1;
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Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study.
Díaz-López A, Sans JC, Julvez J, Fernandez-Bares S, Llop S, Rebagliato M, Lertxundi N, Santa-Marina L, Guxens M, Sunyer J, Arija V
Sci Rep. 2022 Dec 1;12(1):20762
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Corrigendum to 'Suicide-related thoughts and behavior and suicide death trends during the COVID-19 in the general population of Catalonia, Spain' [European Neuropsychopharmacology 56 (2021) 4-12].
Pérez V, Elices M, Vilagut G, Vieta E, Blanch J, Laborda-Serrano E, Prat B, Colom F, Palao D, Alonso J
Eur Neuropsychopharmacol. 2022 Nov 30;66:66
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Implementing re-configurable biological computation with distributed multicellular consortia.
Canadell D, Ortiz-Vaquerizas N, Mogas-Diez S, de Nadal E, Macia J, Posas F
Nucleic Acids Res. 2022 Nov 28;50(21):12578-12595
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Are antihistamines still used during omalizumab treatment for chronic spontaneous urticaria?
Melé-Ninot G, Serra-Baldrich E, Spertino J, Guilarte M, Ribó González P, Lleonart-Bellfill R, Figueras-Nart I, Bonfill-Ortí M, Depreux N, Sala-Cunill A, Bielsa-Marsol I, Baliu-Piqué C, Sanmartín-Novell V, Garcia-Navarro X, Expósito-Serrano V, Garnica-Velandia D, Diaz-Sarrió MC, Gómez-Armayones S, Gich Saladich I, Giménez-Arnau A
Eur J Dermatol. 2022 Sep 1;32(5):629-631
Mid- and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: A randomized, clinical trial.
Hernando-Redondo J, Toloba A, Benaiges D, Salas-Salvadó J, Martínez-Gonzalez MA, Corella D, Estruch R, Tinahones FJ, Ros E, Goday A, Castañer O, Fitó M
Front Nutr. 2022;9:950900
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Corrigendum: Reliability and validation of the child eating behavior questionnaire in 3- to 6-year-old Spanish children.
Jimeno-Martínez A, Maneschy I, Moreno LA, Bueno-Lozano G, De Miguel-Etayo P, Flores-Rojas K, Jurado-Castro JM, de Lamas C, Vázquez-Cobela R, Martinez-Lacruz R, Portoles O, Martínez JA, Navas-Carretero S, Schröder H, Fitó M, Babio N, Salas-Salvadó J, Leis R, Gil-Campos M, Rupérez AI
Front Psychol. 2022;13:1075681
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Experimental Validation of Transposable Element Insertions Using the Polymerase Chain Reaction (PCR).
Merenciano M, Coronado-Zamora M, González J
Methods Mol Biol. 2023;2607:95-114
EUROVISCO Good Practice Recommendations for a First Viscosupplementation in Patients with Knee Osteoarthritis.
Conrozier T, Diraçoglù D, Monfort J, Chevalier X, Bard H, Baron D, Jerosch J, Migliore A, Richette P, Henrotin Y
Cartilage. 2022 Nov 28;:19476035221138958
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.
Fernandez-Jimenez N, Fore R, Cilleros-Portet A, ... , Vrijheid M, Marsit CJ, Karagas MR, Räikkönen K, Bouchard L, Heude B, Santa-Marina L, Bustamante M, Hivert MF, Bilbao JR
Commun Biol. 2022 Nov 30;5(1):1313
The European baseline series and recommended additions: 2023.
Wilkinson SM, Gonçalo M, Aerts O, Badulici S, Dickel H, Gallo R, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Hervella M, Isaksson M, Johansen JD, Mahler V, Niklasson B, Pigatto P, Ponyai G, Rustemeyer T, Schuttelaar MLA, Spiewak R, Stingeni L, Thyssen JP, Uter W
Contact Dermatitis. 2023 Feb;88(2):87-92
GENCODE: reference annotation for the human and mouse genomes in 2023.
Frankish A, Carbonell-Sala S, Diekhans M, Jungreis I, Loveland JE, Mudge JM, Sisu C, Wright JC, Arnan C, Barnes I, Banerjee A, Bennett R, Berry A, Bignell A, Boix C, Calvet F, Cerdán-Vélez D, Cunningham F, Davidson C, Donaldson S, Dursun C, Fatima R, Giorgetti S, Giron CG, Gonzalez JM, Hardy M, Harrison PW, Hourlier T, Hollis Z, Hunt T, James B, Jiang Y, Johnson R, Kay M, Lagarde J, Martin FJ, Gómez LM, Nair S, Ni P, Pozo F, Ramalingam V, Ruffier M, Schmitt BM, Schreiber JM, Steed E, Suner MM, Sumathipala D, Sycheva I, Uszczynska-Ratajczak B, Wass E, Yang YT, Yates A, Zafrulla Z, Choudhary JS, Gerstein M, Guigo R, Hubbard TJP, Kellis M, Kundaje A, Paten B, Tress ML, Flicek P
Nucleic Acids Res. 2023 Jan 6;51(D1):D942-D949
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Determinants of mortality in cancer patients with unscheduled admission to the Intensive Care Unit: A prospective multicenter study.
