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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.


Hospital del Mar Medical Research Institute (IMIM)

Cancer

The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 

Neuroscience

The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Medicine and Life Sciences at Pompeu Fabra University (MELIS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry.

Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.

Radiation

The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.

Other

ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.


Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:

⟶ recercaambanimals.prbb.org

⟶ estabulari-prbb@prbb.org

⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news


Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza
marbiobanc@imim.es

Web:
https://marbiobanc.imim.es

The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko
biocore@crg.eu

Web:
https://biocore.crg.eu

The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut
projectmanager@cnag.crg.eu

Web:
https://www.cnag.crg.eu

This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet
bespinet@parcdesalutmar.cat

Web:
https://www.imim.es/sct/citogen_tica

The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals. The CEEA-PRBB has been authorized by the Catalan government to carry out the tasks as a competent body (OH) defined in Royal Decree 53/2013 which is framed in Directive 2010/63/EU adopted by the European Parliament.

Contact: Dirección de secretaría
ceea@prbb.org

Web:
https://www.prbb.org (Acceso: Portal PRBB)

This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas
oscar.fornas@upf.edu

Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit

The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría
cbs@prbb.org

Web:
https://www.prbb.org (Acceso: Portal PRBB)

Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop
CEIC-PSMAR@imim.es

Web:
https://www.imim.es/comitesetics/ceic/es_index.html

This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis
bmspt@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit

BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso
bibliopro@imim.es

Web:
https://www.bibliopro.org

The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro
helpdesk@ega-archive.org

Web:
https://ega-archive.org

This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht
ngs@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/genomics-unit

The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà
margenomics@imim.es

Web:
https://margenomics.imim.es

The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals
genomica@upf.edu

Web:
https://www.upf.edu/web/sct-genomics/home

The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera
laura.batlle@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0

This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea
aaldea@imim.es

Web:
https://www.imim.es/ofertadeserveis/assajos_clinics

This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger
mif@embl.es

Web:
https://www.embl.es/services/mesoscopic-imaging-facility

The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi
nadia.halidi@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit

Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu
david.andreu@upf.edu

Web:
https://www.upf.edu/web/sct-peptide-synthesis

This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade
eduard.sabido@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit


Scientific publications
(keywords, journal, author,...)

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction.

Duran-Castells C, Llano A, Kawana-Tachikawa A, Prats A, Martinez-Zalacain I, Kobayashi-Ishihara M, Oriol-Tordera B, Peña R, Gálvez C, Silva-Arrieta S, Clotet B, Riveira-Muñoz E, Ballana E, Prado JG, Martinez-Picado J, Sanchez J, Mothe B, Hartigan-O'Connor D, Wyss-Coray T, Meyerhans A, Gisslén M, Price RW, Soriano-Mas C, Muñoz-Moreno JA, Brander C, Ruiz-Riol M

J Virol. 2023 Jan 31;:e0165522

http://www.ncbi.nlm.nih.gov/en...

Prevalence of atherogenic dyslipidemia, related factors and level of lipid control in the general population of Galicia. GALIPEMIAS study.

Názara C, Argüeso RM, Pedro-Botet J, Pintó X, Millán J, Pena Seijo M, Fernández PA, Eugenia Ameneiros M, Del Alamo A, Rodríguez A, Díaz-Peromingo JA, Vázquez Freire MR, Muñiz J, Pérez-Castro TR, Díaz-Díaz JL, Pose Reino A

Clin Investig Arterioscler. 2023 Jan 28;

http://www.ncbi.nlm.nih.gov/en...

Metabolomics in COPD.

Gea J, Enríquez-Rodríguez CJ, Pascual-Guardia S

Arch Bronconeumol. 2023 Jan 18;

http://www.ncbi.nlm.nih.gov/en...

Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit.

Johnson SC, Suárez-Calvet M, Suridjan I, Minguillón C, Gispert JD, Jonaitis E, Michna A, Carboni M, Bittner T, Rabe C, Kollmorgen G, Zetterberg H, Blennow K

Alzheimers Res Ther. 2023 Jan 28;15(1):25

http://www.ncbi.nlm.nih.gov/en...

Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03.

Garcia-Donas J, Hurtado A, Garrigos L, Santaballa A, Redondo A, Vidal L, Lainez N, Guerra E, Rodriguez V, Cueva J, Bover I, Palacio I, Rubio MJ, Prieto M, Lopez-Guerrero JA, Rodriguez-Moreno JF, Garcia-Casado Z, Garcia-Martinez E, Taus A, de Castro IP, Navarro P, Grande E, Spanish Group for Research in Orphan, Infrequent Tumors (GETHI)

Clin Transl Oncol. 2023 Jan 28;

http://www.ncbi.nlm.nih.gov/en...

Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men.

Zamora A, Ramos R, Comas-Cufi M, García-Gil M, Martí-Lluch R, Plana N, Alves-Cabratosa L, Ponjoan A, Rodríguez-Borjabad C, Ibarretxe D, Roman-Degano I, Marrugat J, Elosua R, Martín-Urda A, Masana L

Sci Rep. 2023 Jan 27;13(1):1492

http://www.ncbi.nlm.nih.gov/en...

Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation.

Fuertes G, Del Valle-Pérez B, Pastor J, Andrades E, Peña R, García de Herreros A, Duñach M

EMBO Rep. 2023 Jan 27;:e54895

http://www.ncbi.nlm.nih.gov/en...

Higher lymphocyte count associated with larger hippocampal volume and fewer depressive symptoms in drug-na ïve first-episode psychosis.

Toll A, Blanco-Hinojo L, Berge D, Martín-Subero M, Casanovas F, El-Abidi K, Perez-Solà V, Mané A

Eur Neuropsychopharmacol. 2023 Jan 27;69:47-55

http://www.ncbi.nlm.nih.gov/en...

Multi-omics data integration methods and their applications in psychiatric disorders.

Sathyanarayanan A, Mueller TT, Ali Moni M, Schueler K, Baune BT, Lio P, Mehta D, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Network, Baune BT, Dierssen M, Ebert B, Fabbri C, Fusar-Poli P, Gennarelli M, Harmer C, Howes OD, Janzing JGE, Lio P, Maron E, Mehta D, Minelli A, Nonell L, Pisanu C, Potier MC, Rybakowski F, Serretti A, Sqassina A, Stacey D, van Westrhenen R, Xicota L

Eur Neuropsychopharmacol. 2023 Jan 25;69:26-46

http://www.ncbi.nlm.nih.gov/en...

The impact of climate change on health needs structured evidence assessment and an evidence to action framework to make decisions: A proposal to adopt the GRADE approach.

Neumann I, Antó JM, Bousquet J, Schünemann HJ

J Clin Epidemiol. 2023 Jan 24;

http://www.ncbi.nlm.nih.gov/en...

Gut-associated lymphoid tissue attrition associates with response to anti-?4?7 therapy in ulcerative colitis.

Canales-Herrerias P, Uzzan M, Seki A, Czepielewski RS, Verstockt B, Livanos A, Raso F, Dunn A, Dai D, Wang A, Al-Taie Z, Martin J, Ko HM, Tokuyama M, Tankelevich M, Meringer H, Cossarini F, Jha D, Krek A, Paulsen JD, Nakadar MZ, Wong J, Erlich EC, Onufer EJ, Helmink BA, Sharma K, Rosenstein A, Chung G, Dawson T, Juarez J, Yajnik V, Cerutti A, Faith J, Suarez-Farinas M, Argmann C, Petralia F, Randolph GJ, Polydorides AD, Reboldi A, Colombel JF, Mehandru S

bioRxiv. 2023 Jan 20;

http://www.ncbi.nlm.nih.gov/en...

Defective engram allocation contributes to impaired fear memory performance in Down syndrome.

Fernández-Blanco Á, Zamora-Moratalla A, Sabariego-Navarro M, Dierssen M

bioRxiv. 2023 Jan 11;

http://www.ncbi.nlm.nih.gov/en...

Modelling of daily radiofrequency electromagnetic field dose for a prospective adolescent cohort.

Eeftens M, Shen C, Sönksen J, Schmutz C, van Wel L, Liorni I, Vermeulen R, Cardis E, Wiart J, Toledano M, Röösli M

Environ Int. 2023 Jan 5;172:107737

http://www.ncbi.nlm.nih.gov/en...

The "Bayés Spirit" as a guide for new generations: How to combine one's personal life and friendships with science and profession.

Martínez-Sellés M, Elosua R, Baranchuk A

J Electrocardiol. 2023 Jan 4;78:17-20

http://www.ncbi.nlm.nih.gov/en...

Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration.

Buxeda A, Llinàs-Mallol L, Gimeno J, Redondo-Pachón D, Arias-Cabrales C, Burballa C, Puche A, López-Botet M, Yélamos J, Vilches C, Naesens M, Pérez-Sáez MJ, Pascual J, Crespo M

Am J Transplant. 2023 Jan 3;

http://www.ncbi.nlm.nih.gov/en...

Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-air(®) approach.

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Clin Transl Allergy. 2023 Jan;13(1):e12215

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Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies.

Vinther JL, Cadman T, Avraam D, Ekstrøm CT, I A Sørensen T, Elhakeem A, Santos AC, Pinot de Moira A, Heude B, Iñiguez C, Pizzi C, Simons E, Voerman E, Corpeleijn E, Zariouh F, Santorelli G, Inskip HM, Barros H, Carson J, Harris JR, Nader JL, Ronkainen J, Strandberg-Larsen K, Santa-Marina L, Calas L, Cederkvist L, Popovic M, Charles MA, Welten M, Vrijheid M, Azad M, Subbarao P, Burton P, Mandhane PJ, Huang RC, Wilson RC, Haakma S, Fernández-Barrés S, Turvey S, Santos S, Tough SC, Sebert S, Moraes TJ, Salika T, Jaddoe VWV, Lawlor DA, Nybo Andersen AM

PLoS Med. 2023 Jan;20(1):e1004036

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Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis.

Molnar C, Reina J, Herrero A, Heinen JP, Méndiz V, Bonnal S, Irimia M, Sánchez-Jiménez M, Sánchez-Molina S, Mora J, Gonzalez C

PNAS Nexus. 2022 Sep;1(4):pgac222

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Severity in the ICD-11 personality disorder model: Evaluation in a Spanish mixed sample.

Gutiérrez F, Aluja A, Rodríguez C, Gárriz M, Peri JM, Gallart S, Calvo N, Ferrer M, Gutiérrez-Zotes A, Soler J, Pascual JC

Front Psychiatry. 2022;13:1015489

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The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees.

Fibla J, Maceda I, Laplana M, Guerrero M, Álvarez MM, Burgueño J, Camps A, Fàbrega J, Felisart J, Grané J, Remón JL, Serra J, Moral P, Lao O

Front Genet. 2022;13:1100440

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Corrigendum: Role of NAFLD on the health related QoL response to lifestyle in patients with metabolic syndrome: The PREDIMED plus cohort.

Martínez-Urbistondo D, San-Cristóbal R, Villares P, Martínez-González MÁ, Babio N, Corella D, Del Val JL, Ordovás JM, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Marcos A, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Vázquez C, Ros E, Vela MVB, Palau A, Sorli JV, Masagué M, Abete I, Moreno-Rodríguez A, Candela-García I, Konieczna J, García-Ríos A, Juárez OL, Portolés O, Martín P, Goday A, Zulet MÁ, Vaquero-Luna J, Orea MDCS, Megías I, Baltasar E, Martínez JA, Daimiel L

Front Endocrinol (Lausanne). 2022;13:1113532

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Cost-Effectiveness of Screening for Open Angle Glaucoma Compared With Opportunistic Case Finding.

Anton A, Serrano D, Nolivos K, Fatti G, Zmuc N, Crespo C, Monleon-Getino T, Sotelo K, Morilla A, García V, Comas M, Castells X

J Glaucoma. 2023 Feb 1;32(2):72-79

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Author Correction: The repertoire of mutational signatures in human cancer.

Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN, Islam SMA, Lopez-Bigas N, Klimczak LJ, McPherson JR, Morganella S, Sabarinathan R, Wheeler DA, Mustonen V, PCAWG Mutational Signatures Working Group, Getz G, Rozen SG, Stratton MR, PCAWG Consortium

Nature. 2023 Jan 25;

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Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

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Nature. 2023 Jan 25;

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Which outcomes should be measured in hand eczema trials? Results from patient interviews and an expert survey.

Rönsch H, Schiffers F, Ofenloch R, Weisshaar E, Buse AS, Hansen A, John SM, Giménez Arnau AM, Pesqué D, Agner T, Nørreslet LB, Loman L, Romeijn GLE, Schuttelaar MLA, Koš?ec Bjelajac A, Macan J, Bauer A, Apfelbacher C

J Eur Acad Dermatol Venereol. 2023 Jan 25;

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State-of-the-art therapy for Down syndrome.

Lorenzon N, Musoles-Lleó J, Turrisi F, Gomis-González M, De La Torre R, Dierssen M

Dev Med Child Neurol. 2023 Jan 24;

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Incidence of mental disorders in the general population aged 1-30 years disaggregated by gender and socioeconomic status.

Mar J, Larrañaga I, Ibarrondo O, González-Pinto A, Las Hayas C, Fullaondo A, Izco-Basurko I, Alonso J, Zorrilla I, Vilagut G, Mateo-Abad M, de Manuel E, UPRIGHT Consortium

Soc Psychiatry Psychiatr Epidemiol. 2023 Jan 24;:1-11

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Occupational contact allergy: The European perspective - analysis of patch test data from ESSCA between 2011-2020.

Bauer A, Pesonen M, Brans R, Caroppo F, Dickel H, Dugonik A, Larese Filon F, Geier J, Gimenez-Arnau AM, Napolitano M, Patruno C, Rustemeyer T, Simon D, Schuttelaar MLA, Spiewak R, Stingeni L, Vok M, Weisshaar E, Wilkinson M, Valiukeviciene S, Uter W

Contact Dermatitis. 2023 Jan 24;

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Effects of Supplemented Mediterranean Diets on Plasma-Phospholipid Fatty Acid Profiles and Risk of Cardiovascular Disease after 1 Year of Intervention in the PREDIMED Trial.

Razquin C, Ruiz-Canela M, Wernitz A, Toledo E, Corella D, Alonso-Gómez Á, Fitó M, Gómez-Gracia E, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Arós F, Salas-Salvadó J, Schulze MB, Martinez-Gonzalez MA

Clin Chem. 2023 Jan 23;

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Application of machine learning to improve the efficiency of electrophysiological simulations used for the prediction of drug-induced ventricular arrhythmia.

Rodríguez-Belenguer P, Kopa?ska K, Llopis-Lorente J, Trenor B, Saiz J, Pastor M

Comput Methods Programs Biomed. 2023 Jan 9;230:107345

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Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients.

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Arch Bronconeumol. 2023 Jan 7;

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ERJ Open Research receives its first impact factor and plans for the next step.

Song WJ, Barreiro E

ERJ Open Res. 2023 Jan;9(1)

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Epidermotropic B-Cell Lymphoma: A Case of Secondary Cutaneous Splenic Marginal Zone B-Cell Lymphoma With Autoinvolutive and Recurrent Cutaneous Lesions.

Rovira-López R, Gallardo F, Salar A, Colomo L, Pujol RM

Am J Dermatopathol. 2023 Feb 1;45(2):81-85

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Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.

Generoso SF, Neguembor MV, Hershberg EA, Sadreyev RI, Kurimoto K, Yabuta Y, Ricci R, Audergon P, Bauer M, Saitou M, Hochedlinger K, Beliveau BJ, Cosma MP, Lee JT, Payer B

Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2213810120

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YAP1 fusion in poroid neoplasms: A molecular and immunohistochemical study of 48 adnexal skin tumors.

Tormo-Mainar S, Andrades E, Salido M, Rodríguez-Rivera M, Pujol RM, Deza G

J Eur Acad Dermatol Venereol. 2023 Jan 22;

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Insular Role in Blood Pressure and Systemic Vascular Resistance Regulation.

Sanchez-Larsen A, Principe A, Ley M, Vaquerizo B, Langohr K, Rocamora R

Neuromodulation. 2023 Jan 20;

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Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms.

Mazzolini R, Rodríguez-Arce I, Fernández-Barat L, Piñero-Lambea C, Garrido V, Rebollada-Merino A, Motos A, Torres A, Grilló MJ, Serrano L, Lluch-Senar M

Nat Biotechnol. 2023 Jan 19;

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Genomic insights into the population history of the Resande or Swedish Travellers.

Vilà-Valls L, Aizpurua-Iraola J, Casinge S, Bojs K, Flores-Bello A, Font-Porterias N, Comas D

Genome Biol Evol. 2023 Jan 19;

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Impact of the "Zero Resistance" program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study.

Álvarez-Lerma F, Catalán-González M, Álvarez J, Sánchez-García M, Palomar-Martínez M, Fernández-Moreno I, Garnacho-Montero J, Barcenilla-Gaite F, García R, Aranaz-Andrés J, Lozano-García FJ, Ramírez-Galleymore P, Martínez-Alonso M

Med Intensiva (Engl Ed). 2023 Jan 18;

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[Economic cost estimation of a sample of occupational disease cases accepted by the National Institute of Social Security and evaluated at Parc de Salut Mar, 2014-2021].

Gayá Pérez H, Torres Ordóñez MB, Díaz P, Ramada JM, Serra C, G Benavides F

Arch Prev Riesgos Labor. 2023 Jan 16;26(1):41-48

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Predictors of Preeclampsia in the First Trimester in Normotensive and Chronic Hypertensive Pregnant Women.

Vázquez S, Pascual J, Durán-Jordà X, Hernández JL, Crespo M, Oliveras A

J Clin Med. 2023 Jan 11;12(2)

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Mood disorders in higher education in Flanders during the 2(nd) and 3(rd) COVID-19 wave: Prevalence and help-seeking: Findings from the Flemish College Surveys (FLeCS).