Cantón-Bulnes ML, Jiménez-Sánchez M, Alcántara-Carmona S, Gimeno-Costa R, Berezo-García JÁ, Beato C, Álvarez-Lerma F, Mojal S, Olaechea P, Gordo-Vidal F, Garnacho-Montero J
Med Intensiva (Engl Ed). 2022 Dec;46(12):669-679
Living-donor kidney transplant: guidelines with updated evidence.
Frutos MÁ, Crespo M, de la Oliva Valentín M, Hernández D, de Sequera P, Domínguez-Gil B, Pascual J
Nefrologia (Engl Ed). 2022 Dec;42 Suppl 2:1-4
The genomic analysis of current-day North African populations reveals the existence of trans-Saharan migrations with different origins and dates.
Lucas-Sánchez M, Fadhlaoui-Zid K, Comas D
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Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke.
Bretzner M, Bonkhoff AK, Schirmer MD, Hong S, Dalca A, Donahue K, Giese AK, Etherton MR, Rist PM, Nardin M, Regenhardt RW, Leclerc X, Lopes R, Gautherot M, Wang C, Benavente OR, Cole JW, Donatti A, Griessenauer C, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McArdle PF, McDonough CW, Meschia JF, Phuah CL, Rolfs A, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Wu O, Zand R, Worrall BB, Maguire J, Lindgren AG, Jern C, Golland P, Kuchcinski G, Rost NS
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The relevance of rich club regions for functional outcome post-stroke is enhanced in women.
Bonkhoff AK, Schirmer MD, Bretzner M, Hong S, Regenhardt RW, Donahue KL, Nardin MJ, Dalca AV, Giese AK, Etherton MR, Hancock BL, Mocking SJT, McIntosh EC, Attia J, Cole JW, Donatti A, Griessenauer CJ, Heitsch L, Holmegaard L, Jood K, Jimenez-Conde J, Kittner SJ, Lemmens R, Levi CR, McDonough CW, Meschia JF, Phuah CL, Ropele S, Rosand J, Roquer J, Rundek T, Sacco RL, Schmidt R, Sharma P, Slowik A, Sousa A, Stanne TM, Strbian D, Tatlisumak T, Thijs V, Vagal A, Wasselius J, Woo D, Zand R, McArdle PF, Worrall BB, Jern C, Lindgren AG, Maguire J, Wu O, Rost NS, MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium
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Ligelizumab improves angioedema, disease severity and quality-of-life in patients with chronic spontaneous urticaria.
Metz M, Bernstein JA, Giménez-Arnau AM, Hide M, Maurer M, Sitz K, Soong W, Sussman G, Hua E, Barve A, Barbier N, Balp MM, Severin T
World Allergy Organ J. 2022 Nov;15(11):100716
3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.
Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J
Nat Aging. 2022 Sep;2:851-866
Periodic spatial patterning with a single morphogen.
Wang S, Garcia-Ojalvo J, Elowitz MB
Cell Syst. 2022 Dec 21;13(12):1033-1047.e7
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Scaling up complexity in synthetic developmental biology.
Martínez-Ara G, Stapornwongkul KS, Ebisuya M
Science. 2022 Nov 25;378(6622):864-868
POSITION PAPER OF THE CATALAN SOCIETY OF GASTROENTEROLOGY ABOUT HEPATIC ELASTOGRAPHY 2022.
Carrión JA, Graupera I, Vergara M, Morillas RM, Pericàs JM, Poca M, Amador A, Fernández R, Monllor T, Muñoz L, Bartres MC, Genescà J, Ginés P, Forns X
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Correction: Impulsivity is longitudinally associated with healthy and unhealthy dietary patterns in individuals with overweight or obesity and metabolic syndrome within the framework of the PREDIMED-Plus trial.
Gómez-Martínez C, Babio N, Júlvez J, Nishi SK, Fernández-Aranda F, Martínez-González MÁ, Cuenca-Royo A, Fernández R, Jiménez-Murcia S, de la Torre R, Pintó X, Bloemendaal M, Fitó M, Corella D, Arias A, Salas-Salvadó J
Int J Behav Nutr Phys Act. 2022 Nov 23;19(1):140
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Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome.
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Contact Urticaria Syndrome: a Comprehensive Review.
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Musculoskeletal Ultrasound Shows Muscle Mass Changes during Post-Acute Care Hospitalization in Older Men: A Prospective Cohort Study.
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Meat Intake, Cooking Methods, Doneness Preferences and Risk of Gastric Adenocarcinoma in the MCC-Spain Study.
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Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature.
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Sensitization to isothiazolinones in the spanish contact dermatitis registry (reidac): 2019-2021 epidemiological situation.