Bootsma E, Jansen L, Kiekens G, Voorpoels W, Mortier P, Proost S, Vande Poel I, Jacobs K, Demyttenaere K, Alonso J, Kessler RC, Cuijpers P, Auerbach RP, Bruffaerts R

J Psychiatr Res. 2023 Jan 11;159:33-41

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A Genome-Wide Functional Screen Identifies Enhancer and Protective Genes for Amyloid Beta-Peptide Toxicity.

Picón-Pagès P, Bosch-Morató M, Subirana L, Rubio-Moscardó F, Guivernau B, Fanlo-Ucar H, Zeylan ME, Senyuz S, Herrera-Fernández V, Vicente R, Fernández-Fernández JM, García-Ojalvo J, Gursoy A, Keskin O, Oliva B, Posas F, de Nadal E, Muñoz FJ

Int J Mol Sci. 2023 Jan 9;24(2)

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Specific biomarker comparison in current smokers, e-cigarette users, and non-smokers.

Melero-Ollonarte JL, Lidón-Moyano C, Perez-Ortuño R, Fu M, Ballbè M, Martín-Sánchez JC, González-Marrón A, Cartanyà-Hueso À, Pascual JA, Fernández E, Martínez-Sánchez JM

Addict Behav. 2023 Jan 8;140:107616

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Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer.

Pérez-Martín H, Lidón-Moyano C, González-Marrón A, Fu M, Pérez-Ortuño R, Ballbè M, Martín-Sánchez JC, Pascual JA, Fernández E, Martínez-Sánchez JM

Healthcare (Basel). 2023 Jan 6;11(2)

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Clinical Guideline on Perioperative Management of Patients with Advanced Chronic Liver Disease.

Canillas L, Pelegrina A, Álvarez J, Colominas-González E, Salar A, Aguilera L, Burdio F, Montes A, Grau S, Grande L, Carrión JA

Life (Basel). 2023 Jan 3;13(1)

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Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.

Jiménez-Balado J, Giralt-Steinhauer E, Fernández-Pérez I, Rey L, Cuadrado-Godia E, Ois Á, Rodríguez-Campello A, Soriano-Tárraga C, Lazcano U, Macias-Gómez A, Suárez-Pérez A, Revert A, Estragués I, Beltrán-Mármol B, Medrano-Martorell S, Capellades J, Roquer J, Jiménez-Conde J

Biology (Basel). 2022 Dec 24;12(1)

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Sex Differences in the Association between Risk of Anterior Cruciate Ligament Rupture and COL5A1 Polymorphisms in Elite Footballers.

Rodas G, Cáceres A, Ferrer E, Balagué-Dobón L, Osaba L, Lucia A, González JR

Genes (Basel). 2022 Dec 22;14(1)

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Evaluation of the host immune response assay SeptiCyte RAPID for potential triage of COVID-19 patients.

Montero MM, Hardy-Werbin M, Gonzalez-Gallardo S, Torres E, Rueda R, Hannet I, Kirk JT, Yager TD, Navalkar K, Arenas MDM, Arietta-Aldea I, Castañeda S, Gómez-Junyent J, Gómez-Zorrilla S, Guerri-Fernandez R, Sanchez-Martinez F, López-Montesinos I, Pelegrín I, Sendra E, Sorlí L, Villar-García J, Bellosillo B, Horcajada JP

Sci Rep. 2023 Jan 18;13(1):944

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Parallel duplication and loss of aquaporin-coding genes during the 'out of the sea' transition as potential key drivers of animal terrestrialization.

Martínez-Redondo GI, Simón Guerrero C, Aristide L, Balart-García P, Tonzo V, Fernández R

Mol Ecol. 2023 Jan 18;

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Author Correction: Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study.

Díaz-López A, Canals-Sans J, Julvez J, Fernandez-Barrés S, Llop S, Rebagliato M, Lertxundi N, Santa-Marina L, Guxens M, Sunyer J, Arija V

Sci Rep. 2023 Jan 18;13(1):993

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Trends in the Prevalence of Methylchloroisothiazolinone/Methylisothiazolinone Contact Allergy in North America and Europe.

Reeder MJ, Warshaw E, Aravamuthan S, Belsito DV, Geier J, Wilkinson M, Atwater AR, White IR, Silverberg JI, Taylor JS, Fowler JF Jr, Maibach HI, DeKoven JG, Buhl T, Botto N, Giménez-Arnau AM, Gallo R, Mowad C, Lang CCV, DeLeo VA, Johnston G, Pratt MD, Brockow K, Adler BL, Houle MC, Dickel H, Schuttelaar MLA, Yu J, Spiewak R, Dunnick C, Filon FL, Valiukeviciene S, Uter W

JAMA Dermatol. 2023 Jan 18;

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Women in Spanish institutional medicine leadership: The glass ceiling remains seemingly invulnerable.

Gómez-Durán E, Gassó AM, Bisbe E, Virumbrales M

Med Clin (Barc). 2023 Jan 16;

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Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress.

Shabardina V, Charria PR, Saborido GB, Diaz-Mora E, Cuenda A, Ruiz-Trillo I, Sanz-Ezquerro JJ

Open Biol. 2023 Jan;13(1):220314

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A Bioengineered Model for Studying Vascular-Pericyte Interactions of the Placenta.

Cherubini M, Haase K

Methods Mol Biol. 2023;2608:409-423

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The relationship between air pollution and multimorbidity: Can two birds be killed with the same stone?

Arias de la Torre J, Ronaldson A, Alonso J, Dregan A, Mudway I, Valderas JM, Vineis P, Bakolis I

Eur J Epidemiol. 2023 Jan 16;:1-5

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Correction: Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.

Mansouri L, Thorvaldsdottir B, Sutton LA, Karakatsoulis G, Meggendorfer M, Parker H, Nadeu F, Brieghel C, Laidou S, Moia R, Rossi D, Catherwood M, Kotaskova J, Delgado J, Rodríguez-Vicente AE, Benito R, Rigolin GM, Bonfiglio S, Scarfo L, Mattsson M, Davis Z, Gogia A, Rani L, Baliakas P, Foroughi-Asl H, Jylhä C, Skaftason A, Rapado I, Miras F, Martinez-Lopez J, de la Serna J, Rivas JMH, Thornton P, Larráyoz MJ, Calasanz MJ, Fésüs V, Mátrai Z, Bödör C, Smedby KE, Espinet B, Puiggros A, Gupta R, Bullinger L, Bosch F, Tazón-Vega B, Baran-Marszak F, Oscier D, Nguyen-Khac F, Zenz T, Terol MJ, Cuneo A, Hernández-Sánchez M, Pospisilova S, Mills K, Gaidano G, Niemann CU, Campo E, Strefford JC, Ghia P, Stamatopoulos K, Rosenquist R

Leukemia. 2023 Jan 12;

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Analysis of Psychological Symptoms Following Disclosure of Amyloid-Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline.

Caprioglio C, Ribaldi F, Visser LNC, Minguillon C, Collij LE, Grau-Rivera O, Zeyen P, Molinuevo JL, Gispert JD, Garibotto V, Moro C, Walker Z, Edison P, Demonet JF, Barkhof F, Scheltens P, Alves IL, Gismondi R, Farrar G, Stephens AW, Jessen F, Frisoni GB, Altomare D, AMYPAD consortium

JAMA Netw Open. 2023 Jan 3;6(1):e2250921

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Exposure to outdoor residential noise during pregnancy, embryonic size, fetal growth, and birth outcomes.

Graafland N, Essers E, Posthumus A, Gootjes D, Ambrós A, Steegers E, Guxens M

Environ Int. 2023 Jan;171:107730

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Long-read sequencing in the era of epigenomics and epitranscriptomics.

Lucas MC, Novoa EM

Nat Methods. 2023 Jan;20(1):25-29

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Reference values of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L for women with non-metastatic breast cancer at diagnosis and 2 years after.

Miret C, Orive M, Sala M, García-Gutiérrez S, Sarasqueta C, Legarreta MJ, Redondo M, Rivero A, Castells X, Quintana JM, Garin O, Ferrer M, REDISSEC-CaMISS Group

Qual Life Res. 2023 Jan 11;

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Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration.

Marques I, Santos S, Monasso GS, Fossati S, Vrijheid M, Nieuwenhuijsen M, Jaddoe VWV, Felix JF

Epigenetics. 2023 Jan 11;:1-11

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Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.

Alfano R, Zugna D, Barros H, Bustamante M, Chatzi L, Ghantous A, Herceg Z, Keski-Rahkonen P, de Kok TM, Nawrot TS, Relton CL, Robinson O, Roumeliotaki T, Scalbert A, Vrijheid M, Vineis P, Richiardi L, Plusquin M

BMC Med. 2023 Jan 11;21(1):17

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Perturbed fatty-acid metabolism is linked to localized chromatin hyperacetylation, increased stress-response gene expression and resistance to oxidative stress.

Princová J, Salat-Canela C, Dan?k P, Marešová A, de Cubas L, Bähler J, Ayté J, Hidalgo E, P?evorovský M

PLoS Genet. 2023 Jan 10;19(1):e1010582

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Pharmacokinetics/pharmacodynamics and therapeutic drug monitoring of ceftazidime/avibactam administered by continuous infusion in patients with MDR Gram-negative bacterial infections.

Fresan D, Luque S, Benítez-Cano A, Sorlí L, Montero MM, De-Antonio M, Prim N, Vega V, Horcajada JP, Grau S

J Antimicrob Chemother. 2023 Jan 10;

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Sociodemographic characteristics, functional status, and health resource use of older patients treated in Spanish emergency departments: a description of the EDEN cohort.

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Prospective Association between Adherence to the Mediterranean Diet and Health-Related Quality of Life in Spanish Children.

Juton C, Berruezo P, Rajmil L, Lerin C, Fíto M, Homs C, Según G, Gómez SF, Schröder H

Nutrients. 2022 Dec 14;14(24)

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Anti-TNF vs tocilizumab in refractory uveitic cystoid macular edema due to Behcet's disease. Multicenter study of 49 patients.

Barroso-García N, Atienza-Mateo B, Ferraz-Amaro I, Prieto-Peña D, Beltrán E, Adán A, Hernández-Garfella M, Martínez-Costa L, Cordero-Coma M, Díaz-Llopis M, Herreras JM, Maíz-Alonso O, Torre-Salaberri I, De Vicente-Delmás A, Díaz-Valle D, Atanes-Sandoval A, Francisco F, Insua S, Sánchez J, Almodóvar-González R, Jiménez-Sosa A, Ruiz-Moreno O, Gandía-Martínez M, Nolla JM, Calvo-Río V, Castañeda S, González-Gay MA, Blanco R

Semin Arthritis Rheum. 2022 Dec 14;58:152153

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Sialyltransferase Inhibitor Ac(5)3F(ax)Neu5Ac Reverts the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice.

Miró L, López J, Guerrero PE, Martínez-Bosch N, Manero-Rupérez N, Moreno M, Ortiz MR, Llop E, Navarro P, Peracaula R

Cancers (Basel). 2022 Dec 12;14(24)

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Mid-childhood fat mass and airflow limitation at 15?years: The mediating role of insulin resistance and C-reactive protein.

Peralta GP, Granell R, Bédard A, Carsin AE, Fuertes E, Howe LD, Márquez S, Jarvis DL, Garcia-Aymerich J

Pediatr Allergy Immunol. 2022 Dec;33(12):e13894

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Study of Excipients in Delayed Skin Reactions to mRNA Vaccines: Positive Delayed Intradermal Reactions to Polyethylene Glycol Provide New Insights for COVID-19 Arm.

Pesqué D, Pujol RM, Marcantonio O, Vidal-Navarro A, Ramada JM, Arderiu-Formentí A, Albalat-Torres A, Serra C, Giménez-Arnau AM

Vaccines (Basel). 2022 Nov 30;10(12)

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Editorial: Neurodevelopmental, neuropsychiatric and psychosocial correlates of joint hypermobility and related disorders.

Guinchat V, Baeza-Velasco C, Bulbena A, Castori M

Front Psychiatry. 2022;13:1109515

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Editorial: Stromal and immune microenvironment in breast cancer metastasis.

Lu X, Liu X, Celià-Terrassa T, Ren G

Front Immunol. 2022;13:1104362

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Prevalence of clozapine-induced sialorrhea and its effect on quality of life.

Sanagustin D, Martin-Subero M, Hogg B, Fortea L, Gardoki I, Guinart D, Roldán M, Angelats M, Cerro L, Navas D, Jiménez JD, Ortiz L, Ros R, Polo X, Ventura Y, Contreras J, Moreno-Alcázar A, Pérez-Sola V, Amann BL, Valiente-Gómez A

Psychopharmacology (Berl). 2023 Jan;240(1):203-211

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Long-term outcomes of extended DAPT in a real-life cohort of consecutive STEMI patients.

Tizón-Marcos H, Toloba A, Subirana Cachinero I, Elosua R, Sionis A, Fernández-Avilés F, Bueno H, Carrillo A, Bayés A, Sánchez PL, Roqué M, Milà L, Elorriaga A, Vaquero J, Fernández-Bergés D, Bosch D, Alameda J, Martí Almor J, Jiménez-Navarro M, Martínez L, Sanchis J, Sánchez E, Rubert C, Ruiz-Valdepeñas L, Rodríguez M, Lozano Í, Abu-Assi E, González VB, Marrugat J

Rev Esp Cardiol (Engl Ed). 2022 Dec 17;

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Nano3P-seq: transcriptome-wide analysis of gene expression and tail dynamics using end-capture nanopore cDNA sequencing.

Begik O, Diensthuber G, Liu H, Delgado-Tejedor A, Kontur C, Niazi AM, Valen E, Giraldez AJ, Beaudoin JD, Mattick JS, Novoa EM

Nat Methods. 2023 Jan;20(1):75-85

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Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation.

Hernandez-Alias X, Katanski CD, Zhang W, Assari M, Watkins CP, Schaefer MH, Serrano L, Pan T

Nucleic Acids Res. 2022 Dec 20;

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Isolated Patchy Heterochromia With Pili Annulati Features on Light and Electron Microscopy.

Lobato-Berezo A, Pesqué D, Pujol RM

Dermatol Pract Concept. 2022 Nov;12(4):e2022204

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Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome.

Soldevila-Domenech N, Pastor A, Sala-Vila A, Lázaro I, Boronat A, Muñoz D, Castañer O, Fagundo B, Corella D, Fernández-Aranda F, Martínez-González MÁ, Salas-Salvadó J, Fitó M, de la Torre R

Front Nutr. 2022;9:1076677

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Obesity and related comorbidities in a large population-based cohort of subjects with type 1 diabetes in Catalonia.

Genua I, Franch-Nadal J, Navas E, Mata-Cases M, Giménez-Pérez G, Vlacho B, Mauricio D, Goday A

Front Endocrinol (Lausanne). 2022;13:1015614

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Editorial: Unconventional protein secretion: From basic mechanisms to dysregulation in disease.

Chiritoiu-Butnaru M, Stewart SE, Zhang M, Malhotra V, Villeneuve J

Front Cell Dev Biol. 2022;10:1088002

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Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data.

de Villarreal JM, Kalisz M, Piedrafita G, Graña-Castro O, Chondronasiou D, Serrano M, Real FX

Bioinformatics. 2023 Jan 1;39(1)

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Protective ileostomy creation after anterior resection of the rectum: shared decision-making or still subjective?

Balla A, Saraceno F, Rullo M, Morales-Conde S, Targarona Soler EM, Di Saverio S, Guerrieri M, Lepiane P, Di Lorenzo N, Adamina M, Alarcón I, Arezzo A, Bollo Rodriguez J, Boni L, Biondo S, Carrano FM, Chand M, Jenkins JT, Davies J, Delgado Rivilla S, Delrio P, Elmore U, Espin-Basany E, Fichera A, Flor Lorente B, Francis N, Gómez Ruiz M, Hahnloser D, Licardie E, Martinez C, Ortenzi M, Panis Y, Pastor Idoate C, Paganini AM, Pera M, Perinotti R, Popowich DA, Rockall T, Rosati R, Sartori A, Scoglio D, Shalaby M, Simó Fernández V, Smart NJ, Spinelli A, Sylla P, Tanis PJ, Valdes-Hernandez J, Wexner SD, Sileri P

Colorectal Dis. 2022 Dec 17;

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Design and validation of a multi-task, multi-context protocol for real-world gait simulation.

Scott K, Bonci T, Salis F, Alcock L, Buckley E, Gazit E, Hansen C, Schwickert L, Aminian K, Bertuletti S, Caruso M, Chiari L, Sharrack B, Maetzler W, Becker C, Hausdorff JM, Vogiatzis I, Brown P, Del Din S, Eskofier B, Paraschiv-Ionescu A, Keogh A, Kirk C, Kluge F, Micó-Amigo EM, Mueller A, Neatrour I, Niessen M, Palmerini L, Sillen H, Singleton D, Ullrich M, Vereijken B, Froehlich M, Brittain G, Caulfield B, Koch S, Carsin AE, Garcia-Aymerich J, Kuederle A, Yarnall A, Rochester L, Cereatti A, Mazzà C, Mobilise-D consortium

J Neuroeng Rehabil. 2022 Dec 16;19(1):141

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Sleep and breast and prostate cancer risk in the MCC-Spain study.

Turner MC, Gracia-Lavedan E, Papantoniou K, Aragonés N, Castaño-Vinyals G, Dierssen-Sotos T, Amiano P, Ardanaz E, Marcos-Delgado A, Molina-Barceló A, Alguacil J, Benavente Y, Belmonte T, Jiménez-Moleón JJ, Marcos-Gragera R, Pérez B, Gómez-Acebo I, Pollán M, Kogevinas M

Sci Rep. 2022 Dec 16;12(1):21807

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Corrigendum to "Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up": [Annals of Oncology 31 (2020) 17-29].