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Treatment of hypertriglyceridaemia with icosapent ethyl in patients with high/very high cardiovascular risk. Consensus document of the Sociedad Española de Cardiología [Spanish Society of Cardiology] and the Sociedad Española de Diabetes [Spanish Diabetes Society].
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Validation of the Spanish Activity Questionnaire in COPD (SAQ-COPD) in Patients with Chronic Obstructive Pulmonary Disease.
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Responding to the need of postgraduate education for Planetary Health: Development of an online Master's Degree.
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Cutaneous Lymphangitis Carcinomatosa: Dermoscopic and Reflectance Confocal Microscopy Features.
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Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer.
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A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase.
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Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia.
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The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study.
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Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation.
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Minimally invasive pancreatic anastomosis after pancreaticoduodenectomy: multi-institutional step by step video description of the technique.
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Mediterranean Diet, Energy Restriction, Physical Activity and Atherogenicity of Very-Low Density Lipoproteins: Findings from Two Randomized Controlled Trials.
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Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis: A Nation-Wide cohort study.
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The long-term risk of endoleak-related-complications may be falsely elevated according to a competing risk analysis.
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Moderate sedation with dexmedetomidine-remifentanil is safer than deep sedation with propofol-remifentanil for endobronchial ultrasound while providing comparable quality: A randomized double-blind trial.
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Qual Life Res. 2022 Nov 9;
http://www.ncbi.nlm.nih.gov/en...
Comparison of two radiofrequency-based hemostatic devices: saline-linked bipolar vs. cooled-electrode monopolar.
Moll X, Fondevila D, García-Arnas F, Burdio F, Trujillo M, Irastorza RM, Berjano E, Andaluz A
Int J Hyperthermia. 2022;39(1):1397-1407
http://www.ncbi.nlm.nih.gov/en...
Mental health inequalities in times of crisis: evolution between 2005 and 2021 among the Spanish salaried population.
Esteve-Matalí L, Llorens-Serrano C, Alonso J, Vilagut G, Moncada S, Navarro-Giné A
J Epidemiol Community Health. 2022 Nov 7;
http://www.ncbi.nlm.nih.gov/en...
Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study.
Rodríguez-Fernández B, Vilor-Tejedor N, Arenaza-Urquijo EM, Sánchez-Benavides G, Suárez-Calvet M, Operto G, Minguillón C, Fauria K, Kollmorgen G, Suridjan I, de Moura MC, Piñeyro D, Esteller M, Blennow K, Zetterberg H, De Vivo I, Molinuevo JL, Navarro A, Gispert JD, Sala-Vila A, Crous-Bou M, ALFA study.
Alzheimers Res Ther. 2022 Nov 7;14(1):167
Endocrine resistance and breast cancer plasticity are controlled by CoREST.
Garcia-Martinez L, Adams AM, Chan HL, Nakata Y, Weich N, Stransky S, Zhang Z, Alshalalfa M, Sarria L, Mahal BA, Kesmodel SB, Celià-Terrassa T, Liu Z, Minucci S, Bilbao D, Sidoli S, Verdun RE, Morey L
Nat Struct Mol Biol. 2022 Nov;29(11):1122-1135
Migratory behavior is positively associated with genetic diversity in butterflies.
García-Berro A, Talla V, Vila R, Wai HK, Shipilina D, Chan KG, Pierce NE, Backström N, Talavera G
Mol Ecol. 2023 Feb;32(3):560-574
Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults.
Blackman J, Stankeviciute L, Arenaza-Urquijo EM, Suárez-Calvet M, Sánchez-Benavides G, Vilor-Tejedor N, Iranzo A, Molinuevo JL, Gispert JD, Coulthard E, Grau-Rivera O, European Prevention of Alzheimer’s Disease (EPAD) Consortium.
Brain Commun. 2022;4(6):fcac257
Top quality research with the utmost integrity
The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.
At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:
- The PRBB Code of Good Scientific Practices, approved by all the centres.
- An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
- Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.
To learn more about the code, the working group on good scientific practices and the various activities organised, visit:
More information
Contact
●Latest news
Patents and companies
- The following links allow you to explore the technology on offer in the park’s centres:
Technology at the IMIM-Hospital del Mar
UPF Business Shuttle and Innovation Unit
Technology and Business Development Office at the CRG
Analysis and Global Development at ISGlobal
EMBLEM Technology Transfer
- The following start-ups have been created within the PRBB environment:
Acellera
Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.
→ https://www.acellera.comChemotargets
Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.
→ http://www.chemotargets.com/qGenomics
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qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.
→ https://qgenomics.comZeClinics
ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.
→ http://www.zeclinics.comMicroomics
Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.
→ http://www.microomics.euFlomics
World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.
→ http://www.flomics.comBioinspired Materials
This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.
→ https://www.bioinspiredmaterials.com/MedBioinformatics Solutions
MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.
→ https://www.medbioinformatics.com/Pulmobiotics
A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.
→ https://www.pulmobio.com/Integra Therapeutics
Integra Therapeutics, a spin-off company from MELIS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.
→ https://integra-tx.com/●Latest news