Zucca E, Arcaini L, Buske C, Johnson PW, Ponzoni M, Raderer M, Ricardi U, Salar A, Stamatopoulos K, Thieblemont C, Wotherspoon A, Ladetto M, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org

Ann Oncol. 2022 Dec 16;

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Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects.

Rogalska ME, Vivori C, Valcárcel J

Nat Rev Genet. 2022 Dec 16;

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Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.

Falkenhain-López D, Muniesa C, Estrach MT, Morillo-Andújar M, Peñate Y, Acebo E, Pujol RM, García-Muret MP, Machan S, Medina S, Botella-Estrada R, Fernández de Misa R, Blanes M, Flórez A, Pérez-Paredes G, Izu R, Yanguas I, Silva-Díaz E, Pérez-Ferriols A, Prieto-Torres L, Zayas A, Parera-Amer ME, Pérez A, Aspe L, Román C, Sánchez-Caminero MP, Bassas-Vila J, Domínguez-Auñón JD, Calzado L, Navedo M, Ortiz-Prieto A, Servitje O, Polo-Rodríguez I, Torres I, Hernández-Hernández MN, Mitxelena-Eceiza J, García-Vázquez A, García-Doval I, Ortiz-Romero PL

Actas Dermosifiliogr. 2022 Dec 15;

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When and how did the first blood cells evolve?

Graf T

Blood. 2022 Dec 15;140(24):2531-2532

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Patterns of Heterochromatin Transitions Linked to Changes in the Expression of Plasmodium falciparum Clonally Variant Genes.

Michel-Todó L, Bancells C, Casas-Vila N, Rovira-Graells N, Hernández-Ferrer C, González JR, Cortés A

Microbiol Spectr. 2022 Dec 14;:e0304922

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Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.

Pintado V, Ruiz-Garbajosa P, Aguilera-Alonso D, Baquero-Artigao F, Bou G, Cantón R, Grau S, Gutiérrez-Gutiérrez B, Larrosa N, Machuca I, Martínez Martínez L, Montero MM, Morte-Romea E, Oliver A, Paño-Pardo JR, Sorlí L

Enferm Infecc Microbiol Clin (Engl Ed). 2022 Dec 13;

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A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1.

Closa A, Reixachs-Solé M, Fuentes-Fayos AC, Hayer KE, Melero JL, Adriaanse FRS, Bos RS, Torres-Diz M, Hunger SP, Roberts KG, Mullighan CG, Stam RW, Thomas-Tikhonenko A, Castaño JP, Luque RM, Eyras E

NAR Cancer. 2022 Dec;4(4):zcac041

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Studying the Immunomodulatory Functions of PARP1 and PARP2 in Mouse Models of Cancer.

Lutfi N, Martínez C, Yélamos J

Methods Mol Biol. 2023;2609:195-212

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Antimicrobial resistance in Gram-negative bacilli in Spain: an experts' view.

Retamar-Gentil P, Cantón R, Abril López de Medrano V, Barberán J, Canut Blasco A, Dueñas Gutiérrez C, García-Vidal C, Larrosa Escartín N, Lora-Tamayo J, Martínez Marcos FJ, Martín Ruíz C, Pasquau Liaño J, Rascado P, Sanz Peláez O, Yagüe Girao G, Horcajada JP

Rev Esp Quimioter. 2023 Feb;36(1):65-81

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PFAS levels and exposure determinants in sensitive population groups.

Fábelová L, Beneito A, Casas M, Colles A, Dalsager L, Den Hond E, Dereumeaux C, Ferguson K, Gilles L, Govarts E, Irizar A, Lopez Espinosa MJ, Montazeri P, Morrens B, Patayová H, Rausová K, Richterová D, Rodriguez Martin L, Santa-Marina L, Schettgen T, Schoeters G, Haug LS, Uhl M, Villanger GD, Vrijheid M, Zaros C, Palkovi?ová Murínová ?

Chemosphere. 2023 Feb;313:137530

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Advancing the treatment of long-lasting borderline personality disorder: a feasibility and acceptability study of an expanded DBT-based skills intervention.

Soler J, Casellas-Pujol E, Pascual JC, Schmidt C, Domínguez-Clavé E, Cebolla A, Alvear D, Muro A, Elices M

Borderline Personal Disord Emot Dysregul. 2022 Dec 12;9(1):34

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Recommendations for living donor kidney transplantation.

Frutos MÁ, Crespo M, Valentín MO, Alonso-Melgar Á, Alonso J, Fernández C, García-Erauzkin G, González E, González-Rinne AM, Guirado L, Gutiérrez-Dalmau A, Huguet J, Moral JLLD, Musquera M, Paredes D, Redondo D, Revuelta I, Hofstadt CJV, Alcaraz A, Alonso-Hernández Á, Alonso M, Bernabeu P, Bernal G, Breda A, Cabello M, Caro-Oleas JL, Cid J, Diekmann F, Espinosa L, Facundo C, García M, Gil-Vernet S, Lozano M, Mahillo B, Martínez MJ, Miranda B, Oppenheimer F, Palou E, Pérez-Saez MJ, Peri L, Rodríguez O, Santiago C, Tabernero G, Hernández D, Domínguez-Gil B, Pascual J

Nefrologia (Engl Ed). 2022 Dec;42 Suppl 2:5-132

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Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study.

Gardoki-Souto I, Redolar-Ripoll D, Fontana M, Hogg B, Castro MJ, Blanch JM, Ojeda F, Solanes A, Radua J, Valiente-Gómez A, Cirici R, Pérez V, Amann BL, Moreno-Alcázar A

Pain Res Manag. 2022;2022:2114451

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Drug-related problems in patients admitted for SARS-CoV-2 infection during the COVID-19 pandemic.

Barceló-Vidal J, Echeverría-Esnal D, Carballo N, De Antonio-Cuscó M, Fernández-Sala X, Navarrete-Rouco ME, Colominas-González E, Luque S, Fuster-Esteva M, Domingo L, Sala M, Duran X, Grau S, Ferrández O

Front Pharmacol. 2022;13:993158

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Brain cancer after radiation exposure from CT examinations of children and young adults: results from the EPI-CT cohort study.

Hauptmann M, Byrnes G, Cardis E, Bernier MO, Blettner M, Dabin J, Engels H, Istad TS, Johansen C, Kaijser M, Kjaerheim K, Journy N, Meulepas JM, Moissonnier M, Ronckers C, Thierry-Chef I, Le Cornet L, Jahnen A, Pokora R, Bosch de Basea M, Figuerola J, Maccia C, Nordenskjold A, Harbron RW, Lee C, Simon SL, Berrington de Gonzalez A, Schüz J, Kesminiene A

Lancet Oncol. 2023 Jan;24(1):45-53

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Methodological challenges in the genomic analysis of an endangered mammal population with low genetic diversity.

Escoda L, Hawlitschek O, González-Esteban J, Castresana J

Sci Rep. 2022 Dec 10;12(1):21390

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The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors.

Green L, Coronado-Zamora M, Radío S, Rech GE, Salces-Ortiz J, González J

BMC Biol. 2022 Dec 8;20(1):275

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Dysphagia in Hospitalized Patients: Prevalence, Related Factors and Impact on Aspiration Pneumonia and Mortality.

Bosch G, Comas M, Domingo L, Guillen-Sola A, Duarte E, Castells X, Sala M

Eur J Clin Invest. 2022 Dec 7;:e13930

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Quantification of [(18) F]florbetaben amyloid-PET imaging in a mixed memory clinic population: The ABIDE project.

Collij LE, Salvadó G, de Wilde A, Altomare D, Shekari M, Gispert JD, Bullich S, Stephens A, Barkhof F, Scheltens P, Bouwman F, van der Flier WM

Alzheimers Dement. 2022 Dec 7;

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The benefit of complete response to treatment in patients with chronic spontaneous urticaria - CURE results.

Kolkhir P, Laires PA, Salameh P, Asero R, Bizjak M, Košnik M, Dissemond J, van Doorn M, Hawro T, Kasperska-Zajac A, Zajac M, Kocatürk E, Peter J, Parisi CAS, Ritchie CA, Kulthanan K, Tuchinda P, Fomina D, Kovalkova E, Khoshkhui M, Kouzegaran S, Papapostolou N, Du-Thanh A, Kamegashira A, Meshkova R, Vitchuk A, Bauer A, Grattan C, Staubach P, Bouillet L, Giménez-Arnau AM, Maurer M, Weller K

J Allergy Clin Immunol Pract. 2022 Dec 5;

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Amyloid Beta-Peptide Causes the Permanent Activation of CaMKII-alfa through Its Oxidation.

Picón-Pagès P, Fanlo-Ucar H, Herrera-Fernández V, Ausellé-Bosch S, Galera-López L, Gutiérrez DA, Ozaita A, Álvarez AR, Oliva B, Muñoz FJ

Int J Mol Sci. 2022 Dec 2;23(23)

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Current challenges in understanding the role of enhancers in disease.

Zaugg JB, Sahlén P, Andersson R, Alberich-Jorda M, de Laat W, Deplancke B, Ferrer J, Mandrup S, Natoli G, Plewczynski D, Rada-Iglesias A, Spicuglia S

Nat Struct Mol Biol. 2022 Dec;29(12):1148-1158

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Chronic spontaneous urticaria: focus on pathophysiology to unlock treatment advances.

Kaplan A, Lebwohl M, Giménez-Arnau AM, Hide M, Armstrong AW, Maurer M

Allergy. 2023 Feb;78(2):389-401

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Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoids.

Barrera-Conde M, Veza-Estévez E, Gomis-Gonzalez M, Garcia-Quintana J, Trabsa A, Martínez-Sadurní L, Pujades M, Perez V, de la Torre R, Bergé D, Robledo P

Neurobiol Dis. 2023 Jan;176:105942

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APC couples neuronal mRNAs to multiple kinesins, EB1, and shrinking microtubule ends for bidirectional mRNA motility.

Baumann SJ, Grawenhoff J, Rodrigues EC, Speroni S, Gili M, Komissarov A, Maurer SP

Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2211536119

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robustica: customizable robust independent component analysis.

Anglada-Girotto M, Miravet-Verde S, Serrano L, Head SA

BMC Bioinformatics. 2022 Dec 5;23(1):519

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Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy.

Morales-Curiel LF, Gonzalez AC, Castro-Olvera G, Lin LL, El-Quessny M, Porta-de-la-Riva M, Severino J, Morera LB, Venturini V, Ruprecht V, Ramallo D, Loza-Alvarez P, Krieg M

Commun Biol. 2022 Dec 3;5(1):1330

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Chemoinformatics and artificial intelligence colloquium: progress and challenges in developing bioactive compounds.

Bajorath J, Chávez-Hernández AL, Duran-Frigola M, Fernández-de Gortari E, Gasteiger J, López-López E, Maggiora GM, Medina-Franco JL, Méndez-Lucio O, Mestres J, Miranda-Quintana RA, Oprea TI, Plisson F, Prieto-Martínez FD, Rodríguez-Pérez R, Rondón-Villarreal P, Saldívar-Gonzalez FI, Sánchez-Cruz N, Valli M

J Cheminform. 2022 Dec 2;14(1):82

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Y-chromosome target enrichment reveals rapid expansion of haplogroup R1b-DF27 in Iberia during the Bronze Age transition.

García-Fernández C, Lizano E, Telford M, Olalde Í, de Cid R, Larmuseau MHD, M de Pancorbo M, Calafell F

Sci Rep. 2022 Dec 1;12(1):20708

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Comparison between an exact and a heuristic neural mass model with second-order synapses.

Clusella P, Köksal-Ersöz E, Garcia-Ojalvo J, Ruffini G

Biol Cybern. 2022 Dec 1;

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Maternal iron status during pregnancy and attention deficit/hyperactivity disorder symptoms in 7-year-old children: a prospective cohort study.

Díaz-López A, Sans JC, Julvez J, Fernandez-Bares S, Llop S, Rebagliato M, Lertxundi N, Santa-Marina L, Guxens M, Sunyer J, Arija V

Sci Rep. 2022 Dec 1;12(1):20762

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Corrigendum to 'Suicide-related thoughts and behavior and suicide death trends during the COVID-19 in the general population of Catalonia, Spain' [European Neuropsychopharmacology 56 (2021) 4-12].

Pérez V, Elices M, Vilagut G, Vieta E, Blanch J, Laborda-Serrano E, Prat B, Colom F, Palao D, Alonso J

Eur Neuropsychopharmacol. 2022 Nov 30;66:66

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Implementing re-configurable biological computation with distributed multicellular consortia.

Canadell D, Ortiz-Vaquerizas N, Mogas-Diez S, de Nadal E, Macia J, Posas F

Nucleic Acids Res. 2022 Nov 28;50(21):12578-12595

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Are antihistamines still used during omalizumab treatment for chronic spontaneous urticaria?

Melé-Ninot G, Serra-Baldrich E, Spertino J, Guilarte M, Ribó González P, Lleonart-Bellfill R, Figueras-Nart I, Bonfill-Ortí M, Depreux N, Sala-Cunill A, Bielsa-Marsol I, Baliu-Piqué C, Sanmartín-Novell V, Garcia-Navarro X, Expósito-Serrano V, Garnica-Velandia D, Diaz-Sarrió MC, Gómez-Armayones S, Gich Saladich I, Giménez-Arnau A

Eur J Dermatol. 2022 Sep 1;32(5):629-631

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Mid- and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: A randomized, clinical trial.

Hernando-Redondo J, Toloba A, Benaiges D, Salas-Salvadó J, Martínez-Gonzalez MA, Corella D, Estruch R, Tinahones FJ, Ros E, Goday A, Castañer O, Fitó M

Front Nutr. 2022;9:950900

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Corrigendum: Reliability and validation of the child eating behavior questionnaire in 3- to 6-year-old Spanish children.

Jimeno-Martínez A, Maneschy I, Moreno LA, Bueno-Lozano G, De Miguel-Etayo P, Flores-Rojas K, Jurado-Castro JM, de Lamas C, Vázquez-Cobela R, Martinez-Lacruz R, Portoles O, Martínez JA, Navas-Carretero S, Schröder H, Fitó M, Babio N, Salas-Salvadó J, Leis R, Gil-Campos M, Rupérez AI

Front Psychol. 2022;13:1075681

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Experimental Validation of Transposable Element Insertions Using the Polymerase Chain Reaction (PCR).

Merenciano M, Coronado-Zamora M, González J

Methods Mol Biol. 2023;2607:95-114

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EUROVISCO Good Practice Recommendations for a First Viscosupplementation in Patients with Knee Osteoarthritis.

Conrozier T, Diraçoglù D, Monfort J, Chevalier X, Bard H, Baron D, Jerosch J, Migliore A, Richette P, Henrotin Y

Cartilage. 2022 Nov 28;:19476035221138958

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A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.

Fernandez-Jimenez N, Fore R, Cilleros-Portet A, ... , Vrijheid M, Marsit CJ, Karagas MR, Räikkönen K, Bouchard L, Heude B, Santa-Marina L, Bustamante M, Hivert MF, Bilbao JR

Commun Biol. 2022 Nov 30;5(1):1313

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The European baseline series and recommended additions: 2023.

Wilkinson SM, Gonçalo M, Aerts O, Badulici S, Dickel H, Gallo R, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Hervella M, Isaksson M, Johansen JD, Mahler V, Niklasson B, Pigatto P, Ponyai G, Rustemeyer T, Schuttelaar MLA, Spiewak R, Stingeni L, Thyssen JP, Uter W

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Nucleic Acids Res. 2023 Jan 6;51(D1):D942-D949

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The genomic analysis of current-day North African populations reveals the existence of trans-Saharan migrations with different origins and dates.

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Ligelizumab improves angioedema, disease severity and quality-of-life in patients with chronic spontaneous urticaria.

Metz M, Bernstein JA, Giménez-Arnau AM, Hide M, Maurer M, Sitz K, Soong W, Sussman G, Hua E, Barve A, Barbier N, Balp MM, Severin T

World Allergy Organ J. 2022 Nov;15(11):100716

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3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.

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Cell Syst. 2022 Dec 21;13(12):1033-1047.e7

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Scaling up complexity in synthetic developmental biology.

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POSITION PAPER OF THE CATALAN SOCIETY OF GASTROENTEROLOGY ABOUT HEPATIC ELASTOGRAPHY 2022.

Carrión JA, Graupera I, Vergara M, Morillas RM, Pericàs JM, Poca M, Amador A, Fernández R, Monllor T, Muñoz L, Bartres MC, Genescà J, Ginés P, Forns X

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Correction: Impulsivity is longitudinally associated with healthy and unhealthy dietary patterns in individuals with overweight or obesity and metabolic syndrome within the framework of the PREDIMED-Plus trial.

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Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome.

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Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app.

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TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages.

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Neuron. 2022 Nov 18;

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Contact Urticaria Syndrome: a Comprehensive Review.

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Musculoskeletal Ultrasound Shows Muscle Mass Changes during Post-Acute Care Hospitalization in Older Men: A Prospective Cohort Study.

Meza-Valderrama D, Marco E, Muñoz-Redondo E, Morgado-Pérez A, Sánchez MT, Curbelo Peña Y, De Jaime E, Canchucaja L, Meza Concepción F, Perkisas S, Sánchez-Rodríguez D

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Meat Intake, Cooking Methods, Doneness Preferences and Risk of Gastric Adenocarcinoma in the MCC-Spain Study.

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Nutrients. 2022 Nov 16;14(22)

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Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders.

Wedemeyer H, Di Marco V, Garcia-Retortillo M, Teti E, Fraser C, Morano Amado LE, Rodriguez-Tajes S, Acosta-López S, O'Loan J, Milella M, Buti M, Guerra-Veloz MF, Ramji A, Fenech M, Martins A, Borgia SM, Vanstraelen K, Mertens M, Hernández C, Ntalla I, Ramroth H, Milligan S

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Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study.

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J Clin Med. 2022 Nov 10;11(22)

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Recommendations for the diagnosis and treatment of hypoglycaemia after bariatric surgery.

Vilarrasa N, Bretón I, Ballesteros-Pomar M, Lecube A, Goday A, Pellitero S, Sánchez R, Zugasti A, Ciudin A, de Hollanda A, Rubio MA, GOSEEN (Grupo de Obesidad de la Sociedad Española de Endocrinología y Nutrición)

Endocrinol Diabetes Nutr (Engl Ed). 2022 Nov;69(9):723-731

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Current situation of shared decision making in osteoporosis: A comprehensive literature review of patient decision aids and decision drivers.

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Health Sci Rep. 2022 Nov;5(6):e849

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Real-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities.

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Clin Transl Allergy. 2022 Nov;12(11):e12208

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Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.

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Drug-induced ultraviolet B photosensitivity due to hydroxychloroquine: the unexpected side effect.

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Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature.

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SEGCOND predicts putative transcriptional condensate-associated genomic regions by integrating multi-omics data.

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Bioinformatics. 2023 Jan 1;39(1)

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Sensitization to isothiazolinones in the spanish contact dermatitis registry (reidac): 2019-2021 epidemiological situation.

Hernández Fernández CP, Borrego L, Mercader García P, Giménez Arnau AM, Sánchez Pérez J, Silvestre Salvador JF, González Pérez R, Sanz Sánchez T, Sánchez Gilo A, Melé Ninot G, Zaragoza Ninet V, Miquel Miquel FJ, Carrascosa Carrillo JM, Córdoba Guijarro S, Gatica Ortega ME, Ruiz González I, Serra Baldrich E, Tous Romero F, Rodríguez Serna M, Pastor Nieto MA, Pérez Feal P, Hervella Garcés M, de Vega Martínez M, García Doval I

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ASO Author Reflections: Superior Mesenteric Artery Dissection for Minimally Invasive Pancreaticoduodenectomy: A Technique That All Surgeons Should be Familiar With.

Ielpo B, Anselmo A, Masuda Y, Xuan MYH, Burdio F, De Blasi V, Sanchez-Velazquez P, Giuliani A, Azagra JS, Viola GM, Podda M, Pellino G, Rosso E

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Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope.

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Commun Biol. 2022 Nov 18;5(1):1265

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Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development.

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Stem Cells Transl Med. 2022 Nov 18;11(11):1123-1134

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Parallel evolution of amphioxus and vertebrate small-scale gene duplications.

Brasó-Vives M, Marlétaz F, Echchiki A, Mantica F, Acemel RD, Gómez-Skarmeta JL, Hartasánchez DA, Le Targa L, Pontarotti P, Tena JJ, Maeso I, Escriva H, Irimia M, Robinson-Rechavi M

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An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation.

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Changes in Population Health-Related Behaviors During a COVID-19 Surge: A Natural Experiment.

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Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis.

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Treatment of hypertriglyceridaemia with icosapent ethyl in patients with high/very high cardiovascular risk. Consensus document of the Sociedad Española de Cardiología [Spanish Society of Cardiology] and the Sociedad Española de Diabetes [Spanish Diabetes Society].

Pedro-Botet J, Barrios V, Sánchez-Margalet V, Tamargo J, Arrieta F, Gámez JM, Gimeno-Orna JA, Escobar C, Gómez-Doblas JJ, Pérez A, Working Groups of Cardiovascular Pharmacotherapy of the Sociedad Española de Cardiología and Cardiovascular Disease of the Sociedad Española de Diabetes

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Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington's disease.

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Sci Rep. 2022 Nov 16;12(1):19642

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Safety and tolerability of a 90-minute rapid infusion of Sandoz biosimilar rituximab in B-cell lymphoproliferative disorders in a real-world setting.

Muntañola A, Arguiñano-Pérez JM, Dávila J, de Villambrosia SG, Carpio C, Jiménez-Ubieto A, Salar A, GELTAMO (Grupo español de linfomas y trasplante de médula ósea)

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DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium.

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A cultural evolutionary theory that explains both gradual and punctuated change.

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Validation of the Spanish Activity Questionnaire in COPD (SAQ-COPD) in Patients with Chronic Obstructive Pulmonary Disease.

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IgTreeZ, A Toolkit for Immunoglobulin Gene Lineage Tree-Based Analysis, Reveals CDR3s Are Crucial for Selection Analysis.

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Relationship between estimated desaturase enzyme activity and metabolic syndrome in a longitudinal study.

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Responding to the need of postgraduate education for Planetary Health: Development of an online Master's Degree.

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Cutaneous Lymphangitis Carcinomatosa: Dermoscopic and Reflectance Confocal Microscopy Features.

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Indian J Dermatol. 2022 May-Jun;67(3):316

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Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer.

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A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase.

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Sci Rep. 2022 Nov 14;12(1):19501

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Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia.

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The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study.

Erber AC, Wagner A, Karachaliou M, Jeleff M, Kalafatis P, Kogevinas M, Pep?o?ska B, Santonja I, Schernhammer E, Stockinger H, Straif K, Wiedermann U, Waldhör T, Papantoniou K

J Biol Rhythms. 2023 Feb;38(1):98-108

http://www.ncbi.nlm.nih.gov/en...

Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation.

Serra-Camprubí Q, Verdaguer H, Oliveros W, Lupión-Garcia N, Llop-Guevara A, Molina C, Vila-Casadesús M, Turpin A, Neuzillet C, Frigola J, Querol J, Yáñez-Bartolomé M, Castet F, Fabregat-Franco C, Escudero-Iriarte C, Escorihuela M, Arenas EJ, Bernadó-Morales C, Haro N, Giles FJ, Pozo ÓJ, Miquel JM, Nuciforo PG, Vivancos A, Melé M, Serra V, Arribas J, Tabernero J, Peiró S, Macarulla T, Tian TV

Clin Cancer Res. 2023 Jan 17;29(2):432-445

http://www.ncbi.nlm.nih.gov/en...

Minimally invasive pancreatic anastomosis after pancreaticoduodenectomy: multi-institutional step by step video description of the technique.

Ielpo B, Anselmo A, Koh Y, Burdio F, De Blasi V, Sanchez-Velazquez P, Azagra JS, Huscher C, Giuliani A, Pellino G, Rosso E

Updates Surg. 2023 Jan;75(1):255-259

http://www.ncbi.nlm.nih.gov/en...

Mediterranean Diet, Energy Restriction, Physical Activity and Atherogenicity of Very-Low Density Lipoproteins: Findings from Two Randomized Controlled Trials.

Pérez-Vega KA, Castañer O, Sanllorente A, Lassale C, Ros E, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez ÁM, Serra-Majem L, Razquin C, Fiol M, Lapetra J, Gómez-Gracia E, Tinahones FJ, Hernáez Á, Fitó M

Mol Nutr Food Res. 2023 Jan;67(1):e2200338

http://www.ncbi.nlm.nih.gov/en...

Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis: A Nation-Wide cohort study.

Ródenas-Quiñonero I, Chen-Liang T, Martín-Santos T, Salar A, Fernández-González M, Celades C, Navarro JT, Martínez-Garcia AB, Andreu R, Balaguer A, Martin García-Sancho A, Baile M, López-Jiménez J, Marquet-Palomanes J, Teruel AI, Terol MJ, Benet C, Frutos L, Navarro JL, Uña J, Suarez M, Cortes M, Contreras J, Ruiz C, Tamayo P, Mucientes J, Sopena-Novales P, Reguilón-Gallego L, Sánchez-Blanco JJ, Pérez-Ceballos E, Jerez A, Ortuño FJ

Cancer Med. 2022 Nov 13;

http://www.ncbi.nlm.nih.gov/en...

Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays.

Ashton NJ, Puig-Pijoan A, Milà-Alomà M, Fernández-Lebrero A, García-Escobar G, González-Ortiz F, Kac PR, Brum WS, Benedet AL, Lantero-Rodriguez J, Day TA, Vanbrabant J, Stoops E, Vanmechelen E, Triana-Baltzer G, Moughadam S, Kolb H, Ortiz-Romero P, Karikari TK, Minguillon C, Hernández Sánchez JJ, Navalpotro-Gómez I, Grau-Rivera O, María Manero R, Puente-Periz V, de la Torre R, Roquer J, Dage JL, Zetterberg H, Blennow K, Suárez-Calvet M

Alzheimers Dement. 2022 Nov 12;

http://www.ncbi.nlm.nih.gov/en...

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.

Boix O, Martinez M, Vidal S, Giménez-Alejandre M, Palenzuela L, Lorenzo-Sanz L, Quevedo L, Moscoso O, Ruiz-Orera J, Ximénez-Embún P, Ciriaco N, Nuciforo P, Stephan-Otto Attolini C, Albà MM, Muñoz J, Tian TV, Varela I, Vivancos A, Ramón Y Cajal S, Muñoz P, Rivas C, Abad M

Nat Commun. 2022 Nov 11;13(1):6840

http://www.ncbi.nlm.nih.gov/en...

Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients.

Pujol J, Blanco-Hinojo L, Doreste A, Ojeda F, Martínez-Vilavella G, Pérez-Sola V, Deus J, Monfort J

Arthritis Res Ther. 2022 Nov 11;24(1):252

http://www.ncbi.nlm.nih.gov/en...

The long-term risk of endoleak-related-complications may be falsely elevated according to a competing risk analysis.

Clara A, Romero-Montaña L, Mellado M, Casajuana E, Elosua R, Subirana I

Eur J Vasc Endovasc Surg. 2022 Nov 8;

http://www.ncbi.nlm.nih.gov/en...

Population Genetics of the European Roma-A Review.

Ena GF, Aizpurua-Iraola J, Font-Porterias N, Calafell F, Comas D

Genes (Basel). 2022 Nov 8;13(11)

http://www.ncbi.nlm.nih.gov/en...

Childhood exposure to non-persistent pesticides and pubertal development in Spanish girls and boys: Evidence from the INMA (Environment and Childhood) cohort.

Castiello F, Suárez B, Beneito A, Lopez-Espinosa MJ, Santa-Marina L, Lertxundi A, Tardón A, Riaño-Galán I, Casas M, Vrijheid M, Olea N, Fernández MF, Freire C

Environ Pollut. 2022 Nov 7;316(Pt 2):120571

http://www.ncbi.nlm.nih.gov/en...

Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats.

Ramos-Romero S, Ponomarenko J, Amézqueta S, Hereu M, Miralles-Pérez B, Romeu M, Méndez L, Medina I, Torres JL

Nutrients. 2022 Nov 3;14(21)

http://www.ncbi.nlm.nih.gov/en...

Role of SALL4 in HER2+ Breast Cancer Progression: Regulating PI3K/AKT Pathway.

Pattanayak B, Lameirinhas A, Torres-Ruiz S, Burgués O, Rovira A, Martínez MT, Tapia M, Zazo S, Albanell J, Rojo F, Bermejo B, Eroles P

Int J Mol Sci. 2022 Oct 31;23(21)

http://www.ncbi.nlm.nih.gov/en...

Comparative Analysis of Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum B-Lactamase-Producing Klebsiella pneumoniae.

Sendra E, López Montesinos I, Rodriguez-Alarcón A, Du J, Siverio-Parés A, Arenas-Miras M, Cañas-Ruano E, Prim N, Durán-Jordà X, Blasco-Hernando F, García-Alzorriz E, Cots F, Ferrández O, Gómez-Zorrilla S

Antibiotics (Basel). 2022 Oct 29;11(11)

http://www.ncbi.nlm.nih.gov/en...

Editorial overview: Understanding the biology of cancer genomes in the context of DNA, RNA, histone marks, and 3D chromatin organization.

Di Croce L, Skok J

Curr Opin Genet Dev. 2022 Oct 26;77:102001

http://www.ncbi.nlm.nih.gov/en...

Effectiveness and Cost-Effectiveness of Case Management in Advanced Heart Failure Patients Attended in Primary Care: A Systematic Review and Meta-Analysis.

Checa C, Canelo-Aybar C, Suclupe S, Ginesta-López D, Berenguera A, Castells X, Brotons C, Posso M

Int J Environ Res Public Health. 2022 Oct 24;19(21)

http://www.ncbi.nlm.nih.gov/en...

Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa: In Vivo and In Vitro Evidence.

Lopez-Montesinos I, Montero MM, Domene-Ochoa S, López-Causapé C, Echeverria D, Sorlí L, Campillo N, Luque S, Padilla E, Prim N, Grau S, Oliver A, Horcajada JP

Antibiotics (Basel). 2022 Oct 22;11(11)

http://www.ncbi.nlm.nih.gov/en...

MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles.

Laguillo-Diego A, Kiewisz R, Martí-Gómez C, Baum D, Müller-Reichert T, Vernos I

Mol Biol Cell. 2023 Jan 1;34(1):ar1

http://www.ncbi.nlm.nih.gov/en...

Moderate sedation with dexmedetomidine-remifentanil is safer than deep sedation with propofol-remifentanil for endobronchial ultrasound while providing comparable quality: A randomized double-blind trial.

Bermejo S, Covas B, Silva-Costa-Gomes T, Sánchez-Font A, Curull V, Pérez-Ramos À, Mases A, Gallart L

Expert Rev Respir Med. 2022 Nov-Dec;16(11-12):1237-1245

http://www.ncbi.nlm.nih.gov/en...

Patient-centered care in Coronary Heart Disease: what do you want to measure? A systematic review of reviews on patient-reported outcome measures.

Pardo Y, Garin O, Oriol C, Zamora V, Ribera A, Ferrer M

Qual Life Res. 2022 Nov 9;

http://www.ncbi.nlm.nih.gov/en...

Comparison of two radiofrequency-based hemostatic devices: saline-linked bipolar vs. cooled-electrode monopolar.

Moll X, Fondevila D, García-Arnas F, Burdio F, Trujillo M, Irastorza RM, Berjano E, Andaluz A

Int J Hyperthermia. 2022;39(1):1397-1407

http://www.ncbi.nlm.nih.gov/en...

Mental health inequalities in times of crisis: evolution between 2005 and 2021 among the Spanish salaried population.

Esteve-Matalí L, Llorens-Serrano C, Alonso J, Vilagut G, Moncada S, Navarro-Giné A

J Epidemiol Community Health. 2022 Nov 7;

http://www.ncbi.nlm.nih.gov/en...

Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study.

Rodríguez-Fernández B, Vilor-Tejedor N, Arenaza-Urquijo EM, Sánchez-Benavides G, Suárez-Calvet M, Operto G, Minguillón C, Fauria K, Kollmorgen G, Suridjan I, de Moura MC, Piñeyro D, Esteller M, Blennow K, Zetterberg H, De Vivo I, Molinuevo JL, Navarro A, Gispert JD, Sala-Vila A, Crous-Bou M, ALFA study.

Alzheimers Res Ther. 2022 Nov 7;14(1):167

http://www.ncbi.nlm.nih.gov/en...

Museomics.

Lalueza-Fox C

Curr Biol. 2022 Nov 7;32(21):R1214-R1215

http://www.ncbi.nlm.nih.gov/en...

Endocrine resistance and breast cancer plasticity are controlled by CoREST.

Garcia-Martinez L, Adams AM, Chan HL, Nakata Y, Weich N, Stransky S, Zhang Z, Alshalalfa M, Sarria L, Mahal BA, Kesmodel SB, Celià-Terrassa T, Liu Z, Minucci S, Bilbao D, Sidoli S, Verdun RE, Morey L

Nat Struct Mol Biol. 2022 Nov;29(11):1122-1135

http://www.ncbi.nlm.nih.gov/en...

Migratory behavior is positively associated with genetic diversity in butterflies.

García-Berro A, Talla V, Vila R, Wai HK, Shipilina D, Chan KG, Pierce NE, Backström N, Talavera G

Mol Ecol. 2023 Feb;32(3):560-574

http://www.ncbi.nlm.nih.gov/en...

Cross-sectional and longitudinal association of sleep and Alzheimer biomarkers in cognitively unimpaired adults.

Blackman J, Stankeviciute L, Arenaza-Urquijo EM, Suárez-Calvet M, Sánchez-Benavides G, Vilor-Tejedor N, Iranzo A, Molinuevo JL, Gispert JD, Coulthard E, Grau-Rivera O, European Prevention of Alzheimer’s Disease (EPAD) Consortium.

Brain Commun. 2022;4(6):fcac257

http://www.ncbi.nlm.nih.gov/en...


Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:


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Innovation

Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar

→ https://www.imim.es/en_dareaestrategica.html

UPF Business Shuttle and Innovation Unit

→ www.upf.edu/web/innovacio

Technology and Business Development Office at the CRG

→ https://tbdo.crg.eu

Analysis and Global Development at ISGlobal

→ www.isglobal.org/es/policy-and-development

EMBLEM Technology Transfer

→ https://embl-em.de

  • The following start-ups have been created within the PRBB environment:

Acellera

Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.

→ https://www.acellera.com

Chemotargets

Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.

→ http://www.chemotargets.com/

qGenomics

qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.

→ https://qgenomics.com

ZeClinics

ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.

→ http://www.zeclinics.com

Microomics

Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.

→ http://www.microomics.eu

Flomics

World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.

→ http://www.flomics.com

Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.

→ https://www.bioinspiredmaterials.com/

MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.

→ https://www.medbioinformatics.com/

Pulmobiotics

A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.

→ https://www.pulmobio.com/

Integra Therapeutics

Integra Therapeutics, a spin-off company from MELIS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.

→ https://integra-tx.com/

Latest news